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1Deep Learning and Its Applications in Biomedicine显示文摘Advances in biological and medical technologies have been providing us explosive volumes of biological and physiological data,such as medical images,electroencephalography,genomic and protein sequences.Learning from these data facilitates the understanding of human health and disease.Developed from arti?cial neural networks,deep learning-based algorithms show great promise in extracting features and learning patterns from complex data.The aim of this paper is to provide an overview of deep learning techniques and some of the state-of-the-art applications in the biomedical?eld.We?rst introduce the development of arti?cial neural network and deep learning.We then describe two main components of deep learning,i.e.,deep learning architectures and model optimization.Subsequently,some examples are demonstrated for deep learningapplications,including medical image classi?cation,genomic sequence analysis,as well as protein structure classi?cation and prediction.Finally,we offer our perspectives for the future directions in the?eld of deep learning.Chensi Cao Feng Liu Hai Tan Deshou Song Wenjie Shu Weizhong Li Yiming Zhou Xiaochen Bo Zhi Xie 2018Genomics, Proteomics & Bioinformatics2018,16,1:22
2The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China.Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao 2016Translational Neurodegeneration2016,5,1:23
3Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018显示文摘Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more serious.This study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and 2018.Methods:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this study.Viral RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)protocol.The Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral drugs.Results:The prevalence of TDR was not significantly increased over time.The prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,respectively.Conclusions:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance.Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing 2021China CDC weekly2021,3,53:13
4In situ preparation of g-C3N4/Bi4O5I2 complex and its elevated photoactivity in Methyl Orange degradation under visible light显示文摘A graphite carbon nitride(g-C3N4)modified Bi4O5I2 composite was successfully prepared insitu via the thermal treatment of a g-C3N4/Bi OI precursor at 400°C for 3 hr.The as-prepared g-C3N4/Bi4O5I2 showed high photocatalytic performance in Methyl Orange(MO)degradation under visible light.The best sample presented a degradation rate of 0.164 min^-1,which is 3.2 and 82 times as high as that of Bi4O5I2 and g-C3N4,respectively.The g-C3N4/Bi4O5I2 was characterized by X-ray powder diffractometer(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Raman,X-ray photoelectron spectroscopy(XPS),ultraviolet-visible diffuse reflectance spectra(DRS),electrochemical impedance spectroscopy(EIS)and transient photocurrent response in order to explain the enhanced photoactivity.Results indicated that the decoration with a small amount of g-C3N4 influenced the specific surface area only slightly.Nevertheless,the capability for absorbing visible light was improved measurably,which was beneficial to the MO degradation.On top of that,a strong interaction between g-C3N4 and Bi4O5I2 was detected.This interplay promoted the formation of a favorable heterojunction structure and thereby enhanced the charge separation.Thus,the g-C3N4/Bi4O5I2 composite presented greater charge separation efficiency and much better photocatalytic performance than Bi4O5I2.Additionally,g-C3N4/Bi4O5I2 also presented high stability.·O2^- and holes were verified to be the main reactive species.Zhe Feng Lin Zeng Qingle Zhang Shifeng Ge Xinyue Zhao Hongjun Lin Yiming He 2020Journal of Environmental Sciences2020,32,1:12
