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| 1 | MiR-122 in hepatic function and liver diseases显示文摘As the most abundant liver-specific microRNA,mi-croRNA-122(miR-122)is involved in various physio-logical processes in hepatic function as well as in liver pathology.There is now compelling evidence that miR-122,as a regulator of gene networks and pathways in hepatocytes,plays a central role in diverse aspects of hepatic function and in the progress of liver diseases.This liver-enriched transcription factors-regulated miRNA promotes differentiation of hepatocytes and regulates lipid metabolism.With regard to liver diseases,miR-122 was shown to stimulate hepatitis C virus(HCV)replication through a unique and unusual interaction with two binding sites in the 5′-UTR of HCV genome to mediate the stability of the viral RNA,whereas inhibit the expression and replication of hepatitis B virus(HBV)by a miR-122-cylin G1/p53-HBV enhancer regulatory pathway.In addition,miR-122 acts as a suppressor of cell prolif-eration and malignant transformation of hepatocytes with remarkable tumor inhibition activity.Notably,a clinical trial targeting miR-122 with the anti-miR-122 oli-gonucleotides miravirsen,the first miRNA targeted drug,has been initiated for treatment of HCV infection.With further understanding of the comprehensive roles of miR-122 in hepatic functions and the mechanisms in-volved in miR-122 down-regulation in chronic hepatitis or hepatocellular carcinoma,miR-122 appears to be a promising candidate for effective therapeutic ap-proaches against tumor and infectious diseases. | Jun Hu Yaxing Xu Junli Hao Saifeng Wang Changfei Li Songdong Meng | 2012 | Protein & Cell2012，3，5： | 22 |
| 2 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 3 | Constructing confidence intervals of extreme rainfall quantiles using Bayesian,bootstrap,and profile likelihood approaches显示文摘Hydrological risk is highly dependent on the occurrence of extreme rainfalls.This fact has led to a wide range of studies on the estimation and uncertainty analysis of the extremes.In most cases,confidence intervals(CIs)are constructed to represent the uncertainty of the estimates.Since the accuracy of CIs depends on the asymptotic normality of the data and is questionable with limited observations in practice,a Bayesian highest posterior density(HPD)interval,bootstrap percentile interval,and profile likelihood(PL)interval have been introduced to analyze the uncertainty that does not depend on the normality assumption.However,comparison studies to investigate their performances in terms of the accuracy and uncertainty of the estimates are scarce.In addition,the strengths,weakness,and conditions necessary for performing each method also must be investigated.Accordingly,in this study,test experiments with simulations from varying parent distributions and different sample sizes were conducted.Then,applications to the annual maximum rainfall(AMR)time series data in South Korea were performed.Five districts with 38-year(1973–2010)AMR observations were fitted by the three aforementioned methods in the application.From both the experimental and application results,the Bayesian method is found to provide the lowest uncertainty of the design level while the PL estimates generally have the highest accuracy but also the largest uncertainty.The bootstrap estimates are usually inferior to the other two methods,but can perform adequately when the distribution model is not heavy-tailed and the sample size is large.The distribution tail behavior and the sample size are clearly found to affect the estimation accuracy and uncertainty.This study presents a comparative result,which can help researchers make decisions in the context of assessing extreme rainfall uncertainties. | CHEN Si LI YaXing SHIN JiYae KIM TaeWoong | 2016 | Science China(Technological Sciences)2016，59，4： | 4 |
