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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | CYP2D6的多态性与文拉法辛的临床效应显示文摘 | Shams ME Arneth B Hiemke C 王小艳 | 2006 | 中国处方药2006，5，10： | 12 |
| 3 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 4 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 5 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 6 | Trends in incidence and management of cancer of the ampulla of Vater显示文摘AIM:To provide trends in incidence,management and survival of cancer of the ampulla of Vater in a welldefined French population.METHODS:Data were obtained from the populationbased digestive cancer registry of Burgundy over a34-year period.Age-standardized incidence rates were computed using the world standard population.Average annual variations in incidence rates were estimated using a poisson regression.A univariate and multivariate relative survival analysis was performed.RESULTS:Age-standardized incidence rates were0.46 and 0.30 per 100000 inhabitants for men and women,respectively.Incidence rate increased from0.26(1976-1984)to 0.58(2003-2009)for men and remained stable for women.Resection for cure was performed in 48.3%of cases.This proportion was stable over the study period.Among cases with curative resection,pancreatico-duodenectomy was performed in94.0%of cases and ampullectomy in 6.0%of cases.A total of 50.8%of cancers of the ampulla of Vater were diagnosed at an advanced stage.Their proportion remained stable throughout the study period.The overall1-and 5-year relative survival rates were 60.2%and27.7%,respectively.Relative survival did not vary over time.Treatment and stage at diagnosis were the most important determinants of survival.The 5-year relative survival rate was 41.5%after resection for cure,9.5%after palliative surgery and 6.7%after symptomatic treatment.In multivariate analysis,only stage at diagnosis significantly influenced the risk of death.CONCLUSION:Cancer of the ampulla of Vater is still uncommon,but its incidence increased for men in Burgundy.Diagnosis is often made at an advanced stage,dramatically worsening the prognosis. | Florian Rostain Samia Hamza Antoine Drouillard Jean Faivre Anne-Marie Bouvier C?me Lepage | 2014 | World Journal of Gastroenterology2014，20，29： | 5 |
| 7 | 平均动脉压、脉压与全因死亡率的纵向变化:来自71629名未经治疗的正常高值血压参与者的数据显示文摘血压通常包括平稳成分[平均动脉压(mean arterial pressure,MAP)]和波动成分,都可独立预测死亡率。目前还没有针对中心脉压(central pulse pressure,cPP)、肱动脉脉压(brachial pulse pressure,bPP)、MAP的纵向变化与死亡率之间关系的调查。方法:对年龄16~95岁未接受高血压治疗的71 629例参与者进行2次常规检查. | Protogerou AD Vlachopoulos C Thomas F Zhang Y Pannier B Blacher J Safar ME 陈云 | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 8 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 9 | 输尿管及膀胱深部浸润型子宫内膜异位症的手术治疗效果显示文摘目的报告泌尿道子宫内膜异位症的手术治疗效果以及探讨保守型手术和根治性手术的选择。方法对5个手术科室参与的输尿管或膀胱深部浸润型子宫内膜异位症外科治疗的CIRENDO前瞻性数据库管理数据进行回顾性研究。对术前、术中和术后数据结果进行分析。结果数据库中的数据显示,30例中有15例为输尿管子宫内膜异位症,14例为膀胱结节病变(bladder nodules),1例同时存在这2种类型的病变。输尿管松解术14例,其中输尿管完全恢复解剖解构10例。4例40岁以上的患者术后出现闭经和可忍受的中度输尿管狭窄,其中3例好转,1例行二次输尿管切除和输尿管膀胱吻合术。4例初次手术行输尿管切除术。5例输尿管标本中发现2例输尿管子宫内膜异位症。4例并发症中有2例与输尿管结节病灶切除有关,2例与膀胱子宫内膜异位病灶切除有关。远期效果较为满意,如疼痛症状显著改善、泌尿系不适症状消失,仅有1例较长时间膀胱神经功能障碍。结论建议保守性手术联合术后假绝经疗法治疗大多数泌尿道子宫内膜异位症。尽管总体结果满意,由于术中可能同时施行其他一些复杂手术如结直肠手术,术后并发症的风险仍不容忽视。 | 陈旭 刘彦 Francisc Rozsnyai Horace Roman Benoit Resch Fabrice Dugardin Juan Berrocal Gérme Descargues Remi Schmied Malik Boukerrou Loc Marpeau CIRENDO Study Group | 2013 | 中国微创外科杂志2013，13，2： | 3 |
| 10 | Transcatheter Arterial Embolization of Splenic Artery Aneurysms and Pseudoaneurysms: Short- and Long-Term Results显示文摘 | Romaric Loffroy Boris Guiu Jean-Pierre Cercueil C?me Lepage Nicolas Cheynel Eric Steinmetz Frédéric Ricolfi Denis Krausé | 2008 | Annals of Vascular Surgery2008，，5： | 2 |
| 11 | Epidemiology and Management of Liver Metastases From Colorectal Cancer显示文摘 | Sylvain Manfredi C?me Lepage Cyril Hatem Olivier Coatmeur Jean Faivre Anne-Marie Bouvier | 2006 | Annals of Surgery2006，，2： | 2 |
| 12 | VEGF-D promotes spread of tumor cells via the lymphatic显示文摘 | Stacker SA Caesar C Baldwin ME | 2004 | Nat Med2004，7，2： | 1 |
| 13 | Use of a free radical method to evaluate antioxidant activity显示文摘 | Brand-Williams W Cuvelier ME Berset C | 1995 | Technology1995，28，1： | 1 |
| 14 | Primary immunodeficiencies : 2009 update 显示文摘 | Chapel H Conley ME Cunningham -Rundles C | 2009 | Allergy Clin lmmunol2009，124，6： | 1 |
| 15 | Complementary recognition of actemative pathway activator by decay - accelerating factor and factor H 显示文摘 | Kraus D Medof ME Mold C | 1998 | Infect Immun1998，66，2： | 1 |
| 16 | Herbal supplement sales experience slight increase in 2008 显示文摘 | Cavaliere C Rea P Lynch ME | 2009 | Herbal Gram2009，82，： | 1 |
| 17 | Advancing bioluminescence imaging technology for the evaluation of anticancer agents in the MDA-MB-435-HAL-Luc mammary fat pad and subrenal capsule tumor models 显示文摘 | Zhang C Yan Z Arango ME | 2009 | Clin Cancer Res2009，15，1： | 1 |
| 18 | Dynamic susceptibility contrast perfusion MRI identifies persistent vessel pathology in acute pontine stroke 显示文摘 | Forster A Ottomeyer C Wolf ME | 2010 | Cerebrovasc Dis2010，29，4： | 1 |
| 19 | A comparison of single and combined visual, cytologic, and virologic tests as screening strategies in a region at high risk of cervical cancer显示文摘 | Ferreccio C Bratti MC Sherman ME | 2003 | Cancer Epidemiol Biomarkers Prev2003，12，9： | 1 |
| 20 | Helix-loop-helix proteins: regulators of transcription in eukaryotic organisms 显示文摘 | Massari ME Murre C | 2000 | Mol Cell Biol2000，20，2： | 1 |
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