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| 1 | Reduced antioxidant level and increased oxidative damage in intact liver lobes during ischaemia-reperfusion显示文摘瞄准:为了决定是否增加了,并且详细描述对在老鼠模型上在肝的外科期间测量抗氧化剂防卫合适的方法,肝的血流能引起氧化应力和 hepatocyte 损坏。方法:在戊巴比妥钠昏迷状态,侧面的左和肝的中间的脑叶被抓紧让 45 min 让全部的血供给通过另外的脑叶流动。全部的抗氧化剂地位,谷胱甘肽过氧化物酶和超级氧化物 dysmutase 活动,以及 diene 的集中结合,免费 sulphydril 组织,捐赠 H 能力和肝样品的减少的力量被决定。肝的 Chemiluminescent 紧张也被测量。金属离子(艾尔, Ca, Cu, Fe, Mg, Mn, Zn ) 并且肝的 P 和 S 集中与诱导地联合的血浆被决定光排放分光计和 Se 内容被阴极的的脱衣的 voltammetry 测量。结果:谷胱甘肽过氧化物酶和肝的超级氧化物 dysmutase 活动与在假冒的操作的组观察的那些相比在充血组显著地减少了。全部的抗氧化剂地位的水平在充血组也是显著地更低的。捐赠 H 能力,减少的力量和免费 sulphydril 组集中显示出一样的趋势。重要关联(P<0.05 ) 在非特定的抗氧化剂活动在变化之间被发现。这指向了抗氧化剂防卫系统的同时的活动。当 Ca, Fe, Mg, Se 和 P 离子的层次在充血期间是更高的时,艾尔, Cu, Mn, Zn,和 S 比在假冒的操作的组在充血组是更低的。结论:氧化应力在 ischaemia-reperfusion 期间是为未经触动的肝脑叶的损害的主要因素之一。 | LászlóVáli Gabriella Taba KláraSzentmihályi HedvigFébel TímeaKurucz Zsolt Pallai PéterKupcsulik AnnaBlázovics | 2006 | World Journal of Gastroenterology2006，12，7： | 6 |
| 2 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | Impact of proteolytic enzymes in colorectal cancer development and progression显示文摘Tumor invasion and metastasis is a highly complicated, multi-step phenomenon. In the complex event of tumor progression, tumor cells interact with basement membrane and extracellular matrix components. Proteolytic enzymes(proteinases) are involved in the degradation of extracellular matrix, but also in cancer invasion and metastasis. The four categories of proteinases(cysteine-, serine-, aspartic-, and metalloproteinases) are named and classified according to the essential catalytic component in their active site. We and others have shown that proteolytic enzymes play a major role not only in colorectal cancer(CRC) invasion and metastasis, but also in malignant transformation of precancerous lesions into cancer. Tissue and serumplasma antigen concentrations of proteinases might be of great value in identifying patients with poor prognosis in CRC. Our results, in concordance with othersindicate the potential tumor marker impact of proteinases for the early diagnosis of CRC. In addition, proteinases may also serve as potential target molecules for therapeutic agents. | László Herszényi Loránd Barabás István Hritz Gábor István Zsolt Tulassay | 2014 | World Journal of Gastroenterology2014，20，37： | 3 |
| 4 | Microscopic colitis: A retrospective study of clinical presentation in 53 patients显示文摘AIM: To evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and diarrhea.METHODS: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. The existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively analyzed.RESULTS: Twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). Twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation subgroup.CONCLUSION: The Janus face of MC resembles the subgroups of irritable bowel syndrome. The co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups. | Zsolt Barta Gabriella Mekkel István Csíp(o|') László Tóth Szabolcs Szakáll Gábor G.Szabó Gyula Bakó Gyula Szegedi Margit Zeher | 2005 | World Journal of Gastroenterology2005，11，9： | 3 |
| 5 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 6 | Relationship between diabetes mellitus and cataract in Hungary显示文摘AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in Hungary.The effects of DM on the cataract surgical results were also in the focus of analysis.METHODS:Statistical data analysis of the results of the Rapid Assessment of Avoidable Blindness with Diabetic Retinopathy(RAAB+DR)module conducted in Hungary in 2015.This cross-sectional,population-based,national survey included 3523 people aged 50 years and over.Participants