|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Aminosaccharide-gold nanoparticle assemblies as narrow-spectrum antibiotics against methicillin-resistant Staphylococcus aureus显示文摘Bacterial infection has continued to be a leading cause of death or disability worldwide because of antibiotic resistance.Antibiotic agents specific to certain taxa of bacteria,i.e.,narrow-spectrum antibiotics,have become useful because they can kill bacteria without resulting in broad-spectrum drug resistance.In this study,we describe a series of antibiotics based on combining gold nanoparticles (AuNPs) with aminosaccharides,even though these AuNPs or aminosaccharides by themselves are ineffective against any bacteria.The AuNP-based multivalent aminosaccharides can effectively and selectively inhibit the growth of Gram-positive bacteria (including drug-resistant superbacteria).In particular,aminosaccharidemodified AuNPs are effective against methicillin-resistant Staphylococcus aureus (MRSA),a particularly hard-to-treat strain.This report carves out a way to explore antibiotics by combining AuNPs and an aminosaccharide as multivalent nanostructures,neither of which by itself is effective as an antibiotic. | Xinglong Yang Lingmin Zhang Xingyu Jiang | 2018 | Nano Research2018，11，12： | 5 |
| 2 | Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies显示文摘Brain tumors are among the most challenging human tumors for which the mechanisms driving progression and heterogeneity remain poorly understood.We combined single-cell RNA-seq with multi-sector biopsies to sample and analyze single-cell expression profiles of gliomas from 13 Chinese patients.After classifying individual cells;we generated a spatial and temporal landscape of glioma that revealed the patterns of invasion between the different sub-regions of gliomas.We also used single-cell inferred copy number variations and pseudotime trajectories to inform on the crucial branches that dominate tumor progression.The dynamic cell components of the multi-region biopsy analysis allowed us to spatially deconvolute with unprecedented accuracy the transcriptomic features of the core and those of the periphery of glioma at single-cell level.Through this rich and geographically detailed dataset,we were also able to characterize and construct the chemokine and chemokine receptor interactions that exist among different tumor and non-tumor cells.This study provides the first spatial-level analysis of the cellular states that characterize human gliomas.It also presents an initial molecular map of the cross-talks between glioma cells and the surrounding microenvironment with single-cell resolution. | Kai Yu Yuqiong Hu Fan Wu Qiufang Guo Zenghui Qian Waner Hu Jing Chen Kuanyu Wang Xiaoying Fan Xinglong Wu John EJ Rasko Xiaolong Fan Antonio lavarone Tao Jiang Fuchou Tang Xiao-Dong Su | 2020 | National Science Review2020，7，8： | 4 |
| 3 | Photoelectric detection technology of laser seeker signals显示文摘The measurement of the rolling angle of the projectile is one of the key technologies for the terminal correction projectile.To improve the resolution accuracy of the rolling angle in the laser seeker weapon system, the imaging model of the detector, calculation model of the position and the signal-to-noise ratio(SNR) model of the circuit are built to derive both the correlation between the resolution error of the rolling angle and the spot position, and the relation between the position resolution error and the SNR. Then the influence of each parameter on the SNR is analyzed at large,and the parameters of the circuit are determined. Meanwhile, the SNR and noise voltage of the circuit are calculated according to the SNR model and the decay model of the laser energy. Finally,the actual photoelectric detection circuit is built, whose SNR is measured to be up to 53 d B. It can fully meet the requirement of0.5° for the resolution error of the rolling angle, thereby realizing the analysis of critical technology for photoelectric detection of laser seeker signals. | ZHU Likun JIA Fangxiu JIANG Xiaodong LI Xinglong | 2019 | Journal of Systems Engineering and Electronics2019，30，6： | 4 |
| 4 | H3K4me3 epigenomic landscape derived from ChIP-Seq of 1000 mouse early embryonic cells显示文摘 | Jie Shen Dongqing Jiang Yusi Fu Xinglong Wu Hongshan Guo Binxiao Feng Yuhong Pang Aaron M Streets Fuchou Tang Yanyi Huang | 2015 | Cell Research2015，25，1： | 4 |