| 4 | Efficient separation between trivalent americium and lanthanides enabled by a phenanthroline-based polymeric organic framework显示文摘Separation of the minor actinides(Am and Cm)from lanthanides in high-level liquid wastes(HLLW)is one of the most challenging chemical separation tasks known owing to their chemical similarities and is highly significant in nuclear fuel reprocessing plants because it could practically lead to sustainable nuclear energy by closing the nuclear fuel cycle.The solid phase extraction is proposed to be a possible strategy but all reported sorbent materials severely suffer from limited stability and/or efficiency caused by the harsh conditions of high acidity coupled with intense irradiation.Herein,a phenanthroline-based polymeric organic framework(PhenTAPB-POF)was designed and tested for the separation of trivalent americium from lanthanides for the first time.Due to its fully conjugated structure,PhenTAPB-POF exhibits previously unachieved stability under the combined extreme conditions of strong acids and high irradiation field.The americium partitioning experiment indicates that PhenTAPB-POF possesses an ultrahigh adsorption selectivity towards Am(Ⅲ)over lanthanides(e.g.,SFAm(Ⅲ)/Eu(Ⅲ)=3326)in highly acidic simulated HLLW and relatively fast adsorption kinetics in both static and dynamic experiments.Am(Ⅲ)can be almost quantitatively eluted from the PhenTAPB-POF packed-column using a concentrated nitric acid elution.The high stability and superior separation performance endow PhenTAPB-POF with the promising alternative for separating minor actinides over lanthanides from highly acidic HLLW streams. | Afshin Khayambashi Long Chen Xue Dong Kai Li Zhipeng Wang Linwei He Suresh Annam Lixi Chen Yaxing Wang Matthew V.Sheridan Chao Xu Shuao Wang | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 5 | The laser measurement for slight deformation of large-scale structure显示文摘 | YI YAXING LI ZHONGKE LI XINGSHE DENG FANGLIN | 2000 | Proceeding of SPIE2000，4221，： | 1 |
| 6 | Correction to:Efficient derivation of extended pluripotent stem cells from NOD-scid II2rg^-/-mice显示文摘Figure 1.Generation of NOD-scid II2rg^-1-extended pluripotent stem cells.(A)Schematic of two approaches used for generating NOD-scid II2rg^-1-extended pluripotent stem cells:de novo derivation from blastocysts(upper panels)and chemical reprogramming from embryonic fibroblasts(lower panels).(B)Phase-contrast images of de novo derived outgrowth and EPS colonies for 17 passages in LCDM medium.Scale bars,100 pm.(C)qRT-PCR analysis of XEN marker genes expression during the chemical induction process(day 16).Error bars indicate SEM(n=2).(D)Co-immunostaining of XEN marker genes during the chemical induction process(day 16).Upper panels:GATA6 and SALL4;lower panels:SOX17 and SALL4.Scale bars,100 pm. | Yaqin Du Ting Wang Jun Xu Chaoran Zhao Haibo Li Yao Fu Yaxing Xu Liangfu Xie Jingru Zhao Weifeng Yang Ming Yin Jinhua Wen Hongkui Deng | 2019 | Protein & Cell2019，10，2： | 1 |
| 7 | Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation显示文摘One major strategy to generate genetically modified mouse models is gene targeting in mouse embryonic stem(ES)cells,which is used to produce gene-targeted mice for wide applications in biomedicine.However,a major bottleneck in this approach is that the robustness of germiine transmission of gene-targeted ES cells can be significantly reduced by their genetic and epigenetic instability after long-term culturing,which impairs the efficiency and robustness of mouse model generation.Recently,we have established a new type of pluripotent cells termed extended pluripotent stem(EPS)cells,which have superior developmental potency and robust germline competence compared to conventional mouse ES cells.In this study,we demonstrate that mouse EPS cells well maintain developmental potency and genetic stability after long-term passage.Based on gene targeting in mouse EPS cells,we established a new approach to directly and rapidly generate gene-targeted mouse models through tetraploid complementation,Haibo