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| 1 | Portal vein embolization by fine needle ethanol injection :experimental and clinicalstudies显示文摘AIM To improve the technique of intraportal embolization (PVE) therapy, a new embolic method, was devised and the safety, effectiveness and feasibility were evaluated. METHODS PVE with intraportal ethanol injection via a fine needle was performed in 28 normal dogs, 22 SD rats, and 24 cirrhotic SD rats. After PVE, portography, histological and functional alteration of the liver were evaluated in dogs and rats, and the changes in portal hemodynamics as well as hepatic anatomy were observed in rats. In the clinical study, PVE by ethanol injection was performed in 61 patients with hepatocellular carcinoma under the guidance of portoechography with intraportal injection of CO 2. The effect of PVE was evaluated by ultrasonography and laparotomy. RESULTS The effectiveness and toxicity were dependent on the dose of ethanol. In the dogs, 0 25*!mg/*!kg of ethanol caused incomplete embolization with least liver damage, while 1 0*!mg/*!kg induced complete embolization with a high mortality of 57 1% (4/*!7) due to respiratory arrest. The dose of 0 5*!mg/*!kg resulted in complete embolization with slight toxicity to the liver. In the rats, the survival rate was 100% in normal group but 40 9% in cirrhotic models after ethanol injection by dose of 0 05*!mg/*!100*!g . PVE for cirrhotic rats with 0 03*!mg/*!100*!g of ethanol induced satisfactory embolization with significant hypertrophy in nonembolized lobes, and only slight damage to the hepatic parenchyma, and transient alteration in liver function, portal pressure and portal flow. In the clinical study, 12 cases with reverse portal flow were excluded judged by portoechography. Satisfactory embolization was gained in 90 2% (55/*!61) of the remaining patients determined by ultrasonography and surgery. All cases ran an uneventful postembolization course with no aberrant embolization. CONCLUSION PVE with intraportal ethanol injection of appropriate dosage via a fine needle is safe and effective and has several advantages comparing with transcatheter method. Portoechography is a mandatory approach for the prevention of aberrant embolization. | Lu MD Chen JW Xie XY Liang LJ Huang JF | 1999 | World Journal of Gastroenterology1999，5，6： | 15 |
| 2 | Lipopolysaccharide decreasing albumin expression in rat hepatocytes显示文摘The relations of the severity of hypoalbu-minemia to morbidity and mortality of patients with critical illness illustrate the need for better understanding of molecular mechanism of hypoalbuminemia. This study was undertaken to investigate the response of albumin synthesis to lipopolysaccharide(LPS)in rat hepatocytes in vitro in early acute phase of sepsis. METHODS:Hepatocytes were cultured at an initial cell density of 1.5×106 cells/well in 3 ml culture medium. There were two groups of samples which received either normal saline or 1 μg/L LPS randomly. Albumin mRNA in hepatocytes was assessed by reverse transcription-poly-merase chain reaction(RT-PCR) and albumin level in the supernatant was measured by ELISA at 0,2,8,12,24 hours after exposure. Meanwhile, the albumin precursor was evaluated at the same time points by flow cytometry. RESULTS:The quantitative changes of mRNA, albumin precursor and its protein were analogous. All of them tended to decline at 12 hours post-treatment and did not decrease significantly until 24 hours after LPS exposure. Meanwhile, albumin mRNA decreased about 30% and the levels of albumin precursor and albumin reduced approximately 50%. CONCLUSIONS: LPS can inhibit albumin synthesis in rat hepatocytes by prevention of albumin transcription. Moreover, the response of hepatic albumin synthesis to LPS changes with the stage of sepsis process. The results show that albumin metabolism in sepsis is a complicated process and further studies are required to understand the molecular mechanism of LPS-induced hypoalbuminemia in sepsis. | Research Institute of General Surgery, Jinling Hospital, Nanjing 210002, China (Wang XY, Li WQ, Li N and Li JS) and Department of Orthopaedics, Zhongda Hospital, Nanjing 210009, China (Lu J) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 2 |
