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| 1 | Layer-by-layer deposition of bioactive layers on magnesium alloy stent materials to improve corrosion resistance and biocompatibility显示文摘Magnesium alloy is considered as one of the ideal cardiovascular stent materials owing to its good mechanical properties and biodegradability.However,the in vivo rapid degradation rate and the insufficient biocompatibility restrict its clinical applications.In this study,the magnesium alloy(AZ31B)was modified by combining the surface chemical treatment and in-situ self-assembly of 16-phosphonyl-hexadecanoic acid,followed by the immobilization of chitosan-functionalized graphene oxide(GOCS).Heparin(Hep)and GOCS were alternatively immobilized on the GOCS-modified surface through layer by layer(LBL)to construct the GOCS/Hep bioactive multilayer coating,and the corrosion resistance and biocompatibility were extensively explored.The results showed that the GOCS/Hep bioactive multilayer coating can endow magnesium alloys with an excellent in vitro corrosion resistance.The GOCS/Hep multilayer coating can significantly reduce the hemolysis rate and the platelet adhesion and activation,resulting in an excellent blood compatibility.In addition,the multilayer coating can not only enhance the adhesion and proliferation of the endothelial cells,but also promote the vascular endothelial growth factor(VEGF)and nitric oxide(NO)expression of the attached endothelial cells on the surfaces.Therefore,the method of the present study can be used to simultaneously control the corrosion resistance and improve the biocompatibility of the magnesium alloys,which is expected to promote the application of magnesium alloys in biomaterials or medical devices,especially cardiovascular stent. | Fan Gao Youdong Hu Guicai Li Sen Liu Li Quan Zhongmei Yang Yanchun Wei Changjiang Pan | 2020 | Bioactive Materials2020，5，3： | 12 |
| 2 | WWOX suppresses KLF5 expression and breast cancer cell growth显示文摘The WW domain-containing oxidoreductase(WWOX) is a tumor suppressor in a variety of cancers, including breast cancer. Reduced WWOX expression is associated with the basal-like subtype and a relatively poor disease-free survival rate among breast cancer patients. Though several WWOX partners have been identified, the functional mechanisms of WWOX's role in cancers have not been fully addressed to date. In the current study, we found WWOX suppresses expression of KLF5—an oncogenic transcription factor—at protein level, and suppresses cancer cell proliferation in both bladder and breast cancer cell lines. Furthermore, we demonstrated that WWOX physically interacts with KLF5 via the former's WW domains and the latter's PY motifs. Interestingly, we found the expression of WWOX negatively correlates with KLF5 expression in a panel of breast cancer cell lines. Taken together, we conjecture that WWOX may suppress cancer cell proliferation partially by reducing the expression of KLF5. | Fei Ge Wenlin Chen Runxiang Yang Zhongmei Zhou Nanshan Chang Ceshi Chen Tianning Zou Rong Liu Jing Tan Guosheng Ren | 2014 | Chinese Journal of Cancer Research2014，26，5： | 7 |
| 3 | CC chemokine receptor 7 promotes triple-negative breast cancer growth and metastasis显示文摘 | Jiao Wu Lu Li Jianing Liu Yang Wang Zehua Wang Yangdan Wang Wenjing Liu Zhongmei Zhou Ceshi Chen Rong Liu Runxiang Yang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 5 |
