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| 1 | The global image of the Moon obtained by the Chang'E-1:Data processing and lunar cartography显示文摘The global lunar image of the first phase of Chinese Lunar Exploration Program is the first image that covered all over the surface of the Moon. It will serve as a critical foundation for succeeding exploration and scientific research. In this paper, the acquisition, characteristics, and data quality of Chang'E-1 CCD image data are described in detail. Also described are the methodology and procedure of data processing. According to rule of planetary cartography, the image data have been processed, geometrically corrected, and then mosaicked and merged in a scale of 1:2.5 million. The results of data processing and charting show that the image data of Chang'E-1 CCD and their geometric precision meet the demand of charting a map in the scale of 1:2.5 million. The relative geometric positioning precision of the global image is better than 240 m, and the absolute geometric positioning precision is slightly better than that of the ULCN2005 and Clementine lunar basemap (V2.0). The plane positioning precision is approximately 100-1500 m. This global image proves to be the best global image of the Moon so far in terms of space coverage, image quality, and positioning precision. | LI ChunLai1, LIU JianJun1, REN Xin1, MOU LingLi1, ZOU YongLiao1, ZHANG HongBo1, Lü Chang1, LIU JianZhong1, ZUO Wei1, SU Yan1, WEN WeiBin1, BIAN Wei1, ZHAO BaoChang2, YANG JianFeng2, ZOU XiaoDuan1, WANG Min1, XU Chun1, KONG DeQing1, WANG XiaoQian1, WANG Fang1, GENG Liang1, ZHANG ZhouBin1, ZHENG Lei1, ZHU XinYing1, LI JunDuo1 & OUYANG ZiYuan11 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China 2 Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China | 2010 | Science China Earth Sciences2010，53，8： | 22 |
| 2 | Modified bottleneck-based heuristic for large-scale job-shop scheduling problems with a single bottleneck显示文摘A modified bottleneck-based (MB) heuristic for large-scale job-shop scheduling problems with a well- defined bottleneck is suggested,which is simpler but more tailored than the shifting bottleneck (SB) procedure. In this algorithm,the bottleneck is first scheduled optimally while the non-bottleneck machines are subordinated around the solutions of the bottleneck schedule by some effective dispatching rules.Computational results indicate that the MB heuristic can achieve a better tradeoff between solution quality and computational time compared to SB procedure for medium-size problems.Furthermore,it can obtain a good solution in a short time for large-scale job- shop scheduling problems. | Zuo Yan Gu Hanyu Xi Yugeng | 2007 | Journal of Systems Engineering and Electronics2007，18，3： | 20 |
| 3 | Primary scientific results of Chang'E-1 lunar mission显示文摘The strategic plan for the development of the unmanned Chinese Lunar Exploration Program is characterized by three distinct stages: 'orbiting around', 'landing on' and 'returning from' the Moon. The first Chinese lunar probe, Chang'E-1, which was successfully launched on October 24th, 2007 at Xichang Satellite Launch Center, and guided to crash on the Moon on March 1st, 2009, at 52.36°E, 1.50°S, in the north of Mare Fecunditatis, is the first step towards the 'orbiting around' stage. The Chang'E-1 mission lasted 495 days, exceeding the expected life-span by about four months. A total of 1.37 TB raw data was received from Chang'E-1. It was then processed into 4 TB scientific data products at various levels. Many scientific results have been obtained by analyzing these data, including especially the 'global lunar image from the first Chinese lunar explora- tion mission'. All scientific goals of Chang'E-1 have been achieved. It provides much useful materials for further advances of lunar sciences and planetary chemistry. Meanwhile, these results will serve as a firm basis for future Chinese lunar missions. | OUYANG ZiYuan1,2, LI ChunLai1, ZOU YongLiao1, ZHANG HongBo1, Lü Chang1, LIU JianZhong1, LIU JianJun1, ZUO Wei1, SU Yan1, WEN WeiBin1, BIAN Wei1, ZHAO BaoChang3, WANG JianYu4, YANG JianFeng3, CHANG Jin5, WANG HuanYu6, ZHANG XiaoHui7, WANG ShiJin7, WANG Min1, REN Xin1, MU LingLi1, KONG DeQing1, WANG XiaoQian1, WANG Fang1, GENG Liang1, ZHANG ZhouBin1, ZHENG Lei1, ZHU XinYing1, ZHENG YongChun1, LI JunDuo1, ZOU XiaoDuan1, XU Chun1, SHI ShuoBiao1, GAO YiFei1 & GAO GuanNan1 1 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China 2 Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 3 Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China 4 Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China 5 Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008, China 6 Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China 7 Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China Earth Sciences2010，53，11： | 11 |
