|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 2 | Schistosoma japonicum egg antigens stimulate CD4(+) CD25(+) T cells and modulate airway inflammation in a murine model of asthma显示文摘 | Yang, J. H. Zhao, J. Q. Yang, Y. F. Zhang, L. Yang, X. Zhu, X. Ji, M. J. Sun, N. X. Su,C. | 2007 | 南京医科大学学报(自然科学版)2007，27，4： | 25 |
| 3 | THE INFLUENCE OF CAVITY DAMAGE ON MECHANICAL PROPERTIES OF SUPERPLASTICALLY-DEFORMED MATERIALS AND ITS PREDICTION显示文摘Aluminium alloy LY12CZ sheet without any pre-treatment has been used to study the influence of cavity damage on the mechanical properties of the superplastically-deformed materials room temper- ature. The experimental results show that: (1) the lower the rate of cavitation as the superplastic strain increases, the higher the superplasticity is; (2) the mechanical properties of superplastically- deformed materials at room temperature decrease as the superplastically-deformed strain increases, especially, a noteworthy decrease in elasticity modulus, yield strenth and ultimate strength at room temperature begins to appear as the level of cavitation by area comes up to about 4%, while at the same level the reduction in area drops down a very large quantity. Then, a three-layer back- propagation neural network has been developed to predict the machanichl properties of the superplasti- cally-deformed material.The results acquired from the neural network are very | M. B. Liu, Z. C. Zhao,H. Gao,M. Q. Li and S. C. Wu College of Materials Science and Engineering, Northwestern Polytechnical University, Xi’an 710072, China | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 18 |
| 4 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 5 | Scale Effect of Climate and Soil Texture on Soil Organic Carbon in the Uplands of Northeast China显示文摘Understanding how spatial scale inffuences commonly-observed effiects of climate and soil texture on soil organic carbon (SOC) storage is important for accurately estimating the SOC pool at different scales. The relationships among climate factors, soil texture and SOC density at the regional, provincial, city, and county scales were evaluated at both the soil surface (0-20 cm) and throughout the soil profile (0-100 cm) in the Northeast China uplands. We examined 1022 profiles obtained from the Second National Soil Survey of China. The results indicated that the relationships between climate factors and SOC density generally weakened with decreasing spatial scale. The provincial scale was optimal to assess the relationship between climate factors and SOC density because regional differences among provinces were covered up at the regional scale. However, the relationship between soil texture and SOC density had no obvious trend with increasing scale and changed with temperature. There were great differences in the impacts of climate factors and soil texture on SOC density at different scales. Climate factors had a larger effect on SOC density than soil texture at the regional scale. Similar trends were seen in Heilongjiang and eastern Inner Mongolia at the provincial scale. But, soil texture had a greater effect on SOC density compared with climate factors in Jilin and Liaoning. At the city and county scales, the inffuence of soil texture on SOC density was more important than climate factors. | WANG Dan-Dan SHI Xue-Zheng WANG Hong-Jie D. C. WEINDORF YU Dong-Sheng SUN Wei-Xia REN Hong-Yan ZHAO Yong-Cun | 2010 | Pedosphere2010，20，4： | 17 |