5Devonian Sea-Level Change Rhythms in South China and Coupling Relationships Among the Earth-spheres显示文摘Twenty orthosequences and their corresponding sea-level change (SLC) cycles have been recognized in the Devonian overlying the Caledonian unconformity, of which 9, 5.5 and 5.5 occurred in the Lower, Middle and Upper Devonian respectively. They can be grouped into 4 orthosequence sets, in which the maximum flooding surfaces lie in the sulcutus Zone (D12), perbonus Zone (D13), Middle and Upper varcus Zone (D22) and gigas Zone (D21) respectively. Four instant palaeogeographical reconstructions of South China have been made in the Emsian and Givetian. Devonian sea-level change rhythms of South China can be divided into 3 categories: the autorhythmic, the worldwide and regional allorhythmic, and the coupling-rhythmic. They developed respectively in the Famennian, Pragian, Eifelian, Lochkovian, Emsian, Givetian, Frasnian and the F / F (between the Frasnian and Famennian) event. The cause of the worldwide allorhythmic SLC of the Pragian and Eifelian under comparatively dry, warm and tranquil conditions mayGong Yiming,Faculty of Earth Science, China University of Geosciences, Wuhan,Hubei, 430074Wu Yi,Guangxi Institute of Geology, Nanning, GuangxiDu Yuansheng, Feng Qinglai and Liu BenpeiChina University of Geosciences, Wuhan, Hubei, 430074 1997Acta Geologica Sinica(English Edition)1997,71,4:10
6Research on operation and management muti-node model of mega city energy Internet显示文摘This paper conducts comprehensive analysis about operational characteristics, market value, stakeholders, and operating modes of a megacity energy Internet. An innovating 'one platform, two centers, and multiple nodes' operation management model is proposed. The study provides an in-depth explanation of the new operation and management model of the connotation and logical relationship. Building a comprehensive energy service platform, developing an integrated energy dispatch center, a market trading service center, communication, and other parts of the system needed to achieve benefits for all parties is including in the discussion. The proposed new model of operation and management has important guiding significance and reference for the development and construction of energy Internets in megacities.Cheng Yao Zhang Zhang Jiancheng Yu Wei Feng Changxin Zhou Yiming Han 2018Global Energy Interconnection2018,1,2:5
7Geology and Geochemistry of the Yangtizishan-Moshishan Metamorphosed Sedimentary Anatase Deposit in Zhenglan Qi,Inner Mongolia:Discovery of a New Genetic Type of Titanium Deposit显示文摘锐钛矿和它的 allomorphic 矿物质金红石在钛矿物质资源之中有最突出的经济意义并且在中国当前组成非常需要的矿物质资源之一。Yantizishan-Moshishan 锐钛矿沉积物先前被叫作基于作者相信的最近的调查和探索的铁沉积物属于一种新基因类型是大变形沉积锐钛矿主导的沉积物的。矿石身体在 Mesoproterozoic (1751 妈) 发生在 stratoid 和透镜的形式片岩, metasandstone (metasiltstone ) ,和角闪岩。富有的矿石让 perthitic 组织主要包括 interbedded 石英 perthite (与传播锐钛矿和金红石) 并且锐钛矿 perthite。矿石矿物质主要是锐钛矿并且辅助地金红石和钛铁矿(?????????? £吗?ZHAO Yiming LI Daxin WU Liangshi CHEN Wenming FENG Chengyou WANG Peihua GAO Xuedong 2011Acta Geologica Sinica(English Edition)2011,85,6:4
8Spatio-temporal Variations in Drought with Remote Sensing from the Mongolian Plateau During 1982–2018显示文摘The Mongolian Plateau is one of the regions most sensitive to climate change,the more obvious increase of temperature in 21 st century here has been considered as one of the important causes of drought and desertification.It is very important to understand the multi-year variation and occurrence characteristics of drought in the Mongolian Plateau to explore the ecological environment and the response mechanism of surface materials to climate change.This study examines the spatio-temporal variations in drought and its frequency of occurrence in the Mongolian Plateau based on the Advanced Very High Resolution Radiometer(AVHRR)Normalized Difference Vegetation Index(NDVI)(1982–1999)and the Moderate-resolution Imaging Spectroradiometer(MODIS)(2000–2018)datasets;the Temperature Vegetation Dryness Index(TVDI)was used as a drought evaluation index.The results indicate that drought was widespread across the Mongolian Plateau between1982 and 2018,and aridification incremented in the 21 st century.Between 1982 and 2018,an area of 164.38×10^4 km^2/yr suffered from drought,accounting for approximately 55.28%of the total study area.An area of approximately 150.06×10^4 km^2(51.43%)was subject to more than 160 droughts during 259 months of the growing seasons between 1982 and 2018.We observed variable frequencies of drought occurrence depending on land cover/land use