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| 1 | Pharmacological effects of Chinese herb aconite(Fuzi) on cardiovascular system显示文摘Fuzi(aconite,Radix Aconiti praeparata),a widely used Chinese herb,plays a significant role in the cardiovascular system.This is mainly reflected by Fuzi's cardiotonic effect,its protective effect on myocardial cells,and its effect on heart rate and rhythm,blood pressure,and hemodynamics.In this article,the pharmacological effects and the corresponding mechanisms of Fuzi(aconite) and its active components on cardiovascular system are reviewed. | Dandan Zhao Jie Wang Yanjing Cui Xinfang Wu | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 19 |
| 2 | Incremental value of contrast echocardiography in the diagnosis of left ventricular noncompaction显示文摘 | Xiaoxiao Zhang Li Yuan Linli Qiu Yali Yang Qing Lv Lin Li Jing Wang Lin He Li Zhang Xinfang Wang Mingxing Xie Xu Yu Jin | 2016 | Frontiers of Medicine2016，10，4： | 10 |
| 3 | Systematic review and meta analysis of randomized controlled trials on Tianmagouteng decoction in treatment of primary hypertension with liverYang hyperactivity syndrome显示文摘OBJECTIVE: To assess the efficacy of Tianma-gouteng decoction in the treatment of primary hypertension with liver yang hyperactivity syndrome. METHODS: The databases of MEDLINE (1950-2012), EMbase (1980-2012), China biology medicine (CBM) (1994-2012), China national knowledge infrastructure (CNKI) (1989-2012), Weipu (VIP) (1995-2012) and Wanfang (1989-2012) were searched and we performed manual searches for conference proceedings to select randomized controlled trials (RCTs) on Tianmagouteng decoction for the treatment of primary hypertension with liver Yang hyperactivity syndrome. Studies were enrolled according to the study-selecting criteria. The methodological quality was evaluated, data were extracted and meta-analyses were conducted with RevMan 4.2 software. RESULTS: Nine RCTs were selected involving 784 patients with no significant difference in decrease in systolic blood pressure (SBP) [OR=1.02, 95% CI (-0.24, 2.29), P=0.10] and diastolic blood pressure(DBP) [OR=0.56, 95% CI (-0.10,1.23), P=0.11] between the Tianmagouteng group and the control group. While there was a significantly larger increase in serum superoxide dismutase (SOD)[OR= 6.26, 95% CI (1.27,11.66), P=0. 01] in the Tianma-gouteng group than that in the control group CONCLUSION: Tianmagouteng decoction can decrease both systolic and diastolic blood pressure and greatly increase serum SOD. Due to poor quality of included studies, the efficacy needs to be further assessed. | Xinfang Wu Xiuxin Jiang | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 8 |
| 4 | Liquid crystal-templated chiral nanomaterials: from chiral plasmonics to circularly polarized luminescence显示文摘Chiral nanomaterials with intrinsic chirality or spatial asymmetry at the nanoscale are currently in the limelight of both fundamental research and diverse important technological applications due to their unprecedented physicochemical characteristics such as intense light-matter interactions, enhanced circular dichroism, and strong circularly polarized luminescence. Herein, we provide a comprehensive overview of the state-of-the-art advances in liquid crystal-templated chiral nanomaterials. The chiroptical properties of chiral nanomaterials are touched, and their fundamental design principles and bottom-up synthesis strategies are discussed. Different chiral functional nanomaterials based on liquid-crystalline soft templates, including chiral plasmonic nanomaterials and chiral luminescent nanomaterials, are systematically introduced, and their underlying mechanisms, properties, and potential applications are emphasized. This review concludes with a perspective on the emerging applications, challenges, and future opportunities of such fascinating chiral nanomaterials. This review can not only deepen our understanding of the fundamentals of soft-matter chirality, but also shine light on the development of advanced chiral functional nanomaterials toward their versatile applications in optics, biology, catalysis, electronics, and beyond. | Xuan Zhang Yiyi Xu Cristian Valenzuela Xinfang Zhang Ling Wang Wei Feng Quan Li | 2022 | Light(Science & Applications)2022，11，8： | 6 |
