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| 1 | Fields of applications,diagnostic yields and findings of OMOM capsule endoscopy in 2400 Chinese patients显示文摘AIM:To retrospectively analyze the fields of application,diagnostic yields and findings of OMOM capsule endoscopy in Chinese patients.METHODS:A database including 2400 Chinese patients who received OMOM capsule endoscopy in 27 endoscopy centers in China was retrieved from the Jianshan Science and Technology Ltd.OMOM capsule endoscopy database.The patient's age,gender,fields of application,the potentially relevant findings,pyloric transit time(PTT),small bowel transit time(SBTT),and complete small-bowel examination rate(CSER) were recorded and analyzed.RESULTS:Two thousand four hundred patients aged 9-91 years(mean,49 years),of whom 1510 were males(62.9%),underwent 2400 OMOM capsule endoscopy procedures.One thousand two hundred and thirty two(51.3%) were referred with obscure gastrointestinal bleeding(OGIB),642(26.8%) with abdominal pain,and 223(9.3%) with chronic diarrhea.The overall diagnostic yield was 47.7%(1144/2400).The diagnostic yield of OMOM capsule endoscopy in OGIB subgroup was much higher than in the non-OGIB subgroup(62.4% vs 32.1%,P<0.001).The most common findings of the small bowel in Chinese patients with OGIB were arteriovenous malformation(28.1%) and tumors(18.9%).There was no significant difference in the diagnostic yield between the male and female patients with OGIB.However,the diagnostic yield in patients aged more than 60 was higher than in patients aged less than 60(69.8% vs 58.9%,P<0.001).The median PTT was 41 min(range:1-544 min) and the mean SBTT was 247.2 ± 88.9 min.The overall CSER was 86.8%.CONCLUSION:The OMOM capsule endoscopy is a valuable tool for small bowel evaluation with good overall diagnostic yield and CSER. | Liao, Zhuan Gao, Rui Li, Feng Xu, Can Zhou, Yi Wang, Jin-Shan Li, Zhao-Shen | 2010 | World Journal of Gastroenterology2010，16，21： | 35 |
| 2 | Clinical application of magnetically controlled capsule gastroscopy in gastric disease diagnosis: recent advances显示文摘Magnetically controlled capsule gastroscopy(MCCG) is a novel system primarily used for the diagnosis of gastric disease. It consists of an endoscopic capsule with magnetic material inside, external guidance magnet equipment, data recorder and computer workstation. Several clinical trials have demonstrated that MCCG is comparable in accuracy in diagnosing gastric focal disease when compared to conventional gastroscopy. Further clinical studies are needed to test the diagnostic accuracy and improve the functioning of MCCG. This novel MCCG system could be a promising alternative for screening for gastric diseases,with the advantages of no anesthesia required, comfort and high acceptance across populations. | Zhuan Liao Wenbin Zou Zhao-Shen Li | 2018 | Science China(Life Sciences)2018，61，11： | 12 |
| 3 | Audiovisual Sexual Stimulation and RigiScan Test for the Diagnosis of Erectile Dysfunction显示文摘 | Tao Wang Li Zhuan Zhuo Liu Ming-Chao Li Jun Yang Shao-Gang Wang Ji-Hong Liu Qing Ling Wei-Min Yang Zhang-Qun Ye | 2018 | Chinese Medical Journal2018，，12： | 10 |
| 4 | Preparation,Properties and Application of C/C-SiC Composites Fabricated by Warm Compacted-in situ Reaction显示文摘Carbon fibre reinforced carbon and SiC dual matrices composites (C/C-SiC) show superior tribological properties,high thermal shock resistance and good abrasive resistance,and they are promising candidates for advanced brake and clutch systems.The microstructure,mechanical properties,friction and wear properties,and application of the C/C-SiC composites fabricated by warm compacted-in situ reaction were introduced.The results indicated that the composites were composed of 50-60 wt pct carbon,2-10 wt pct residual silicon and 30-40 wt pct silicon carbide.The C/C-SiC brake composites exhibited good mechanical properties.The