| 5 | Microglia activation mediated by toll-like receptor-4 impairs brain white matter tracts in rats显示文摘Microglia activation and white matter injury coexist after repeated episodes of mild brain trauma and ischemic stroke. Axon degeneration and demyelination can activate microglia; however, it is unclear whether early microglia activation can impair the function of white matter tracts and lead to injury. Rat corpus callosum(CC) slices were treated with lipopolysaccharide(LPS) or LPS + Rhodobacter sphaeroides(RS)-LPS that is a toll-like receptor 4(TLR-4) antagonist. Functional changes reflected by the change of axon compound action potentials(CAPs) and the accumulation of β-amyloid precursor protein(β-APP) in CC nerve fibers. Microglia activation was monitored by ionized calcium binding adaptor-1 immunofluorescent stain, based on well-established morphological criteria and paralleled proportional area measurement. Input-output(I/O) curves of CAPs in response to increased stimuli were significantly downshifted in a dose-dependent manner in LPS(0.2, 0.5 and 1.0μg/mL)-treated slices, implying that axons neurophysiological function was undermined. LPS caused significant β-APP accumulation in CC tissues,reflecting the deterioration of fast axon transport. LPS-induced I/O curve downshift and P-APP accumulation were significantly reversed by the pre-treatment or co-incubation with RS-LPS. RS-LPS alone did not change the I/O curve.The degree of malfunction was correlated with microglia activation, as was shown by the measurements of proportional areas. Function of CC nerve fibers was evidently impaired by microglia activation and reversed by a TLP-4 antagonist, suggesting that the TLP-4 pathway lead to microglia activation. | Xinglong Yang Jingdong Zhang Lian Duan Huangui Xiong Yanping Jiang Houcheng Liang | 2018 | The Journal of Biomedical Research2018，32，2： | 2 |
| 6 | Preliminary survey of estrogenic activity in part of waters in Haihe River, Tianjin显示文摘A preliminary survey of estrogenic activity of the contaminant in part of waters (Ziya River and the estu- ary of Haihe River) in Haihe River, Tianjin has been per- formed with the plasma vitellogenin (Vtg) in feral fish as a biomarker for estrogenic activity. The concentrations of bisphenol A (BPA), 4-tert-octylphenol (OP) and 4-nonyl- phenol (NP) in surface water were also determined. The presence of Vtg in male fish plasma as well as that in female can be detected at different sites and different seasons. The results indicate that the water in the sampling sites was con- taminated by some estrogenic compounds. Although BPA, OP and NP can be detected in all of the water samples, their concentrations were much lower than the effective concen- trations for those chemicals to induce Vtg production in male fish. | SHAO Jing SHI Guoqing JIN Xinglong SONG Maoyong SHI Jianbo JIANG Guibin | 2005 | Chinese Science Bulletin2005，50，22： | 2 |
| 7 | Study on the damping properties of magnetorheological elastomers based on cis-polybutadiene rubber显示文摘 | Sun Taolin Gong Xinglong Jiang Wanquan | 2008 | Polymer Testing2008，27，4： | 1 |
| 8 | Investi-gallon of the durability of anisotropic magnetorheological elas- tomers based on mixed rubber显示文摘 | Zhang Wei Gong Xinglong Jiang Wanquan | 2010 | Smart Materials & Struc- tures2010，19，8： | 1 |
| 9 | Relationship between organic carbon concentration and potential pond bottom soil respiration显示文摘 | Jiang Xinglong Claude E Boyd | 2006 | Aquacultural Engineering2006，35，2： | 1 |
| 10 | An Artificial Light-Harvesting System with Tunable Fluorescence Color in Aqueous Sodium Dodecyl Sulfonate Micellar Systems for Photochemical Catalysis显示文摘Main observation and conclusion In the present work,an artificial light-harvesting system with fluorescence resonance energy transfer(FRET)is successfully fabricated in aqueous sodium dodecyl sulfonate(SDS)micellar systems.Since the tight and orderly arrangement of dodecyl in the SDS micelles is hydrophobic,tetra-(4-pyridylphenyl)ethylene(4PyTPE)can be easily encapsulated into the hydrophobic layer of SDS micelles through noncovalent interaction,which exhibits aggregation-induced emission(AIE)phenomenon and can be used as energy donor.By using amphoteric sulforhodamine 101(SR101)fluorescent dye attached to the negatively charged surface of SDS micelles through electrostatic interaction as energy acceptor,the light-harvesting FRET process can be efficiently simulated.Through the steady-state emission spectra analysis in the micelle-mediated energy transfer from 4PyTPE to SR101,the fluorescence emission can be tuned and white light emission with CIE coordinates of(0.31,0.29)can be successfully achieved by tuning the donor/acceptor ratio.More importantly,to better mimic natural photosynthesis,the SDS micelles with 4PyTPE and SR101 FRET system showed enhanced catalytic activity in photochemical catalysis for dehalogenation ofα-bromoacetophenone in aqueous solution and the photocatalytic reaction could be extended to gram levels. | Xinglong Li Ying Wang Ao Song Minghui Zhang Mengning Chen Man Jiang Shengsheng Yu Rongzhou Wang Lingbao Xing | 2021 | Chinese Journal of Chemistry2021，39，10： | 1 |
