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| 1 | MiRNA as potential biomarkers and therapeutic targets for gastric cancer显示文摘Gastric cancer is one of the leading causes of cancer mortality in the world.Aberrant expression of microRNAs(miRNAs)is the hallmarks of this disease.MiRNAs are endogenous non-coding RNAs that involved in many biological processes(e.g.,cell proliferation,differentiation,apoptosis,invasion and development)through gene repression.Deregulation of miRNA expression in gastric tumors and cancer cell lines have been documented to contribute in tumorigenesis,and the expression signature may correlate with different cancer types and clinicopathological features.Here,we summarized the updated gastric cancer-associated miRNAs and the downstream targets in the process of tumorigenesis.Recently,many researchers make use of the miRNA microarray platform to profile miRNA expression in gastric cancer and correlated with different clinical parameters.Its application on cancer diagnosis,prognosis and predictive treatment response rate are still underway and needs further investigation.Emerging roles of miRNAs with oncogenic or tumor suppressive properties in gastric tumorigenesis were discussed.Epigenetic silencing of miRNA by hypermethylation of promoter CpG island was also observed in gastric cancer.However,detailed mechanisms of how miRNAs regulate gene expression in gastric cancer has not been well studied.In this review,we highlight the upto-date findings on the deregulated miRNAs in gastric cancer,and the potential use of miRNA in the clinical settings,such as diagnostic/prognostic markers and chemotherapeutic tools. | Vivian Yvonne Shin Kent-Man Chu | 2014 | World Journal of Gastroenterology2014，20，30： | 59 |
| 2 | Protective Role of Salidroside against Aging in A Mouse Model Induced by D-galactose显示文摘Objective To investigate the protective effects of putative AGEs (advanced glycation endproducts) inhibitor salidroside against aging in an accelerated mouse aging model induced by D-galactose. Methods A group of 5-month-old C57BL/6J mice were treated daily with D-galactose, D-galactose combined with salidroside, salidroside alone, and control buffer for 8 weeks. At the end of the treatment, serum AGEs levels, neurological activities, expression of glial fibrillary acidic protein (GFAP) and neurotrophin-3 (NT-3) in the cerebral cortex, as well as lymphocyte proliferation and IL-2 production were determined. Results D-galactose induced mouse aging model was developed as described before. As expected, salidroside blocked D-galactose induced increase of serum AGEs levels. It also reversed D-galactose induced aging effects in neural and immune system, as evidenced by improving motor activity, increasing memory latency time, and enhancing lymphocyte mitogenesis and interleukin-2 (IL-2) production. Furthermore, elevated expression of GFAP and NT-3 in the aged model mice was also reduced upon salidroside treatment. Conclusion Salidroside inhibits AGEs formation in vivo, which at least partially contributes to its anti-aging effect in D-galactose induced aging model. | YI-YANG YVONNE LI | 2010 | Biomedical and Environmental Sciences2010，23，2： | 34 |