| 5 | Could CMIP6 climate models reproduce the early-2000s global warming slowdown?显示文摘The unexpected global warming slowdown during 1998–2013 challenges the existing scientific understanding of global temperature change mechanisms,and thus the simulation and prediction ability of state-of-the-art climate models since most models participating in phase 5 of the Coupled Model Intercomparison Project(CMIP5)cannot simulate it.Here,we examine whether the new-generation climate models in CMIP6 can reproduce the recent global warming slowdown,and further evaluate their capacities for simulating key-scale natural variabilities which are the most likely causes of the slowdown.The results show that although the CMIP6 models present some encouraging improvements when compared with CMIP5,most of them still fail to reproduce the warming slowdown.They considerably overestimate the warming rate observed in 1998–2013,exhibiting an obvious warming acceleration rather than the observed deceleration.This is probably associated with their deficiencies in simulating the distinct temperature change signals from the human-induced long-term warming trend and/or the three crucial natural variabilities at interannual,interdecadal,and multidecadal scales.In contrast,the 4 models that can successfully reproduce the slowdown show relatively high skills in simulating the long-term warming trend and the three keyscale natural variabilities.Our work may provide important insight for the simulation and prediction of near-term climate changes. | Meng WEI Qi SHU Zhenya SONG Yajuan SONG Xiaodan YANG Yongqing GUO Xinfang LI Fangli QIAO | 2021 | Science China Earth Sciences2021，64，6： | 5 |
| 6 | New flame retardant epoxy resins based on cyclophosphazene-derived curing agents显示文摘To obtain high-efficiency flame retardancy of epoxy resins,a cyclophosphazene derivative tri-(ohenylenediamino)cyclotriphosphazene(3 ACP)was successfully synthesized and used as a curing agent for the thermosetting of an epoxy resin system.The flame retardant properties,thermal stability,and pyrolysis mechanism of the resultant thermosets were investigated in detail.The experiments indicated that the synthesized thermoset achieved a UL-94 V-0 rate under a vertical burning test as well as a limiting oxygen index(LOI)of 29.2%,which was able to reach V-0 even when a small amount of 3 ACP was incorporated.Scanning electronic microscopic observation demonstrated that the char residue of the thermosets was extremely expanded after the vertical flame test.Thermal analysis showed that the samples had a lower initial decomposition temperature when 3 ACP was introduced into the epoxy resin systems.This indicates that the carbonization ability of the thermosets was significantly improved at elevated temperatures.In addition,the incorporation of 3 ACP can effectively suppress the release of combustible gases during the pyrolysis process,and the decomposition of E-44/DDS-3 ACP curing systems also promotes the formation of polyphosphoramides charred layer in the condensed phase.The investigation on the chemical structures of both the gaseous and condensed phase pyrolysis process confirmed the flame-retardant mechanism of the 3 ACP-cured epoxy resins.Therefore,the nonflammable halogen-free epoxy resin developed in this study has potential applications in electric and electronic fields for environment protection and human health. | Zhenwei Miao Dongpeng Yan Xiaodong Wang Xinfang Zhang Wenqi Zhou Munan Qiu Fan Yang Zhanpeng Wu | 2022 | Chinese Chemical Letters2022，33，8： | 3 |