| 6 | THE EFFECT STRESS ON THE MAGNETOSTRICTION IN TWIN- FREE SINGLE CRYSTALS Tb_y Dy_(1-y) (Fe_(1-x) T_x)_2 (T=Al,Mn)显示文摘Magnetostriction at room temperature under various conditions of compressive prestress and applied fields in Tb yDy 1-y (Fe 1-x T x) 2 (T=Al,Mn) twin-free single crystals were investigated. The substitution of Al or Mn for Fe lowers the magnetostriction un-der ordinary temperature and pressure, but it also decreases the saturation field, which enables these materials with potential benefits for applications. | Y.X.Li, G.Z.Xu,J.P.Qu, F.G.Liu and B.W. Wang Hebei University of Technology, Tianjin 300130, China C. Zhao Tianjin University, Tianjin 300072, China S.X. Gao Hebei Normal University,Shijiazhuang 050091, China C.C. Tang, G.H.Wu, J.H.Wang, J.Du and W | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 14 |
| 7 | Two Divergent Members of 4-Coumarate: Coenzyme A Ligase from Salvia miltiorrhiza Bunge: cDNA Cloning and Functional Study显示文摘4-Coumarate:辅酶 A ligase (4CL ) 是在导致 phenolics 的系列的 phenylpropanoid 新陈代谢的关键酶之一,包括水溶性的酉分的酸,它是决定 Danshen (鼠尾草植物 miltiorrhiza Bunge ) 的药用的质量的重要混合物,繁体中文药用的植物。在 Danshen 在水溶性的酉分的酸的生合成调查 4CL 的功能,我们克隆由使用嵌套的反向的抄写聚合酶链反应( RT-PCR ),退化教材由 cDNA 的快速的扩大结束的 5/3 (种族)列在后面编码分叉的 4CL 成员的二 cDNAs ( Sm4CL1 和 Sm4CL2 )(笔记,这些顺序数据在就职数字 AY237163 和 AY237164 下面被提交了到 GenBank 数据库)。编码,区域被插入到 pRSET 向量,运动试金与净化的 recombinant 蛋白质被执行。Sm4CL1 的底层利用侧面从 Sm4CL2 的是不同的。到 4-coumaric 酸的 Sm4CL1 和 Sm4CL2 的 Km 价值是(72.20 獥敳 ? 楷桴吗? | Shu-Juan Zhao Zhi-Bi Hu DI Liu Frederick C. C. Leungt | 2006 | Journal of Integrative Plant Biology2006，48，11： | 13 |
| 8 | Regional Simulation of Soil Organic Carbon Dynamics for Dry Farmland in East China by Coupling a 1:500000 Soil Database with the Century Model显示文摘Changes in soil organic carbon (SOC) in agricultural soils influence soil quality and greenhouse gas concentrations in the atmosphere. Dry farmland covers more than 70% of the whole cropland area in China and plays an important role in mitigating carbon dioxide (CO2) emissions. In this study, 4109 dry farmland soil polygons were extracted using spatial overlay analysis of the soil layer (1:500000) and the land use layer (1:500000) to support Century model simulations of SOC dynamics for dry farmland in Anhui Province, East China from 1980 to 2008. Considering two field-validation sites, the Century model performed relatively well in modeling SOC dynamics for dry farmland in the province. The simulated results showed that the area-weighted mean soil organic carbon density (SOCD) of dry farmland increased from 18.77 Mg C ha1 in 1980 to 23.99 Mg C ha1 in 2008 with an average sequestration rate of 0.18 Mg C ha1 year?1. Approximately 94.9% of the total dry farmland area sequestered carbon while 5.1% had carbon lost. Over the past 29 years, the net SOC gain in dry farmland soils of the province was 19.37 Tg, with an average sequestration rate of 0.67 Tg C year1. Augmentation of SOC was primarily due to increased consumption of nitrogen fertilizer and farmyard manure. Moreover, SOC dynamics were highly differentiated among dry farmland soil groups. The integration of the Century model with a fine-scale soil database approach could be conveniently utilized as a tool for the accurate simulation of SOC dynamics at the regional scale. | WANG Shi-Hang SHI Xue-Zheng ZHAO Yong-Cun D. C. WEINDORF YU Dong-Sheng XU Sheng-Xiang TAN Man-Zhi SUN Wei-Xia | 2011 | Pedosphere2011，21，3： | 9 |