| 11 | Determination of 4-tert octylphenol,4-nonylphenol and bisphenol A in surface waters from the Haihe River in Tianjin by gas chromatography-mass spectrometry with selected ion monitoring显示文摘 | JIN Xinglong JIANG Guibin HUANG Guolan | 2004 | Chemosphere2004，56，11： | 1 |
| 12 | Investigation on magnetorheological elastomers based on natural rubber显示文摘 | Chen Lin Gong Xinglong Jiang Wanquan | 2007 | Journal of Materials Science2007，42，14： | 1 |
| 13 | Immunosensor based on optical heterodyne phase detection 显示文摘 | YU Xinglong ZHAO Lequn JIANG Hong | 2001 | Sensors and Actuators B2001，76，： | 1 |
| 14 | Influence of polyurethane properties on mechanical performances of magnetorheological elastomers显示文摘 | Wei Bing Gong Xinglong Jiang Wanquan | 2010 | Journal of Applied Polymer Science2010，116，2： | 1 |
| 15 | Event-triggered shared lateral control for safe-maneuver of intelligent vehicles显示文摘With the increasing number of cars,road traffic accidents have caused a lot of losses every year and human factors play an important role in many cases.Applying active safety assistance control or shared control techniques in intelligent vehicles is promising to reduce the number of traffic accidents.In this context,the dynamic optimization of the shared control policy and the smooth transitions of control authority between human drivers and intelligent driving systems are critical issues to be solved.Motivated by this,this paper proposes an event-triggered shared control approach for safe-maneuver of intelligent vehicles with online risk assessment.In the proposed approach,a Bayesian regularized artificial neural network(BRANN)is designed to predict vehicle trajectories and build a quantization function to assess the risk level owing to potential collision events.The shared controller dynamically optimizes the shared control policies between the human and the intelligent driving system via solving a model predictive control(MPC)problem.The predicted driving behaviors in the prediction horizon are pre-computed with a finite-horizon model predictor steering the predicted trajectories contributed by human driving.Moreover,smooth transitions back to human driving mode are realized via adding penalties on the shared control of the intelligent driving system.Three simulation scenarios in the PreScan environment,i.e.,rear-end collision avoidance,lane-keeping and unskilled driving,are studied to test the effectiveness of the proposed approach.The simulation results,including the comparison with a linear quadratic regulator(LQR)-based shared controller,are reported,which show that the proposed approach can timely evaluate dangerous events and realize safe driving in terms of collision avoidance and lane-keeping.Also,the proposed approach outperforms the LQR-based shared controller in terms of smooth transitions. | Yan JIANG Xinglong ZHANG Xin XU Xing ZHOU Zhengzheng DONG | 2021 | Science China(Information Sciences)2021，64，7： | 1 |
| 16 | Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis(ALS)is the most common motor neuron disease characterized by progressive loss of motor neurons in the brainstem and spinal cord.Currently,there is no cure or effective treatment for ALS and the cause of disease is unknown in the majority of ALS cases.Neuronal mitochondria dysfunction is one of the earliest features of ALS.Mitochondria are highly dynamic organelles that undergo continuous fission,fusion,trafficking and turnover,all of which contribute to the maintenance of mitochondrial function.Abnormal mitochondrial dynamics have been repeatedly reported in ALS and increasing evidence suggests altered mitochondrial dynamics as possible pathomechanisms underlying mitochondrial dysfunction in ALS.Here,we provide an overview of mitochondrial dysfunction and dynamic abnormalities observed in ALS,and discuss the possibility of targeting mitochondrial dynamics as a novel therapeutic approach for ALS. | Zhen Jiang Wenzhang Wang George Perry Xiongwei Zhu Xinglong Wang | 2015 | Translational Neurodegeneration2015，4，1： | 1 |
| 17 | Relationship between organic carbon concentration and potential pond bottom soil respiration 显示文摘 | JIANG XINGLONG CLAUDE E BOYD | 2006 | Aquacultural Engineering2006，35，2： | 1 |
| 18 | A method for determining cirrus height with multiple scattering显示文摘 | Xiong Xinglong Li Meng Jiang Lihui | 2013 | Chinese Opt/cs Letters2013，1，10： | 1 |
| 19 | SnO2-based hierarchical nanomicrostructure: Facile synthesis and their applications in gas sensors and lith- ium-ion batteries显示文摘 | Jiang Lingyan Wu Xinglong Guo Yuguo | 2009 | The Journal of Physical Chemis- try C2009，113，14： | 1 |
| 20 | Structure and electrorheological properties of nanoporous BaTiO 3 crystalline powders prepared by sol–gel method显示文摘 | Wanquan Jiang Chuanxia Jiang Xinglong Gong Zhong Zhang | 2009 | Journal of Sol-Gel Science and Technology2009，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员