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| 1 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 2 | Low temperature induced changes in activity and protein levels of the enzymes associated to conversion of starch to sucrose in banana fruit显示文摘 | Roberta Ghedini Der Agopian Fernanda Helena Gon?alves Peroni-Okita Claudinéia Aparecida Soares Janaína Aparecida Mainardi Jo?o Roberto Oliveira do Nascimento Beatriz Rosana Cordenunsi Franco Maria Lajolo Eduardo Purgatto | 2011 | Postharvest Biology and Technology2011，，2： | 2 |
| 3 | The influence of n -butanol/diesel fuel blends utilization on a small diesel engine performance and emissions显示文摘 | O?uzhan Do?an | 2011 | Fuel2011，，7： | 2 |
| 4 | Genetic varia bility of hepatitis B and C viruses in Brazilian patients with and without hepatocellular carcinoma显示文摘 | Araujo OC Barros JJ do O KM | 2014 | J Med Virol2014，86，2： | 1 |
| 5 | Vascular targeting of solid tumours: a major ' inverse' volume -response relationship following combretastatin A - 4 phosphate treatment of rat rhabdomyosarcomas显示文摘 | Landuyt W Yerdoes O Darius DO | 2000 | Eur J Cancer2000，36，： | 1 |
| 6 | QSulfl remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signling显示文摘 | Ai X Do AT Lozynska O | 2003 | J Cell Biol2003，162，2： | 1 |
| 7 | Identification of an Escherichia coli protein impurity in preparations of a recombinant pharmaceutical显示文摘 | O′keefe DO DePhillips P Will ML | 1993 | Pharmaceutical Research1993，10，7： | 1 |
| 8 | Nontrival solutions for a class of semilinear biharmonie problems involving critical exponents 显示文摘 | Alves C O Joao Marcos do O Miyagaki O H | 2001 | Nonlinear Analysis2001，46，： | 1 |
| 9 | Allogeneic versus autologous purged bone marrow transplantation for neuroblastoma: a report from the Children's Cancer Group显示文摘 | Matthay KK Seeger RC Reynolds CP Stram DO O'Leary MC Harris RE | 1994 | J Clin Oncol1994，12，11： | 1 |
| 10 | Soliton solutions for quasi- linear Schrodinger equations显示文摘 | Joao M Bezerra do O | | 0，，： | 1 |
| 11 | Cat-transmitted sporotrichosis epidemic in Rio de Janeiro, Brazil: description of a series of cases 显示文摘 | Barros MB Schubach Ade O do Valle AC | 2004 | Clin Infect Dis2004，38，4： | 1 |
| 12 | Phased-array intracardiac echocardiography monitoring during pulmonary vein isolation inpatients with atrial fibrillation: impact on outcome and complications 显示文摘 | Marrouche NF Martin DO Wazni O | 2003 | Circulation2003，107，21： | 1 |
| 13 | Zeolite--coated mesostructured cellular silica foams显示文摘 | Do T O Kaliaguine S | 2003 | JACS2003，125，3： | 1 |
| 14 | Randomized study comparing combined pulmonary vein-left atrial junction disconnection and cavotricuspid isthmus ablation versus pulmonary vein-left atrial junction disconnection alone in patients presenting with typical atrial flutter and atrial fibrillation显示文摘 | Wazni O Marrouche NF Martin DO | 2003 | Circulation2003，108，20： | 1 |
| 15 | Robust controller design for uncertain systems with time delays: LMI approach显示文摘 | EUN T J DO C O JONG H K | 1996 | Automatic1996，32，8： | 1 |
| 16 | Pollution by hexachlorobenzene and pentachlorophenol in the coastal plain of Sao Paulo state, Brazil 显示文摘 | do Nascimento N R Nicola S M C Rezende M 0 O | 2004 | Geoderma2004，121，34： | 1 |
| 17 | On the ontogeny and physiology of regulatory T cells显示文摘 | Annacker O Pimenta AR Burierr DO | 2001 | Immunol Rev2001，182，1： | 1 |
| 18 | Additional support for the association of SLITRK1 var321 and Tourette syndrome显示文摘 | O'Roak B J Morgan TM Fishman DO | 2010 | Mol Psychiatry2010，15，5： | 1 |
| 19 | Inhibition of β-amylase activity, starch degradation and sucrose formation by indole-3-acetic acid during banana ripening显示文摘 | Eduardo Purgatto Franco Maria Lajolo Jo?o Roberto Oliveira do Nascimento Beatriz Rosana Cordenunsi | 2001 | Planta (-)2001，，5： | 1 |
| 20 | Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition 显示文摘 | Doing B Shynlova O Tsui P | 2006 | J Cell Sci2006，119，9： | 1 |
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