| 4 | Diagnostic value of 5 serum biomarkers for hepatocellular carcinoma with different epidemiological backgrounds:A large-scale,retrospective study显示文摘Objective:Hepatocellular carcinoma(HCC)is a lethal global disease that requires an accurate diagnosis.We assessed the potential of 5 serum biomarkers(AFP,AFU,GGT-II,GPC3,and HGF)in the diagnosis of HCC.Methods:In this retrospective study,we measured the serum levels of each biomarker using ELISAs in 921 participants,including 298 patients with HCC,154 patients with chronic hepatitis(CH),122 patients with liver cirrhosis(LC),and 347 healthy controls from 3 hospitals.Patients negative for hepatitis B surface antigen and hepatitis C antibody(called'NBNC-HCC')and patients positive for the above indices(called'HBV-HCC and HCV-HCC')were enrolled.The selected diagnostic model was constructed using a training cohort(n=468),and a validation cohort(n=453)was used to validate our results.Receiver operating characteristic analysis was used to evaluate the diagnostic accuracy.Results:Theα-L-fucosidase(AFU)/α-fetoprotein(AFP)combination was best able to distinguish NBNC-HCC[area under the curve:0.986(95%confidence interval:0.958–0.997),sensitivity:92.6%,specificity:98.9%]from healthy controls in the test cohort.For screening populations at risk of developing HCC(CH and LC),the AFP/AFU combination improved the diagnostic specificity for early-stage HCC[area under the curve:0.776(0.712–0.831),sensitivity:52.5%,specificity:91.6%in the test group].In all-stage HBV-HCC and HCV-HCC,AFU was also the best candidate biomarker combined with AFP[area under the curve:0.835(0.784–0.877),sensitivity 69.1%,specificity:87.4%in the test group].All results were verified in the validation group.Conclusions:The AFP/AFU combination could be used to identify NBNC-HCC from healthy controls and hepatitis-related HCC from at-risk patients. | Dongming Liu Yi Luo Lu Chen Liwei Chen Duo Zuo Yueguo Li Xiaofang Zhang Jing Wu Qing Xi Guangtao Li Lisha Qi Xiaofen Yue Xiehua Zhang Zhuoyu Sun Ning Zhang Tianqiang Song Wei Lu Hua Guo | 2021 | Cancer Biology & Medicine2021，18，1： | 10 |
| 5 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 6 | Disentangling the factors that contribute to variation in forest biomass increments in the mid-subtropical forests of China显示文摘Mid-subtropical forests are the main vegetation type of global terrestrial biomes, and are critical for maintaining the global carbon balance. However, estimates of forest biomass increment in mid-subtropical forests remain highly uncertain. It is critically important to determine the relative importance of different biotic and abiotic factors between plants and soil, particularly with respect to their influence on plant regrowth. Consequently,it is necessary to quantitatively characterize the dynamicspatiotemporal distribution of forest carbon sinks at a regional scale. This study used a large, long-term dataset in a boosted regression tree(BRT) model to determine the major components that quantitatively control forest biomass increments in a mid-subtropical forested region(Wuyishan National Nature Reserve, China). Long-term,stand-level data were used to derive the forest biomass increment, with the BRT model being applied to quantify the relative contributions of various biotic and abiotic variables to forest biomass increment. Our data show that total biomass(t) increased from 4.62 9 106 to 5.30 9 106 t between 1988 and 2010, and that the mean biomass increased from 80.19 ± 0.39 t ha-1(mean ± standard error) to 94.33 ± 0.41 t ha-1in the study region. The major factors that controlled biomass(in decreasing order of importance) were the stand, topography, and soil. Stand density was initially the most important stand factor, while elevation was the most important topographic factor. Soil factors were important for forest biomass increment but have a much weaker influence compared to the other two controlling factors. These results provide baseline information about the practical utility of spatial interpolationmethods for mapping forest biomass increments at regional scales. | Yin Ren Shanshan Chen Xiaohua Wei Weimin Xi Yunjian Luo Xiaodong Song Shudi Zuo Yusheng Yang | 2016 | Journal of Forestry Research2016，27，4： | 5 |