| 3 | LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration显示文摘新兴的研究在少些在染色质水平,但是相对调整基因表示记录长非编码的 RNA (LncRNAs ) 的角色被知道他们怎么调整 DNA methylation。这里,我们识别 lncRNA, Dum (发展联系 pluripotency 2 (Dppa2 ) 在上游的有约束力的肌肉 lncRNA ) 在骨胳的 myoblast 房间。Dum 的表示动态地在 vitro 并且在 vivo 在 myogenesis 期间被调整。它被在 myoblast 区别之上有约束力的 MyoD transcriptionally 也导致。功能的分析证明它支持 myoblast 区别和导致损坏的肌肉新生。机械学地, Dum 被发现它的附近的基因到沉默, Dppa2,在通过招募的 cis Dnmt1, Dnmt3a 和 Dnmt3b。而且, intrachromosomal 在 Dum 地点和 Dppa2 倡导者之间循环为 Dum/Dppa2 相互作用是必要的。一起,我们识别了与 Dnmts 交往调整 myogenesis 的新奇 lncRNA。 | Lijun Wang Yu Zhao Xichen Bao Xihua Zhu Yvonne Ka-yin Kwok Kun Sun Xiaona Chen Yongheng Huang Ralf Jauch Miguel A Esteban Hao Sun Huating Wang | 2015 | Cell Research2015，25，3： | 34 |
| 4 | 华为公司专利产学研合作:特征、网络演化及其启示显示文摘华为公司作为中国通信行业的领军者,在专利活动与技术创新方面非常活跃,也开展了大量的专利产学研合作。通过统计华为公司产学研合作的发明专利数据,采用专利计量和社会网络分析方法,分析了华为公司专利产学研合作的基本特征,并采用UCINET软件进行可视化描述,揭示出专利产学研合作的阶段演化特征和网络属性,得出企业专利产学研合作的有益规律和启示,为我国企业开展专利产学研合作以及专利合作网络的发展与管理提供参考和借鉴。 | 王珊珊 邓守萍 Sarah Yvonne Cooper 王宏起 | 2018 | 科学学研究2018，36，4： | 27 |
| 5 | Organic carbon stratification and size distribution of three typical paddy soils from Taihu Lake region,China显示文摘为中国的持续农业开发现实主义的土壤碳(C) 隐遁策略依靠数量,保留和在水稻土存储的 C 的周转率的精确估计。到日期的可得到的 C 估计是主要为 tilled 和灌溉洪水的表面表层土(ca。30 厘米) 。自从器官的碳(SOC ) 通常显示出的土壤,如此的估计不能被用来外推到 100 厘米的土壤深度有深度的锋利的减少。在这研究,合成土壤样品在泰胡·莱克区域从三代表性的水稻土在几深度被收集到 100 厘米,中国。在侧面玷污器官的碳分发,在总数尺寸,部分被决定。当 SOC 与深度指数地减少了到 100 厘米时,结果显示出那,全部的 SOC 的一个实质的比例(30%40%) 在 30 厘米深度下面被存储。在充实碳的稻表层土, SOC 被发现在 2 0.25 和 0.25 0.02 公里总数尺寸部分优先地积累。? 粗糙的微总数的部分的 13C 分析证明在稻表层土的 C 层化的高度与打火机的出现一致 ? 1313C 在上面 30 厘米深度。这些结果建议在侧面以内的层化关于泥土和铁 oxyhydrates 分布与水稻土的不同 pedogenetical 类型改变的那 SOC。在水稻土系统的总数的沙大小的部分可以在碳隐遁和周转起一个很重要的作用,对另外的学习农业系统不一样。 | PAN Genxing WU Laosheng LI Lianqing ZHANG Xuhui GONG Wei WOOD Yvonne | 2008 | Journal of Environmental Sciences2008，20，4： | 21 |
| 6 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 7 | Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients显示文摘AIM: To investigate Fusobacterium nucleatum(F. nucleatum) abundance in colorectal cancer(CRC) tissues and its association with CRC invasiveness in Chinese patients.METHODS: The resected cancer and adjacent normal tissues(10 cm beyond cancer margins) from 101 consecutive patients with CRC were collected. Fluorescent quantitative polymerase chain reaction(FQ-PCR) was applied to detect F. nucleatum in CRC and normal tissues. The difference of F. nucleatum abundance between cancer and normal tissues and the relationship of F. nucleatum abundance with clinical variables were evaluated. Fluorescence in situ hybridization(FISH) analysis was performed on 22 CRC tissues with the highest F. nucleatum abundance by FQ-PCR testing to confirm FQ-PCR results.RESULTS: The median abundance of F. nucleatum in CRC tissues [0.242(0.178-0.276)] was significantly higher than that in normal controls [0.050(0.023-0.067)](P < 0.001). F. nucleatum was over-represented in 88/101(87.1%) CRC samples. The abundance of F. nucleatum determined by 2^(-ΔCT) was significantly greater in tumor samples [0.242(0.178, 0.276)] than in normal controls [0.050(0.023, 0.067)](P < 0.001). The frequency of patients with lymph node metastases was higher in the over-abundance group [52/88(59.1%)] than in the under-abundance group [0/13(0%)](P < 0.005). No significant association of F. nucleatum with other clinico-pathological variables was observed(P > 0.05). FISH analysis also found more F. nucleatum in CRC than in normal tissues(median number 6, 25^(th) 3, 75^(th) 10 vs 2, 25^(th) 1, 75^(th) 5)(P < 0.01).CONCLUSION: F. nucleatum was enriched in CRC tissues and associated with CRC development and metastasis. | Yu-Yuan Li Quan-Xing Ge Jie Cao Yong-Jian Zhou Yan-Lei Du Bo Shen Yu-Jui Yvonne Wan Yu-Qiang Nie | 2016 | World Journal of Gastroenterology2016，22，11： | 17 |
