R-(+)-ABP a novel derivative of 3-n-butyl-phthalide possesses anti-convulsant and neuroprotective properties in rodents

查看全文 作　　者：[1]ELESTAGE;[1]A.ROGER;[1]L.DANOBER;[1]ERENARD;X-[2]Q.PENG;[2]Z.GUO;[2]J.T.ZHANG 机构地区：[1]Servier,125ChemindeRonde,78290Croissy/Seine,France;[2]BeijingInstituteofMateriaMedica,ChineseAcademyo~Medi-calSciences,Beijing100050,China 出　　处：《Acta Pharmacologica Sinica》索引2004年第25卷第11期,共1页 摘　　要：ABP is a novel phthalide derivative of 3-n-butyl-phthalide (NBP) synthesized at the Beijing Institute of Materia Medica.NBP was isolated from several plants including Apium graveolens Linn. The juice squeezed from fresh celery leaves has long been used in Southeastern China for the treatment of epilepsy, and NBP has been reported to possess anti-convulsant properties (Drugs Future 2000; 25: 16-23). The present 关 键 词：R-(+)-ABP 衍生物 3-n-丁基1-苯酞 反惊厥药 神经蛋白 啮齿动物 NBP