Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans

查看全文 作　　者：Dae Hee [1]Choi;Sung Joon [1]Lee;Chang Don [1]Kang;Myoung Ok [1]Park;Dong Wook [1]Choi;Tae Suk [1]Kim;Wonho [1]Lee;Byung Ryul [1]Cho;Yong Hoon [1]Kim;Bong-ki [1]Lee;Dong Ryeol [1]Ryu;Ji Won [2]Lee

机构地区：[1]Department of Internal Medicine,Kangwon National University School of Medicine;[2]Department of Radiology,Kangwon National University School of Medicine

出　　处：《World Journal of Gastroenterology》索引2013年第19卷第38期,共5页

基　　金：Supported by A 2009 Research Grant from Kangwon National University 摘　　要：AIM:To investigate whether nonalcoholic fatty liver disease(NAFLD)affects coronary artery disease(CAD)and identify candidate mediators.METHODS:Patients who underwent coronary angiography were consecutively recruited.The patients were classified into four groups by coronary artery stenosis:A,insignificant;B,one-vessel disease;C,two-vessel disease;and D,three-vessel disease.Abdominal ultrasonography was performed to determine the presence of a fatty liver and categorize by grade:0,no evidence;1,mild;2,moderate;and 3,severe.We measured not only known CAD risk factors,but also serum insulin,HOMA-index,adiponectin,interleukin-6,tumor necrosis factor-αand high-sensitivity C-reactive protein levels.RESULTS:Of the 134 patients who met the inclusion criteria,82(61.2%)had ultrasonographically diagnosed NAFLD.Among the 46 patients with CAD,37(80.4%)had evidence of a fatty liver.The two groups(A vs B-D)were significantly different in terms of age,total cholesterol,triglycerides,low-density lipoprotein levels and fatty liver.Coronary artery stenosis was strongly associated with fatty liver in a grade-dependent manner(P=0.025).In binary logistic regression,NAFLD was a significant independent predictor of CAD(P=0.03,OR=1.685;95%CI:1.051-2.702).Among the candidate mediators,the serum adiponectin level showed a trend toward lowering based on CAD progression(P=0.071).CONCLUSION:NAFLD is an independent risk factor for CAD in a grade-dependent manner.Moreover,adiponectin might be related to the pathogenesis of NAFLD. 关键词：NONALCOHOLIC fatty liver DISEASE CORONARY artery DISEASE CORONARY ANGIOGRAPHY ADIPONECTIN Insulin resistance

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Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans

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