Li and Chaoran Zhao contributed equally to this work.Electronic supplementary material The online version of this article(http://gffzzd3cc09b8251d45dfsfv6kop6x0cw96bkq.ffgz.tsg.suse.edu.cn/10.1007/s13238-018-0556-1)contains supplementary material,which is available to authorized users.which could be accomplished in approximately 2 months.Importantly,using this approach,we successfully constructed mouse models in which the human interleukin 3(IL3)or interleukin 6(IL6)gene was knocked into its corresponding locus in the mouse genome.Our study demonstrates the feasibility of using mouse EPS cells to rapidly generate mouse models by gene targeting,which have great application potential in biomedical research. | Haibo Li Chaoran Zhao Jun Xu Yaxing Xu Chunmei Cheng Yinan Liu Ting Wang Yaqin Du Liangfu Xie Jingru Zhao Yanchuang Han Xiaobao Wang Yun Bai Hongkui Deng | 2019 | Protein & Cell2019，10，1： | 1 |
| 8 | Causes of blindness and visual impairment in urban and rural areas in Beijing显示文摘 | Liang Xu Yaxing Wang Yibin Li | 2006 | Ophthalmology2006，113，7： | 1 |
| 9 | Competing Crystallization between Lanthanide and Actinide in Acidic Solution Leading to Their Efficient Separation显示文摘Summary of main observation and conclusion We present a new method for generating europium oxalate compounds by decomposing of N-methyl 2-pyrrolidone in HNO3 media.The reaction exhibits high selectivity towards Eu^3+ over UO2^2+,which suggests that these conditions could be applied to a selective crystallization based separation system for trivalent lanthanides and hexavalent actinides. | Xuemiao Yin Yaxing Wang Xiaoyan Li Jian Xie Mark A.Silver Lanhua Chen Daopeng Sheng Guoxun Ji Zhifang Chai Shuao Wang | 2019 | Chinese Journal of Chemistry2019，37，1： | 1 |
| 10 | Derivation of totipotent-like stem cells with blastocyst-like structure forming potential显示文摘It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos.Here,we report that a chemical cocktail enables the derivation of totipotent-like stem cells,designated as totipotent potential stem(TPS)cells,from 2-cell mouse embryos and extended pluripotent stem cells,and that these TPS cells can be stably maintained long term in vitro.TPS cells shared features with 2-cell mouse embryos in terms of totipotency markers,transcriptome,chromatin accessibility and DNA methylation patterns.In vivo chimera formation assays show that these cells have embryonic and extraembryonic developmental potentials at the single-cell level.Moreover,TPS cells can be induced into blastocyst-like structures resembling preimplantation mouse blastocysts.Mechanistically,inhibition of HDAC1/2 and DOT1L activity and activation of RARγsignaling are important for inducing and maintaining totipotent features of TPS cells.Our study opens up a new path toward fully capturing totipotent stem cells in vitro. | Yaxing Xu Jingru Zhao Yixuan Ren Xuyang Wang Yulin Lyu Bingqing Xie Yiming Sun Xiandun Yuan Haiyin Liu Weifeng Yang Yenan Fu Yu Yu Yinan Liu Rong Mu Cheng Li Jun Xu Hongkui Deng | 2022 | Cell Research2022，32，6： | 1 |
| 11 | Stabilization of Plutonium(V)Within a Crown Ether Inclusion Complex显示文摘Crystalline coordination complexes of actinides,especially in atypical oxidation states,are not only fundamentally important for expanding the notably limited knowledge on the bonding nature of actinides but could also provide critical information toward the development of nuclear fuel cycle,waste management,and national security.Plutonium(Pu)is the only element in the periodic table that could exist in four oxidation states in aqueous solutions simultaneously. | Yaxing Wang Shu-Xian Hu Liwei Cheng Chengyu Liang Xuemiao Yin Hailong Zhang Ao Li Daopeng Sheng Juan Diwu Xiaolin Wang Jun Li Zhifang Chai Shuao Wang | 2020 | CCS Chemistry2020，2，4： | 1 |
| 12 | Causes of Blindness and Visual Impairment in Urban and Rural Areas in Beijing显示文摘 | Liang Xu Yaxing Wang Yibin Li Yun Wang Tongtong Cui Jianjun Li Jost B. Jonas | 2006 | Ophthalmology2006，，7： | 1 |
