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| 1 | Confinedly implanted NiFe2O4-rGO: Cluster tailoring and highly tunable electromagnetic properties for selective-frequency microwave absorption显示文摘 | Yanlan Zhang Xixi Wang Maosheng Cao | 2018 | Nano Research2018，11，3： | 36 |
| 2 | Central Limit Theorems for Asymptotically Negatively Associated Random Fields | Lixin Zhang Department of Mathematics, Zhejiang University. Xixi Campus. Hangzhou 310028. P. R. China | 2000 | Acta Mathematica Sinica,English Series2000，16，4： | 25 |
| 3 | Continuity of Higher Order Commutators on Certain Hardy Spaces | DING Yong LU Shan Zhen Department of Mathematics,Beijing Normal University,Beijing 100875.P.R.China E-mail:dingy@bnu.edu.cn lusz@bnu.edu.cnZHANG Pu Department of Mathematics.Zhejiang University(at Xixi Campus).Hangzhou 310028,P.R.China,E-mail:zhpjj@263,net | 2002 | Acta Mathematica Sinica,English Series2002，18，2： | 21 |
| 4 | Soil Erosion Changes over the Past Five Decades in the Red Soil Region of Southern China显示文摘This paper reports the dynamic changes of soil and water loss in the red soil region of Southern China since the 1950s. The red soil region covers eight provinces: Jiangxi, Zhejiang, Fujian, Anhui, Hubei, Hunan, Guangdong and Hainan. From the 1950s to 1986, the annual rate of soil erosion increased by 3.4%. From 1986 to 1996 and from 1996 to 2000, the annual rates of soil erosion decreased by 2.0% and 0.32%, respectively. Field surveys showed that from 2000 to 2005, the area of soil and water loss decreased annually by 1.2%. This decrease was a result of large-scale erosion control activities across China. Although the eroded soil has been restored, the restoration process is very slow and full restoration will take a long time. Our report suggests that controlling soil and water loss is a challenging task, and additional measures must be taken to effectively control the soil erosion in the red soil region. | LIANG Yin LI Decheng LU Xixi YANG Xuan PAN Xianzhang MU Huan SHI Deming ZHANG Bin | 2010 | Journal of Mountain Science2010，7，1： | 18 |
| 5 | 藏北乌兰乌拉湖地区第三纪陆相红层古地磁研究的初步结果及地质意义显示文摘过对乌兰乌拉湖地区第三纪风火山群上部岩性段共计 15 6件样品的古地磁采样和室内退磁研究 ,揭示出一组高温特征剩磁分量 ,在 95 %置信度下通过正倒转检验和正褶皱检验 ,说明这组高温分量很可能代表岩石形成时的原生剩磁。采样剖面获得的磁性地层显示多个正、反极性带交替出现的图案 ,参考晚期侵入红层中浅成岩脉钾 氩法同位素年龄对陆相红层沉积顶界的限定 ,可对比国际标准地磁年代表的C2 3n至C2 0n极性带 ,沉积时限为 5 2~ 4 2Ma ,相当于始新世中期。根据野外调查及区域地层对比 ,本文提出风火山群是一个跨区分布的穿时性岩石地层单元 ,它的沉积充填历史与印度 亚洲大陆碰撞是同步发生的。 | 伊海生 Zhao Xixi 林金辉 时志强 李保华 赵兵 | 2004 | 地球学报2004，25，6： | 16 |
| 6 | Potential role of strike-slip faults in opening up the South China Sea显示文摘Radiometric dates of key rock units indicate that a remnant Late Mesozoic ocean of the Huatung Basin is still preserved today east of the South China Sea(SCS).We integrate regional geology with a Cretaceous oceanic basement in the vicinity of the Huatung Basin to reconstruct the Huatung Plate east of the Eurasian continent.Results of geophysical investigations,four expeditions of deep-sea drilling and a renaissance of regional geology allow us to propose a hypothesis that the mechanism responsible for the SCS opening was raised from strike-slip fault on the east.The hypothesis suggests that the SCS opening could highly relate to the strike-slip faults inherited from Late Mesozoic structures onshore–offshore the SE Cathaysia Block to develop rhombic-shaped extensional basins en echelon on the thinned Eurasian continental