value of flexural strength and compressive strength could reach 160 and 112 MPa,respectively.The impact strength was about 2.5 kJ·m-2.The C/C-SiC brake composites showed excellent tribological performance,including high coefficient of friction (0.38),good abrasive resistance (1.10 μm/cycle) and brake steadily on dry condition.The tribological properties on wet condition could be mostly maintained.The silicon carbide matrix in C/C-SiC brake composites improved the wear resistance,and the graphite played the lubrication function,and right volume content of graphite was helpful to forming friction film to reduce the wear rate.These results showed that C/C-SiC composites fabricated by warm compacted-in situ reaction had excellent properties for use as brake materials. | Peng Xiao Zhuan Li Zibing Zhu Xiang Xiong | 2010 | Journal of Materials Science & Technology2010，26，3： | 8 |
| 5 | Diagnosis and treatment of autoimmune pancreatitis: experience with 100 patients显示文摘BACKGROUND: Autoimmune pancreatitis (AIP) is increasingly recognized as a unique subtype of pancreatitis. This study aimed to analyze the diagnosis and treatment of AIP patients from a tertiary care center in China.METHODS: One hundred patients with AIP who had been treated from January 2005 to December 2012 in our hospital were enrolled in this study. We retrospectively reviewed the data of clinical manifestations, laboratory tests, imaging examinations, pathological examinations, treatment and outcomes of the patients.RESULTS: The median age of the patients at onset was 57 years (range 23-82) with a male to female ratio of 8.1:1. The common manifestations of the patients included obstructive jaundice (49 patients, 49.0%), abdominal pain (30, 30.0%), and acute pancreatitis (11, 11.0%). Biliary involvement was one of the most extrapancreatic manifestations (64, 64.0%). Fifty-six (56.0%) and 43 (43.0%) patients were classified into focaltype and diffuse-type respectively according to the imaging examinations. The levels of serum Ig G and Ig G4 were elevated in 69.4% (43/62) and 92.0% (69/75) patients. Pathological analysis of specimens from 27 patients supported the diagnosis of lymphoplasmacytic sclerosing pancreatitis, and marked (>10 cells/HPF) Ig G4 positive cells were found in 20 (74.1%) patients.Steroid treatment and surgery as the main initial treatments were given to 41 (41.0%) and 28 (28.0%) patients, respectively. The remission rate after the initial treatment was 85.0%. Steroid was given as the treatment after relapse in most of the patients and the total remission rate at the end of follow-up was 96.0%.CONCLUSIONS: Clinical manifestations, laboratory tests, imaging and pathology examinations in combination could increase the diagnostic accuracy of AIP. Steroid treatment with an initial dose of 30 or 40 mg prednisone is effective and safe in most patients with AIP. | Lei Xin Yuan-Xiang He Xiao-Fei Zhu Qun-Hua Zhang Liang-Hao Hu Duo-Wu Zou Zhen-Dong Jin Xue-Jiao Chang Jian-Ming Zheng Changhai Hospital Second Military Medical University Chang-Jing Zuo Cheng-Wei Shao Gang Jin Zhuan Liao Zhao-Shen Li | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 6 |
| 6 | Guidelines for the diagnosis and treatment of chronic pancreatitis in China(2018 edition)显示文摘Chronic pancreatitis(CP)is a progressive inflammatory disease of pancreas that alters the organ’s normal structure and functions.CP seriously affects the quality of life of patients and greatly increases the public medical burden of society.In recent years,the incidence of CP has increased worldwide.The concepts of etiology and therapies have been continuously updated. | Wen-Bin Zou Nan Ru Hao Wu Liang-Hao Hu Xu Ren Gang Jin Zheng Wang Yi-Qi Du Ya-Nan Cao Lei Zhang Xiao-Yan Chang Rong-Chun Zhang Xiao-Bin Li Yan Shen Peng Li Zhao-Shen Li Zhuan Liao Pancreatitis Group of Chinese Medical Doctor Association | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 6 |
