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| 1 | Effects of partial portal vein arterialization on the hilar bile duct in a rat model显示文摘BACKGROUND: Liver revascularization is frequently required during the enlarged radical operation for hilar cholangio carcinoma involving the hepatic artery. Researchers have carried out a number of experiments applying partial porta vein arterialization (PVA) in clinical practice. In this study we aimed to establish a theoretical basis for clinical application o partial PVA and to investigate the effects of partial PVA on ra hilar bile duct and hepatic functions. METHODS: Thirty rats were randomly and equally assigned into 3 groups: control (group A), hepatic artery ligation+bile duct recanalization (group B), and partial PVA+bile duc recanalization (group C). Proliferation and apoptosis o rat hilar bile duct epithelial cells, arteriolar counts of the peribiliary plexus (PBP) of the bile duct wall, changes in serum biochemistry, and pathologic changes in the bile duc were assessed 1 month after operation. RESULTS: The proliferation of hilar bile duct epithelial cells in group B was greater than in groups A and C (P<0.01). No apoptotic hilar bile duct epithelial cells were detected in any of the groups. The PBP arteriolar counts of the hilar bile duc wall were similar in groups A and C (P>0.05), but the coun was lower in group B than in group A (P<0.01). No statistically significant differences in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin were found in the 3 groups. The gamma-glutamyltransferase value was higher in group B than in groups A and C (P<0.01) The hepatic tissues of groups A and C showed no significan abnormality. Chronic inflammatory changes in the hilar bile duct walls were observed only in group B. CONCLUSION: Partial PVA can restore the arterial blood supply of the hilar bile duct and significantly extenuate the injury to hilar bile duct epithelial cells resulting from hepatic artery ligation. | Shao-Hua Guo, Chong-Hui Li,Yong-Liang Chen, Jian-Ning Song,Ai-Qun Zhang and Cheng Zhou Department of Hepatobiliary Surgery (Guo SH, Li CH, Chen YL, Song JN, Zhang AQ and Zhou C) and Department of Surgical Oncology (Guo SH), General Hospital of PLA, Beijing 100853, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 8 |
| 2 | Antioxidant activity of polyphenols from seeds of Vitis amurvitro in vitro显示文摘 | Wang JN Chen YJ Hano Y | 2000 | Acta Pharmacol Sin2000，21，： | 2 |
| 3 | Effect of HSP70 antisense RNA on normal sorghum pollen formation显示文摘IT has been found that heat shock proteins (hsp) exist universally in animals, plants, microbesand human beings. Some of hsps possess functions of molecular chaperons, such as hsp60,hsp70 and hsp90, which participate in folding and assembling polypeptides to functional struc-tures and transferring them into suitable sites. They also undertake repairing damaged cellularDNA and nucleolus. Therefore, they are house-keeping proteins and play an importantrole in maintaining normal cellular life and functions and in cellular response to environmentalstresses. There exists high homology in DNA sequence among the hsp of the same molecularweight across species. We have first reported the close relationship between hsps | Chen, JN Fu, HY Lu, ZX Qin, HY Zhang, L Guo, ZB | 1997 | Chinese Science Bulletin1997，42，23： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects显示文摘 | Huang ZP Chen JF Regan JN | 2010 | Arterioscler Thromb Vasc Biol2010，30，12： | 1 |
| 6 | Adverse effects of anticancer agents that target the VEGF pathway显示文摘 | Chen HX Cleck JN | 2009 | Nat Rev Clin Oncol2009，6，8： | 1 |
| 7 | Plasmacytoid dendritic cells and interferon levels are increased in lymphatic malformations 显示文摘 | Fleming JN Hostikka SL Chen EY | 2008 | Otolaryngol Head Neck Surg2008，139，5： | 1 |
| 8 | Sequence variations of latent membrane protein 2A in Epstein-Barr virus-associated gastric carcinomas from Guangzhou, southern China 显示文摘 | Han J Chen JN Zhang ZG | 2012 | PLoS One2012，7，34： | 1 |
| 9 | A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen显示文摘 | Chen AT Billaud JN Matti S | | 0，，： | 1 |
| 10 | Capsaicinoids lower plasma cholesterol and improve endothelial function in hamsters 显示文摘 | LIANG YT TIAN XY CHEN JN | 2012 | Eur J Nutr2012，，： | 1 |
| 11 | Fasudil hydrochloride hy- drate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine- induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway显示文摘 | Chen XY Dun JN Miao QF | 2009 | Pharmacology2009，83，： | 1 |
| 12 | The dynamics of cardiac fibrillation 显示文摘 | Weiss JN Qu Z Chen PS | 2005 | Circulation2005，112，： | 1 |
| 13 | Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation 显示文摘 | Chen JN Fishman MC | 1996 | Development1996，122，12： | 1 |
| 14 | Homocysteine disrupts outgrowth of microvascular endothelium by an iNOS-dependent mechanism 显示文摘 | Mayo JN Chen CH Liao FF | 2014 | Microcirculation2014，21，6： | 1 |
| 15 | Factors affecting the photocatalytic degradation of dichlorvos over titanium dioxide supported on glass 显示文摘 | Lu MC Roam GD Chen JN | 1993 | J Photochem Photobiol A:1993，76，： | 1 |
| 16 | The dynamics of cardiac fibrillation 显示文摘 | Weiss JN Qu ZL Chen PS | 2005 | Circulation2005，112，： | 1 |
| 17 | Effect of EDTA with and without surfactants or ultrasonics on removal of smear layer显示文摘 | Lui JN Kuah HG Chen NN | 2007 | J Endod2007，33，4： | 1 |
| 18 | Energy performance of a dual airflow window under different climates 显示文摘 | Wei JS Zhao JN Chen QY | 2010 | Energy and Buildings2010，42，1： | 1 |
| 19 | Simultaneous analysis of nine active components in Gegen Qinlian preparations by high-performance liquid chromatography with diode array detection 显示文摘 | CHEN LH WANG Q LIU JN | 2006 | Sep Sci2006，29，14： | 1 |
| 20 | Fingerprint comparison between Gegen Qinlian preparations of three different pharmaceutical forms including decoction, dispensing granule and pill 显示文摘 | CHEN LH WANG Q LIU JN | 2009 | Chromatographia2009，69，： | 1 |
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