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| 1 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 2 | 前瞻随机对照比较射频消融联合/不联合经导管肝动脉栓塞化疗术治疗肝细胞癌的临床研究显示文摘背景和目的射频消融术(RFA)是近年发展比较快的肝癌治疗手段,具有微创、操作简单、可反复治疗的特点,多项研究证明其对于小肝癌的疗效与手术切除相似,被认为是不能手术小肝癌的主要替代手段,甚至可作为小肝癌的一线治疗手段。经导管肝动脉栓塞化疗术(TACE)是中晚期肝癌的主要治疗手段。TACE联合射频消融,TACE可发现和治疗一些以前没有发现的微小病灶,控制肝肿瘤周围可能存在的微卫星灶,并有利于日后射频治疗的施行;此外,射频消融术前行TACE治疗,可以减少肝肿瘤的血流,从而减少射频消融过程中的热流失,从而增加消融范围;射频消融过程中产生的热量可以协同发挥TACE过程中注入化疗药物的疗效。因此TACE联合射频消融可提高肝细胞癌的疗效。本研究是第一项研究RFA联合TACE的前瞻随机对照研究,目的在于比较RFA联合或不联合TACE治疗肝细胞癌(HCC)的效果。方法此项单中心随机对照临床试验在中山大学肿瘤医院完成。自2006年10月至2009年6月,189例直径小于7 cm的肝细胞癌患者符合入选标准完成对照试验。入选标准:1年龄18~75岁;2HCC单个病灶≤7 cm,或3个或以下病灶,每个≤3 cm;3无影像学证据显示大血管侵犯且无肝外转移;4B超下可见病灶且病灶和腹壁之间有安全距离;5ECOG体力状态评分0;6之前未接受过HCC治疗;7患者Child-Pugh肝功能A或B级。患者随机接受TACE联合RFA治疗(TACE-RFA,n=94)或单纯RFA治疗(n=95)。该研究的主要终点为总体生存率,次要终点为无复发生存率,第三终点为不良事件。结果随访7至62月期间,TACE-RFA组死亡34例,复发33例;RFA组死亡48例,复发52例。TACE-RFA组与RFA组患者1年、3年及4年总体生存率分别为92.6%、66.6%、61.8%以及85.3%、59%和45.0%。两组对应的无复发生存率分别为79.4%、60.6%、54.8%以及66.7%、44.2%和38.9%。TACE-RFA组患者的总体生存率(RR=0.525,95%CI:0.335~0.822;P=0.002)以及无复发生存率(RR=0.575,95%CI:0.374~0.897;P=0.009)均优于RFA组患者。研究中未出现治疗相关死亡病例。Logistic回归分析显示,治疗分组、肿瘤大小以及肿瘤数量为患者总体生存率的显著预后因素,同时,治疗分组与肿瘤数量为患者无复发生存率的显著预后因素。结论对于直径小于7 cm的HCC患者,接受TACERFA较单纯RFA治疗生存获益更显著。 | Peng ZW Zhang YJ Chen MS 张信华 | 2013 | 消化肿瘤杂志(电子版)2013，5，3： | 23 |
| 3 | A New Capillary Electrophoresis Apparatus with Piezoelectric Ceramics High Voltage Source and Amperometric Detector显示文摘IntroductionHighperformancecapiliar}'electrophoresis(HPCE)isanewanalyticaltechnology'rapidly'developedinrecentyears.Withtheadvantagesofsmallsample.highsensitivity,highresolution.rapidanalysisandverycheaprunning,ithasbeenappliedinchemistry'.lifescienc... | Chen, ZG Mo, JYM Yang, XY Wang, LS Mei, XT Zhang, MS | 1999 | Chinese Chemical Letters1999，10，3： | 19 |
| 4 | The compression of IR spectra by using wavelet neural network显示文摘IR spectra play an important role in determining the structure of compounds qualitatively andquantitatively.In general a great number of data are required to exactly show the features ofthe compounds.Regarding various compounds,there are massive IR spectra.With the basicfeatures of IR spectra being reserved,it is important to compress IR spectra for improving thestorage,index and process of IR spectra.The wavelet neural network(WNN)is a newneural network model based on wavelet analysis.However,its introduction and applica-tion in chemistry have not been reported.In this note,WNN is applied to the compression ofthe IR spectra of polystyrene.The results show that the original spectra can be | Liu, W Li, JP Xiong, JH Pan, ZX Zhang, MS | 1997 | Chinese Science Bulletin1997，42，10： | 8 |
| 5 | P-wave velocities of alkaline olivine basalt at high pressure and temperature and its controlling factors显示文摘SEISMIC wave inversion is one of the most important means for us to recognize the compositionand structure of the Earth’s interior.Although the experimental techniques of elastic wave ve-locity measurement at in situ high pressure and temperature develop very fast in recent | Song, MS Xie, HS Zhang, YM Hou, W Xu, J Xu, YS | 1997 | Chinese Science Bulletin1997，42，9： | 3 |