| 7 | Meta-analysis of capsule endoscopy in patients diagnosed or suspected with esophageal varices显示文摘AIM:To review the literature on capsule endoscopy(CE) for detecting esophageal varices using conventional esophagogas troduodenoscopy(EGD)as the standard. METHODS:A strict literature search of studies comparing the yield of CE and EGD in patients diagnosed or suspected as having esophageal varices was conducted by both computer search and manual search.Data were extracted to estimate the pooled diagnostic sensitivity and specificity. RESULTS:There were seven studies appropriate for meta-analysis in our study,involving 446 patients. The pooled sensitivity and specificity of CE for detecting esophageal varices were 85.8%and 80.5%, respectively.In subgroup analysis,the pooled sensitivity and specificity were 82.7%and 54.8%in screened patients,and 87.3%and 84.7%in the screened/ patients under surveillance,respectively. CONCLUSION:CE appears to have acceptable sensitivity and specificity in detecting esophageal varices.However,data are insufficient to determine the accurate diagnostic value of CE in the screen/ surveillance of patients alone. | Yi Lu Rui Gao Zhuan Liao Liang-Hao Hu Zhao-Shen Li | 2009 | World Journal of Gastroenterology2009，15，10： | 5 |
| 8 | Transgene directionally integrated into C-genome of Brassica napus显示文摘Integration of a transgene into a C-genome chromosome plays an important role in reducing ecological risk of transgenic Brassica napus To obtain C-genome transgenic B. napus, herbi- cide-resistant bar gene was firstly transferred into B. oleracea var. alboglabra mediated by Agrobacterium tumefaciens strain LBA4404. Then using the trans- genic B. oleracea as paternal plants and 8 non- transgenic varieties of B. rapa as maternal plants, C- genome transgenic B. napus with bar gene was arti- ficially resynthesized by means of ovary culture and chromosome doubling. Among 67 lines of the resyn- thesized B. napus, 31 were positive, and 36 were negative according to PCR test for bar gene. At least 2 plants from each line were kept for PPT spray con- firmation. The result was in consistence with the PCR test. Genomic Southern blotting of three randomly chosen lines also showed that bar gene had been integrated into the genome of resynthesized B. napus lines. | LI Jun FANG Xiaoping WANG Zhuan LUO Lixia HU Qiong | 2006 | Chinese Science Bulletin2006，51，13： | 5 |
| 9 | Experiment on Hydraulic Fracturing in Rock and Induced Earthquake显示文摘Experiment on rock hydraulic fracturing strength under different confining pressures was conducted on a series of test specimens with various pre-cracks prepared from 7 types of rock. Combining the data of an actual reservoir-induced earthquake with the experimental results of the contemporary tectonic stress field according to the theory of rock strength and the principle and method of rock fracture mechanics, the authors tentatively investigated the earthquakes induced by pore-water pressure in rock and obtained the initial results as follows: (1) One type of induced earthquake may occur in the case of larger tectonic stress on such weak planes that strike in similar orientation of principle tectonic compressional stress in the shallows of the rock mass; the pore-water pressure σp may generate tensile fracture on them and induce small earthquakes; (2) Two types of induced earthquake may occur in the case of larger tectonic stress, i.e.,① on such weakness planes that strike in similar orientation of principle tectonic compressional stress, σ1, in the shallows of the rockmass, the pore-water pressure, σp, may generate tensile fracture on them and induce small earthquakes; ② When the tectonic stress approximates the shear strength of the fracture, the pore-water pressure σp may reduce the normal stress, σn, on the fracture face causing failure of the originally stable fracture, producing gliding fracture and thus inducing an earthquake. σp may also increase the fracture depth, leading to an induced earthquake with the magnitude larger than the previous potential magnitude; (3) There is a depth limit for each type of rock mass, and no induced earthquake will occur beyond this limit. | Yan Yuding Li Yalin Zhang Zhuan Ouyang Lisheng Xie Mingfu | 2005 | Earthquake Research in China2005，19，4： | 4 |
