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| 1 | Magnesium lithospermate B possesses inhibitory activity on Na^+,K^+-ATPase and neuroprotective effects against ischemic stroke显示文摘瞄准:如果镁 lithospermate B (MLB ) 从 Danshen 提取了,检验,鼠尾草植物 miltiorrhiza 的弄干的根,当为经由一样的分子的机制的这繁体中文植物的 cardiactherapeutic 效果负责的一个活跃部件触发了 bycardiac glycosides,可以行动,例如 ouabain 和异羟基洋地黄毒苷。而且,如果,我们想要测试 MLB 对 ischemic 的 provideneuroprotection 可以是为心脏的 glycosides 观察了摸。方法:在 MLB 和 ouabain 之间的类似 inthe 化学药品结构和分子的配置被分析。Na+ 上的 MLB 和 ouabain 的 Theinhibition 力量,一个商业产品的 K+-ATPase 活动,也, asin 从老鼠大脑和心纸巾净化了膜部分,被检验,对 ischemic 击的 MLB 的 compared.Neuroprotective 效果也用一个外皮的基于 brainslice 的试金模型被评估。结果:商业 Na+ 上的剂量依赖者抑制,为 ouabain 的到那的 K+-ATPaseequivalent 为 MLB 被观察近似由重量的半剂量。ouabain 和 MLB 的 Thisrelative 力量也在 Na+ 上为他们的抑制被观察,从老鼠纸巾净化的 K+-ATPase activityof 血浆膜,尽管这 2 个禁止者有点在这些粗略的摘录展出了 lowercompetence。在 ischemic 沙鼠大脑,与 MLB significantlyreduced 处理以后梗塞尺寸,由 2,3,5-triphenyltetrazolium 氯化物染色设想了, byapproximately 55% 什么时候与控制组相比。结论:这些结果显然 suggestthat Danshen 的心脏的治疗学的效果应该部分至少被归因于 Na+ ,由 MLB 的 K+-ATPase,和那 MLB 的 effectiveinhibition 在 gerbilssubjected 提供 anti-ischemic neuroprotection 给焦点的局部缺血和灌注。 | Jason TC TZEN Tzyy-rong JINN Yi-ching CHEN Feng-yin LI Fu-chou CHENG Li-shian SHI Hank KH SHE Balance CM CHEN Vic HSIEH Mu-lin TU | 2007 | Acta Pharmacologica Sinica2007，28，5： | 25 |
| 2 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 3 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 4 | Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure显示文摘AIM To analyze the expression and function of the notchsignaling target gene Hes1 in a rhesus rotavirusinduced mouse biliary atresia model. METHODS The morphologies of biliary epithelial cells in biliary atresia patients and in a mouse model were examined by immunohistochemical staining. Then, the differential expression of Notch signaling pathway-related molecules was investigated. Further, the effects of the si RNAmediated inhibition of Hes1 expression were examined using a biliary epithelial cell 3 D culture system.RESULTS Both immature(Ep CAM+) and mature(CK19+) biliary epithelial cells were detected in the livers of biliary atresia patients without a ductile structure and in the mouse model with a distorted bile duct structure. The hepatic expression of transcripts for most Notch signaling molecules were significantly reduced on day 7 but recovered to normal levels by day 14, except for the target molecule Hes1, which still exhibited lower m RNA and protein levels. Expression of the Hes1 transcriptional co-regulator, RBP-Jκ was also reduced. A 3 D gel culture system promoted the maturation of immature biliary epithelial cells, with increased expression of CK19+ cells and the formation of a duct-like structure. The administration of Hes1 si RNA blocked this process. As a result, the cells remained in an immature state, and no duct-like structure was observed.CONCLUSION Our data indicated that Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia. | Rui-Zhong Zhang Xin-Hao Zeng Ze-Feng Lin Ming-Fu Yan-Lu Tong Vincent CH Lui Paul KH Tam Jonathan R Lamb Hui-Min Xia Yan Chen | 2018 | World Journal of Gastroenterology2018，24，29： | 5 |