| 8 | Arabidopsis MSI1 Is Required for Negative Regulation of the Response to Drought Stress显示文摘Arabidopsis MSI1 在植物开发有基本功能。MSI1 是 Polycomb 组蛋白质建筑群和染色质集会因素的一个子单元 1,并且它与 Retinoblastoma 相关的蛋白质交往 1。MSI1 的改变的层次导致多种的显型,反映 MSI1 蛋白质功能的复杂性。以便揭开 MSI1 的另外的功能,我们执行了 transcriptional 介绍野类型并且有高度减少的 MSI1 层次(msi1-cs ) 的植物。令人惊讶地, MSI1 的已知的功能能仅仅在 msi1-cs 植物说明 transcriptional 变化的次要的部分。最惹人注目的意外观察之一是得到反应到干旱和盐应力的骆驼毛的织物应答的基因的一个子集的起来规定。我们报导 MSI1 能绑在干旱可诱导的下游的目标 RD20 的染色质并且在 Arabidopsis 干旱压力反应的否定规定为 MSI1 建议一个新角色。 | Cristina Alexandre Yvonne Moller-Steinbach Nicole Sch6nrock Wilhelm Gruissem Lars Hennig | 2009 | Molecular Plant2009，2，4： | 15 |
| 9 | Spinal cord involvement in patients with cirrhosis显示文摘A severe spinal cord involvement may rarely occur in patients with cirrhosis and other chronic liver diseases;this complication is usually associated with overt liver failure and surgical or spontaneous porto-systemic shunt.Hepatic myelopathy(HM)is characterized by progressive weakness and spasticity of the lower extremities,while sensory and sphincter disturbances have rarely been described and are usually less important.The diagnosis is assigned in the appropriate clinical setting on clinical grounds after the exclusion of other clinical entities leading to spastic paraparesis.Magnetic resonance imaging is often unremarkable;however,also intracerebral corticospinal tract abnor-malities have been reported recently.The study of motor evoked potentials may disclose central conduction abnormalities even before HM is clinically manifest.HM responds poorly to blood ammonia-lowering and other conservative medical therapy.Liver transplantation represents a potentially definitive treatment for HM in patients with decompensated cirrhosis of Child-Pugh B and C grades.Other surgical treatment options in HM include surgical ligation,shunt reduction,or occlusion by interventional procedures. | Raffaele Nardone Yvonne Hller Monica Storti Piergiorgio Lochner Frediano Tezzon Stefan Golaszewski Francesco Brigo Eugen Trinka | 2014 | World Journal of Gastroenterology2014，20，10： | 12 |
| 10 | The role of gut microbiota in liver disease development and treatment显示文摘Liver cancer is the sixth most common cancer worldwide,and the third most common cause of cancer-related death.Hepatocellular carcinoma(HCC),which accounts for more than 90%of primary liver cancers,is an important public health problem.In addition to cirrhosis caused by hepatitis B viral(HBV)or hepatitis C viral(HCV)infection,non-alcoholic fatty liver disease(NAFLD)is becoming a major risk factor for liver cancer because of the prevalence of obesity.Non-alcoholic steatohepatitis(NASH)will likely become the leading indication for liver transplantation in the future.It is well recognized that gut microbiota is a key environmental factor in the pathogenesis of liver disease and cancer.The interplay between gut microbiota and liver disease has been investigated in animal and clinical studies.In this article,we summarize the roles of gut microbiota in the development of liver disease as well as gut microbiota-targeted therapies. | Lijun Wang Yu-Jui Yvonne Wan | 2019 | Liver Research2019，3，1： | 12 |