| 10 | Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/ cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1显示文摘我们的以前的研究证明了那可勃起的功能在怀有人的织物 kallikrein 的年老的转基因的老鼠(TGR ) 被保存 1 (hKLK1 ) ,当肉体的纤维变性上的 hKLK1 的分子的水平糟糕被理解禁止年龄相关的可勃起的机能障碍(编辑) 时。男野类型的 Sprague-Dawley 老鼠(WTR ) 和怀有 hKLK1 基因的 TGR 被喂到 4-month-old 或 18-month-old 并且把组划分了成三:年轻 WTR (yWTR ) 作为控制, WTR (aWTR ) ,并且 TGR (aTGR ) 。所有老鼠的可勃起的功能被多孔的神经 electrostimulation 方法估计。Massons 三色的染色被用来在阴茎海绵体评估肉体的纤维变性。我们发现在 aWTR 组的老鼠的可勃起的功能比另外的二个组的显著地低。Massons 三色的染色 yWTR 和 aTGR 组,与那些相比揭示了那 /collagen (C) 是的光滑的肌肉房间(SMC ) 的比率在 aWTR 组显著地更低。Immunohistochemistry 和西方的弄污分析被表现,并且结果示威了 α 的那表情; -SMA 更低,当时转变生长 factor-β 的表情;1 (TGF-β 1 ) , RhoA, ROCK1, p-MYPT1, p-LIMK2,和 p-cofilin 与在另外的二个组的那些相比在 aWTR 组是更高的。然而, LIMK2 和 cofilin 表情没在三个组之中不同。一起拿,这些结果显示 RhoA/ROCK1/LIMK/cofilin 小径可以涉及到先进年龄,和 hKLK1 引起的肉体的纤维变性可以由禁止这条小径的激活改善减少这肉体的纤维变性年龄相关的编辑。 | Kai Cui Yang Luan Tao Wang Li Zhuan Ke Rao Shao-Gang Wang Zhang-Qun Ye Ji-Hong Liu Dao-Wen Wang | 2017 | Asian Journal of Andrology2017，19，1： | 4 |
| 11 | Preparation and properties of C/C-SiC brake composites fabricated by warm compacted-in situ reaction显示文摘碳纤维增强了碳和硅碳化物双矩阵 compositesC/C-SiC 被温暖的压缩在里面的 situ reaction.The 微观结构制作,机械性质, tribological 性质,并且在速度是的不同刹车穿 C/C-SiC composites 的机制 investigated.The 结果显示 composites 由 58wt%C,37wt%SiC 组成,并且 5wt%Si .The 密度和开的孔是 2.0 g.cm^-3 并且10%, respectively.The C/C-SiC 刹车 composites 展览好机械 properties.The | Zhuan Li Peng Xiao Xiang Xiong | 2010 | International Journal of Minerals,Metallurgy and Materials2010，17，4： | 4 |
| 12 | Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review显示文摘 | Zhuan Liao Rui Gao Can Xu Zhao-Shen Li | 2010 | Gastrointestinal Endoscopy2010，，2： | 4 |
| 13 | Analysis of F_1 hybrid and BC_1 monosomic alien addition line plants from Brassica oleracea × Sinapis alba by GISH显示文摘Sterile and semi-fertile F_1 plants were obtained by intergeneric sexual hybridization between paternal Brassica oleracea var. alboglabra (genome CC, 2n=18) and maternal Sinapis alba (genome SS, 2n=24), BC_1 plants were obtained by backcrossing between paternal B. oleracea and ma-ternal semi-fertile F_1 plants. Genomic in situ hybridization (GISH) combined with dual-colour fluorescence in situ hybridization (dcFISH) showed that sterile F_1 plants contained 21 chromosomes consist-ing of one B. oleracea chromosome set and one S. alba chromosome set, belonging to expected hybrids, and semi-fertile F_1 plants contained 30 chromosomes consisting of two B. oleracea chromosome sets and one S. alba chromosome set. It is obvious that the semi-fertile F_1 plants belong to unexpected hybrids. 1―3 trivalents were detected at meiotic metaphase I of semi-fertile F_1 pollen mother cells (PMCs). Different separation ratios of S chromosomes were detected at anaphase I. A monosomic alien addition line (MAAL) was identified by GISH-dcFISH from BC_1 plants; it contained 19 chromosomes consisting of 18 C chromosomes and 1 S chromosome. At meiotic metaphase I, 9 divalents from B. oleracea and one univalent from S. alba could be detected. Sometimes, one putative C-S trivalent could also be detected. The achievement of B. oleracea-S. alba monosomic alien addition lines lays a foundation for gene introgression, location and cloning. | WEI Wenhui ZHANG Sufeng LI Jun WANG Lijun CHEN Bo FANG Xiaoping WANG Zhuan LUO Lixia | 2006 | Chinese Science Bulletin2006，51，23： | 3 |
