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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor显示文摘AIM: To investigate the effects of 1400W-a selective inducible nitric oxide synthase(iN OS) inhibitor in a model of donation after circulatory death(DCD) kidneys. METHODS: Porcine kidneys were retrieved after 25 min warm ischemia. They were then stored on ice for 18 h before being reperfused ex vivo with oxygenated autologous blood on an isolated organ perfusion system. The selective i NOS inhibitor 1400W(10 mg/kg) was administered before reperfusion(n = 6) vs control group(n = 7). Creatinine(1000 μmol/L) was added to the system, renal and tubular cell function and the level of ischemia reperfusion injury were assessed over 3 h of reperfusion using plasma, urine and tissue samples. RESULTS: Kidneys treated with 1400 W had a higher level of creatinine clearance(CrC l) [area under the curve(AUC) CrC l: 2.37 ± 0.97 mL /min per 100 g vs 0.96 ± 0.32 mL /min per 100 g, P = 0.004] and urine output [Total: 320 ± 96 mL vs 156 ± 82 mL, P = 0.008]. There was no significant difference in levels of fractional excretion of sodium(AUC, Fr ex Na+: Control, 186.3% ± 81.7%.h vs 1400 W, 153.4% ± 12.1%.h, P = 0.429). Levels of total protein creatinine ratio were significantly lower in the 1400 W group after 1 h of reperfusion(1h Pr/Cr: 1400 W 9068 ± 6910 mg/L/mmol/L vs Control 21586 ± 5464 mg/L/mmol/L, P = 0.026). Levels of 8-isoprostane were significantly lower in the 1400 W group [8-iso/creatinine ratio: Control 239 ± 136 pg/L/mmol/L vs 1400 W 139 ± 47 pg/L/mmol/L, P = 0.041].CONCLUSION: This study demonstrated that 1400 W reduced ischaemia reperfusion injury in this porcine kidney model of DCD donor. Kidneys had improved renal function and reduced oxidative stress. | Sarah A Hosgood Phillip J Yates Michael L Nicholson | 2014 | World Journal of Transplantation2014，4，4： | 2 |
| 3 | Photocatalysis on TiO2 surface: principles, mechanisms and selected re sults显示文摘 | LINSEBIGLER A L LUG Q YATES etal | 1995 | Chem Rev1995，95，3： | 1 |
| 4 | Stickler syndrome:correlation between vitreoretinal phenotypes and linkage to COL 2A1显示文摘 | Snead MP Payne SJ Barton DE Yates JR Al-Imara L Pope FM | 1994 | Eye1994，8，： | 1 |
| 5 | Photo-catalysis on TiO2 surface: :principles, mechanism and selected results显示文摘 | Linsebiger A L Lu Gangquan Yates J T | 1995 | Chem Rev1995，95，3： | 1 |
| 6 | Reproducible electrochemical etching of tungsten probe tips显示文摘 | GUISE O L AHNER J W JUNG M C GOUGHNOUR P C YATES J | 2002 | Nano Letters2002，2，3： | 1 |
| 7 | Canine distemper epizootic in lions,tigers,and leopards in North America显示文摘 | APPEL M J YATES R A FOLEY G L | 1994 | J Vet Diagn Invest1994，6，3： | 1 |
| 8 | Photocatalysis on TiO2 Surfaces: Principles, Mechanisms, and Selected Results 显示文摘 | Linsebigler A L Lu G Yates J T | 1995 | Chemical Reviews1995，95，3： | 1 |
| 9 | Photocatalysis on TiO2 surface: principles, mechanisms and selected results 显示文摘 | Linsebiger A L Lu G Q Yates J T | 1995 | Chem Rev1995，95，： | 1 |
| 10 | Photocatalysis on TiO2 surface:principles,mechanisms and selected results显示文摘 | Linsebigler A L Lu G Q Yates J T | 1995 | Chem Rev1995，95，3： | 1 |
| 11 | The effect of alkali metals on combustion and pyrolysis of Lolium and Festuca grasses,switchgrass and willow显示文摘 | FAHMI R BRIDGWATER A DARVELL L JONES J YATES N THAIN S DONNISON I | 2007 | Fuel2007，86，10： | 1 |
| 12 | Photocatalysis on TiO2Surfaces:Principles,Mechanisms,and Selected Results显示文摘 | LINSEBIGLER A L LU G Q YATES J T | 1995 | Chemical Reviews1995，95，3： | 1 |
| 13 | Multiple EBNAl-binding sites are required to form an EBNAl-dependent enhancer and to aetivate a minimal replieative origin within oriP of Epstein-Barr virus 显示文摘 | WYSOKENSKI D A YATES J L | 1989 | J Virol1989，63，： | 1 |
| 14 | Surface science studies of the photoacti- ration of TiO2 new photochemical processes 显示文摘 | Thompson T L Yates J T | 2006 | Chemical Re- views2006，106，10： | 1 |
| 15 | photo-catalysis on TiO2 surfaces: principles, mechanisms, and selected results 显示文摘 | Linsebigler A L Lu G Q Yates JT | 1995 | Chemical Review1995，25，： | 1 |
| 16 | Photocatalysis on TiO2 surfaces: Principles, mechanism, and selected results 显示文摘 | Linsebigler A L Lu G Yate J T | 1995 | Chem Rev1995，95，3： | 1 |
| 17 | Photocatalysis on TiO2 Surface:Principles,Mechanisms and Selected Results显示文摘 | Linsebigler A L Lu G Q Yates J T | 1995 | ChemRev1995，95，3： | 1 |
| 18 | Surface science studies of the photo activation of TiO2--New photo chemical processes显示文摘 | Thompson T L Yates J T | 2006 | Chem Rev2006，106，10： | 1 |
| 19 | Photocatalysis on TiO2 surfaces:principles,Mechanisms,and selected results显示文摘 | Linsebigler A L Lu G Yates J T | 1995 | Chemical Reviews1995，，95： | 1 |
| 20 | Photochemical activity of nitrogen-doped futile TiO2(110) in visible light显示文摘 | DIWALD O THOMPSON T L ZUBKOV T GORALSKJ E G WALCK S D YATES J T | 2004 | J Phys Chem B2004，108，19： | 1 |
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