Effect of Dermal Exposure to Paraphenylenediamine and Linear Alkylbenzene Sulphonate in Guinea Pigs

查看全文 作　　者：A. K. [1]MATHUR;R. B. [1]RAIZADA;M. K. [1]SRIVASTAVA;A. [1]SINGH

机构地区：[1]Industrial Toxicology Research Centre, P. B. No. 80, Mahatma Gandhi Marg, Lucknow-226001 (U. P.), India,Industrial Toxicology Research Centre, P. B. No. 80, Mahatma Gandhi Marg, Lucknow-226001 (U. P.), India,Industrial Toxicology Research Centre, P. B. No. 80, Mahatma Gandhi Marg, Lucknow-226001 (U. P.), India,Industrial Toxicology Research Centre, P. B. No. 80, Mahatma Gandhi Marg, Lucknow-226001 (U. P.), India

出　　处：《Biomedical and Environmental Sciences》索引2005年第18卷第4期,共3页

摘　　要：Objective To study the effects of paraphenylenediamine (PPD) and linear alkylbenzene sulphonate (LAS) alone and in combination on the skin. Methods Forty-eight guinea pigs were divided equally into 4 groups and exposed to PPD (4 mg/kg), LAS (12 mg/kg) and PPD (4 mg/kg) plus LAS (12 mg/kg) for 30 days. The biochemical parameters such as acid phosphatase, gtutathione-s-transferase, glutathione peroxidase, glutathione, lipid peroxidation and histamine contents in exposed skin were estimated. The histopathological examination of the exposed skin was also carried out. Results The skin enzymes, lipid peroxidation, and histamine increased while glutathione decreased in skin. The simultaneously exposed group showed additive toxic effects. The histopathological examination showed severe hyperkeratosis, thickening of collagen fibres and vacuolisation of epidermal cells in PPD plus LAS exposed skin. Conclusion The findings of the present study suggest that simultaneous exposure to PPD and LAS has additive toxic effects. 关键词：皮肤暴露表皮细胞线性烷基苯几内亚猪动物实验胶原质纤维角化过度

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Effect of Dermal Exposure to Paraphenylenediamine and Linear Alkylbenzene Sulphonate in Guinea Pigs

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