| 6 | Measurement of electrical conductivity of 0.001 mol NaCl solution under high pressures显示文摘The experiments were carried out in a YJ-3000 ton press fitted with a wedge-type cubic anvil. The samples were pressed using pyropgyllite as the pressure medium. The conductance cell for the experiments was made of Teflon and platinum metal was used as electrodes. The detailed method for setting up of sample has been reported. | Zheng, HF Xie, HS Xu, YS Song, MS Guo, J Zhang, YM | 1997 | Chinese Science Bulletin1997，42，18： | 2 |
| 7 | A toll-like receptor that prevents infection by uropathogenic bacteria显示文摘 | Zhang D Zhang G Hayden MS | 2004 | Science2004，303，5663： | 1 |
| 8 | Soluble TGF-β type Ⅱ receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats 显示文摘 | Rabbani ZN Anscher MS Zhang XW | 2003 | Int J Radiat Oncol Biol Phys2003，57，2： | 1 |
| 9 | A Toll-like receptor that prevents infection by uropathogenic bacteria 显示文摘 | Zhang D Zhang G Hayden MS | 2004 | Science2004，303，5663： | 1 |
| 10 | Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain 显示文摘 | Brambrink AM Evers AS Avidan MS Farber NB Smith DJ Zhang X | 2010 | Anesthesiology2010，112，4： | 1 |
| 11 | Purification and character- ization of angiotensin I converting enzyme inhibitory peptides from jellyfish Rhopilema esculentum 显示文摘 | Liu X Zhang MS Jia AR | 2013 | Food Res Inter- national2013，50，： | 1 |
| 12 | Sustainability indices as a tool for urban managers, evidence from four medium - sized Chinese cities 显示文摘 | van Dijk MP Zhang MS | 2005 | Environmental Impact Assessment Review2005，25，6： | 1 |
| 13 | Soluble TGFbeta typeI receptor gene therapy amelicrates acute radiation - induced pulmonary injuty in rat 显示文摘 | Rabbani ZA Anscher MS Zhang X | 2003 | Radiat Oncol Biol Phys2003，57，： | 1 |
| 14 | Anesthesia awareness and the bispeetral index 显示文摘 | Avidan MS Zhang L Burnside BA | 2008 | N Engl J Med2008，358，11： | 1 |
| 15 | Calmodulin kinaseⅡ inhibition protects against structural heart disease显示文摘 | Zhang R Khoo MS Wu Y | 2005 | Nat Med2005，11，4： | 1 |
| 16 | Effects of taurine on aortic rings i-solated from fructose-fed insulin resistance and normal rat aorticrings are different显示文摘 | Xue WX Zhang MS Li J | 2008 | Cardiovasc Drug Ther2008，22，： | 1 |
| 17 | Anesthesia awareness and the bispectral index显示文摘 | Avidan MS Zhang LN Burnside BA | 2008 | N Engl J Med2008，358，： | 1 |
| 18 | In vivo bioluminescence imaging of transplanted islets and early detection of graft rejection显示文摘 | Chen X Zhang X Larson CS Baker MS Kaufman DB | | 0，，： | 1 |
| 19 | The beneficial effect of resveratrol on severe acute panereatitis显示文摘 | Ms QY Zhang M Wang z | 2011 | Ann NY Aead sei2011，1215，： | 1 |
| 20 | Uterine artery embolization combined with methotrexate in the treatment of cesarean scar pregnancy: results of acase series and review of the literature 显示文摘 | Zhang B Jiang ZB Huang MS | 2012 | J Vasc Interv Radiol2012，23，： | 1 |
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