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| 1 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 2 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 3 | A simple method to synthesize NiO fibers显示文摘 | Zhan Y J Yim C R Zheng C L | 2004 | Solid-State Chemistry2004，，177： | 1 |
| 4 | Willingness to Pay for Travel Information显示文摘 | Khattak A J Yim Y Stalker P L | 2003 | Transporta- tion Research Part C2003，11，2： | 1 |
| 5 | Dose-finding study for the use of long-acting gonadotrophin-releasing hormone analogues prior to ovarian stimulation for IVF 显示文摘 | Yim S Lok I Cheung L | 2001 | Hum Reprod2001，16，： | 1 |
| 6 | Antimicrobial peptides in the airway 显示文摘 | Laube D M Yim S Ryan L K | 2006 | Curr Top Microbiol Immunol2006，306，： | 1 |
| 7 | Gray-scale skeletonization of small vessels in magnetic resonance angiography 显示文摘 | Yim P J Choyke P L Summers R M | 2000 | IEEE Transactions on Medical Imaging2000，19，6： | 1 |
| 8 | The effects of apigenin-7-O-13-D-glucuronopyranoside on reflux oesophagitis and gastritis in rats 显示文摘 | Min Y S Yim S H Bai K L | 2005 | Auton Autacoid Pharmacol2005，25，3： | 1 |
| 9 | An assessment indicator for air ventilation and pollutant dispersion potential in an urban canopy with complex natural terrain and significant wind variations显示文摘 | S H L Yim J C H Fung E Y Y Ng | 2014 | Atmospheric Environment2014，，94： | 1 |
| 10 | Dose-finding Study for the Use of Long-acting Gonadotrophin-releasing Hormone Analoges Prior to Ovarian Stimulation for IVF显示文摘 | Yim S F Lok I H Cheng L P | 2001 | Human Reprod2001，16，3： | 1 |
| 11 | Peffluorinated com- pounds in tap water from China and several other countries显示文摘 | YIM L M SACHI T YEUNG L W Y | 2009 | Envi- ronmental Science and Technology2009，43，13： | 1 |
| 12 | Disposition towards critical thinking: A study of chinese undergraduate nursing students显示文摘 | Yim W Diana L Iris L | 2000 | Journal of Advanced Nursing2000，32，1： | 1 |
| 13 | Histologic features are important prognostic indicators in early stages lung adenocarcinomas 显示文摘 | Yim J Zhu LC Chiriboga L | 2007 | Mod Pathol2007，20，2： | 1 |
| 14 | Magnetic resonance imaging - guided breast biopsy in lesions not visualized by mammogram or ultrasound 显示文摘 | Oxner CR Vora L Yim J | 2012 | Am Surg2012，78，： | 1 |
| 15 | Epstein-Barr virus encodes a novel homolog of the bcl-2oncogene that inhibits apoptosis and associates with Bax and Bak显示文摘 | MARSHALL W L YIM C GUSTAFSON E | 1999 | J Virol1999，73，： | 1 |
| 16 | Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation 显示文摘 | Yim H Erikson R L | 2009 | Mol Cell Biol2009，29，10： | 1 |
| 17 | Video-assisted thoracoscopic thymectomy for myasthenia gravis显示文摘 | Yim A P Kay R L Ho J K | 1995 | Chest1995，108，5： | 1 |
| 18 | The effects of apigenin-7-0-(3-D-glucuronopyranoside on reflux oesophagitis and gastritis inrats 显示文摘 | Min Y S Yim S H Bai K L | 2005 | Autonomic & Autonomic Pharmacology2005，25，3： | 1 |
| 19 | Dysfunctional pancreaticbeta-cells of critical stress play a more prominent role in the de-velopment of stress diabetes in critically burned Korean subjects显示文摘 | Byung-Wan L Jun H Yim HJ | 2010 | Metabolism2010，59，9： | 1 |
| 20 | Same -day ultra- sound guidance in reoperation for locally recurrent papillary thyroid cancer显示文摘 | MCCOY K L YIM J H TUBLIN M E | 2007 | Surgery2007，142，6： | 1 |
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