Syntheses of haptens and hapten-protein conjugates for insecticide propoxur and cyhalothrin

查看全文 作　　者：Sang, [1,2]GuangMing; Luo, [1,2]ShiNeng; Lin, [1]JianGuo; Qiu, [1]Ling; Chen, [2]ChuanQing; Yang, [3]HaiLin; Xia, [2]YongMei

机构地区：[1] Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China; [2] School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China; [3] Key Laboratory of Industrial Biotechnology, Jiangnan University, Wuxi 214122, China

出　　处：《Science China Chemistry》索引2010年第53卷第5期,共6页

基　　金：supported by the National High Technology Research and Development Program of China(2006AA10Z449);the National Natural Science Foundation of China(20801024);Wu Jieping Medical Foundation(32067500615) 摘　　要：A facile procedure was described for the hapten design of the N-methylcarbamate insecticide propoxur.Two new haptens of propoxur(hapten 1a and hapten 1b) were synthesized by introducing appropriate spacers in the pesticide aromatic moiety of the analyte molecular structure.First,the propoxur reacted with nitric acid to yield the intermediate product.Then hapten 1a was prepared via the reduction of the intermediate product,and hapten 1b was formed by the acylation of hapten 1a with succinic anhydride.In addition,we have also developed a simple method to prepare hapten 2 for the pyrethroid insecticide cyhalothrin,which only requires two steps including the reactions of nitration and reduction.Three haptens were coupled to carrier proteins to prepare the corresponding artificial antigens.The molecular structures of these three haptens were identified by 1H NMR and MS,and those of the artificial antigens were confirmed by UV-vis. 关键词：HAPTEN design INSECTICIDE synthesis artificial antigen

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Syntheses of haptens and hapten-protein conjugates for insecticide propoxur and cyhalothrin

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