| 7 | FABRICATION OF HIGH-MELTING POINT METAL COATING显示文摘FABRICATIONOFHIGHMELTINGPOINTMETALCOATING①TangBin,HuXinfang,XuKeweiSchoolofMaterialsScienceandEnginering,Xi′anJiaotongUniver... | Tang Bin, Hu Xinfang, Xu Kewei School of Materials Science and Engineering, Xi′an Jiaotong University, Xi′an 710049 Wang Congzeng Research Institute of Surface Engineering, Taiyuan Polytechnic University, Taiyuan 030024 | 1997 | 中国有色金属学会会刊:英文版1997，7，4： | 3 |
| 8 | Current-driving intergranular corrosion performance regeneration below the precipitates solvus temperature in Al–Mg alloy显示文摘Heat treatment is an effective method to improve the intergranular corrosion resistance of the sensitized Al–Mg alloy due to dissolution of the grain boundary precipitates above the solvus temperature ofβ-phase.The grain boundary precipitates will grow and coarsening below the solvus temperature.In this study,the in-situ intergranular corrosion performance regeneration of the sensitized Al–Mg alloy can be realized by low-density electro-pulsing treatment below the solvus temperature ofβ-phase.Our findings show that the dissolution of grain boundary precipitates by electro-pulsing treatment is accelerated at relatively low temperature in comparison to traditional heat treatment.The athermal effect produced by the interaction between atoms and electrons on the dissolution of grain boundary precipitates is the main reason for the improved corrosion resistance below the solvus temperature ofβ-phase. | Di Zhang Zhen Zhang Yanlin Pan Yanbin Jiang Linzhong Zhuang Jishan Zhang Xinfang Zhang | 2020 | Journal of Materials Science & Technology2020，52，18： | 3 |
| 9 | Effects of CIITA antisense RNA on the expression of HLA class Ⅱ molecules显示文摘To study the effect of the major histocompatibility complex class Ⅱ (MHC Ⅱ ) transactivator (CIITA) antisense RNA on the expression of the human leukemia (HLA) class Ⅱ molecules, 5’ end cDNA sequence of CIITA gene was cloned, and antisense RNA expression vector pcDNA-Ⅱ was constructed. HeLa cells transfected with pcDNA-Ⅱ and pcDNA3 were induced by IFN-γ for 3 d. The expression of HLA class Ⅱ molecules on HeLa/pcDNA-Ⅱ cells was significantly decreased, while it has no effect on the expression of HLA class Ⅰ molecules. This result suggests that the CIITA antisense RNA can inhibit the expression of HLA class Ⅱ molecules in HeLa cells. It also implies a promising approach to generate immune tolerance in qraft transplantation. | ZHOU Caihong, LU Daru, ZHU Qiquan, QIU Xinfang & XUE JinglunInstitute of Genetics, Fudan University, Shanghai 200433, China | 2000 | Chinese Science Bulletin2000，45，22： | 2 |
| 10 | Topological naming mechanism in feature-based modelling显示文摘Topologicalnamingmechanisminfeature_basedmodelingJunjunWu,TongyangWang,XinfangZhangandJizhouComputerAidedDesignCenter,HuaZhon... | Junjun Wu, Tongyang Wang, Xinfang Zhang and Ji zhou Computer Aided Design Center, HuaZhong Univ.of Sci.& Tech. Wu Han, China, 430074. (e_amil:rm039@mecad.hust.edu.cn) | 1997 | Computer Aided Drafting,Design and Manufacturing1997，7，2： | 2 |
| 11 | Equalization of Ti 6Al 4V alloy welded joint by scanning electron beam welding显示文摘The equalization of Ti 6Al 4V alloy welded joint with base metal on corrosion resistance, strength and ductility was studied. The solidification microstructure is transformed from 650 μm columnar grains to 100 μm equiaxed grains by scanning electron beam welding. The anodic polarization curve of 150 μm equiaxed grains coincides with that of base metal. Equal corrosion resistance between weld metal and base metal was obtained. Uniform microstructure and solute distribution are the basis of equalization. Corrosion rate of weld with 150 μm equiaxed grains is the lowest, 2.45 times lower than that of 650 μm columnar grains. Weld strength is 98% as much as that of base metal, yield strength ratio is 99.5%, which is 3.6% higher than that of base metal. | Chen Xiaofeng(陈晓风) Han Zhong(韩忠) Lou Xinfang(楼新芳) Hu Chuanshun(胡传顺) Sun Changyi(孙长义) | 1999 | 中国有色金属学会会刊:英文版1999，9，3： | 2 |