| 14 | Chemiluminescence determination of 20 amino acids and the mechanism study显示文摘20 氨基酸能禁止发光氨鈥揌2 O2 鈥揅u SO4 化合光系统的紧张,这被发现。用这个人物,氨基酸与流动注射被开发的为 20 的决心的一个快速、敏感的方法结合了化合光察觉。在最佳的条件下面, 20 氨基酸的察觉限制在 4.5 脳的范围 10 ? 7 鈥 ?.3 脳 10 ? 10 mol/L,和相对标准差是不到 3.2% 。建议方法成功地被用于药分析。可能的机制也被讨论。 | Yan Ming Liu Zhuan Li Liu | 2010 | Chinese Chemical Letters2010，21，7： | 3 |
| 15 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
| 16 | Development and Evaluation of a MAb-Based ELISA for Detection of Chlamy- dophila pneumoniae Infection with Variable Domain 2 and 3 of the Major Outer Membrane protein显示文摘Objective This paper aims to develop a monoclonal antibodies (MAbs)- based ELISA for detecting Chlamydophila pneumoniae (C. pneumoniae) antigens in humans with the variable domains (VD) 2 and 3 of the major outer membrane protein (MOMP VD2-VD3 ) and to assess its sensitivity and specificity by comparing with a widely used MAb that is able to recognize the elementary bodies of C. pneumoniae. Methods MOMP VD2-VD3 were overexpressed in Escherichia coli and purified by affinity chromatography. Mice were immunized with the recombinant antigen, and hybridomas secreting MAbs were screened. Three stable hybridomas clones were selected and named 5D6, 7G3, and 8C9. The MAbs-based ELISA was scrutinized for species-specific recognition with a number of human throat swab samples from Group I (156 patients with typical respiratory illness clinically confirmed before) and Group II (57 healthy donors). Results In Group I, 55 positive cases were detected by anti-EB MAb-based ELISA, 51 cases were positive by MAbs 5D6-based ELISA, and 33 and 38 cases were positive by MAb 8C9 and 7G3-based ELISA respectively. Of the 57 samples from Group II 'healthy donors', 5 were positive and 52 were negative with both anti-EB and 5D6-based tests, while 2 and 3 positive cases were identified by the other two MAb-based ELISAs respectively. Conclusion The novel MOMP VD2-VD3 MAb-based assay may have higher specificity than the anti-EB MAb, which may possibly be used as an alternative tool for the diagnosis of C. pneumoniae infection. | ZHOU Zhou WU Yi Mou CHEN Li Li LIU Guang Chao LIU Liang Zhuan ZHOU An Wen ZHANG Jun Hua | 2012 | Biomedical and Environmental Sciences2012，25，6： | 2 |
| 17 | A novel STAT3 inhibitor negatively modulates platelet activation and aggregation显示文摘抄写 3 的信号变换器和使活跃之物(STAT3 ) 在血小板函数起一个关键作用。这研究寻求了在血小板激活和聚集上理解 STAT3 禁止者 SC99 的效果。Immunoblotting 试金被使用在表明小径的 STAT3 上测量 SC99 的效果。ChronoLog aggregometer 被用来评估血小板聚集。流动 cytometer 被用来面对 SC99 计算 P-selectin 表达式。染色的 AlamarBlue 和 Annexin-V 被用来分别地评估血小板生存能力和 apoptosis。一台荧光显微镜被使用分析血小板传播。SC99 在人的血小板禁止了 JAK2 和 STAT3 的 phosphorylation,但是没在 AKT, p65 或 Src 的 phosphorylation 上有效果,所有哪个涉及血小板激活。进一步的研究表明 SC99 禁止了骨胶原和凝血酵素以一种剂量依赖者方式导致的人的血小板聚集。SC99 禁止了导致凝血酵素的 P-selectin 表示和纤维蛋白原绑定挑选血小板。而且, SC99 禁止了血小板在纤维蛋白原上传播,块收回由在外面在里面发信号调停了。在老鼠而是它的禁止的血小板聚集显著地没延长的 SC99 流血时间。一起拿,现在的学习表明 SC99 作为一个 STAT3 禁止者禁止了血小板激活和聚集。这个代理人能为 thrombotic 混乱作为一个有希望的处理被开发。 | Zhuan XU Yu-jia XU Ya-nan HAO Li-jie REN Zu-bin ZHANG Xin XU Bi-yin CAO Ke-sheng DAI Li ZHU Qi FANG Yan KONG Xin-liang MAO | 2017 | Acta Pharmacologica Sinica2017，38，5： | 2 |
| 18 | Indications, detectability, positive findings, total enteroscopy, and complications of diagnostic double-balloon endoscopy: a systematic review of data over the first decade of use显示文摘 | Lei Xin Zhuan Liao Yue-Ping Jiang Zhao-Shen Li | 2011 | Gastrointestinal Endoscopy2011，，3： | 2 |
| 19 | Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review显示文摘 | Zhuan Liao Rui Gao Can Xu Zhao-Shen Li | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 20 | Hepatitis C and Alcohol Exacerbate Liver Injury by Suppression of FOXO3显示文摘 | Batbayar Tumurbaatar Irina Tikhanovich Zhuan Li Jinyu Ren Robert Ralston Sudhakiranmayi Kuravi Roosevelt Campbell Gaurav Chaturvedi Ting-Ting Huang Jie Zhao Junfang Hao Maura O’Neil Steven A. Weinman | 2013 | The American Journal of Pathology2013，，6： | 2 |
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