| 13 | Thoracoscopic Esophagectomy in Prone Versus Decubitus Position: Ergonomic Evaluation From a Randomized and Controlled Study显示文摘 | Yaxing Shen Mingxiang Feng Lijie Tan Hao Wang Jingpei Li Yong Xi Qun Wang | 2014 | The Annals of Thoracic Surgery2014，，： | 1 |
| 14 | Graphlike Manifolds显示文摘 | Liu Yaxing Li Qisheng | 1994 | Chinese Quart J Math1994，9，4： | 1 |
| 15 | Graphlike Manifolds with Contraction ×显示文摘Graphlike Manifolds with Contraction ×GraphlikeManifoldswithContraction×￥LiuYaxing;LiQisheng(Dept.ofMath.HenanUniversity,... | Liu Yaxing Li Qisheng(Dept.of Math. Henan University,Kaifeng, 475001 ) | 1996 | Chinese Quarterly Journal of Mathematics1996，11，1： | 1 |
| 16 | Assessment on Fault Diagnosis and State Evaluation of New Power Grid:AReview显示文摘1 Introduction The proposal of the concept of“New Power System”aims to illustrate the transform direction of the traditional power system,acting as the development core of the future new power grid.To achieve this,the proposed strategic targets of“carbon neutralization and carbon peaking”must be implemented and insisted[1].The core feature of the new power system is that renewable energy plays a leading role and becomes the main source of energy supply,meanwhile,the goal of green energy utilization has also been put forward on the agenda.Green energy utilization includes two aspects,one is the exploitation and promotion of various green energy technologies,and the other is the digitalization of energy management.Under this trend,stochastic and fluctuating energy sources such as wind power and photovoltaic power replace deterministic controllable power sources such as thermal power,bringing challenges to power grid regulation and dispatching,as well as flexible operation.The large-scale integration of renewable energy and increasingly high proportion of power electronic equipment tend to bring about fundamental changes in the operation characteristics,safety control,and production mode of the power system. | Bo Yang Yulin Li Yaxing Ren Yixuan Chen Xiaoshun Zhang Jingbo Wang | 2023 | Energy Engineering2023，120，6： | 0 |
| 17 | Chromate separation by selective crystallization显示文摘A new paradigm to remove toxic chromate anions from aqueous solution by crystallization of chromatewater clusters with imine-linked guanidinium cationic ligands is introduced.The guanidium-based cationic ligand was easily prepared through the imine condensation of an alde hyde and aminoguanidine hydrochloride.The cationic imine-linked guanidinium liga nd(BBIG-CI)showed a high re moval capacity(292.5 mg/g)in the solutions.Rapid decontamination of chromate anions from the wastewater by this cationic ligand was resulted from an instantaneous crystallization.The produced guanidium chromate salts have an extremely low solubility(Ksp,BBIG=8.19×10^9).Such superior removal performance of these mate rials was attributed to the cha rge-assisted hydrogen bonding between the cationic ligand and chromate-water hydrate anions,which was revealed by the single-crystal X-ray diffraction analysis and density functional theory(DFT)calculations.In addition,the succes s ful recove ry of the guanidium-based ligand makes it more attractive for real-world applications. | Xijian Chen Xing Dai Rongzhen Xie Jie Li Afshin Khayambashi Lei Xu Chuang Yang Nannan Shen Yaxing Wang Linwei He Yugang Zhang Chengliang Xiao Zhifang Chai Shuao Wanga | 2020 | Chinese Chemical Letters2020，31，7： | 0 |
| 18 | A Trivalent Americium Organic Framework with Decent Structural Stability against Self-Irradiation显示文摘We reported the synthesis,single crystal structure,and solid-state UV-Vis-NIR spectroscopy of a new transplutonium metal-organic framework(MOFs),Am(H_(2)O)[PO[(C6H4)COO]_(3)],denoted as AmTPO(TPO=tris(4-carboxylphenyl)-phosphineoxide).AmTPO forms a three-dimensional metal-organic framework structure with americium dimers as the secondary building unit.Clear 5f→5f transi-tions attributed to trivalent americium was observed in the absorption spectrum of AmTPO ranging from 300 to 1200 nm.Notably,AmTPO can maintain the crystallinity with no observable structural degradation within several months after being synthesized,re-vealing a long-term radiation resistance of this structure and the potential application of MOFs as a platform for nuclear waste dis-posal. | Yugang Zhang Kai Li Sida Zhang Xia Wang Hailong Zhang Yanlong Wang Yaxing Wang Zhifang Chai Shuao Wang | 2022 | Chinese Journal of Chemistry2022，40，7： | 0 |