| 9 | Modeling Carbon Dynamics in Paddy Soils in Jiangsu Province of China with Soil Databases Differing in Spatial Resolution显示文摘A number of process-based models have been developed for quantifying carbon(C)sequestration in agro-ecosystems.The DeNitrification-DeComposition(DNDC)model was used to simulate and quantify long-term(1980-2008)soil organic carbon(SOC)dynamics in the important rice-producing province,Jiangsu,China.Changes in SOC storages were estimated from two soil databases differing in spatial resolution:a county database consisting of 68 polygons and a soil patch-based database of 701 polygons for all 3.7 Mha of rice fields in Jiangsu.The simulated SOC storage with the coarse resolution county database ranged between 131.0-320.6 Tg C in 1980 and 170.3-305.1 Tg C in 2008,respectively,while that estimated with the fine resolution database was 201.6 and 216.2 Tg C in 1980 and 2008,respectively.The results modeled with the soil databases differing in spatial resolution indicated that using the soil input data with higher resolution substantially increased the accuracy of the modeled results;and when lacking detailed soil datasets,the DNDC model,parameterized with the most sensitive factor(MSF) method to cope with attribute uncertainty,could still produce acceptable results although with deviations of up to 60% for the case study reported in this paper. | XU Sheng-Xiang SHI Xue-Zheng ZHAO Yong-Cun YU Dong-Sheng WANG Shi-Hang ZHANG Li-Ming C. S. LI TAN Man-Zhi | 2011 | Pedosphere2011，21，6： | 9 |
| 10 | Cryo-EM structure of human mTOR complex 2显示文摘 | Xizi Chen Mengjie Liu Yuan Tian Jiabei Li Yilun Qi Dan Zhao Zihan Wu Min Huang Catherine C. L. Wong Hong-Wei Wang Jiawei Wang Huirong Yang Yanhui Xu | 2018 | Cell Research2018，28，5： | 8 |
| 11 | Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts显示文摘 | You, Y. P. Geng, X. Z. Zhao, P. FU, Z. Wang, C. Z. Chao, S. W. Liu, N. Lu, A. L. Gardner, K. Pu, P. Y. Kong, C. S. Ge, Y. Judge, S. I. V. Li, Q. D. Q | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 6 |
| 12 | Primary Hyperparathyroidism:A Tale of Two Cities Revisited-New York and Shanghai显示文摘In the 1970s,with the advent of biochemical multichannel screening in the United States and other western countries,the clinical presentation of primary hyperparathyroidism(PHPT) changed from a symptomatic to an asymptomatic disorder.However,in Asian countries,like China,PHPT did not show this evolution,but rather continued to be a symptomatic disease with target organ involvement.In this paper,we revisit the clinical features of PHPT in New York and Shanghai,representative United States and Chinese cites,over the past decade.The questions we address are whether the disease evolved in China to a more asymptomatic one and,whether in the United States further changes are evident.The results indicate that while PHPT con-tinues to present primarily as an asymptomatic disease in the United States,a new phenotype characterized by normal serum calcium and high parathyroid hormone levels,normocalcemic PHPT,has emerged.Data from Shanghai demonstrates a trend for PHPT to present more commonly as an asymptomatic disorder in China.However,most patients with PHPT in China still manifest classical symptoms,i.e.nephrolithiasis and fractures.A comparison of the two cohorts shows that Chinese patients with PHPT are younger,with higher serum calcium and PTH levels,and lower 25-hydroxyvitamin D levels than patients in New York.Normocalcemic PHPT has not yet been recognized in Shanghai.In summary,although the phenotypes of PHPT in both cities are evolving towards less evident disease,sharp clinical and biochemical differences are still apparent in PHPT as expressed in China and the United States. | Jian-min Liu Natalie E. Cusano Barbara C. Silva Lin Zhao Xiao-yan He Bei Tao Li-hao Sun Hong-yan Zhao Wen-wei Fan Megan E. Romano Guang Ning John P. Bilezikian | 2013 | Bone Research2013，1，2： | 6 |
| 13 | The role and clinical implications of microRNAs in hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis. | ZHAO Xue YANG Zhen LI GuangBing LI DongKai ZHAO Yi WU Yan ROBSON Simon C. HE Lian XU YiYao MIAO R-uoYu ZHAO HaiTao | 2012 | Science China(Life Sciences)2012，55，10： | 6 |
