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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Observed and simulated muhidecadal variability in the Northern Hemisphere显示文摘 | DELWORTH T L MANN M E | 2000 | Climate Dynamics2000，16，9： | 1 |
| 3 | Axin-mediated CKI phosphorylation of beta -catenin at Set 45:a molecular switch for the Wnt pathway显示文摘 | Amit S Hatzubai A Birman Y Andersen J S Ben Shushan E Mann M | 2002 | Genes Dev2002，16，： | 1 |
| 4 | Variable Zinc coordination in endostatin显示文摘 | Hohenester E Sasaki T Mann K | 2000 | J Mol Biol2000，297，1： | 1 |
| 5 | Climate over past millennia 显示文摘 | Jones P D Mann M E | 2004 | Rev Geophys2004，42，2002： | 1 |
| 6 | Global-Scale temperature patterns and climate forcing over the past six Centuries显示文摘 | Mann M E Bradley R S Hughes M K | 1998 | Nature1998，392，： | 1 |
| 7 | Alert system to detect possible school-based outbreaks of influenza-like illness 显示文摘 | MANN P OCONNELL E ZtfANG G | 2011 | Emerg Infect Dis2011，17，2： | 1 |
| 8 | MyD88-depen- dent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mime- tics显示文摘 | Davis CN Mann E Behrens MM | 2006 | Proc Natl Acad Sci U S A2006，103，8： | 1 |
| 9 | Degenerative marrow (modic) changes on cervical spine magnetic resonance imaging scans: preva- lence, inter- and intra-examiner reliability and linkto disc herniation 显示文摘 | Mann E Peterson CK Hodler J | 2011 | Spine (Phila Pa 1976)2011，36，： | 1 |
| 10 | Negative regulation of transforming growth factor-beta by the proteoglycan decorin显示文摘 | Yamaguchi Y Mann D M Ruoslahti E | 1990 | Nature1990，346，19： | 1 |
| 11 | European evidence based consensus on the diagnosis and management of Crohn's disease:current management显示文摘 | Travis SPL Stange E F Lémann M | 2006 | Gut2006，55，： | 1 |
| 12 | A five body--Three dimensional dynamic analysis of walking 显示文摘 | Hardt D E Mann R W | 1980 | Journal of Biomechanics1980，13，5： | 1 |
| 13 | Aberrant repair and fibrosis development in skeletal muscle显示文摘 | Mann CJ Perdiguero E Kharraz1 Y | | 0，，01： | 1 |
| 14 | The suppressive effect that myrioein has on hepatitis C virus RNA replica- tion is independent of inhibition of serine palmitoyl trans- ferase显示文摘 | Ciesek S Steinmann E Manns MP | 2008 | J Infect Dis2008，198，7： | 1 |
| 15 | Determining the most important criteria in maintenance decision making显示文摘 | TRIANTAPHYLLOU E KOVALERCHUK B MANN L | 1997 | Journal of Quality in Maintenance Engineering1997，3，1： | 1 |
| 16 | Status review of mercury control options for coal-fired power plants 显示文摘 | Pavlish J H Sondreal E A Mann M D | 2003 | Fuel Process Technol2003，82，： | 1 |
| 17 | 显示文摘 | Garcia J J Mann B E Adams H | 1995 | J Am Chem See1995，117，8： | 1 |
| 18 | Concentration of the phytoalex in resvertrol in wine 显示文摘 | SIE MANN E H CREASY L L | 1992 | Am Jenol Vitic1992，43，1： | 1 |
| 19 | A central role of salicylic acid in plant disease resistance显示文摘 | DELANEY T P UKNES S VERNOOIJ B FRIEDRICH L WER- MANN K NEGROTYO D GAFFNEY T GUT-RELLA M KESS- MANN H WARD E RYALS J | 1994 | Science1994，266，5188： | 1 |
| 20 | Experimental tests of the dependence of arthropod diversity on plant diversity 显示文摘 | Mann E Tilman D Haarstad J | 1998 | American Naturalist1998，152，5： | 1 |
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