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| 1 | OPTICAL PROPERTIES OF GeO_2 AND Ge NANOCRYSTALS显示文摘he co m pound m aterial of n m size particles Ge O2 Si O2 w as synthesied through hydrolysis of Si( O C2 H4) and Ge Cl4 . A heat treatm ent w as carried out for the sa m ples at 100 ~1200 ℃in air . Its optical property w as deter mined by U V Vis spectur m . We have found that theabsorption edge of spectru m shifted progressively to longer w avelengths . The quantu m size ef fect of nanocrystals appears because crystals gro w and energy of optical band gap reduces d ueto the influence of te m perature . By the analysis of X ray diffraction w e have observed theprocess in w hich the structure of particles changed fro m disorder into order . | Y.H.Zhou 1) ,Y.Y.Feng 2) and H.Y.Lu 2) 1)Department of Physics Nanjing Normal University, Nanjing 210097,China 2)Physics and Ch寁O P T I C A L P R O P E R T I E S O F Ge O2 A N D Ge N A N O C R Y S T A L S Y. H. Zhou1) , Y. Y. Feng2) | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 22 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Pathological and biochemical alterations of astrocytes in ovariectomized rats injected with D-galactose:A potential contribution to Alzheimer's disease processes显示文摘Astrocytes are implicated in the pathological changes of Alzheimer's disease. Our previous studies have demonstrated that estrogen deprivation and oxidative stress act synergistically to accelerate the progress of Alzheimer's disease. Long-term D-galactose injection combined with ovariectomy may serve as a rodent model for Alzheimer's disease. To address the potential contribution of astroglia to the Alzheimer's disease pathogenesis, we investigated pathological and biochemical alterations of astrocytes under this animal model. Ovadectomized rats injected with D-galactose for 2 weeks showed extensive localization of glial fibrillary acidic protein immunoreactive astrocytes and slightly elevated glutathione levels in the hippocampus without significant impairments in the water maze test and deficits of the cholinergic analyses, compared to the saline-injected rats. Ovariectomized rats injected with D-galactose for 6 weeks, however, exhibited degeneration of astrocytes and decreased glutathione levels in the hippocampus, accompanied with severe dysfunction of behavioral test and deficiency of cholinergic terminals. Electron microscopy further confirmed the pathological changes of astrocytes, especially in the aggregated area of synapse and brain microvessels. Consistent with degeneration of perivascular astrocytic endfeet, analysis of the horseradish peroxidase demonstrated an impairment of the blood-brain barrier permeability. These findings indicate that biochemical and pathological alterations of astrocytes may partially contribute to exacerbating neuronal deficits in the course of Alzheimer's disease. Restoring neuroprotective potential of astrocytes may be a useful therapeutic target for Alzheimer's disease and other neurodegenerative diseases. | Hua, X. D. Lei, M. Ding, H. Han, Q. Y. Hu, G. Xiao, M. Nanjing Med Univ,Dept Anat Histol & Pharmacol,Jiangsu Prov Key Lab Neurodegenerat,Nanjing 210029,Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 4 |
| 4 | Emission inventory of anthropogenic air pollutants and VOC species in the Yangtze River Delta region, China显示文摘 | Huang C. Chen C. H. Li L. Cheng Z. Wang H. L. Huang H. Y. Streets D. G. Wang Y. J. Zhang G. F. Chen Y. R | 2011 | Atmospheric Chemistry and Physics2011，，230： | 4 |
| 5 | The level of oncogene H-Ras correlates with tumorigenicity and malignancy显示文摘Normal bovine adrenocortical cells and some human fibroblasts can be transformed by SV40T and H-Ras in a Ras-dependent manner. We recently reported that high levels of Ras derived from 5' LTR of retrovirrus can induce highly malignant and fast growing tumors, while lower levels of Ras derived from internal ribosome entry site(IRES) promotes slower tumor growth and loss of malignancy. Ras derived from CMV promoters resulted in much lower Ras levels and loss of tumor malignancy and growth. Further studies showed that the tumors formed in the presence of lower levels of Ras and dominant negative P53(P53DD) had fewer apoptotic cells and grew faster than the tumors formed from cells with same level Ras and SV40T. Our studies suggest that low levels of Ras are insufficient to inhibit apoptosis induced by pRb inactivation. In contrast, high levels of Ras not only allow normal cells to exit senescence and form tumors, but also protect against pRb inhibition-induced cell apoptosis. | Sun, B. C. Gao, Y. Deng, L. Li, G. Q. Cheng, F. Wang, X. H. Nanjing Med Univ, Liver Transplantat Ctr, Affiliated Hosp 1, Jiangsu 210029, Peoples R China. Nanjing Med Univ, Liver Transplantat Ctr, Ctr Canc, Jiangsu 210029, Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 3 |
| 6 | Emission inventory of anthropogenic air pollutants and VOC species in the Yangtze River Delta region, China显示文摘 | Huang C. Chen C. H. Li L. Cheng Z. Wang H. L. Huang H. Y. Streets D. G. Wang Y. J. Zhang G. F. Chen Y. R | 2011 | Atmospheric Chemistry and Physics2011，，230： | 2 |