| 19 | Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons显示文摘The expression of linear DNA sequence is precisely regulated by the three-dimensional(3D)architecture of chromatin.Morphine-induced aberrant gene networks of neurons have been extensively investigated;however,how morphine impacts the 3D genomic architecture of neurons is still unknown.Here,we applied digestion-ligation-only high-throughput chromosome conformation capture(DLO Hi-C)technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical neurons.After receiving continuous morphine administration for 90 days on rhesus monkeys,we discovered that morphine re-arranged chromosome territories,with a total of 391 segmented compartments being switched.Morphine altered over half of the detected topologically associated domains(TADs),most of which exhibited a variety of shifts,followed by separating and fusing types.Analysis of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential loops.Moreover,all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops,and were further validated for changed expression.Collectively,an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine effects.Our finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans. | Liang Wang Xiaojie Wang Chunqi Liu Wei Xu Weihong Kuang Qian Bu Hongchun Li Ying Zhao Linhong Jiang Yaxing Chen Feng Qin Shu Li Qinfan Wei Xiaocong Liu Bin Liu Yuanyuan Chen Yanping Dai Hongbo Wang Jingwei Tian Gang Cao Yinglan Zhao Xiaobo Cen | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 20 | TiO_(2) nanorods based self-supported electrode of 1T/2H MoS_(2) nanosheets decorated by Ag nano-particles for efficient hydrogen evolution reaction显示文摘Molybdenum disulfide(MoS_(2))has shown significant promise as an economic hydrogen evolution reaction(HER)catalyst for hydrogen generation,but its catalytic performance is still lower than noble metalbased catalysists.Herein,a silver nanoparticles(Ag NPs)-decorated 1T/2H phase layered MoS_(2) electrocatalyst grown on titanium dioxide nanorod arrays(Ag NPs/1T(2H)MoS_(2)/TNRs)was prepared through acid-tunable ammonium ion intercalation.Taking advantage of MoS_(2) layered structure and crystal phase controllability,as-prepared Ag NPs/1T(2H)MoS_(2)/TNRs exhibited ultrahigh HER activity.As-proposed strategy combines facile hydrogen desorption(Ag NPs)with efficient hydrogen adsorption(1T/2H MoS_(2))effectively circumventes the kinetic limitation of hydrogen desorption by 1T/2H MoS_(2).The as-prepared Ag NPs/1T(2H)MoS_(2)/TNRs electrocatalyst exhibited excellent HER activity in 0.5 mol/L H2SO4 with low overpotential(118 mV vs.reversible hydrogen electrode(RHE))and small Tafel slope(38.61 mV/dec).The overpotential exhibts no obvious attenuation after 10 h of constant current flow.First-principles calculation demonstrates that as-prepared 1T/2H MoS_(2) exhibit a large capacity to store protons.These protons can be subsequently transferred to Ag NPs,which significantly increases the hydrogen coverage on the surface of Ag NPs in HER process and thus change the rate-determining step of HER on Ag NPs from water dissociation to hydrogen recombination.This study provides a unique strategy to improve the catalytic activity and stability for MoS_(2)-based electrocatalyst. | Changzheng Lin Yunpeng Liu Yaxing Sun Zhenyu Wang Hao Xu Mingtao Li Jiangtao Feng Bo Hou Wei Yan | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
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