Design and Synthesis of Pyrido[1,2-e]purin-4(3H)-one Derivatives as Potential PDE 5 Inhibitors

查看全文 作　　者：Guang Xin [1,3]XIA;Jian Feng [1,3]LI;Shun An [2]LAI;Ai Ming [2]PENG;Shu Jun [1]ZHANG;Xiao Hui [1]WEI;Xin Jian [1]CHEN;Jing Shan [1]SHEN;Ru Yun [1]JI

机构地区：[1]Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203;[2]Topharman Shanghai Co., Ltd, Shanghai 201209;[3]Graduate School of the Chinese Academy of Sciences, Beijing 100039

出　　处：《Chinese Chemical Letters》索引2005年第16卷第10期,共4页

摘　　要：A novel series of pyrido[1,2-e]purin-4(3H)-one derivatives containing polar substituents on 5’-position were designed and prepared as potential PDE5 inhibitors. This paper reports the synthetic routes, 1H-NMR data, and the PDE5 inhibitory activities of the target compounds. The polar piperazinyl group contained (on 5’-position) compound, 3B2, showed the highest activity among the tested derivatives but less potency than sildenafil 1. 关键词：嘌呤衍生物抑制剂磷酸二酯酶合成方法

相关文献

参考文献（13）
引证文献（1）
耦合文献（0）

参考文献(13)

引证文献(1)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Design and Synthesis of Pyrido[1,2-e]purin-4(3H)-one Derivatives as Potential PDE 5 Inhibitors

参考文献(13)

引证文献(1)

用户提示