| 5 | 社区人群血压和颈动脉血流速度与脑容量和脑小血管病的关系显示文摘做脑磁共振成像(magnetic resonance imaging,MRI)经常发现脑小血管病(cerebral small vessel disease,CSVD)。研究已证明高血压和低颈动脉血流速度与脑血管病存在关联。但是,这种关联与脑容量和CSVD的相关性仍有待研究。本文纳入基于社区的I-Lan纵向衰老研究(I-Lan longitudinal aging study)中年龄≥50岁的成年人721例进行分析,采用多普勒超声测量颈总动脉和颈内动脉血流速度,包括收缩期峰值血流速度(peak systolic velocity,PSV)和舒张终末期血流速度(end-diastolic velocity,EDV)。 | 袁源(摘译) 郑武洪(审校) Chuang SY Wang PN Chen LK Chou KH Chung CP Chen CH Mitchell GF Pan WH Cheng HM | 2021 | 中华高血压杂志2021，29，9： | 4 |
| 6 | Tissue inhibitor of metalloproteinases-I deficiency amplifies acute lung injury in bleomycin-exposed mice显示文摘 | Kim KH Burkhart K Chen P | 2005 | Am J Respir Cell Mol Biol2005，33，3： | 1 |
| 7 | In vitro susceptibility of ten clinical isolates of SARS coronavirus to selected antiviral compounds显示文摘 | Chen F Chan KH Jiang Y | 2004 | J Clin Virol2004，31，： | 1 |
| 8 | Biomechanics of whiplash injury 显示文摘 | Chen HB Yang KH Wang ZG | 2009 | Chin J Traumatol2009，12，5： | 1 |
| 9 | In vitro susceptibility of 10 clinical isolates of SARS coronavirus toselected antiviral compounds 显示文摘 | Chen F Chart KH Jiang Y | 2004 | Journal of Clinical Virology2004，31，1： | 1 |
| 10 | Territrems: naturally occurring specific irreversible inhibitors of acetyleholinesterase显示文摘 | Chen JW Ling KH | 1996 | J Biomed Sci1996，3，： | 1 |
| 11 | In vitro susceptibility of 10 clinical isolales of SARS eoronavirua to selected antiviral compounds显示文摘 | Chen F Chan KH Jiang Y | 2004 | J clin-Virol2004，31，1： | 1 |
| 12 | Development of hepatocellular carcinoma after successful management of esophageal variceal bleeding显示文摘 | Chen WC Lo GH Lai KH | 2004 | J Chin Med Assoc2004，67，11： | 1 |
| 13 | Mitochondrial glutathione modulates TNFa-induced endothelial cell dysfunction显示文摘 | Chen KH Reece LM Leary JF | 1999 | FreRad Biol Med1999，27，1： | 1 |
| 14 | Cucurbitacin Ⅰ suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44 (+)ALDH1 (+) cells显示文摘 | Chen YW Chen KH Huang PI | | 0，，11： | 1 |
| 15 | Increased interleukin-6 in aqueous humor of a patient with lung-metastatic intraocular adenocarcinoma显示文摘 | Chen KH Hsu WM Wu CC | 2003 | Am J Ophthalmol2003，135，2： | 1 |
| 16 | Association between duodenal contents reflux and squamous cell carcinoma-establishment of an esophageal cancer cell line derived from the metastatic tumor in a rat reflux model显示文摘 | Chen KH Mukaisho K Ling ZQ | 2007 | Anticancer Res2007，27，1： | 1 |
| 17 | Reprint of'Evaluating organophosphate poisoning in human serum with paper'显示文摘 | Yen TH Chen KH Hsu MY | 2015 | Talanta2015，1，145： | 1 |
| 18 | Effect of two fiber post types and two luting cement systems on regional post retention using the push-out test 显示文摘 | Wang VJ Chen YM Yip KH | 2008 | Dent Mater2008，24，3： | 1 |
| 19 | Evaluation of thermal cycling and mechanical loading on bonding strength of a self-etching primer system to dentln显示文摘 | NIKAIDO T KUNZELMANN KH CHEN H | 2002 | Dent Mater2002，18，3： | 1 |
| 20 | An epidemic of enterovirus 71 infection in Taiwan显示文摘 | Ho M Chen ER Hsu KH | 1999 | N Engl J Med1999，341，13： | 1 |
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