| 7 | Role of TRIM33 in Wnt signaling during mesendoderm differentiation显示文摘Tripartite motif 33(TRIM33), a member of the transcription intermediate factor 1(TIF1) family of transcription cofactors,mediates transforming growth factor-beta(TGF-β) signaling through its PHD-Bromo cassette in mesendoderm differentiation during early mouse embryonic development. However, the role of the TRIM33 RING domain in embryonic differentiation is less clear. Here, we report that TRIM33 mediates Wnt signaling by directly regulating the expression of a specific subset of Wnt target genes, and this action is independent of its RING domain. We show that TRIM33 interacts with β-catenin, a central player in Wnt signaling in mouse embryonic stem cells(mESCs). In contrast to previous reports in cancer cell lines, the RING domain does not appear to function as the E3 ligase for β-catenin, since neither knockout nor overexpression of TRIM33 had an effect on β-catenin protein levels in mESCs. Furthermore, we show that although TRIM33 seems to be dispensable for Wnt signaling through a reporter assay, loss of TRIM33 significantly impairs the expression of a subset of Wnt target genes, including Mixl1,in a Wnt signaling-dependent manner. Together, our results indicate that TRIM33 regulates Wnt signaling independent of the E3 ligase activity of its RING domain for β-catenin in mESCs. | Xiaojie Xia Feifei Zuo Maoguo Luo Ye Sun Jianbo Bai Qiaoran Xi | 2017 | Science China(Life Sciences)2017，60，10： | 4 |
| 8 | Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism显示文摘The improved 3 step preparation of a key antitumor agent, 7 ethyl 10 hydroxycamptothecin(SN 38), which consists of ethylation, oxidation and photo chemical rearrangement, is described. The proposed reaction mechanism is also discussed. | LEI Ying jie *, ZHU Chun hua, WANG Zuo quan and LIU Hong (Xian Modern Chemistry Research Institute, Xian 710065, P.R. China) | 2001 | Chemical Research in Chinese Universities2001，17，1： | 4 |
| 9 | Nomograms based on HPV load for predicting survival in cervical squamous cell carcinoma: An observational study with a longterm follow-up显示文摘Objective: To investigate the prognostic value of pretreatment human papillomavirus(HPV) viral load for cervical cancer, and to develop nomograms based on HPV load and other clinicopathological factors for long-term survival.Methods: We conducted a prospective study on cervical squamous cell carcinoma(SCC) patients diagnosed between January 2003 and December 2008. Cervical samples were tested for HPV viral load by the Hybrid Capture II(HCII) assay before treatment and 6 months after treatment. Clinical characteristics and follow-up information were also collected. A multivariable Cox proportional hazards model was used to adjust covariates in both the radical hysterectomy(RH) treatment group and concurrent chemoradiotherapy(CCRT) treatment group to identify relevant covariates, and then nomograms were constructed and used for internal validation.Results: A total of 520 SCC patients enrolled in this study with a median follow-up of 127 months, 360 patients received RH, whereas 160 patients received CCRT. The median HPV viral load in RH and CCRT groups was356.10 and 294.29, respectively. Tumor size was positively correlated with high pretreatment HPV load in both groups. In CCRT group, the advanced International Federation of Gynecology and Obstetrics(FIGO) stage and enlarged retroperitoneal lymph node status determined by computed tomography(LNSCT) were correlated with low HPV load group. Initial HPV viral load, FIGO stage and lymph node metastasis were prognostic factors for RH group, whereas HPV viral