types.Drought predominantly occurred in bare land and grassland,both of which accounting for approximately 79.47%of the total study area.These terrains were characterized by low vegetation and scarce precipitation,which led to frequent and extreme drought events.We also noted significant differences between the areal distribution of drought,drought frequency,and degree of drought depending on the seasons.In spring,droughts were widespread,occurred with a high frequency,and were severe;in autumn,they were localized,frequent,and severe;whereas,in summer,droughts were the most widespread and frequent,but less severe.The increase in temperature,decrease in precipitation,continuous depletion of snow cover,and intensification of human activities have resulted in a water deficit.More severe droughts and aridification have affected the distribution and functioning of terrestrial ecosystems,causing changes in the composition and distribution of plants,animals,microorganisms,conversion between carbon sinks and carbon sources,and biodiversity.We conclude that regional drought events have to be accurately monitored,whereas their occurrence mechanisms need further exploration,taking into account nature,climate,society and other influencing factors.CAO Xiaoming Feng Yiming SHI Zhongjie 2020Chinese Geographical Science2020,30,6:4
9A comparison between acute large vessel occlusion in the posterior circulation and anterior circulation after endovascular treatment:the ANGEL-ACT registry experience显示文摘Background and purpose Endovascular treatment(EVT)has shown an overwhelming benefit for acute anterior circulation artery occlusion(ACO).Whether it can achieve the same outcomes in posterior circulation artery occlusion(PCO)has not been well explained.We aimed to evaluate the characteristics and prognosis of ACO and PCO after EVT in a nationwide registry.Method The present analysis was based on the prospective ANGEL-ACT Registry in China between November 2017 and March 2019.Demographic data,periprocedural times,recanalisation rate,intracranial haemorrhage(ICH)and 90-day functional outcomes were compared between the ACO and PCO groups.Results A total of 1793 patients were analysed including 397(22.1%)consecutive patients with PCO and 1396(77.9%)patients with ACO treated with EVT.A larger proportion of patients with PCO had intracranial atherosclerotic disease and received extra angioplasty during EVT.Successful recanalisation and 90-day favourable functional outcomes did not differ significantly between the two groups.Patients with PCO showed lower 24-hour ICH and symptomatic ICH rates.There was a trend towards higher mortality rate in the PCO group(22.09%vs 14.44%;adjusted OR 1.286(95%CI 0.820 to 2.017),p=0.2731),especially when the onset to puncture time was over 6 hours(30.77%vs 11.13%;adjusted OR 2.673(95%CI 1.280 to 5.583),p=0.0089,interactive p=0.0002).Conclusions In this large prospective multicentre registry,there was a significant difference in the characteristics and periprocedural features between patients with PCO and ACO.However,successful recanalisation and 90-day favourable functional outcomes in PCO were equivalent to those in ACO.Xuan Sun Jingyu Zhang Xu Tong Baixue Jia Dapeng Mo Ning Ma Feng Gao Lian Liu Xiaochuan Huo Ligang Song Yiming Deng Zhongrong Miao 2022Stroke & Vascular Neurology2022,7,4:4
10eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive.Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li 2019National Science Review2019,6,5:4
11Devonian Sequence Stratigraphy and Sea Level Change Cycles in South China显示文摘The Devonian is well developed in South China and has drawn a great attention from the geologists both at domestic and abroad. On the basis of study on the sequence stratigraphy in more than 10 sections in Guizhou, Guangxi, Longmenshan and Southern Qinling within South China we have identified 21 sequences and T-R cycles that correspond to third-order sea level changes. These sea level change cycles were controlled by autorhythm(Pragian,Eifelian), allorhythm(Lochkovian,Emsian,Givetian) and coupling rhythm mechanisms (frasian, Famennian and F-F boundary).Du Yuansheng Gong Yiming (Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074) Wu Yi (Guangxi Institute of Geology, Nanning 530023) Liu Benpei Feng Qinglai (Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074) 1996Journal of Earth Science1996,15,1:3
