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	题名	作者	年代	出处	被引量
1	Outcome of nonerosive gastro-esophageal reflux disease patients with pathological acid exposure显示文摘AIM: To assess the management and outcome of nonerosive gastro-esophageal reflux disease (NERD) patients who were identified retrospectively, after a 5-year follow-up.METHODS: We included patients with gastro-esophageal reflux disease (GERD) symptoms who had a negative endoscopy result and pathological 24-h esophageal pH-monitoring while off therapy. We interviewed them after an average period of 5 years (range 3.5-7 years) by means of a structured questionnaire to assess presence of GERD symptoms, related therapy, updated en-doscopic data and other features. We assessed predictors of esophagitis development by means of univariate and multivariate statistical analysis.RESULTS: 260 patients (137 women) were included. Predominant GERD symptoms were heartburn andregurgitation in 103/260 (40%). 70% received a maintenance treatment, which was proton pump inhibitor (PPI) in 55% of cases. An average number of 1.5 symptomatic relapses per patient/year of follow-up were observed. A progression to erosive gastro-esophageal reflux disease (ERD) was found in 58/193 (30.0%) of patients undergoing repeat endoscopy; 72% of these were Los Angeles grade A-B. CONCLUSION: This study shows that progression to ERD occurs in about 5% of NERD cases per year, despite therapy. Only two factors consistently and independently influence progression: smoking and absence of PPI therapy.	Fabio Pace Stefano Pallotta Gianpiero Manes Annalisa de Leone Patrizia Zentilin Luigi Russo Vincenzo Savarino Matteo Neri Enzo Grossi Rosario Cuomo	2009	World Journal of Gastroenterology2009，15，45：	8
2	Notchl signaling stimulates proliferation of immature cardiomyocytes显示文摘	COLLESI C ZENTILIN L SINAGRA G	2008	J Cell Biol2008，183，：	1
3	Effect of Helieobaeter pylori Eradication on 24-hour gastric PH and duodenal gastric rnetaplasia显示文摘	Savarino V Mela GS Zentilin P		0，，07：	1
4	Intravenous genetherapy with PIM-1 via a eardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling 显示文摘	Katare R Caporali A Zentilin L	2011	Circ Res2011，108，10：	1
5	A novel procedure for quantitative polymerase chain reaction by coamplification of competitive templates显示文摘	Diviacco S Norio P Zentilin L	1992	Gene1992，122，2：	1
6	Management strategy forpatients with gastroesophageal reflux disease: a comparison betweenempirical treatment with esomeprazole and endoscopy-orientedtreatment 显示文摘	Giannini EG Zentilin P Dulbecco P	2008	Am J Gastroenterol2008，103，2：	1
7	Management strategy for patients with gastroesophageal reflux disease:a comparison between empirical treatment with esomeprazole and endoscopy-oriented treatment 显示文摘	Giannini EG Zentilin P Dulbecco P	2008	Am J Gastroentero12008，103，2：	1
8	Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet显示文摘	Zentilin P liritano E Dulbecco P	2006	Dig Liver Dis2006，38，4：	1
9	Gastroe-sophageal reflux and pulmonary fibrosis in scleroderma: astudy using pH-impedance monitoring显示文摘	Savarino E Bazzica M Zentilin P	2009	Am J Respir CritCare Med2009，179，5：	1
10	Esophageal acid exposure still plays a major role in patients with NERD 显示文摘	Savarino E Zentilin P Savarino V	2013	J Gastroenterol2013，48，4：	1
11	Recruitmcnt of bone márrow stem cells in postnatal neovascularization induced by VEGF gene transfer using AAV vectors and characterization of circulating endothelial progenitor cells显示文摘	Tafuro S Zentilin L Arsic N	2004	Gene Therapy2004，1，：	1
12	The role of nonacid reflux in NERD:lessons learned from impedance-Ph monitoring in 150 patients off therapy 显示文摘	Savarino E Zentilin P Tntuian R	2008	Am J Gastroenterol2008，103，10：	1
13	A ten day levofloxaci based therapy in patients with resistant Helicobacter pylori infection:a controlled trial显示文摘	Bilardi C Dulbeceo P Zentilin P	2004	Clin Gastroenterol Hepatol2004，2，：	1
14	Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy 显示文摘	Pepe M Mamdani M Zentilin L	2010	Circ Res2010，106，：	1
15	Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels显示文摘	Zentilin L Tafuro S Zacchigna S	2006	Blood2006，107，9：	1
16	Gastroesophageal reflux and pulmonary fibrosis in scleroderma:a study using pH-impedance monitoring显示文摘	Savarino E Bazzica M Zentilin P	2009	Am J Respir Crit Care Med2009，179，5：	1
17	Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction 显示文摘	Zentilin L Puligadda U Lionetti V	2010	FASEB J2010，24，：	1
18	Functional heartburn has more in common with functional dyspepsia than with non- erosive reflux disease显示文摘	Savarino E Pohl D Zentilin P	2009	Gut2009，58，11：	1
19	The role of nonacid reflux in NERD: lessons learned from impedance-pH monitoring in 150 patients off therapy显示文摘	Savarino E Zentilin P Tutuian R	2008	Am J Gastroentero12008，103，11：	1
20	The role of nonacid reflux in NERD= lessons learned from impedance-pH monitoring in 150 patients off therapy 显示文摘	Savarino E Zentilin P Tutuian R	2008	Am J Gastroenterol2008，103，11：	1

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