load, squamous cell carcinoma antigen(SCC-Ag) level and LNSCT were identified as prognostic factors for CCRT group. Nomograms incorporating these predictors for 10-year progression-free survival(PFS) were constructed [concordance index(C-index): 0.756, 0.749].Conclusions: A low pretreatment HPV viral load is an independent prognostic factor for poor prognosis of cervical SCC and is related to other clinicopathological factors. The survival nomogram based on HPV viral load could predict the long-term prognosis. | Jing Zuo Ying Huang Jusheng An Xi Yang Ning Li Manni Huang Lingying Wu | 2019 | Chinese Journal of Cancer Research2019，31，2： | 4 |
| 10 | Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women显示文摘 | Yan-yong LIU Ling HU Chao JI Dong-wen CHEN Xi SHEN Nan YANG Yun YUE Jing-mei JIANG Xia HONG Qin-sheng GE Ping-ping ZUO | 2009 | Acta Pharmacologica Sinica2009，30，7： | 3 |
| 11 | Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice显示文摘Dear Editor,Hearing loss is the most common sensory disorder in the world.Among cases of non-syndromic hearing loss,which account for 70%of all cases of genetic hearing loss,around 80%of cases arise from autosomal recessive loss-of-function mutations that require repair,rather than disruption,of the mutant allele.1 CRISPR/Cas9-mediated homology-directed repair(HDR)-based therapies have the potential to cure many genetic diseases because this class of therapeutics can achieve arbitrary base changes as well as the insertion or deletion of DNA fragments/However. | Xi Gu Xinde Hu Daqi Wang Zhijiao Xu Fang Wang Di Li Geng-lin Li Hui Yang Huawei Li Erwei Zuo Yilai Shu | 2022 | Cell Research2022，32，7： | 3 |
| 12 | Study on RS-and GIS-based ecological capital assessment in arid areas显示文摘生态的大写的评价当前是生态学,资源经济,环境经济和生态的经济的学科交差的领域里的重要研究内容之一。为了科学地估计生态的资本,增加到决策人在经济开发考虑生态的费用,并且为在干旱区域的持续经济开发也是必要的。基于风景生态学的理论,在这篇论文生态的资本在干旱区域珍视的per 单位区域被使用 Landsat TM 数据, CBERS 卫星数据,气象学的数据, MODIS 卫星数据和另外的生态的数据研究,并且 RS --并且在干旱区域估计生态的大写的价值的官方补给底的模型被开发。而且基于测量地的数据,在在威信河盆的生态的大写的评价以后的案例研究,在 2003 的 Xinjiang 被执行。盆被划分成 4 个生态的大写的区域以便份量上计算生态系统的生态的大写的价值,分析生态的资本的空间分发,并且制定生态的资本的空间分发的地图。结果证明在在 2003 的威信河盆的生态系统的全部的生态的大写的价值是 1.494 54 癮 吗?? | ZHOU Kefa CHEN Xi ZHOU Huarong ZHANG Qing ZUO Qiting ZHANG Haibo YAN Jinfeng CHEN Chuan | 2006 | Chinese Science Bulletin2006，51，A01： | 3 |
| 13 | Prognostic significance of the hemoglobin A1c level in non-diabetic patients undergoing percutaneous coronary intervention: a meta-analysis显示文摘Background:The predictive value of hemoglobin A1c(HbA1c)levels in non-diabetic patients with myocardial infarction undergoing percutaneous coronary intervention(PCI)is still controversial.This study aimed to evaluate whether HbA1c levels were independently associated with adverse clinical outcomes in non-diabetic patients with coronary artery disease(CAD)who had undergone PCI by performing a meta-analysis of cohort studies.Methods:This meta-analysis included non-diabetic patients with CAD who had undergone PCI.A systematic search for publications listed in the PubMed,Embase,and Cochrane Library databases from commencement to December 2018 was conducted.Studies evaluating the adverse clinical outcomes according to abnormal HbA1c levels in non-diabetic patients diagnosed with CAD who had undergone PCI were eligible.The primary outcomes were long-term all-cause deaths and long-term major adverse cardiac events,and the secondary outcome was short-term all-cause deaths.The meta-analysis was conducted with RevMan 5.3 and Stata software 14.0.Odds ratios(ORs)were pooled using a random or fixed-effects model,depending on the heterogeneity of the included studies.Sub-group analysis or sensitivity analysis was conducted to explore potential sources of heterogeneity,when necessary.Results:Six prospective cohort studies involving 10,721 patients met the inclusion criteria.From the pooled analysis,abnormal HbA1c levels were associated with increased risk for long-term all-cause death(OR 1.39,95%confidence interval[CI]1.16-1.68,P=0.001,I2=45%).Sub-group analysis suggested that abnormal HbA1c levels between 6.0%and 6.5%predicted higher long-term major adverse cardiac event(including all-cause deaths,non-fatal myocardial infarction,target lesion revascularization,target vessel revascularization,recurrent acute