crust in the Early Cenozoic.It was followed by sinistral strike-slip movements along the boundary between the Eurasian Plate and the Huatung Plate driven by oblique subduction of the Huatung Plate to the northwest coupled with slab-pull force by southward subduction of the Proto-SCS to open up the triangle-shaped oceanic East Sub-basin in the Early Oligocene(33/34 Ma).The spreading ridge then propagated southwestward in the step-over segment between the Zhongnan-Lile and the Red River strike-slip fault systems to open the triangle-shaped oceanic Southwest Sub-basin by 23 Ma.The plate boundary fault was subsequently converted into the Manila Trench when the Eocene Sierra Madre arc of the Huatung Plate had moved from the south to its present latitude by the Middle Miocene. | Chi-Yue Huang Pinxian Wang Mengming Yu Chen-Feng You Char-Shine Liu Xixi Zhao Lei Shao Guangfa Zhong Graciano P.Yumul Jr | 2019 | National Science Review2019，6，5： | 16 |
| 7 | 白垩纪中期地球磁场与全球地质现象(英文)显示文摘白垩纪超静磁带(CNS)是指白垩纪中期约40 Ma内(Aptian Santonian, 121~83 Ma)地球磁场没有出现倒转的异常现象。这一现象引起地球学界的极大关注,原因在于它与白垩纪中期(124~90 Ma)其他一系列事件在时间上非常吻合,包括洋底扩张速率的快速增加和洋底高原、海山链、大型火成岩省等生产速率的快速增加。过去20多年许多研究强调所有这些现象与下地幔对流的联系。近期研究的一个重要的进展在于把地球磁场的变化(反转频率和古强度)与许多重要的地质和地球物理过程结合起来,如周期性地幔对流、地幔柱活动、全球热流、真极移、大型火成岩省的产生和生物群集绝灭。文中回顾了白垩纪地球磁场研究以及与白垩纪中期所发生的全球性的地质事件之间的可能存在的关联,并讨论在这一重要研究领域内未来研究的发展方向。 | Xixi ZHAO | 2005 | 地学前缘2005，12，2： | 15 |
| 8 | Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME显示文摘Chemotherapy drugs can induce cancer cell death via a series of regulated cell death(RCD)pathways including apoptosis and regulated necrosis(Vanden Berghe et al.,2014).Characterized by activation of the caspase family of cystine proteases,the occurrence of apoptosis leads to cell shrinkage and formation of apoptotic bodies.In vivo。 | Xixi Zhang Haibing Zhang | 2018 | Science China(Life Sciences)2018，61，6： | 15 |
| 9 | Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes显示文摘Being infected by SARS-CoV-2 may cause damage to multiple organs in patients, such as the lung, liver and heart. Angiotensin-converting enzyme 2(ACE2), reported as a SARS-CoV-2 receptor, is also expressed in human male testes. This suggests a potential risk in human male reproductive system. However, the characteristics of ACE2-positive cells and the expression of other SARS-CoV-2 process-related genes are still worthy of further investigation. Here, we performed singlecell RNA seq(scRNA-seq) analysis on 853 male embryo primordial germ cells(PGCs) and 2,854 normal testis cells to assess the effects of the SARS-CoV-2 virus on the male reproductive system from embryonic stage to adulthood. We also collected and constructed the scRNA-seq library on 228 Sertoli cells from three non-obstructive azoospermia(NOA) patients to assess the effects at disease state. We found that ACE2 expressing cells existed in almost all testis cell types and Sertoli cells had highest expression level and positive cells ratio. Moreover, ACE2 was also expressed in human male PGCs. In adulthood, the level of ACE2 expression decreased with the increase of age. We also found that ACE2 positive cells had high expressions of stress response and immune activation-related genes. Interestingly, some potential SARS-CoV-2 process-related genes such as TMPRSS2, BSG, CTSL and CTSB had different expression patterns in the same cell type. Furthermore, ACE2 expression level in NOA donors’ Sertoli cells was significantly decreased. Our work would help to assess the risk of SARS-CoV-2 infection in the male reproductive system. | Xixi Liu Yidong Chen Wenhao Tang Li Zhang Wei Chen Zhiqiang Yan Peng Yuan Ming Yang Siming Kong Liying Yan Jie Qiao | 2020 | Science China(Life Sciences)2020，63，7： | 14 |