| 14 | A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction显示文摘 | Yin, L. Chung, C. M. Huo, R. Liu, H. Zhou, C. Xu, W. Zhu, H. Zhang, J. Shi, Q. Wong, H. Y.C. Chen, J. Lu, Y. Bi, Y. Zhao, C. Du, Y. Ma, M. Cai, Y. Chen, W. Y. Fok, K. L. Tsang, L. L. Li, K. Ni, Y. Chung, Y. W. Zhou, Z. Sha, J. Chan, H. C. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 5 |
| 15 | Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions显示文摘Active host-pathogen interactions take place during infection of human immunodeficiency virus type 1 (HIV-1). Outcomes of these interactions determine the efficiency of viral infection and subsequent disease progression. HIV- infected cells respond to viral invasion with various defensive strategies such as innate, cellular and humoral immune antiviral mechanisms. On the other hand, the virus has also developed various offensive tactics to suppress these host cellular responses. Among many of the viral offensive strategies, HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in the host-pathogen interaction and thus have significant impacts on the outcome of HIV infection. One of the best examples is the interaction of Vif with a host cytidine deaminase APOBEC3G. Although specific roles of other auxiliary proteins are not as well described as Vif-APOBEC3G interaction, it is the goal of this brief review to summarize some of the preliminary findings with the hope to stimulate further discussion and investiga- tion in this exhilarating area of research. | Lin LI Hai Shan LI C. David PAUZA Michael BUKRINSKY Richard Y ZHAO | 2005 | Cell Research2005，15，11： | 5 |
| 16 | Schistosoma japonicum egg antigens stimulate CD4(+) CD25(+) T cells and modulate airway inflammation in a murine model of asthma显示文摘 | Yang, J. H. Zhao, J. Q. Yang, Y. F. Zhang, L. Yang, X. Zhu, X. Ji, M. J. Sun, N. X. Su, C. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 4 |
| 17 | High viral load is associated with poor overall and recurrence-free survival of hepatitis B virus-related hepatocellular carcinoma after curative resection: A prospective cohort study显示文摘 | T. Yang J.-H. Lu J. Zhai C. Lin G.-S. Yang R.-H. Zhao F. Shen M.-C. Wu | 2012 | European Journal of Surgical Oncology2012，，8： | 4 |
| 18 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 19 | Green-Naghdi Theory,Part A:Green-Naghdi(GN) Equations for Shallow Water Waves显示文摘In this work,Green-Naghdi (GN) equations with general weight functions were derived in a simple way. A wave-absorbing beach was also considered in the general GN equations. A numerical solution for a level higher than 4 was not feasible in the past with the original GN equations. The GN equations for shallow water waves were simplified here, which make the application of high level (higher than 4) equations feasible. The linear dispersion relationships of the first seven levels were presented. The accuracy of dispersion relationships increased as the level increased. Level 7 GN equations are capable of simulating waves out to wave number times depth . Numerical simulation of nonlinear water waves was performed by use of Level 5 and 7 GN equations, which will be presented in the next paper. | William C. Webster Wenyang Duan Binbin Zhao | 2011 | Journal of Marine Science and Application2011，10，3： | 3 |
| 20 | Revisiting the late Permian coal from the Huayinshang, Sichuan, southwestern China: Enrichment and occurrence modes of minerals and trace elements显示文摘 | Shifeng Dai Yangbing Luo Vladimir V. Seredin Colin R. Ward James C. Hower Lei Zhao Shande Liu Cunliang Zhao Heming Tian Jianhua Zou | 2013 | International Journal of Coal Geology2013，，： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员