90 min内和3 min内静脉滴注蔗糖铁疗法所引起的促红细胞生成素依赖患儿不良事件的发生率均不高

查看全文 作　　者：Anbu A.T.;Kemp T.;O'Donnell K.;M.G. [1]Bradbury;张振 机构地区：[1]Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Hospital Road, Pendlebury, Manchester, M27 4HA, United Kingdom 出　　处：《世界核心医学期刊文摘(儿科学分册)》索引2006年第2卷第6期,共2页 摘　　要：Aim: To define the adverse events following two different rates and methods of intravenous iron sucrose infusions in children with anaemia due to chronic renal impairment. Methods: Two prospective observational studies were undertaken to characterize the adverse events following iron sucrose administration in children with renal impairment and on erythropoietin. Between January 1999 and April 2003, 5 mgkg of intravenous (IV) iron sucrose was given over 90 min and repeated 24 h later. Between May 2003 and September 2004, in children with better venous access, a single dose of 2 mgkg of IV iron sucrose was administered over 3 min during an outpatient clinic visit and haemodialysis sessions. Following infusions, children were monitored for immediate and delayed adverse events. All such events were documented and dealt with appropriately. Test doses were not used. Results: A total of 870 infusions over 90 min were administered to 72 children. Three children developed abdominal pain. One child developed worsening of hypertension (not related to iron sucrose). Sixty-five doses were administered over 3 min to 20 children, and six minor adverse events were documented. Conclusion: Although 90 min infusion is associated with fewer adverse events, no lifethreatening events were documented in either method. 关 键 词：静脉滴注疗法 促红细胞生成素 蔗糖铁 发生率 患儿 慢性肾功能障碍 注射速率 给药方式 非住院患者 试验对象