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| 1 | CT arterial portography and CT hepatic arteriography in detection of micro liver cancer显示文摘AIM To recognize the characteristic findings of micrQliver cancer (MLC) and to evaluate the effect of CT arterial portography (CTAP) and CT hepatic arteriography (CTHA) in diagnosis of MLC. METHODS Between April 1996 to December 1998, CTAP and CTHA were performed in 12patients with MLC, which were not detect ed byconventional CT examinations. After CTHA, 3 mL-- 5 mL mixture of lipiodol, doxorubic in andmitomycin C were injected into hepatic arterythrough the catheter, and then followed up by CTthree or four weeks later (Lipiodol CT LP-CT).RESULTS A total of 22 micro--tumors (0 .2 cm 0.6 cm in diameter ) were detected in 12patients, which manifested as small perfusiondefects in CTAP and small round enhancement inCTHA. The rate of detectability of CTAP andCTHA was 68.2% (15/ 22) and 77.3% (17/ 22)respectively, and the rate of the simultaneoususe of both procedures reached 86. 4% (19/ 22 ).All micro--tumors were demonstrated as punctatelipiodol deposit fool in LP--CT. After LP--CT, theelevated serum level of Q-fetoprotein (AFP)dropped to the normal level in all patients.CONCLUSION The CTAP and CTHA are the mostsensitive imaging methods for detecting microIiver cancer. Confirmed by the change of theelevated serum AFP level and lipiodol depositfool in LP-CT, small perfusion defects in CTAPand punctate enhancement in CTHA may suggestmicro--liver cancer. | Li L Wu PH Mo YX Lin HG Zheng L Li JQ Lu LX Ruan CM Chen L | 1999 | World Journal of Gastroenterology1999，5，3： | 16 |
| 2 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 3 | Investigating lipid-lipid and lipid-protein interactions in model membranes by ToF-SIMS显示文摘 | ZHENG L MCQUAW CM BAKER MJ | 2008 | Appl Surface Sci2008，225，4： | 1 |
| 4 | Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway显示文摘 | Liu CM Zheng GH Ming QL | 2013 | J Agric Food Chem2013，61，5： | 1 |
| 5 | Cyclopeptide from the seeds Annonaglabr显示文摘 | LI CM TAN NH ZHENG HL | 1999 | Phytochemistry1999，50，6： | 1 |
| 6 | Colomclal cancer epidemiology and prevention study in China显示文摘 | ZHENG S CM S R | 2003 | Chinese-German J Clin Oncol2003，2，： | 1 |
| 7 | Fabrication of silicon nanowire devices for ultrasensitive,label-free, real-time detection of biologi- cal and chemical species显示文摘 | Patolsky F Zheng G Lieber CM | 2006 | Nature Protocols2006，1，4： | 1 |
| 8 | Mitofusin-2 is a major determinant of oxidative strss-mediated heart muscle cell apoptosis显示文摘 | Shen T Zheng M Gao CM | 2007 | J Biol Chem2007，282，23： | 1 |
| 9 | Stem cells fromdeciduous tooth repair mandibular defect in swine显示文摘 | Zheng Y Liu Y Zhang CM | 2009 | JDent Res2009，88，3： | 1 |
| 10 | Toxicity and biodistribution of a first-generation recombinant adenoviral vector,encoding aquqporin-1,after retroductal delivery to a single rat submandibular gland显示文摘 | Zheng C Goldsmith CM Mineshiba F | 2006 | Hum Gene Ther2006，17，11： | 1 |
| 11 | Stem cells from deciduous tooth repair mandibular defect in swine 显示文摘 | Zheng Y Liu Y Zhang CM | 2009 | J Dent Res2009，88，3： | 1 |
| 12 | Role of homocysteine n end-stage renal disease显示文摘 | Wu CC Zheng CM | 2012 | Clin Biochem2012，45，1617： | 1 |
| 13 | Learning curve of la- paroscopy spleen-preserving splenic hilar lymph node dissection for advanced upper gastric cancer显示文摘 | Lu J Huang CM Zheng CH | 2012 | Hepato- gastroenterology2012，60，122： | 1 |
| 14 | Identification of human chronic myelogenous leukemia progenitor cells with hemangioblaslic characteristics 显示文摘 | Fang BJ Zheng CM Liao LM | 2005 | Blood2005，105，： | 1 |
| 15 | Effect and mechanism of andrographolide on the recovery of Pseudomonas aeruginosa susceptibility to several antibiotics 显示文摘 | Wu CM Cao JL Zheng MH | 2008 | J hat Med Res2008，36，1： | 1 |
| 16 | Acupuncture for migraine prophylaxis:a randomized controlled trial显示文摘 | LI Y ZHENG H Witt CM | 2012 | CMAJ2012，184，4： | 1 |
| 17 | High prevalence of left ventricular systolic and diastolic asynchrony in patient with congestive heart failure and nomal QRS duration显示文摘 | Yu CM Lin H Zheng Q | 2003 | Heart2003，89，： | 1 |
| 18 | Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis显示文摘 | SHEN T ZHENG M CAO CM | 2007 | J Biol Chem2007，282，： | 1 |
| 19 | Corosolic acid-induced acute kidney injury and lactic acidosis in a patient with impaired kidney function 显示文摘 | Zheng JQ Zheng CM Lu KC | 2010 | Am J Kidney Dis2010，56，2： | 1 |
| 20 | Role of homocysteine in endstage renal disease显示文摘 | Wu CC Zheng CM Lin YF | 2012 | Clin Biochem2012，45，1617： | 1 |
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