| 11 | 基于生命周期评价的绿色房地产开发显示文摘基于生命周期评价体系 ,通过分析房地产开发生命周期各阶段可能造成的环境影响 ,提出了避免环境问题的绿色开发原则要素 。 | 郑燕鸣 李启明 Yvonne 戴佐农 刘成刚 | 2001 | 东南大学学报(自然科学版)2001，31，1： | 10 |
| 12 | Peritoneal carcinomatosis of colorectal origin:Incidence,prognosis and treatment options显示文摘Peritoneal carcinomatosis (PC) is one manifestation of metastatic colorectal cancer (CRC). Tumor growth on intestinal surfaces and associated fluid accumulation eventually result in bowel obstruction and incapacitating levels of ascites, which profoundly affect the quality of life for affected patients. PC appears resistant to traditional 5-fluorouracil-based chemotherapy, and surgery was formerly reserved for palliative purposes only. In the absence of effective treatment, the histori-cal prognosis for these patients was extremely poor, with an invariably fatal outcome. These poor outcomes likely explain why PC secondary to CRC has received little attention from oncologic researchers. Thus, data are lacking regarding incidence, clinical disease course, and accurate treatment evaluation for patients with PC. Recently, population-based studies have revealed that PC occurs relatively frequently among patients withCRC. Risk factors for developing PC have been identi-fied:right-sided tumor, advanced T-stage, advanced N-stage, poor differentiation grade, and younger age at diagnosis. During the past decade, both chemother-apeutical and surgical treatments have achieved prom-ising results in these patients. A chance for long-term survival or even cure may now be offered to selected patients by combining radical surgical resection with intraperitoneal instillation of heated chemotherapy. This combined procedure has become known as hy-perthermic intraperitoneal chemotherapy. This edito-rial outlines recent advancements in the medical and surgical treatment of PC and reviews the most recent information on incidence and prognosis of this disease. Given recent progress, treatment should now be considered in every patient presenting with PC. | Yvonne LB Klaver Valery EPP Lemmens Simon W Nienhuijs Misha DP Luyer Ignace HJT de Hingh | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 13 | Pathological transition as the arising mechanism for drug resistance in lung cancer显示文摘Despite the tremendous efforts for improving therapeutics of lung cancer patients,its prognosis remains disappoint-ing.This can be largely attributed to the lack of comprehensive understanding of drug resistance leading to insuf-ficient development of effective therapeutics in clinic.Based on the current progresses of lung cancer research,we classify drug resistance mechanisms into three different levels:molecular,cellular and pathological level.All these three levels have significantly contributed to the acquisition and evolution of drug resistance in clinic.Our under-standing on drug resistance mechanisms has begun to change the way of clinical practice and improve patient prognosis.In this review,we focus on discussing the pathological changes linking to drug resistance as this has been largely overlooked in the past decades. | Yueqing Chen Waiying Yvonne Tang Xinyuan Tong Hongbin Ji | 2019 | Cancer Communications2019，39，1： | 8 |