| 4 | Dynamics of dissolved organic carbon in the mires in the Sanjiang Plain,Northeast China显示文摘Mires in boreal area had proved to be an important dissolved organic carbon (DOC) reserve for the sensitivity to climate change and human interfering. The study was focused on the temporal and spatial dynamics and controlling factors of DOC in a seasonally-waterlogged mire (SLM) and perennially-waterlogged mire (PLM) in the Sanjiang Plain, Northest China. In the two mires, DOC concentrations in both surface water and upper soil strata experienced pronounced seasonal variation. DOC concentrations in the surface waters were the greatest and averagely was 47.82 in SLM and 34.84 mg/L and PLM, whereas that in soil water at 0.3-m depth had little difference (20.25 mg/L in SLM and 26.51 mg/L in PLM). Results revealed that DOC concentrations declined 5-8 times vertically from the surface down to groundwater. DOC in the groundwater only was in a very small part with the average concentration of 5.18 mg/L. In relation to the surface water, DOC concentrations varied positively with temperature just before 8 August, and only in early spring and later autumn DOC concentrations exhibited identifiable spatial trends along with standing water depths in PLM. It was supposed that the influences from standing water depth took effect only in conditions of low temperature, and temperature should be the most powerful factor controlling DOC dynamics in the mires. Redox potential (Red) showed negative relationship with DOC values while total nitrogen (TN) and the majority of free ions in the soil solution exhibited no relationship. High soil TOC/TN ratio and low redox potentials also led to DOC accumulation in the mires in the Sanjiang Plain. | Yuedong Guo Zhongmei Wan Deyan Liu | 2010 | Journal of Environmental Sciences2010，22，1： | 5 |
| 5 | Receptor,signal transduction and evolution of sweet,umami and bitter taste显示文摘Like olfaction,the sense of taste allows the detection and discrimination of chemicals in the environment.However,while olfaction is specialized in the detection of volatile chemicals,taste is restricted to the detection of contact-chemicals.Two families of mammalian taste receptors,T1R and T2R,involved in recognition of sweet,umami(the taste of monosodium glutamate)and bitter stimuli have been identified and characterized.Although much progress has been made in studies on the basic mechanisms of taste recognition and signal transduction in mammals,we are still far from a full understanding of different taste qualities.This review presents a current perspective on sweet,bitter and umami taste receptors and their signal transduction mechanism.We also discuss the evolution of taste and taste-related molecules. | Zhongmei Ren Zhenhui Liu | 2020 | Marine Life Science & Technology2020，2，1： | 4 |
| 6 | IDENTITY-BASED KEY-INSULATED PROXY SIGNATURE显示文摘In proxy signature schemes,the proxy signer B is permitted to produce a signature on behalf of the original signer A. However,exposure of proxy signing keys can be the most devastating attack on a proxy signature scheme since any adversary can sign messages on behalf of the proxy signer. In this paper,we applied Dodis,et al.’s key-insulation mechanism and proposed an Identity-Based (ID-based) Key-Insulated Proxy Signature (IBKIPS) scheme with secure key-updates. The proposed scheme is strong key-insulated and perfectly key-insulated. Our scheme also supports unbounded period numbers and random-access key-updates. | Wan Zhongmei Lai Xuejia Weng Jian Liu Shengli Hong Xuan | 2009 | Journal of Electronics(China)2009，26，6： | 4 |