12A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform显示文摘The objective of this study was to develop a novel hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier(NLC) drug delivery platform. An ophthalmic antiinflammatory drug, baicalin(BN) was chosen as the model drug. BN –NLC was prepared using melt-emulsification combined with ultra-sonication technique. Additionally, a dual pH-and thermo-sensitive hydrogel composed of carboxymethyl chitosan(CMCS) and poloxamer 407(F127) was fabricated by a cross-linking reaction with a nontoxic crosslinker genipin(GP). GP-CMCS/F127 hydrogel was characterized by FTIR, NMR, XRD and SEM. The swelling studies showed GP-CMCS/F127 hydrogel was both pH-and thermo-sensitive. The results of in vitro release suggested BN –NLC gel can prolong the release of baicalin comparing with BN eye drops and BN –NLC. Ex vivo cornea permeation study was evaluated using Franz diffusion cells. The apparent permeability coefficient(Papp) of BN –NLC gel was much higher(4.46-fold) than that of BN eye drops. Through the determination of corneal hydration levels, BN –NLC gel was confirmed that had no significant irritation to cornea. Ex vivo precorneal retention experiments were carried out by a flow-through approach. The results indicated that the NLC-based hydrogel can prolong precorneal residence time. In conclusion, the hybrid NLCbased hydrogel has a promising potential for application in ocular drug delivery.Yibin Yu Ruoxi Feng Jinyu Li Yuanyuan Wang Yiming Song Guoxin Tan Dandan Liu Wei Liu Xinggang Yang Hao Pan Sanming Li 2019Asian Journal of Pharmaceutical Sciences2019,14,4:3
13Relationship Between Drug Resistance and Death in HIV-Infected Patients Receiving Antiretroviral Therapy—7 PLADs,China,2010−2019显示文摘Summary What is already known about this topic?With increasing coverage of antiretroviral therapy(ART)for HIV-infected patients,more and more attention has been paid to the impact of HIV drug resistance on death in those patients in China.What is added by this report?Among HIV-infected patients receiving ART,the risk of death is higher in patients with HIV drug resistance[adjusted odds ratio(AOR)=4.25.Tianhao Zhang Lingjie Liao Yiming Shao Yi Feng Yuhua Ruan Hui Xing 2021China CDC weekly2021,3,14:3
14The Major Ore Clusters of Super-Large Iron Deposits in the World, Present Situation of Iron Resources in China, and Prospect显示文摘The metamorphosed sedimentary type of iron deposits(BIF) is the most important type of iron deposits in the world, and super-large iron ore clusters of this type include the Quadrilatero Ferrifero district and Carajas in Brazil, Hamersley in Australia, Kursk in Russia, Central Province of India and Anshan-Benxi in China. Subordinated types of iron deposits are magmatic, volcanic-hosted and sedimentary ones. This paper briefly introduces the geological characteristics of major super-large iron ore clusters in the world. The proven reserves of iron ores in China are relatively abundant, but they are mainly low-grade ores. Moreover, a considerate part of iron ores are difficult to utilize for their difficult ore dressing, deep burial or other reasons. Iron ore deposits are relatively concentrated in 11 metallogenic provinces(belts), such as the Anshan-Benxi, eastern Hebei, Xichang-Central Yunnan Province and middle-lower reaches of Yangtze River. The main minerogenetic epoches vary widely from the Archean to Quaternary, and are mainly the Late Archean to Middle Proterozoic, Variscan, and Yanshanian periods. The main 7 genetic types of iron deposits in China are metamorphosed sedimentary type(BIF), magmatic type, volcanic-hosted type, skarn type, hydrothermal type, sedimentary type and weathered leaching type. The iron-rich ores occur predominantly in the skarn and marine volcanic-hosted iron deposits, locally in the metamorphosed sedimentary type(BIF) as hydrothermal reformation products. The theory of minerogenetic series of mineral deposits and minerogenic models has applied in investigation and prospecting of iron ore deposits. A combination of deep analyses of aeromagnetic anomalies and geomagnetic anomalies, with gravity anomalies are an effective method to seeking large and deep-buried iron deposits. China has a relatively great oresearching potential of iron ores, especially for metamorphosed sedimentary, skarn, and marine volcanic-hosted iron deposits. For the lower guarantee degree of iron and steel industry, China should give a trading and open the foreign mining markets.ZHAO Yiming FENG Chengyou LI Daxin 2014Acta Geologica Sinica(English Edition)2014,88,6:2