| 14 | MicroRNA sequences modulating inflammation and lipid accumulation in macrophage “foam” cells: Implications for atherosclerosis显示文摘Accumulation of macrophage'foam'cells,laden with cholesterol and cholesteryl ester,within the intima of large arteries,is a hallmark of early'fatty streak'lesions which can progress to complex,multicellular atheromatous plaques,involving lipoproteins from the bloodstream and cells of the innate and adaptive immune response.Sterol accumulation triggers induction of genes encoding proteins mediating the atheroprotective cholesterol efflux pathway.Within the arterial intima,however,this mechanism is overwhelmed,leading to distinct changes in macrophage phenotype and inflammatory status.Over the last decade marked gains have been made in understanding of the epigenetic landscape which influence macrophage function,and in particular the importance of small non-coding micro-RNA(miRNA)sequences in this context.This review identifies some of the miRNA sequences which play a key role in regulating'foam'cell formation and atherogenesis,highlighting sequences involved in cholesterol accumulation,those influencing inflammation in sterol-loaded cells,and novel sequences and pathways which may offer new strategies to influence macrophage function within atherosclerotic lesions. | Richard James Lightbody Janice Marie Walsh Taylor Yvonne Dempsie Annette Graham | 2020 | World Journal of Cardiology2020，12，7： | 7 |
| 15 | Improvement of pristinamycin I(PI)production in Streptomyces pristinaespiralis by metabolic engineering approaches显示文摘Pristinamycin,produced by Streptomyces pristinaespiralis,which is a streptogramin-like antibiotic consisting of two chemically unrelated components:pristinamycin I(PI)and pristinamycin II(PII),shows potent activity against many antibiotic-resistant pathogens.However,so far pristinamycin production titers are still quite low,particularly those of PI.In this study,we constructed a PI single component producing strain by deleting the PII biosynthetic genes(snaE1 and snaE2).Then,two metabolic engineering approaches,including deletion of the repressor gene papR3 and chromosomal integration of an extra copy of the PI biosynthetic gene cluster(BGC),were employed to improve PI production.The final engineered strain DPIIDpapR3/PI produced a maximum PI level of 132 mg/L,with an approximately 2.4-fold higher than that of the parental strain S.pristinaespiralis HCCB10218.Considering that the PI biosynthetic genes are clustered in two main regions in the 210 kb“supercluster”containing the PI and PII biosynthetic genes as well as a cryptic polyketide BGC,these two regions were cloned separately and then were successfully assembled into the PI BGC by the transformation-associated recombination(TAR)system.Collectively,the metabolic engineering approaches employed is very efficient for strain improvement in order to enhance PI titer. | Jiali Meng Rongrong Feng Guosong Zheng Mei Ge Yvonne Mast Wolfgang Wohlleben Jufang Gao Weihong Jiang Yinhua Lu | 2017 | Synthetic and Systems Biotechnology2017，2，2： | 7 |