| 10 | The Mechanism of Cortico-Striato-Thalamo-Cortical Neurocircuitry in Response Inhibition and Emotional Responding in Attention Deficit Hyperactivity Disorder with Comorbid Disruptive Behavior Disorder显示文摘The neurocircuitries that constitute the corticostriato-thalamo-cortical(CSTC) circuit provide a framework for bridging gaps between neuroscience and executive function in attention deficit hyperactivity disorder(ADHD), but it has been difficult to identify the mechanisms for regulating emotional problems from the understanding of ADHD comorbidity with disruptive behavior disorders(DBD). Research based on 'cool'' and 'hot''executive functional theory and the dual pathway models,which are thought of as applied response inhibition and delay aversion, respectively, within the neuropsychological view of ADHD, has shed light on emotional responding before and after decontextualized stimuli, while CSTC circuit-related domains have been suggested to explain the different emotional symptoms of ADHD with or without comorbid DBD. This review discusses the role of abnormal connections in each CSTC circuit, especially in the emotion circuit, which may be responsible for targeted executive dysfunction at the neuroscience level. Thus, the two major domains – abstract thinking(cool) and emotional trait(hot) – trigger the mechanism of onset of ADHD. | Yuncheng Zhu Xixi Jiang Weidong Ji | 2018 | Neuroscience Bulletin2018，34，3： | 12 |
| 11 | Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission显示文摘 | Xiaohong Shi Xuefei Wang Xixi Xu Yongliang Feng Shuzhen Li Shuying Feng Bo Wang Suping Wang | 2017 | Frontiers of Medicine2017，11，4： | 11 |
| 12 | 中国南方海相油气勘探研究新进展显示文摘中国南方海相油气勘探研究取得6个方面的进展:(1)重塑了华南板块的四个构造演化阶段,将华南板块划分出三个构造区,一个火山岩区和两个造山带,并讨论了南方构造格架与演化对油气地质条件的控制。(2)分析了华南板块南北两个大陆边缘沉积盆地的二级超旋回层序、凝缩层段及其与烃源岩发育的关系,并重点分析了区域性四套主力烃源岩的特点。(3)提出了华南板块北南两个前陆盆地带的发育对中国南方海相油气的后期保存起着重要的作用。(4)分析了四川盆地的海相油气地质的有利条件,对照、比较了中国南方的烃源条件、整体封闭保存条件和晚期成藏可能性。(5)根据整体封闭保存和晚期成藏的思路,划分了中国南方继承型、重建型、构造(推覆一滑覆)型油气保存单元,并作出了分类评价。(6)对中国南方的16个海相盆地(区块)采用专家经验法和综合指标加权评分法进行了评价。 | Petroleum Exploration Project Management of South China,CNPC,Hangzhou Institute of Petroleum Geology,CNPC 166-1 Xixi Rd.,Hangzhou,310023 P.R.China | 1997 | 海相油气地质1997，2，2： | 10 |
| 13 | Pollution assessment of heavy metals along the Mekong River and dam effects显示文摘在湄公河河盆的水文学政体,沉积和水质量的资源发展和变化吸引了大注意。这研究试图在这条国际河里在重金属的 transboundary 污染上提高学习。在这研究,八个采样地点被选择沿着湄公河河的主流收集床沙样品。另外, 5 个重金属元素的内容和他们沿着河的主流的空间可变性被分析。geoaccumulation 索引(Igeo ) 和潜在的生态的风险分析被采用在湄公河河的主流估计重金属污染地位。结果证明重金属元素 Zn 的平均内容是 91.43 mg/kg , Pb 是 41.85 mg/kg ,并且这是在上面的湄公河的床沙的 21.84 mg/kg 河,比那些高, Zn 68.17 mg/kg , Pb 28.22 mg/kg ,作为 14.97 mg/kg )在更低的湄公河。在更低的湄公河的 Cr 的平均内容是 418.86 mg/kg,比那高在上面的湄公河(42.19 mg/kg ) 。Luang Prabang 与 422.90 mg/kg 与 762.93 mg/kg 和 Pakse 有很高的 Cr 集中。8 个采样地点的在所有的 Cu 的集中是类似的,除了在有 11.70 mg/kg 的 Jiajiu 和有 7.00 mg/kg 的 Jiebei。当时, geoaccumulation 索引的结果表明污染由 Zn 和 Pb 引起了 Pb 并且这多于由在上面的湄公河的 Zn 的那些。Cr 是在更低的湄公河的主要污染物质,特别在 Luang Prabang 和 Pakse。细微污染与作为也发生在 Pakse。潜在的生态的风险索引显示在湄公河河的主流的重金属的潜在的生态的风险是低的。我们主张水质量的污染和在床沉积的重金属的污染在湄公河由矿物质资源或 geochemical 背景价值的采矿引起了没被播送从对更低的湄公河上面因为沿着河的水库沉积和冲淡。 | FU Kaidao SU Bin HE Daming LU Xixi SONG Jingyi HUANG Jiangcheng | 2012 | Journal of Geographical Sciences2012，22，5： | 10 |