| 12 | Application of Hydraulic Centralizer in Block Fan 116,Shengli Oilfield显示文摘Wellblock Fan 116 is located in northern Boxing subsag of Dongying Sag,Jiyang Depression.The structural feature of sandbody in the second sand group of the middle part of the third member of Shahejie Formation is a graben structure held by two nearly east-west faults.In the middle of the wellblock is a platform;the strata gradually decrease from east to west and elevate | Zhang Lei Wei Xinfang Peng Zhigang Xu Xin Ma Mingxin | 2013 | China Oil & Gas2013，20，3： | 2 |
| 13 | Efficient transfer and expression of human clotting factor IX cDNA in neonatal hemophilia B mice mediated by VSV-G pseudotyped retrovi-rus显示文摘The feasibility of in vivo gene therapy for hemophilia B by VSV-G pseudotyped retroviral vector was introduced. The novel packaging cell line 293GPG was used to produce VSV-G/G1NaBAIX pseudotyped virus with the highest liters up to 8.5×108cfu .mL-1. In contrast to the conventional retrovirus, VSV-G pseudotyped virus was more resistant to inactivation by serum complements (P<0.001). Our results also demonstrated that VSV-G pseudotyped virus was more stable in neonatal mice serum than in adult mice serum (P<0.01). After intraperitoneal injection of different doses of virus, hFIX antigen was detected and lasted for more than 120 d, the highest level reached (72.5+6.1) ng- mL11. Moreover, the functional activity was improved to some extent in all hFIX-treated mice, the most remarkable improvement was observed in the mice treated with higher dose of virus whose clotting activity increased to (3.4±1.5)% and APTT (activated partial thromboplastin time) reduced to (43.2±7.2) s. The anti-hFIX antibody was | WANG Hongwei YE Chenbo CHEN Li WANG Xuefeng QIU Xinfang XUE Jinglun LU Daru | 2001 | Chinese Science Bulletin2001，46，18： | 2 |
| 14 | Regulating the recrystallized grain to induce strong cube texture in oriented silicon steel显示文摘Cube texture contains two easy magnetization directions<001>parallel to rolling and transverse direction,respectively,which is the most ideal magnetic texture suitable not only for transformers but also for rotating machines.In this study,a strong cube texture with ODF density of 50.73 mrd was successfully obtained by regulating the recrystallized grain orientation using cross-rolling and pulsed electric current,compared to conventional thermal annealing(the average cube texture intensity is~10 mrd in lots of latest studies).Cross cold rolling process intentionally'created'metastable deformed cube orientation in oriented silicon steel and the specific recrystallization texture rotation path was identified under pulsed electric current in 5 min:{114}<261>→{114}<151>→{114}<041>→{001}<150>→{001}<010>.The cube-oriented grains were induced by pulsed electric current(800℃)and rapid heating(51.9℃/s,750℃),while the cube grains were observed in the annealed samples at the high temperature(1060℃).Recrystallized grain size of pulsed samples is about twice that of the annealed sample.This phenomenon is considered that the concurrent effects of electron wind force and Joule heating affected the nucleation,growth and rotation of cube grains by reducing the nuclear barrier,producing higher grain boundary mobility and structural evolution towards a state with lower electrical resistance.This idea of current-controlled texture is worthy of popularization in more materials and the realization of an electromagnetic field to crystal orientation selection is an interesting topic. | Mengcheng Zhou Xinfang Zhang | 2022 | Journal of Materials Science & Technology2022，，1： | 2 |