| 16 | Deposition processes and properties of coatings on steel fasteners——A review显示文摘Mechanical fastening is widely used in joining metals, particularly in automotive, aerospace, building and construction industries. However, the main concern on mechanical fastening is the issue of corrosion. An effective way to prolong the service life of steel fasteners is to apply protective coatings onto these components. This paper reviews and compares a few common coating deposition techniques, i.e., electroplating, hot-dip galvanizing, ion vapour deposition and mechanical plating, in terms of their characteristics. Compositional and microstructural properties including morphology and porosity, corrosion resistance performance and frictional performance of the coatings formed by each process are discussed in details. Hydrogen embrittlement, a premature failure often occurred on high strength steel fasteners, is also reviewed. The key results of recent studies of various metallic coatings on fasteners are presented to provide a fundamental understanding of the evolving topics, and the research gaps have been identified for further investigation. | Ping Ping CHUNG James WANG Yvonne DURANDET | 2019 | Friction2019，7，5： | 7 |
| 17 | Quantification of coarse aggregate shape in concrete显示文摘这研究的目的是为大规模申请为总数形式和角的描述选择索引。为这个目的,为在以前的研究展示的总数形式和角的几个参数被介绍。然后基于这些确定的参数, 200 粗糙石英岩总数被使用图象处理此处分析技术。这篇论文也象在形式和角参数之间的关联一样为总数形式和角分析参数的统计分布。为粗糙的总数的形式或角的参数能被正常分发或木头正常分发在 95% 信心水平适合,这被决定。当使用的方面比率和角构画出斜坡,区域比率和半径角索引,和方面比率时,一些形式参数被变化在角特征影响,角索引分别地独立于对方;并且因而,独立参数能被用来确定为目的总数形式和角在水泥的机械行为上塑造学习总数的影响。而且,源于这深入的调查显示出的研究方面比率和角索引能分别地在具体机械性质上推进粗糙的总数形式和角的效果的理解。最后,有一样的内容,类型和表面质地,而是不同方面比率和角的粗糙的总数索引被用来在水泥的行为上学习粗糙的总数形式和角的影响。这被揭示切开水泥的张力的力量随方面比率或粗糙的总数的角索引的增加增加了。 | Xianglin GU Yvonne TRAN Li HONG | 2014 | Frontiers of Structural and Civil Engineering2014，8，3： | 6 |
| 18 | Aberrant ceRNA activity drives lung cancer显示文摘 | Yvonne Tay Florian A Karreth Pier Paolo Pandolfi | 2014 | Cell Research2014，24，3： | 5 |
| 19 | The Role of Phosphorylation in Redox Regulation of Photosynthesis Genes psaA and psbA during Photosynthetic Acclimation of Mustard显示文摘对轻质量的坡度的长期的反应(LTR ) 在稠密的看台改进植物的性能和幸存。它包含编码 plastome 的基因 psaAB 的控制氧化还原作用的 transcriptional 规定(编码 photosystem 的 P700 apoproteins 我) 并且 psbA (编码 photosystem II 的 D1 蛋白质) 并且要求质体局部性的 kinases 的行动。为了学习潜力,在 LTR 期间 phosphorylation 事件影响质体基因表示,我们分析了芥末幼苗 acclimated 点亮赞成任何一个 photosystem 的来源我或 photosystem II。psaA 抄本的教材延期分析显示氧化还原作用规定发生在主要细菌的倡导者,建议质体编码了 RNA 聚合酶(锐气) 是为氧化还原作用信号的目标。包含锐气和另外的 DNA 有约束力的蛋白质的叶绿体蛋白质部分经由 heparin-Sepharose 层析从芥末被净化。这些部分的生物化学的性质在倡导者识别和特性上与特殊强调被分析, phosphorylation 状态,和 kinase 活动。结果证明 LTR 包含小 DNA 有约束力的蛋白质的行动;他们中的三个处于 phosphorylation 状态展出特定的变化。另外, Auto-phosphorylation 试金在内长的 kinase 活动的活动展出大差别。有 kinase 禁止者 H7 和 reductant DTT 的叶绿体连续接排的印刷物抄写实验显示 phosphorylation 事件为向 psaA 和 psbA 抄写开始的氧化还原作用信号的调停是必要的,但是要求一个 thiol 氧化还原作用信号的 synergistic 行动。数据支持那个氧化还原作用从 thylakoid 膜表明的想法经由 phosphorylation 事件被连接到基因表示;然而,这调停看起来要求交往的蛋白质而非简单 phosphorelay 的一个复杂网络。 | Sebastian Steiner Lars Dietzel Yvonne Schroter Vidal Fey Raik Wagner Thomas Pfannschmidt | 2009 | Molecular Plant2009，2，3： | 5 |
| 20 | Defense-Related Calcium Signaling Mutants Uncovered via a Quantitative High-Throughput Screen in Arabidopsis thaliana显示文摘钙为包括 MAMP (联系微生物的分子的模式) 发信号到许多刺激充当第二个送信人,例如分别地从细菌的 flagellin 和延伸因素 Tu 被导出的 flg22 和 elf18。这里,有响应 flg22 处理的改变的钙举起(cce ) 的 Arabidopsis thaliana 异种被孤立并且描绘。除 flg22 受体的新奇变异的等位基因以外, FLS2 (Flagellin 敏感 2 ) ,并且联系受体的 kinase, BAK1 (Brassinosteroid 受体 1 伙伴 Kinase 1 ) ,新 cce 异种能被分成二主要 groupsthose 与一减少或提高的钙举起。而且,从两个组的 cce 异种显示出微分显型到 MAMP 的不同集合。因此,这些异种将在早 MAMP 发信号便于新奇部件的发现并且在钙在 plantmicrobe 相互作用期间发信号的当前的知识衔接差距。上次然而并非最不,屏蔽方法为速度被优化(盖住 384 在 3 的植物或 10h ) 并且能被改编遗传上把在钙层次导致一个变化的任何另外的刺激。 | Stefanie Ranf Julia Grimmer Yvonne P6schl Pascal Pecher Delphine Chinchilla Dierk Scheel Justin Lee | 2012 | Molecular Plant2012，5，1： | 5 |
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