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| 1 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 2 | Properties of lead-free solder alloys with rare earth element additions显示文摘 | WU C M L YU D Q LAW C M T WANG L | 2004 | Materials Science and Engineering2004，44，1： | 2 |
| 3 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 4 | Association of influenza virus NP and M1 proteins with cellular cytoskeletal elements in influenza virus-infected cells显示文摘 | AVALOS R T YU Z NAYAK D P | 1997 | J Virol1997，71，4： | 1 |
| 5 | Limitations in the Code Acquisition Performance for Adaptive Filter Versus Correlator显示文摘 | Yu T Kang C Hong D | 2006 | IEEE Signal Processing Letters2006，13，11： | 1 |
| 6 | Investigation of solid adsorbents for humidity control in display cases显示文摘 | YU D KLEIN S A REINDLE D T | 2002 | ASHRAE Transactions2002，108，1： | 1 |
| 7 | Overexpression of a Novel Soybean Gene Modulating Na: and K : Transport En- hances Salt Tolerance in Transgenie Tobacco Plants 显示文摘 | Chen H T He H Yu D Y | 2011 | Physiologia Plantarum2011，141，1： | 1 |
| 8 | Effects of covalent surface modifications on the electrical and electrochemical properties of graphene using sodium 4-aminoazobenzene-4'-sulfonate 显示文摘 | Yu D S Kuila T Kim N H | 2013 | Carbon2013，54，： | 1 |
| 9 | Fabrication of twoweirstructure-based packed columns for on-chip solidphaseextraction of DNA显示文摘 | Zhong R T Liu D Y Yu L F | 2007 | Electrophoresis2007，28，： | 1 |
| 10 | The properties of Sn-9Zn lead-free solder alloys doped with trace rare earth elements 显示文摘 | Wu C M L Yu D Q Law C M T | 2002 | Journal of electronic materials2002，31，9： | 1 |
| 11 | Analysis of ignition in a diesel particulate filter显示文摘 | Yu M T Luss D Balakotaiah V | 2013 | Catalysis Today2013，216，： | 1 |
| 12 | The effects of supply chain integration on customer satisfaction and financial performance : An organizational learning perspective 显示文摘 | YU W T JACOBS M A SALISBURY W D ENNS H | 2013 | International Journal of Production Economies2013，146，1： | 1 |
| 13 | Silicon nanowires prepared by laser ablation at high temperature 显示文摘 | Zhang Y F Tang Y H Wang N Yu D P Lee C S Bello I Lee S T | 1998 | Applied Physics Letters1998，72，15： | 1 |
| 14 | Superhydrophobic cotton fabric coating based on a complex layer of silica nanoparticles and perfluoro-octylated quaternary ammonium silane coupling agent显示文摘 | YU M H GU G T MENG W D | 2007 | Applied Sur-face Science2007，253，7： | 1 |
| 15 | Nonlinear analysis of SRC col- umns subjected to fire 显示文摘 | YU J T LU Z D XIE Q | 2007 | Fire Safety Journal2007，42，1： | 1 |
| 16 | Properties of lead-free solder alloys with rare earth element additions 显示文摘 | Wu C M L Yu D Q Law C M T | 2004 | Materials Science and Engineering2004，44，： | 1 |
| 17 | Fe2Ojmaeroporous resin nanocomposites: Some novel highly efficient catalysts for hydroxy lation of phenol with H202 显示文摘 | Wang D A Liu Z Q Liu F Q Ai X Zhang X T Cao Y Yu J F Wu T H Bai Y B Li T J Tang X Y | 1998 | App Catal A1998，174，： | 1 |
| 18 | Synthesis of gold nano- hexapods with controllable arm lengths and their tunable op- tical properties显示文摘 | Kim D Y Yu T Cho E C | 2011 | Angewandte Chemic-International Edi- tion2011，50，28： | 1 |
| 19 | Determination of the optimal energy level in spectral CT imaging for displaying abdominal vessels in pediatric patients显示文摘 | Hu D Yu T Duan X | 2014 | Eur J Radiol2014，83，3： | 1 |
| 20 | Preparation and characterization of steel surfaces for adhesive bonding显示文摘 | Fernando D Teng J G Yu T | 2013 | Journal of Composites for Construction2013，17，6： | 1 |
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