| 15 | Tracking Your Browser with High-Performance Browser Fingerprint Recognition Model显示文摘As the cyber security has attracted great attention in recent years,and with all kinds of tools’(such as Network Agent,VPN and so on)help,traditional methods of tracking users like log analysis and cookie have been not that effective.Especially for some privacy sensitive users who changed their browser configuration frequently to hide themselves.The Browser Fingerprinting technology proposed by Electronic Frontier Foundation(EFF)gives a new approach of tracking users,and then our team designed an enhanced fingerprint dealing solution based on browser fingerprinting technology.Our enhanced solution plays well in recognizing the similar fingerprints,but it is not that efficient.Nowadays we improve the algorithm and propose a high-performance,efficient Browser Fingerprint Recognition Model.Our new model reforms the fingerprint items set by EFF and propose a Fingerprint Tracking Algorithm(FTA)to deal with collected data.It can associate users with some browser configuration changes in different periods of time quickly and precisely.Through testing with the experimental website built on the public network,we prove the high-performance and efficiency of our algorithm with a 20%time-consuming decrease than ever. | Wei Jiang Xiaoxi Wang Xinfang Song Qixu Liu Xiaofeng Liu | 2020 | China Communications2020，17，3： | 2 |
| 16 | Expression of biologically active human clotting factor Ⅸ(hFⅨ) in the mammary gland of transgenic mice显示文摘The DNA of human factor Ⅸ (hFⅨ) gene vector pMCⅨm, which had been proven to be able to express in in vitro and living cells, was introduced into 586 zygotes of Kunming White Mice by positive pressure microinjection technique with manual operation. The 499 survival embryos after microinjection were then transferred into pseudopregnant recipient mice and 216 F 0 pups were born. The analysis of PCR and Southern blot hybridization showed that, of the 216, 6 (2 females and 4 males) were integrated with foreign DNA in their genomes, giving an integration frequency of 3% (6/216). Two F\-0 female transgenic mice could express hFⅨ protein in their milk and the content was over 100 ng/mL as measured with ELISA. The biological activities of hFⅨ in the milk of two F\-0 mice were 44 67% and 79 43%, respectively. | HUANG Ying 1, ZHANG Kezhong 2, HUANG Wenying 1, LU Daru 2, HUANG Ying 1, MA Zhanlu 1, REN Zhaorui 1, QIU Xinfang 2, XUE Jinglun 2, ZENG Yitao 1 and HUANG Shuzhen 1* 1. Shanghai Institute of Medical Genetics, Shanghai Children’s Hospita | 1998 | Chinese Science Bulletin1998，43，15： | 2 |
| 17 | Patterns of leaf N:P stoichiometry along climatic gradients in sandy region, north of China显示文摘Aims Biological and environmental factors determine geographic patterns of plant nutrient stoichiometry jointly.Unraveling the distribution pattern and the potential drivers of nutrient stoichiometry is therefore critical for understanding the adaptive strategies and biogeochem-istry cycling.Aimed to determine how leaf nitrogen(N):phosphorus(P)stoichiometry is linked to biological and environmental factors,we investigated the patterns of psammophyte leaf N:P stoichiometry in sandy region,northern China,and the potential factors affecting leaf N:P stoichiometry were explored.Methods Based on 10 m×10 m quadrates survey,the leaves of 352 dominant psammophyte samples belonging to 167 species were collected cross a 3000 km east-west transect in sandy environments,north-ern China.The samples were further classified into the following groups on the basis of plant life forms and functional groups(pho-tosynthesis pathways and nitrogen fixation).The structural equation modeling was employed to clarify the importance of biological and environmental factors on leaf N:P stoichiometry.Important Findings Generally,the higher leaf N and P concentrations,but lower N:P ratio were found in psammophyte compared with other ecosystems.Mean annual temperature(MAT)influenced the leaf N,P concentra-tions negatively,while mean annual precipitation(MAP)did posi-tively.MAP played greater influence on leaf N,P concentrations than MAT did.MAP affected leaf N,P concentrations directly or indirectly through phylogeny,while MAT only shown direct effect on leaf N concentration.The psammophyte was more limited by N,rather P,in sandy region of northern China.These results suggest that phylogeny of psammophyte and climate jointly influence leaf N:P stoichiometry,and the results could be helpful in modeling bio-geochemical nutrients cycling in vulnerable ecosystems like sandy environment. | Lifang Zhang Lilong Wang Wenliang He Xinfang Zhang Lizhe An Shijian Xu | 2018 | Journal of Plant Ecology2018，11，2： | 2 |