of the survey were examined on-site.Visual acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were examined.RESULTS:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with age.Among the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(OR=15.2%,P<0.001),DM proved to be the most independent influencing risk factor(OR=49.9%,P<0.001).The presence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual acuity.CONCLUSION:DM appears to be one of the main risk factors for developing cataract.Other risk factors,such as age,sex and environment also play an influencing role.Diabetes does not seem to affect the occurrence of cataract surgical complications. | Anita Pék Dorottya Szabó Gábor LászlóSándor Gábor Tóth András Papp Zoltán Zsolt Nagy Hans Limburg János Németh | 2020 | International Journal of Ophthalmology(English edition)2020，13，5： | 2 |
| 7 | Determination of ethyl carbamate in wine by high performance liquid chromatography显示文摘 | Zsolt Ajtony Norbert Szoboszlai László Bencs Erna Viszket Victor G. Mihucz | 2013 | Food Chemistry2013，，2： | 2 |
| 8 | Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis显示文摘 | Ferenc Sipos Orsolya Galamb László Herszényi Béla Molnár Norbert Solymosi Tamás Zágoni Lajos Berczi Zsolt Tulassay | 2008 | Scandinavian Journal of Gastroenterology2008，，3： | 2 |
| 9 | Pulse cyclophosphamide therapy for inflammatory bowel disease显示文摘AIM:To assess the efficacy of intravenous cyclophos-phamide pulse therapy for refractory inflammatory boweldisease(IBD).METHODS:We included in our cohort eight patientswith(moderate/severe)steroid refractory IBD(4 withulcerative colitis and 4 with Crohn's disease).They allreceived 6 cycles of intravenous cyclophosphamide(800mg)per month.RESULTS:Patients entered into remission after the sec-ond/third cyclophosphamide pulse.Disease activity de-creased.There were no side effects and toxicity.All thepatients went into long lasting remission.All Crohn's diseasepatients and 3 of 4 ulcerative colitis patients achievedcomplete remission.One patient with ulcerative colitisshowed an impressive clinical response but did not enterinto remission.For the maintenance,patients with Crohn'sdisease were treated with methotrexate(15 mg/wk)andpatients with ulcerative colitis were treated with azathio-prine(2.5 mg/kg body weight/d).CONCLUSION:Remission was maintained in all pa-tients for 6 mo on the average.The drug was well toler-ated.These findings suggest that aggressive immuno-suppressive therapy may be useful in some refractorypatients and further controlled study should be consid-ered in order to fully evaluate this type of treatment as apotential therapy for IBD. | Zsolt Barta László Tóth Margit Zeher | 2006 | World Journal of Gastroenterology2006，12，8： | 2 |
| 10 | Drag on Hydroid-Fouled Nets – An Experimental Approach显示文摘The present study investigated the drag increase on aquaculture nets due to biofouling of the colonial hydroid Ectopleura larynx. It had two main parts: firstly the growth characteristics of E. larynx were investigated by use of field tests at a Norwegian aquaculture site; secondly the hydrodynamic drag on the fouled twines was studied in a towing tank by using fabricated models of net twines with artificial hydroid fouling. In the field tests, the growth of the hydroids was first measured after three weeks of immersion and then again after six weeks. During this interval, the density of hydroids and the thickness of the hydroid stem were almost constant(1.4 hydroids/mm and 0.29 mm, respectively), while the average length of the hydroids increased from 6.4 to 11.2 mm. The hydroid length followed a Rayleigh distribution, while the thickness was