Epidemiological studies of esophageal cancer in the era of genome-wide association studies

查看全文 作　　者：An-Hui [1]Wang;Yuan [2]Liu;Bo [1]Wang;Yi-Xuan [3]He;Ye-Xian [3]Fang;Yong-Ping [1]Yan

机构地区：[1]Department of Epidemiology, School of Public Health, Fourth Military Medical University;[2]Clinic of Xi’an Communication College;[3]Medical Student of Fourth Military Medical University

出　　处：《World Journal of Gastrointestinal Pathophysiology》索引2014年第5卷第3期,共9页

摘　　要：Esophageal cancer(EC) caused about 395000 deaths in 2010. China has the most cases of EC and EC is the fourth leading cause of cancer death in China. Esophageal squamous cell carcinoma(ESCC) is the predominant histologic type(90%-95%), while the incidence of esophageal adenocarcinoma(EAC) remains extremely low in China. Traditional epidemiological studies have revealed that environmental carcinogens are risk factors for EC. Molecular epidemiological studies revealed that susceptibility to EC is influenced by both environmental and genetic risk factors. Of all the risk factors for EC, some are associated with the risk of ESCC and others with the risk of EAC. However, the details and mechanisms of risk factors involved in the process for EC are unclear. The advanced methods and techniques used in human genome studies bring a great opportunity for researchers to explore and identify the details of those risk factors or susceptibility genes involved inthe process of EC. Human genome epidemiology is a new branch of epidemiology, which leads the epidemiology study from the molecular epidemiology era to the era of genome wide association studies(GWAS). Here we review the epidemiological studies of EC(especially ESCC) in the era of GWAS, and provide an overview of the general risk factors and those genomic variants(genes, SNPs, miRNAs, proteins) involved in the process of ESCC. 关键词：ESOPHAGEAL cancer EPIDEMIOLOGY GENOME wide association study Single NUCLEOTIDE POLYMORPHISM MicroRNA

相关文献

参考文献（11）
引证文献（15）
耦合文献（14）

参考文献(11)

引证文献(15)

耦合文献(14)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Epidemiological studies of esophageal cancer in the era of genome-wide association studies

参考文献(11)

引证文献(15)

耦合文献(14)

用户提示