| 7 | An Authenticated Asymmetric Group Key Agreement for Imbalanced Mobile Networks显示文摘A Group key agreement(GKA) protocol enables a group of communicating parties to negotiate a common secret key over an open, untrusted network. The design goal of GKA is to achieve secure group communication, which is an important research issue for mobile communication. The conventional(symmetric) GKA protocol allows a group of members to establish a common secret key for imbalanced mobile networks. However, only the group members can broadcast secret message to the group. To overcome this limitation, this paper proposes an authenticated asymmetric GKA protocol. Instead of a common secret key, each group member negotiates a common group public key and holds a different decryption key. The paper proposed protocol supports the dynamic nodes update of mobile networks, which has forward secrecy and backward secrecy of group key. This protocol is proven secure under the Bilinear Computational Diffie–Hellman problem assumption and the performance analysis shows that the proposed scheme is highly efficient. | ZHANG Qikun ZHANG Quanxin MA Zhongmei TAN Yu'an | 2014 | Chinese Journal of Electronics2014，23，4： | 4 |
| 8 | Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression显示文摘前列腺 transmembrane 蛋白质,导致雄激素(PMEPA1 ) 1 以前被显示了在许多癌症,而是角色支持稳固的恶意,在乳癌的 PMEPA1 的机制充分没被探讨。这里,我们发现 PMEPA1 是在乳癌房间线以及在一套临床的侵略的胸 ductal 癌的 upregulated。有趣地, PMEPA1 的弄空减少了乳癌干细胞(CSC ) 充实人口,当 PMEPA1 的宫外的 overexpression 增加了胸时充实 CSC 的人口。而且,转变生长因素 --(TGF-) 治疗也在三元组否定的乳癌细胞线被发现到 upregulate PMEPA1 表示和充实 CSC 的人口。TGF -- 导致的 PMEPA1 表示部分贡献了 TGF -- 导致的胸 CSC 维护。这些调查结果建议那 TGF -- PMEPA1 轴可能为乳癌治疗提供新诊断和治疗学的目标。 | Zhi Nie Chunyan Wang Zhongmei Zhou Ceshi Chen Rong Liu Dianhua Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 3 |
| 9 | Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORCl and scavenging ROS显示文摘Weight loss and cachexia are common problems in colorectal cancer patients;thus,parenteral and enteral nutrition support play important roles in cancer care.However,the impact of nonessential amino acid components of nutritional intake on cancer progression has not been fully studied.In this study,we discovered that gastrointestinal cancer patients who received cysteine as part of the parenteral nutrition had shorter overall survival(P<0.001)than those who did not.Cystine indeed robustly promotes colon cancer cell growth in vitro and in immunodeficient mice,predominately by inhibiting SESN2 transcription via the GCN2-ATF4 axis,resulting in mTORCl activation.mTORCl inhibitors Rapamycin and Everolimus block cystine-induced cancer cell proliferation.In addition,cystine confers resistance to oxaliplatin and irinotecan chemotherapy by quenching chemotherapy-induced reactive oxygen species via synthesizing glutathione.We demonstrated that dietary deprivation of cystine suppressed colon cancer xenograft growth without weight loss in mice and boosted the antitumor effect of oxaliplatin.These findings indicate that cyst(e)ine;as part of supplemental nutrition,plays an important role in colorectal cancer and manipulation of cyst(e)ine content in nutritional formulations may optimize colorectal cancer patient survival. | Jiao Wu Sai-Ching Jim Yeung Sicheng Liu Aiham Qdaisat Dewei Jiang Wenli Liu Zhuo Cheng Wenjing Liu Haixia Wang Lu Li Zhongmei Zhou Rong Liu Chuanyu Yang Ceshi Chen Runxiang Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 10 | Efficiently mining positive correlation rules显示文摘 | Zhou Zhongmei | 2011 | Applied Mathematics & Information Science2011，5，2： | 1 |
| 11 | Combinatorial analysis on spatial information statistics for the karst water environment in Guiyang,China显示文摘The karst groundwater system is extremely vulnerable and easily contaminated by human activities.To understand the spatial distribution of contaminants in the groundwater of karst urban areas and contributors to the contamination,this paper employs the spatial information statistics analysis theory and method to analyze the karst groundwater environment in Guiyang City.Based on the karst ground water quality data detected in 61 detection points of the research area in the last three years,we made Kriging evaluation isoline map with some ions in the karst groundwater,such as SO4 2-,Fe 3+,Mn 2+and F -,analyzed and evaluated the spatial distribution,extension and variation of four types of ions on the basis of this isoline map.The results of the analysis show that the anomaly areas of SO4 2-,Fe 3+,Mn 2+,Fand other ions are mainly located in Baba’ao,Mawangmiao and Sanqiao in northwestern Gui- yang City as well as in its downtown area by reasons of the original non-point source pollution and the contamination caused by human activities(industrial and domestic pollution). | WANG Zhongmei ZHU Lijun YANG Ruidong YANG Shengyuan DING Jianping YANG Genlan | 2012 | Chinese Journal Of Geochemistry2012，31，2： | 1 |