| 14 | SCM-198 protects endometrial stromal cells from oxidative damage through Bax/Bcl-2 and ERK signaling pathways显示文摘In creasi ng amounts of evidence dem on strated that accumulative reactive oxyge n species (ROS) and apoptosis of human endometrial stromal cells (ESCs) are closely associated with endometrial dysfunction induced by oxidative stress, which plays an important role in the pathological process of multiple gyn ecological and reproduction-related diseases. SCM-198, an alkaloid active component of Leonurus japonicas Houtt, has been reported to have anti-oxidative activity. However, the specific mechanisms of SCM-198 in the prevention of endometrial damage remain unknown. In the present study, we assessed the effect of SCM-198 on hydrogen peroxide (H2O2Hnduced oxidative injury in ESCs. ESCs were pretreated with SCM-198 for 4 h and then challenged with H2O2.Morphology ch a nges, apoptosis rate, and intracellular ROS producti on were measured to assess the level of oxidative injury. Flow cytometry and western blot analysis were performed to detect the expression levels of Bax, Bcl-2, active-caspase-3, and mitogen-activated protein kinases pathways. Classic inflammation cytokines were measured by real-time polymerase chain reactions. Our results showed that SCM-198 attenuated apoptosis and ROS generation of ESCs induced by H2O2. H2O2 induced the apparent apoptotic characteristics, including fragmentation of DNA, upregulation of Bax/Bcl2, activation of caspase-3, and secretion of inflammation cytokines, which were all ameliorated by SCM-198. Furthermore, H2O2-induced apoptosis-related ERK1/2 pathway activation was restrained by SCM-198 pretreatme nt. These fin dings suggested that SCM-198 could protect ESCs from oxidative injury, mainly by inhibiting oxidative stress and reducing apoptosis. | Yunyun Li Yikong Lin Xixi Huang Chunfang Xu Xinhua Liu Li Wang Min Yu Dajin Li Yizhun Zhu Meirong Du | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 10 |
| 15 | New-type urbanization in China: Predicted trends and investment demand for 2015-2030显示文摘The future development of new-type urbanization has drawn great attention from both the government and public alike. In this context, the present study had three related research aims. Firstly, it sought to predict the urbanization and population dynamics in China at both national and provincial levels for the period of 2015 to 2030. Secondly, on this basis, it sought to examine the spatial variation of urbanization given the predicted national urbanization rate of 70.12%. Thirdly, it sought to estimate and evaluate the national and provincial demands of investment in the development of new-type urbanization. The main conclusions from this study were as follows:(1) The population size and urbanization rate will reach 1.445 billion and 70.12%, respectively, from 2015 to 2030.(2) The demographic dividend will vanish when the population pressure reaches its maximum. During this period, there will be 70.16 million urban population born. The suburban population that becomes urbanized will be 316.7 million, and thus the net increase in urban population will reach 386 million.