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| 1 | Novel nutraceutic therapies for the treatment of metabolic syndrome显示文摘Nutraceutic therapies such as berberine, bitter melon,Gymnema sylvestre, Irvingia gabonensis, resveratrol and ursolic acid have been shown to help control metabolic syndrome(MetS). The effect of berberine on glucose and lipid metabolism, hypertension, obesity and MetS has been evaluated in animal models and humans. Most clinical trials involving bitter melon have been conducted to evaluate its effect on glucose metabolism; nevertheless, some studies have reported favorable effects on lipids and blood pressure although there is little information about its effect on body weight. Gymnema sylvestre helps to decrease body weight and blood sugar levels; however, there is limited information on dyslipidemia and hypertension. Clinical trials of Irvingia gabonensis have shown important effects decreasing glucose and cholesterol concentrations as well decreasing body weight. Resveratrol acts through different mechanisms to decrease blood pressure, lipids, glucose and weight, showing its effects on the population with Met S. Finally, there is evidence of positive effects with ursolic acid in in vitro and in vivo studies on glucose and lipid metabolism and on body weight and visceral fat. Therefore, a review of the beneficial effects and limitations of the above-mentioned nutraceutic therapies is presented. | Esperanza Martínez-Abundis Miriam Mendez-del Villar Karina G Pérez-Rubio Laura Y Zuniga Marisol Cortez-Navarrete Alejandra Ramírez-Rodriguez Manuel González-Ortiz | 2016 | World Journal of Diabetes2016，7，7： | 3 |
| 2 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 3 | Aspects of reproduction in the alpace显示文摘 | Copaira M Zuniga J | 1968 | J Reprod Fertil1968，16，： | 1 |
| 4 | Relative dominance of gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control显示文摘 | Lucchetti A Galvan P | 2006 | J Virol2006，80，6： | 1 |
| 5 | Boundary con- ditions in dissipative particle dynamics显示文摘 | REVENGA M ZUNIGA I ESPANOL P | 1999 | Computer Physics Communication1999，，： | 1 |
| 6 | Biosimilars approval process显示文摘 | Zuniga L Calvo B | 2010 | Regulatory Toxicology and Pharmacology2010，56，3： | 1 |
| 7 | The Effect of Melatonin on the Secretion of Progesterone in Sheep and on the Development of Ovine Embryos in Vitro显示文摘 | Abecia J A Forcada F Zuniga O | 2002 | Vet Res Commun2002，26，2： | 1 |
| 8 | Environmental and economic costs of nonindigenous species in the United States显示文摘 | Pimentel D Lach L Zuniga R | 2000 | BioScience2000，50，1： | 1 |
| 9 | High Frequency and large number of polymorphic microsatellites in cultured shrimp,penaeus(Litopenaeus vannamei)显示文摘 | Meehan D Xu Z Zuniga G | 2003 | Mar Biotechnol(NY)2003，5，4： | 1 |
| 10 | Rearrangementof the cytoskeleton and cell contacts induce process forma-tion during differentiation of conditionally immortalizedmouse podocyte cell lines显示文摘 | Mundel P Reiser J Zuniga MBA | 1997 | Exp Cell Res1997，236，1： | 1 |
| 11 | Biosimilars: pharmacovigilance and risk management显示文摘 | Zuniga L Calvo B | 2010 | Pharmacoepidemiology and Drug Safety2010，19，7： | 1 |
| 12 | Innovation strategies and employment in Latin American firms 显示文摘 | Zuniga P Crespi G | 2013 | Structural Change and Economic Dynamics2013，24，： | 1 |
| 13 | Surveillance in stage I nonsemi- nomatous germ cell tumours of the testis显示文摘 | Zuniga A Kakiashvili D Jewett MA | 2009 | BJU Int2009，104，9： | 1 |
| 14 | Modified radiative transfer theory for a two-layer random medium显示文摘 | Zuniga M Kong J A | 1980 | J Appl Phys1980，51，5228： | 1 |
| 15 | Coasting acts through down regulation of VEGF gene expression and protein secretion 显示文摘 | Garcia-Velasco JA Zuniga A Pacheco A | 2004 | Hum Reprod2004，19，7： | 1 |
| 16 | Relationships between Arginine Degradation, pH and Survival in LactobaciUus sakei显示文摘 | CHAMPOMIER-VERGES M C ZUNIGA M MOREL-DEV- ILLE F | 1999 | FEMS Microbiol Lett1999，180，2： | 1 |
| 17 | Benzalkonium salts:effects on G protein-mediated processes and surface显示文摘 | Patarca R Rosenzwei JA Zuniga AA | | 0，，3： | 1 |
| 18 | Chemokine-like receptor 1 expression by macrophages in vivo:regulation by TGF-beta and TLR ligands显示文摘 | Zabel BA Ohyama T Zuniga L | 2006 | Exp Hematol2006，34，8： | 1 |
| 19 | Multicentre surveillance of antimicrobial resistance in enterococei and staphylocoeeifrom Colombial hospital,2001 - 2002 显示文摘 | Arias CA Reyes J Zuniga M | 2003 | J Antimicrob Chemother2003，51，1： | 1 |
| 20 | Structural and Functional Analysis of the Gene Cluster Encoding the Enzymes of the Arginine Deiminase Pathway of Lactobacillus sakei 显示文摘 | ZUNIGA M CHAMPOMIER-VERGES M C ZAGOREC M | 1998 | J Bacteriol1998，180，16： | 1 |
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