myocardial infarction,heart failure requiring hospitalization,and stent thrombosis)risk(OR 2.05,95%CI 1.46-2.87,P<0.001,I2=0).Contrarily,elevated HbA1c levels were not associated with increased risk of short-term all-cause death(OR 1.16,95%CI 0.88-1.54,P=0.300,I2=0).Conclusions:An abnormal HbA1c level is an independent risk factor for long-term adverse clinical events in non-diabetic patients with CAD after PCI.Strict control of HbA1c levels may improve patient survival.Further studies in different countries and prospective cohort studies with a large sample size are required to verify the association. | Yan Li Xiao-Wen Li Yin-Hua Zhang Lei-Min Zhang Qing-Qing Wu Zhao-Run Bai Jin Si Xue-Bing Zuo Ning Shi Jing Li Xi Chu | 2020 | Chinese Medical Journal2020，，18： | 2 |
| 14 | Reduction of wastewater toxicity and change of microbial community in a hydrolysis acidification reactor pre-treating trimethylolpropane wastewater显示文摘Trimethylolpropane (TMP)wastewater is one of the most toxic petrochemical wastewater.Toxicants with high concentrations in TMP wastewater often inhibit the activity of microorganisms associated with biological treatment processes.The hydrolysis acidification process (HAP)is widely used to pretreat petrochemical wastewater.However,the effects of HAP on the reduction of wastewater toxicity and the relevant underlying mechanisms have rarely been reported.In this study,an HAP reactor was operated for 240 days.fed with actual TMP wastewater diluted by tap water in varying ratios.The toxicity of TMP wastewater was assessed with the inhibition ratio of oxygen uptake rate.When the organic loading rates were lower than 7.5kg COD/m^3/d,the toxicity of TMP wastewater was completely elminated.When the actual TMP wastewater was directly fed into the reactor,the toxicity of TMP wastewater decreased from 100%to 34.9%.According to the results of gas chromatography-mass spectrometry analysis,four main toxicants contained in TMP wastewater,namely,formaldehyde, 2-ethylacrolein.TMP and 2-ethylhexanol.were all significantly removed,with removal efficiencies of 93.42%,95.42%,72.85%and 98.94%,respectively.Compared with the removal efficiency of CODcr, the reduction rate of toxicity is markedly higher by HAP.In addition,the change of microbial community in the HAP reactor,along the operation period,was studied.The results revealed that, compared with the seed sludge.Firmicutes became the dominant phylum (abundance increased from 0.51% to 57.08%),followed by Proteobacteria and Bacteroidetes (abundance increased from 59.75% to 25.99%and from 4.70%to 8.39%,respectively). | Xin Xing Yin Yu Hongbo Xi Guangqing Song Yajiao Wang Jiane Zuo Yuexi Zhou | 2018 | Frontiers of Environmental Science & Engineering2018，12，6： | 2 |
| 15 | Dysregulated adaptive immune response contributes to severe COVID-19显示文摘Dear Editor,The outbreak of the new coronavirus 5ARS-CoV-2 has resulted in a global pandemic.Due to the lack of a specific drug against this virus,the current clinical management of this disease mainly depends on supportive care to reduce inflammatory responses and to keep the lung functioning1. | Kuai Yu Jingjing He Yongjian Wu Baosong Xie Xuefei Liu Bo Wei Haibo Zhou Bingliang Lin Zhixiang Zuo Wen Wen Wenxiong Xu Bin Zou Lai Wei Xi Huang Penghui Zhou | 2020 | Cell Research2020，30，9： | 1 |
| 16 | Microstructure and emission properties of nanometer Ce-W material显示文摘 | Xiaoli Xi Zuoren Nie Jingxia Zou Jiancan Yang Tieyong Zuo | 2006 | Journal of Alloys and Compounds2006，，1： | 1 |
| 17 | Physically-based model for studying the salinization of Bosten Lake in China显示文摘 | ZUO Qi-ting DOU Ming CHEN Xi | 2006 | Hydrological Sciences Journal2006，51，3： | 1 |
| 18 | The enhanced Mi- crowave Absorption property of CoFe204 nanoparticles coated with a Co3 FeT-Co nanoshell by thermal reduc- tion显示文摘 | XI L WANG Z ZUO Y L | 2010 | Nanotechnology2010，22，4： | 1 |
| 19 | Study on the solid solubilityextension of Mo in Cu by mechanical alloying Cu with amor-phous Cr(Mo)显示文摘 | XI S Q ZUO K S LI X G | 2008 | Acta Materialia2008，56，20： | 1 |
| 20 | Kinetic modeling of photocatalytic degradation in TiO2 suspension system显示文摘 | Zuo Y J Xi H L 2001 | 2001 | Catalysis Acta2001，22，2： | 1 |
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