Role of nonsteroidal anti-inflammatory drugs in the prevention of post-ERCP pancreatitis:a meta-analysis

查看全文 作　　者：Dai, Hui-[2]Fen;Wang, Xiao-[3]Wen;Zhao, [1]Kui

机构地区：[1]Zhejiang Univ, Sch Med, Affiliated Hosp 1, PET Ctr, Hangzhou 310003, Zhejiang, Peoples R China;[2]Zhejiang Univ, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China;[3]Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Tradit Chinese Med, Hangzhou 310009, Zhejiang, Peoples R China;

出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2009年第8卷第1期,共6页

摘　　要：BACKGROUND:The role of prophylactic nonsteroidal anti- inflammatory drugs(NSAIDs)for reduction of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP)is debated.We performed a meta-analysis of all published randomized controlled trials to evaluate the efficacy of NSAIDs in the prevention of post-ERCP pancreatitis. DATA SOURCES:Searches were conducted in the databases PubMed,EMBASE and the Cochrane Library. Six randomized clinical trials that fulfilled the inclusion criteria and addressed the clinical questions of this analysis were further assessed.Data were extracted by two independent observers according to predetermined criteria. RESULTS:The risk of pancreatitis was lower in the NSAID group than in the placebo group(OR:0.46,95%CI:0.32 to 0.65,P<0.0001).Two hours after ERCP,prophylactic administration of NSAIDs was associated with a lower serum amylase level(WMD:-91.09,95%CI:-149.78 to-32.40, P=0.002),but there was no difference in mean 24-hour serum amylase values(WMD:-379.00,95%CI:-805.75 to 47.76,P=0.08).No deaths or NSAID-related complications were noted. CONCLUSIONS:Prophylactic administration of NSAIDs can reduce the incidence of post-ERCP pancreatitis; this administration in patients undergoing ERCP is recommended.Further randomized controlled trials are required before its introduction into routine care. 关键词：META-ANALYSIS NONSTEROIDAL ANTI-INFLAMMATORY drugs endoscopic RETROGRADE CHOLANGIOPANCREATOGRAPHY PANCREATITIS

相关文献

参考文献（22）
引证文献（38）
耦合文献（6）

参考文献(22)

引证文献(38)

耦合文献(6)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Role of nonsteroidal anti-inflammatory drugs in the prevention of post-ERCP pancreatitis:a meta-analysis

参考文献(22)

引证文献(38)

耦合文献(6)

用户提示