normal(Gaussian) distributed. Replicas of twines with three different levels of hydroid growth were made(1.5 hydroids/mm twine, hydroid length 9 mm, 16 mm and 20 mm), and the drag on these twines was measured at different towing velocities(0.1 to 1.4 m/s) and with different twine configurations. For the twine with the shortest hydroids(9 mm), the drag was from 1.5 times(Re=4000) to 2.2 times(Re=1000) the drag on a clean twine. For the longest hydroids(21 mm), the drag was 2 times and 3.8 times, respectively. | Pl LADER David W. FREDRIKSSON Jana GUENTHER Zsolt VOLENT Nina BLOCHER David KRISTIANSEN Lars GANSEL Jud DECEW | 2015 | China Ocean Engineering2015，29，3： | 1 |
| 11 | Fusion of fungal protoplasts显示文摘 | Ferenczy L Kevei F Zsolt J | 1974 | Nature1974，248，： | 1 |
| 12 | Relapsing polychondritis with p-ANCA associated vasculitis: Which triggers the other?显示文摘Relapsing polychondritis(RP) is a rare autoimmune disease with chronic inflammatory/destructive lesions of the cartilaginous tissues. In one third of the cases it is associated with other autoimmune disorders, mostly with anti-neutrophil cytoplasmic antibody(ANCA) associated vasculitis(AAV). We report three cases of RP with p-ANCA positive AAV. In the first patient RP developed 1.5 years after the onset of AAV. In the others the signs of RP were present before the onset of severe crescent glomerulonephritis. Patients responded well on steroid and cyclophosphamide. In dialysis dependent cases plasmapheresis was also used successfully. During the 2 and 1.5 years of follow up, they were symptom-free, and had stable glomerular filtration rate. The first patient died after four years of follow-up due to the complications of sudden unset pancytopenia,which raises the possibility of associated hemophagocytic syndrome. In the setting of RP or AAV physicians should always be aware of the possibility of sudden or insidious appearance of the other disease. | Ibolya File Csilla Trinn Zsolt Mátyus László Ujhelyi József Balla János Mátyus | 2014 | World Journal of Clinical Cases2014，2，12： | 1 |
| 13 | Matrix Metalloproteinase-9 Expression in the Normal Mucosa–Adenoma–Dysplasia–Adenocarcinoma Sequence of the Colon显示文摘 | László Herszényi Ferenc Sipos Orsolya Galamb Norbert Solymosi István Hritz Pál Miheller Lajos Berczi Béla Molnár Zsolt Tulassay | 2008 | Pathology & Oncology Research2008，，1： | 1 |
| 14 | Fusion of fungal protoplasts 显示文摘 | Ferenczy L Kevei F Zsolt J | 1974 | Nature1974，248，： | 1 |
| 15 | Update on the pharmacogenomics of proton pump inhibitors显示文摘 | Krisztina Hagymá si Katalin Mü llner Lá szló Herszé nyi Zsolt Tulassay | 2011 | Pharmacogenomics2011，，6： | 1 |
| 16 | N-acetylcysteine treatment prevent the progression of multisystem organ failure:A prospective, randomized,placebo-controlled study显示文摘 | Euan S Derek L | 1999 | Crit Care Med1999，27，： | 1 |
| 17 | Coeliac disease in a 15-year period of observation (1997 and 2011) in a Hungarian referral centre显示文摘 | Dorottya Kocsis Pál Miheller Katalin L?rinczy László Herszényi Zsolt Tulassay Károly Rácz Márk Juhász | 2013 | European Journal of Internal Medicine2013，，5： | 1 |
| 18 | Laying date and polygyny as determinants of annual reproductive success in male collared flycatchers ( Ficedula albicollis ): a long-term study显示文摘 | Márton Herényi László Zsolt Garamszegi Rita Hargitai Gergely Hegyi Balázs Rosivall Eszter Sz?ll?si János T?r?k | 2014 | Naturwissenschaften2014，，： | 1 |
| 19 | Fusion of fungal Protoplast显示文摘 | Ferencezy L Kevei F Zsolt J | 1974 | Nature1974，248，： | 1 |
| 20 | Fusion of fungal Protoplast 显示文摘 | Ferencezy L Kevei F Zsolt J | 1974 | Nature1974，248，： | 1 |
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