| 18 | Effect of two human growth hormone receptor antagonists on glomerulosclerosis in streptozotocin-induced diabetic rats显示文摘AIM: To explore the feasibility of human growth hormone (hGH) receptor antagonist in the treatment of end-stage diabetic renal complications. METHODS: Two hGH mutants, hGHA1 (Cys-hGH-del1-4, G120R, K168A, E174A, C182S, del186-191) and hGHA2 (hGH-H21A, G120R, E174A) were expressed in E coli. The IC50 (Mean±SD) values for the mutants for inhibiting 125I-hGH binding to rabbit growth hormone receptor were (65±10) ng for hGHA1, (27±5.6) ng for hGHA2, and (10±0.6) ng for wild type hGH, respectively. RESULTS: After treatment for 12 weeks, the renal histology analysis showed that treatment with hGHA2 at 4 mg/kg body weight daily markedly suppressed glomerulosclerosis in streptozotocin-induced diabetic Sprague-Dawley (SD) rats; hGHA1 at the same dosage slightly increased the renal damage compared with saline; while wild type hGH at 1 U/kg body weight daily severely worsened the glomerulo-sclerosis in diabetic SD rats. CONCLUSION: The data indicated that hGHA2 inhibited the end-stage glomerulosclerosis in diabetic rats, but hGHA1 mildly increased the glomerulosclerosis. | WeiLI Li-huaZHU En-biWANG Zeng-canYE JunLIN Li-heGUO Fei-hongLUO Xi-hongLIU XinFANG Shui-xianSHEN | 2004 | Acta Pharmacologica Sinica2004，25，4： | 2 |
| 19 | Effect of Cryopreservation on Seed Viability of 4 Species显示文摘In order to explore the feasibility of cryopreservation on dormant forest tree seeds,the seed viability of 4 species(Malus baccata,Prunus davidiana,P.armenica and Amygdalu persica) with moisture content(MC) changing was tested after 30-day storage in liquid nitrogen of -196℃.The results showed that all the 4 species of seeds can keep a stable viability after cryopreservation.In the procedure,the optimum MC was 48 g/kg for M.baccata,27 g/kg for P.davidiana,31 g/kg for P.armenica and 45 g/kg for A.persica,... | LIU Yan~1 LI Qingmei~(2**) LIU Guangquan~(1**) DUAN Xinfang~3 HOU Longyu~1 1.International Research and Training Center on Erosion and Sedimentation,Beijing 100044,P.R.China 2.Research Institute of Forestry,Chinese Academy of Forestry,Beijing 100091,P.R.China 3.Institute of New Forestry Technology,Chinese Academy of Forestry,Beijing 100091,P.R.China | 2009 | Chinese Forestry Science and Technology2009，8，2： | 2 |
| 20 | Uniform texture in Al-Zn-Mg alloys using a coupled force field of electron wind and external load显示文摘Cylindrical Al-Zn-Mg alloys were processed by electroplastic compression with forced air cooling.Compared to a simple compression process,an unequal intensity of {110} <111> was obtained,and other textures were eliminated by electroplastic compression,that is,electroplastic compression can promote a uniform texture.The various textures formed in different regions along the radial direction under a simple compression process were illuminated by analyzing the relationship between the crystal rotation and stress state.Furthermore,the interaction between the electrons and dislocations was studied in electroplastic compression.The electrons enhanced {110} <111> by promoting slipping of the dislocations when the Burgers vectors of the dislocations were parallel to the drift direction of the electrons.However,the electrons also inhibited crystal rotation by pinning the dislocations with the Burgers vectors perpendicular to the drift direction of the electrons.Therefore,textures other than {110} <111>have difficulty forming under electroplastic compression.The effect of the current energy on the texture(enhancement or attenuation) was in accordance with the law of conservation.The results provided reasonable explanations for the test phenomena. | Hexiong Zhang Xinfang Zhang | 2020 | Journal of Materials Science & Technology2020，36，1： | 2 |
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