(3) Although the urbanization rate of every Chinese province will increase during 2015–2030, it will do so unequally, while differences in urbanization quality among provinces will also be substantial. In some provinces, moreover, the urbanization quality is not compatible with their eco-social development.(4) A total of 4,105,380 billion yuan is required to fund new-type urbanization and the investment demand for each province varies greatly; for example, Guangdong province requires the most funding, amounting to approximately 148 times that required by Tibet, the province in least need of funding. In the final part of this study, policy suggestions concerning the investment of the new-type urbanization are put forward and discussed. | SUN Dongqi ZHOU Liang LI Yu LIU Haimeng SHEN Xiaoyan WANG Zedong WANG Xixi | 2017 | Journal of Geographical Sciences2017，27，8： | 9 |
| 16 | Xa7, a new executor R gene that confers durable and broad-spectrum resistance to bacterial blight disease in rice显示文摘Bacterial blight(BB)is a globally devastating rice disease caused by Xanthomonas oryzae pv.oryzae(Xoo).The use of disease resistance(R)genes in rice breeding is an effective and economical strategy for the control of this disease.Nevertheless,a majority of R genes lack durable resistance for long-term use under global warming conditions.Here,we report the isolation of a novel executor R gene,Xa7,that confers extremely durable,broad-spectrum,and heat-tolerant resistance to Xoo.The expression of Xa7 was induced by incompatible Xoo strains that secreted the transcription activator-like effector(TALE)AvrXa7 or PthXo3,which recognized effector binding elements(EBEs)in the Xa7 promoter.Furthermore,Xa7 induction was faster and stronger under high temperatures.Overexpression of Xa7 or co-transformation of Xa7 with avrXa7 triggered a hypersensitive response in plants.Constitutive expression of Xa7 activated a defense response in the absence of Xoo but inhibited the growth of transgenic rice plants.In addition,analysis of over 3000 rice varieties showed that the Xa7 locuswas found primarily in the indica and aus subgroups.A variation consisting of an 11-bp insertion and a base substitution(G to T)was found in EBEAvrXa7 in the tested varieties,resulting in a loss of Xa7 BB resistance.Through a decade of effort,we have identified an important BB resistance gene and characterized its distinctive interaction with Xoo strains;these findings will greatly facilitate research on the molecular mechanism of Xa7-mediated resistance and promote the use of this valuable gene in breeding. | Xifeng Chen Pengcheng Liu Le Mei Xiaoling He Long Chen Hui Liu Shurong Shen Zhandong Ji Xixi Zheng Yuchen Zhang Zhenyu Gao Dali Zeng Qian Qian Bojun Ma | 2021 | Plant Communications2021，2，3： | 9 |
| 17 | A late Mesozoic high plateau in eastern China:Evidence from basalt vesicular paleoaltimetry显示文摘Eastern China is made of a number of large and small continental fragments throughout late Paleozoic and Mesozoic time,and is still the best natural laboratory for examining kinematic models of continent tectonics.The paleoelevation history of eastern China provides direct insight into the tectonic processes in China.Here we present basalt-vesicularity based estimates of the paleoaltimetry of the early Cretaceous basalts in northern East China,which indicate that the studied basalt units were at an elevation of more than 4 kilometers in late Mesozoic.Two vesicular basaltic