| 12 | Rice water weevil ( Coleoptera : Curculionidae) in mainland China : Invasion, spread and control 显示文摘 | Hong Chen Zhongmei Chen Yongshu Zhou | 2005 | Crop Protec- tion2005，，24： | 1 |
| 13 | TMEPAI, a transmembrane TGF-β-Inducible protein, sequesters smad proteins from active participation in TGF-βsignaling 显示文摘 | LIU Rong ZHOU Zhongmei HUANG Jian | 2011 | Journal of Pathology2011，223，2： | 1 |
| 14 | Mining both Associated and Correlated Patterns显示文摘 | Zhongmei Zhou Zhaohui Wu Chunshan Wang Yi Feng | 2006 | ICCS2006，，： | 1 |
| 15 | Combining an Ordersemisensitive text similarity and closest fit approach to textual missing values in knowledge discovery显示文摘 | Yi Feng Zhaohui Wu Zhongmei Zhou | 2005 | LNAI2005，3682，： | 1 |
| 16 | Mining frequent maximum patterns with constraint显示文摘 | Zhou Zhongmei | 2004 | 复旦大学学报(自然版)2004，，5： | 1 |
| 17 | Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity 显示文摘 | Ning An Zhongmei Zou Ze Tian | 2008 | Fitoperapia2008，79，1： | 1 |
| 18 | Practice and Experience of Experimental Teaching Reform for Computer Majors显示文摘 | Li Wenjun Yi Yang Shu Zhongmei | 2007 | Research and Exploration in Laboratory2007，26，29： | 1 |
| 19 | Death receptor regulation and Celecoxib-induced apoptosis in human lung cancer cells显示文摘 | Xiangguo Liu Ping Yue Zhongmei Zhou | 2004 | Journal of the National Cancer Institute2004，96，23： | 1 |
| 20 | Geological Characteristics and Metallogenic Setting of Representative Magmatic Cu-Ni Deposits in the Tianshan-Xingmeng Orogenic Belt, Central Asia显示文摘A great number of magmatic Cu-Ni deposits(including Kalatongke in Xinjiang and Hongqiling in Jilin) are distributed over a distance of almost 3000 km across the Tianshan-Xingmeng Orogenic Belt, from Tianshan Mountains in Xinjiang in the west, to Jilin in eastern China in the east. These deposits were formed during a range of magmatic episodes from the Devonian to the Triassic. Significant magmatic Cu-Ni-Co-PGE deposits were formed from the Devonian period in the Nalati arc(e.g. Jingbulake Cu-Ni in Xinjiang), Carboniferous period in the Puerjin-Ertai arc(e.g. Kalatongke Cu-Ni-Co-PGE in Xinjiang), Carboniferous period in the Dananhu-Touquan arc(e.g. Huangshandong, Xiangshan and Tulaergen in estern Tianshan, Xinjiang) to Triassic period in the Hulan arc(e.g. Hongqiling Cu-Ni in Jilin). In addition to the overall tectonic, geologic and distribution of magmatic Cu-Ni deposits in the Tianshan-Xingmeng Orogenic Belt, the metallogenic setting, deposit geology and mineralization characteristics of each deposit mentioned above are summarized in this paper. Geochronologic data of Cu-Ni deposits indicate that, from west to east, the metallogenic ages in the Tianshan-Xingmeng Orogenic Belt changed with time, namely, from the Late Caledonian(~440 Ma), through the Late Hercynian(300-265 Ma) to the Late Indosinian(225-200 Ma). Such variation could reflect a gradual scissor type closure of the paleo Asian ocean between the Siberia Craton and the North China Craton from west to east. | HAN Chunming XIAO Wenjiao SU Benxun ZHANG Xiaohui WAN Bo SONG Dongfang ZHANG Zhiyong ZHANG Jien WANG Zhongmei XIE Mingcai | 2019 | Acta Geologica Sinica(English Edition)2019，93，5： | 1 |
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