15A Comprehensive Online Database for Exploring ∼20,000 Public Arabidopsis RNA-Seq Libraries显示文摘In the last decade,RNA-sequencing(RNA-seq)has surpassed microarray to become the gold standard for gene expression profiling due to the continuous drop in sequencing cost and the latest development of easy-to-use library construction kits.To date,the Arabidopsis community has collectively released more than 20000 RNA-seq libraries,with over 1300 libraries deposited just in the first quarter of 2019(Figure 1A).This vast resource is tremendously useful for all Arabidopsis researchers to study transcriptional regulation,tissue specificity,stress responses,and developmental dynamics of genes in which they are interested.Hong Zhang Fei Zhang Yiming Yu Li Feng Jinbu Jia Bo Liu Bosheng Li Hongwei Guo Jixian Zhai 2020Molecular Plant2020,13,9:2
16Quality Information Management and Application of AWS显示文摘This paper has designed a unified storage model of Automatic Weather Station Quality Information Inquiries and Feedback( AWSQIF),and has developed an AWSQIF automatic management system,which implements the storage of AWSQIF automatically in national quality information two-way feedback process. Based on the unified storage,AWSQIF data have important application in real-time data management,data quality assessment and quality control effect analysis. The results show that the data quality has been improved significantly,and the data assessment has achieved online operating. In addition,AWSQIF can assist the improvement of the quality control effect.Yan WANG Feng GAO Chao SUN Yu YU Yiming LIU 2016Asian Agricultural Research2016,8,2:2
17CO2Switchable Viscoelastic Fluids Based on a Pseudogemini Surfactant显示文摘Zhang Yiming Feng Yujun 2013Langmuir2013,29,:1
18Estimating risk for the carbon market via extreme value theory:an empiri- cal analysis of EU ETS 显示文摘FENG Zhenhua WEI Yiming WANG Kai 2012Applied Energy2012,99,:1
19Preparation,structural characterization and bioactivities of polysaccharides from mulberry(Mori Fructus)显示文摘Mulberry(Mori Fructus),a highly promising functional food,has long exhibited multiple therapeutic effects as a tonic in traditional Chinese food and pharmacology.Polysaccharides have been regarded as the pivotal pharmacological ingredient in mulberry.In this study,structural characterization and bioactivities of polysaccharides from mulberry(PFM-3)were determined.The results showed that PFM-3 was a pyranose containing carboxyl group,which was mainly composed of glucose(Glc)and a small amount of mannose(Man)and fucose(Fuc).The molecular weight of PFM-3 was 96.17 kDa,and the surface of PFM-3 was compact and uniform crack.PFM-3 markedly decreased lipid accumulation,triglyceride(TG)and low density lipoprotein cholesterin(LDL-C)on hyperlipidemia human hepatocellular carcinoma(HepG2)cells.PFM-3 recovered nuclear morphometry and mitochondrial membrane potential(MMP),enhanced the activity of glutathione peroxidase(GPx)and decreased cell arrest in G2 phase on oxidative stress HepG2 cells.In addition,PFM-3 promoted the decline of tumor necrosis factor-α(TNF-α)and the augment of interleukin-10(IL-10)secretion on inflammatory mouse leukemia cells of monocyte macrophage(RAW 264.7).This work provides a certificate that PFM-3 could markedly improve cellular lipid accumulation,endogenous antioxidant defense capacity and inflammation levels to further use for treatment and amelioration of related diseases.Yumeng Liu Yiming Liu Delun Mu Hui Yang Ying Feng Ruiqin Ji Rina Wu Junrui Wu 2022Food Bioscience2022,46,2:1
20Carbon Price Volatility: Evi- dence from EU ETS显示文摘ZhenHua Feng LeLe Zou YiMing Wei 2011Applied Energy2011,,88:1
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