| 7 | Solar wind entry via flux tube into magnetosphere observed by Cluster measurements at dayside magnetopause during southward IMF显示文摘By analyzing hot ion and electron parameters together with magnetic field measurements from Cluster, an event of magnetopause crossing of the spacecraft has been investigated. At the latitude of about 40° and magnetic local time (MLT) of 13:20 during the southward interplanetary magnetic field (IMF), a transition layer was observed, with the magnetospheric field configuration and cold dense plasma features of the magnetosheath. The particle energy-time spectrograms inside the layer were similar to but still a little different from those in the magnetosheath, obviously indicating the solar wind entry into the magnetosphere. The direction and magnitude of the accelerated ion flow implied that reconnection might possibly cause such a solar wind entry phenomenon. The bipolar signature of the normal magnetic component BN in magnetopause coordinates further supported happening of reconnection there. The solar wind plasma flowed toward the magnetopause and entered the magnetosphere along the reconnected flux tube. The magnetospheric branch of the reconnected flux tube was still inside the magnetosphere after reconnection and supplied the path for the solar wind entry into the dayside magnetosphere. The case analysis gives observational evidence and more details of how the reconnection process at the dayside low latitude magnetopause caused the solar wind entry into the magnetosphere. | M. Dunlop A. Balogh H. Rème Y. V. Bogdanova A. Fazakerley | 2009 | Science China(Technological Sciences)2009，52，7： | 2 |
| 8 | Diagnosis and treatment of common bile duct stones (CBDS)显示文摘 | A. Paul B. Millat U. Holthausen S. Sauerland E. Neugebauer J. C. Berthou H.-J. Brambs J. E. Dominguez-Mu?oz P. Goh L. E. Hammarstr?m E. Lezoche J. Périssat P. Rossi M. A. R?thlin R. C. G. Russell P. Spinelli Y. Tekant | 1998 | Surgical Endoscopy1998，，6： | 2 |
| 9 | Characteristics of distance learners:Research on relationships of learning motivation,learning strategy,self-efficacy,attribution and learning results显示文摘 | Wang Y Peng H Huang R Hou Y. Wang J | | 0，，： | 1 |
| 10 | Differential floral development and gene expression in grapevines during long and short photoperiods suggests a role for floral genes in dormancy transitioning显示文摘 | Lekha Sreekantan Kathy Mathiason Jér?me Grimplet Karen Schlauch Julie A. Dickerson Anne Y. Fennell | 2010 | Plant Molecular Biology2010，，1： | 1 |
| 11 | 查看详情显示文摘 | Chang Z. R Zhao Y. J Ding Y. C | | 0，，： | 1 |
| 12 | Retinal Microvascular Abnormalities and MRI-Defined Subclinical Cerebral Infarction: The Atherosclerosis Risk in Communities Study显示文摘 | Lawton S. Cooper Tien Y. Wong Ronald Klein A Richey Sharrett R Nick Bryan Larry D. Hubbard David J. Couper Gerardo Heiss Paul D. Sorlie | 2006 | Stroke2006，，1： | 1 |
| 13 | Bestimmung der Mineralstoffe und Spurenelemente in Selen-Tee aus dem Enschi-Gebiet, VR China, und in dessen Aufgu? mittels ICP-AES, GFAAS und INAA显示文摘 | Y. H. Ma S. Recknagel P. Br?tter D. Gawlik V. Negretti de Br?tter U. R?sick X. G. Qiu X. H. Jian K. Günther K. Pfeilsticker M. Y. Xie | 1993 | Zeitschrift für Lebensmittel - Untersuchung und - Forschung1993，，5： | 1 |
| 14 | A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals显示文摘 | T. R?nn J. Wen Z. Yang B. Lu Y. Du L. Groop R. Hu C. Ling | 2009 | Diabetologia2009，，5： | 1 |
| 15 | 查看详情显示文摘 | Song Z. J Yuan R Chai Y. Q Zhuo Y Jiang W Su H.L Che X Li J | | 0，，： | 1 |
| 16 | Genome-wide patterns of genetic variation among elite maize inbred lines显示文摘 | Lai J Li R Xu X Jin W. Xu M. Zhao H. Xiang Z. Song W. Ying K. Zhang M. Jiao Y. Ni P. Zhang J. Li D. Guo X. Ye K. Jian M. Wang B. Zheng H. Liang H. Zhang X. Wang S. Chen S. Li J. Fu Y. Springer N.M. Yang H. Wang J. Dai J. Schnable P.S. Wang J | | 0，，11： | 1 |
| 17 | Phenotype-Genotype Correlations of 13 Rare CYP21A2 Mutations Detected in 46 Patients Affected with 21-Hydroxylase Deficiency and in One Carrier显示文摘 | V Tardy R Menassa V. Sulmont A. Lienhardt-Roussie C. Lecointre R. Brauner M. David Y. Morel | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，3： | 1 |
| 18 | New spectrophotometric method for the determination of some drugs with iodine and wool fast blue BL显示文摘 | Chilukuri S.P Sastry Sankuratripati G Rao Petla Y. Naidu Kommula R Srinivas | 1997 | Talanta1997，，6： | 1 |
| 19 | Combustion behaviour of some biodesulphurized coals assessed by TGA/DTA显示文摘 | S.P. Marinov L. Gonsalvesh M. Stefanova J. Yperman R. Carleer G. Reggers Y. Yürüm V. Groudeva P. Gadjanov | 2009 | Thermochimica Acta2009，，1： | 1 |
| 20 | Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice显示文摘 | P. Alberts L. Engblom N. Edling M. Forsgren G. Klingstr?m C. Larsson Y. R?nquist-Nii B. ?hman L. Abrahmsén | 2002 | Diabetologia2002，，11： | 1 |
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