rocks have been collected form bottom to top along the lava flow outcrop in eastern Inner Mongolia.After the digital precessing to the sample cross-sections,and taking advantage of the stereological conversion method to acquire the bubble size distributions,paleoelevation estimate was calculated for East China in the early Cretaceous.The results show that the elevation has been near 4700±750 m when the lava flows was cooling,implying that there were highland regions in the northern part of the East China Plateau during the early Cretaceous.Combined with other geological evidence,we conclude that there was a high plateau with elevation near 5000 m above sea level in Eastern China during the late Mesozoic.This ancient high plateau in eastern China was most likely formed by the collision of the north and south China blocks. | XIA GuoQing YI HaiSheng ZHAO XiXi GONG DaXing JI ChangJun | 2012 | Chinese Science Bulletin2012，57，21： | 9 |
| 18 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 19 | Retrieval of suspended sediment concentrations in the turbid water of the Upper Yangtze River using Landsat ETM+显示文摘为象纵的范围峡区域(LRGR ) 一样的遥远的区域,它是难的测量推迟的沉积集中(SSC ) 。这研究试图由采用三个大气的修正方法估计 SSC:费用, iCOST (从费用修改了) 并且 TZB5 (最新求婚了) 。TZB5 能更精确地从太阳的天顶角度(TZ ) 沿着太阳地面表面路径(TAUz ) 决定大气的发射度,并且消除乐队的路径发光使用乐队 5 14。在 4 获得了使用 TZB5 的乐队的水表面反射在 03000 mg/L 的范围以内与 SSC 有一种更强壮的关系。发达算法能精确地在混浊的上面的长江从 ETM+ 图象直接估计 SSC,并且在中间的长江也是有效的。 | WANG JianJun LU XiXi ZHOU Yue | 2007 | Chinese Science Bulletin2007，52，A02： | 9 |
| 20 | Activation of Rev-erbα attenuates lipopolysaccharide-induced inflammatory reactions in human endometrial stroma cells via suppressing TLR4-regulated NF-κB activation显示文摘Perturbation of the circadian rhythm damages the biological characteristics of cells and leads to their dysfunction. Rev-erbα, an important gene in the transcription-translation loop of circadian rhythm, is involved in regulating the balance between pro-inflammation and anti-inflammation. The disruption of this balance in human endometrial stroma cells (hESCs) destroys their biological behavior function in maintaining the menstrual cycle and embryonic implantation. Whether pharmacological modulation of Rev-erbα affects the inflammation of hESCs remains unclear. In this study, we treated hESCs with lipopolysaccharide (LPS) and found that LPS treatment increased the mRNA levels of pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-8, IL-18, and TNFα, and the secretion of IL-6. SR9009, a Rev-erbα agonist, significantly alleviated the LPS-induced production of pro-inflammatory cytokines in hESCs. Meanwhile, knockdown of Rev-erbα increased the expressions of IL-1β, IL-6, and IL-8, accompanied by an increased mRNA level of the core clock gene Bmal1. Western blot analysis showed that SR9009 inhibited the expression of toll-like receptor 4 (TLR4) and the activation of NF-κB induced by LPS. All these findings suggested that pharmacological activation of Rev-erbα attenuated the LPS-induced inflammatory response of hESCs by suppressing TLR4-regulated NF-κB activation. This study may provide a strategy for preventing inflammation-related endometrial dysfunction and infertility or recurrent implantation failure. | Weijie Zhao Liyuan Cui Xixi Huang Songcun Wang Dajin Li Liping Li Yan Sun Meirong Du | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 8 |
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