| 3 | Hepatocellular carcinoma expressing cholangiocyte phenotype is a novel subtype with highly aggressive behavior显示文摘 | Lu XY Xi T Lau W Y | | 0，，08： | 1 |
| 4 | Color Doppler velocity profile assessment of portal hemodynamics in cirrhotic patients with portal hypertension:correlation with esophageal variceal bleeding显示文摘 | Yin XY Lu MD Huang JF | | 0，，01： | 1 |
| 5 | Percutaneous microwave and radiofrequency ablation for hepatocellular carcinoma: a retro- spective comparative study 显示文摘 | Lu MD Xu HX Xie XY | 2005 | J Gastroenterol2005，40，11： | 1 |
| 6 | hTERT-based therapy: a Universal anticancer approach (review) 显示文摘 | Lu MH Liao ZL Zhao XY | 2012 | Oncology Reports2012，28，： | 1 |
| 7 | Percutaneous ablative therapies of recurrent hepatocellular carcinoma after hepatectomy: proposal of a prognostic model 显示文摘 | Yin XY Xie XY Lu MD | 2012 | Ann Surg Oncol2012，19，13： | 1 |
| 8 | A comparative study of clinical val- ue of single B-mode ultrasound guidance and B-mode combined with color doppler ultrasound guidance in mini invasive percutane- ous nephrolithotomy to decrease hemorrhagic complications显示文摘 | Lu MH Pu XY Gao X | 2010 | U- rology2010，76，4： | 1 |
| 9 | Color Doppler velocity pmfile assessment of portal hemodymamics in cirrhotic patients with portal hypertension : Correlation with esophageal variceal bleeding显示文摘 | Yin XY Lu MD Huang JF | 2001 | J Clin Ultrasound2001，29，1： | 1 |
| 10 | Numerical investigation of the non-Newtonian pulsatile blood flow m a bifurcation model with a non-planar branch 显示文摘 | Chen J Lu XY | 2006 | J Biomech2006，39，5： | 1 |
| 11 | Induction of specific cytolytic T lymphocytes using fusions of hepatocellular carcinoma (HCC) patient-derived dendritic cells and allogeneic HCC cell line显示文摘 | Yin XY Wang L Lu MD | 2008 | Hepatogastroenterology2008，55，81： | 1 |
| 12 | Application of PHBHHx nanoparticles as sustained drug release carrier for ra?pamycin显示文摘 | Li MC Zhang YL Lu XY | 2013 | Journal of Xi'' an Jiaotong University (Medical sciences)2013，34，2： | 1 |
| 13 | Chromosomal amplifica-tions, 3q gain and deletions of 2q33-q37 are the frequentgenetic changes in cervical carcinoma 显示文摘 | Rao PH Arias PH Lu XY | 2004 | BMC Cancer2004，4，1： | 1 |
| 14 | One single standard substance for the determination of multiple anthraquinone derivatives in rhubarb using high-performance liquid chromatography-diode array detection显示文摘 | Gao XY Jiang Y Lu JQ | 2009 | J Chromatogr A2009，1216，11： | 1 |
| 15 | Activated human hydroxy‐carboxylic acid receptor‐3 signals to MAP kinase cascades via the PLC‐dependent PKC and MMP‐mediated EGFR pathways显示文摘 | Q Zhou G Li XY Deng XB He LJ Chen C Wu Y Shi KP Wu LJ Mei JX Lu NM Zhou | 2012 | British Journal of Pharmacology2012，，6： | 1 |
| 16 | Poly-L-Arginine Acts Synergistically with LPS to Promote the Release of IL-6 and IL-8 via p38/ERK Signaling Pathways in NCI-H292 Cells 显示文摘 | Fan XY Chen B Lu ZS | 2015 | Inflammation2015，，： | 1 |
| 17 | Stereotactic radiosurgery of brainstem cavernous malformations: a systematic review and meta-analysis: a review 显示文摘 | Lu XY Sun H Xu JG | 2014 | J Neurosurg2014，120，4： | 1 |
| 18 | Fatty acids modulate protein kinase C activation in porcine vascular smooth muscle cells independently of their effect on de novo diacylglycerol sythesis显示文摘 | Lu X Yang XY Howard RL | 2000 | Diabetologia2000，43，9： | 1 |
| 19 | Hepatocellular carcinoma:USguided percutaneous microwave coagulation therapy显示文摘 | Lu MD Chen JW Xie XY | 2001 | Radiology2001，221，1： | 1 |
| 20 | Percutaneous microwave and radiofrequeney ablation for hepatocelullar carcinoma a retro- spective comparative study 显示文摘 | Lu MD Xu HX Xie XY | 2005 | J Gastroenterol2005，40，11： | 1 |
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