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| 1 | Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome显示文摘AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions(stress management/relaxation therapy(cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome(IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching Pub Med, Embase, the Cochrane Library, CINAHL and Psyc INFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate(PRR) was computed for IBS symptom severity(primary outcome measure) as well as for anxiety, depression and quality of life(secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical interventions.CONCLUSION The PRR is probably determined to a larger extent by patient-related factors, such as expectations and desire for the treatment to be effective, than the content of the placebo intervention. | Carla E Flik Laura Bakker Wijnand Laan Yanda R van Rood André JPM Smout Niek J de Wit | 2017 | World Journal of Gastroenterology2017，23，12： | 7 |
| 2 | A new model for control of systems with friction 显示文摘 | CANUDAS DE WIT C OLSSON H ASTROM K J | 1995 | IEEE Transaction on Automatic Control1995，40，3： | 2 |
| 3 | A New Mod- el for Control of Systems with Friction显示文摘 | Canudas de Wit C Olsson H Astrom K J | 1995 | Automatic Control IEEE Transactions on1995，40，3： | 1 |
| 4 | Tackling Ebola: new in sights into prophylactic and therapeutic intervention strategies 显示文摘 | De Wit E Feldmann H Munster V J | 2011 | Genome &fed2011，3，1： | 1 |
| 5 | Inhibition of novel & coronavirus replica- tion by a combination of interferon-a2b and ribavirin 显示文摘 | Falzarano D de Wit E Martellaro C Callison J Munster VJ Feldmann H | 2013 | Sci Rep2013，3，： | 1 |
| 6 | Thermal stability and functionality of whey protein显示文摘 | DE J N WIT | 1990 | J Dairy Sci1990，73，： | 1 |
| 7 | Modified Range-Doppler Processing for FM-CW Synthetic Aperture Radar显示文摘 | De Wit J J M Meta A Hoogeboom P | 2006 | IEEE Geosci Remote Sensing Letters2006，3，1： | 1 |
| 8 | Identification of distinct specificity deternainants in resistance protein Cf-4 allows construction ofa Cf-9 mutant that confers recognition of avirulence protein Avr4 显示文摘 | van der Hoom R A Roth R and De Wit P J | 2001 | The Plant Cell2001，13，2： | 1 |
| 9 | Photolytic debromination of decabromodiphenyl ether (BDE-209)显示文摘 | Sö derströ m J Sellströ m U de Wit C A | 2004 | Environ Sci Technol2004，38，： | 1 |
| 10 | Growth of preterm born children显示文摘 | Euser AM de Wit CC Finken M J | | 0，，： | 1 |
| 11 | Antiemetic efficacy of the neurokinin-1antagonist, aprepitant, plus a 5HT3 antagonist and a corticosteroid inpatients receiving anthracyclines or cyclophosphamide in addition to highdosecisplatin: analysis of combineddata from two Phase III randomizedclinical trials显示文摘 | Gralla RJ1 de Wit R Herrstedt J | 2005 | Cancer2005，104，4： | 1 |
| 12 | Role of unconditioned and conditioned drug effects in the self-administration of opiates andstimulants显示文摘 | Stewart J de Wit H Eikelboom R | 1984 | Psychol Rev1984，91，2： | 1 |
| 13 | Hemangioblastomas: dia- gnosis of von Hippel-Lindan disease and antiangiogenic treatment with SU5416 显示文摘 | Schuch G de Wit M H hie J | 2005 | J Clin Oncol2005，23，： | 1 |
| 14 | Corrosion behavior of different tempers of AA7075 aluminum alloy显示文摘 | Andreatta F Terryn H de Wit J H W | 2004 | Electrochim Acta2004，49，17： | 1 |
| 15 | A new model for control of systems with friction显示文摘 | de wit C Canudas Astrom K J | 1995 | IEEE Transactions on Automatic Control1995，40，3： | 1 |
| 16 | TPX2 and AURKA promote 20q amplicon-driven eolorectal adenoma to carcinoma progression显示文摘 | Sillars-Hardebol A H Carvalho B Tijssen M Belian J A de Wit M Dells-van Diemen P M | 2012 | Gut2012，61，： | 1 |
| 17 | Late Permian global coal hiatus linked to 13C-depleted CO2 flux into the atmosphere during the final conaolidation of Pangea 显示文摘 | Faure K de Wit M J Willis J P | 1995 | Geology1995，23，6： | 1 |
| 18 | The tomato-Cladosporium fulvum interaction:a versatile experimental system to study plant-patogen interactions显示文摘 | Joosten M H A J De Wit P J G M | 1999 | Annu Rev Phytopathol1999，，37： | 1 |
| 19 | Disease burden of post-infectious irritable bowel syndrome in the netherlands 显示文摘 | Haagsma J A Siersema P D De Wit N J | 2010 | Epidemiol Infect2010，138，： | 1 |
| 20 | A Review on Reaflective Remote Sensing and Data Assimilation Techniques for Enhanced Agroecosystem Modeling显示文摘 | Dorigo W A Milla R Z De wit A J W | 2007 | International Journal of Applied Earth Observation and Geoinformation2007，9，： | 1 |
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