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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | The state-of-the-art of the China Seismo-Electromagnetic Satellite mission显示文摘The China Seismo-Electromagnetic Satellite(CSES) mission was proposed in 2003 and approved in 2013 after ten years' scientific and engineering demonstrations. To meet the requirement of scientific objectives, the satellite is designed to be in a sunsynchronous orbit with an altitude of 507 km and descending node time of 14:00 LT. The CSES satellite carries 8 instruments,including search-coil magnetometer(SCM), electric field detector(EFD), high precision magnetometer(HPM), GNSS occultation receiver(GOR), plasma analyzer package(PAP), langmuir probe(LAP), high energetic particle package(HEPP) and detector(HEPD), and tri-band beacon(TBB), among which HEPD is provided by Italian Space Agency. The CSES satellite was launched successfully on February 2, 2018, and is planned to operate for 5 years. The CSES mission is the first satellite in China to measure geophysical fields, which will have a lot of application prospects in the study of seismology, geophysics, space sciences, and so on. | SHEN XuHui ZHANG XueMin YUAN ShiGeng WANG LanWei CAO JinBin HUANG JianPing ZHU Xing Hong PIERGIORGIO Picozzo DAI JianPing | 2018 | Science China(Technological Sciences)2018，61，5： | 33 |
| 3 | Stability of Ultra-fine Microstructures during Tempering显示文摘The stability of ultra-fine microstructure during tempering at 650℃ was investigated on a Nb-containing steel. The steel had undergone 5 passes controlled rolling, then was relaxed (air cooled) to 730 ℃ and cooled in water The evolution of microstructure was that, in early stage of tempering, no obvious change was detected by means of optical microscopy while dislocation cells were formed inside bainitic laths. With further tempering, bainitic laths started to coalesce in some regions. Finally, polygonal ferrite was formed while hardness decreased dramatically. Some samples taken from the same primary plate were reheated at 930 ℃for 0.5 h followed by quenching into water before tempering. Despite their lower original hardness, the reheated samples softened faster during tempering. Ferrite was quickly formed in the reheated samples. These results indicate that the evolution of microstructures towards equilibrium during tempering of the steel is mainly determined by whether dislocations are pinned rather than the dislocation density. | Shanwu Yang, Chengjia Shang,Xinlai He, Xuemin Wang, Yi Yuan (Material Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China) | 2001 | Journal of University of Science and Technology Beijing2001，8，2： | 25 |
| 4 | Relaxation of Deformed Austenite and Refinement of Bainite in a Nb-Containing Microalloyed Steel显示文摘By means of stress relaxation and strain-induced precipitation in deformed austenite, bainite with micron sheaves size was ob-tained in Nb-containing steel. Microstructures of deformed samples isothermally relaxed for various time followed by cooling in water were examined. Stress relaxation test and transmission electron microscopy (TEM) were employed to detect precipitation of microalloy elements, such as Nb, Ti, during isothermal holding after deformation. All the samples were constituted by lath-like bainite along with acicular ferrite, but the size of bainitic sheaves and the amount of acicular ferrite were changed with relaxation time. To achieve optimum refinement, relaxation should be confined in the stage when the precipitates have sufficiently grown and started to coarsen. The sample having not undergone relaxation does not exhibit obvious refinement despite of its higher dislocation density. These results indicate that relaxation promotes bainite to refine, which is because deformed austenitic grains are divided by dislocation walls formed during rela-xation and acicular ferrite formed before bainitic transformation. | Shanwu Yang, Xuemin Wang, Chengjia Shang, Xinlai He, Yi Yuan Material Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2001 | Journal of University of Science and Technology Beijing2001，8，3： | 24 |
| 5 | Principles,structures,and implementation of reconfigurable ternary optical processors显示文摘This paper discusses the principles,structures,and implementation procedures for reconfiguring a ternary optical processor (TOP).Typical structures,classifications,and naming of the TOP and basic operation units (BOUs) are described in this paper.The circuit implementations,commands,and processes for the reconfiguration are also discussed in detail.A simple analysis of the high performance and low power consumption of ternary optical computers is presented.Finally,an experiment is performed on reconfiguring a 1-bit BOU,which shows that the principles of reconfigurable TOPs are valid,and that the implementations and commands for the reconfiguration are effective. | JIN Yi WANG HongJian OUYANG shan ZHOU Yu SHEN YunPu PENG JunJie LIU XueMin | 2011 | Science China(Information Sciences)2011，54，11： | 23 |
| 6 | Energy-Theft Detection Issues for Advanced Metering Infrastructure in Smart Grid显示文摘With the proliferation of smart grid research,the Advanced Metering Infrastructure(AMI) has become the first ubiquitous and fixed computing platform. However,due to the unique characteristics of AMI,such as complex network structure,resource-constrained smart meter,and privacy-sensitive data,it is an especially challenging issue to make AMI secure. Energy theft is one of the most important concerns related to the smart grid implementation. It is estimated that utility companies lose more than $25 billion every year due to energy theft around the world. To address this challenge,in this paper,we discuss the background of AMI and identify major security requirements that AMI should meet. Specifically,an attack tree based threat model is first presented to illustrate the energy-theft behaviors in AMI. Then,we summarize the current AMI energy-theft detection schemes into three categories,i.e.,classification-based,state estimation-based,and game theory-based ones,and make extensive comparisons and discussions on them. In order to provide a deep understanding of security vulnerabilities and solutions in AMI and shed light on future research directions,we also explore some open challenges and potential solutions for energy-theft detection. | Rong Jiang Rongxing Lu Ye Wang Jun Luo Changxiang Shen Xuemin(Sherman) Shen | 2014 | Tsinghua Science and Technology2014，19，2： | 22 |
| 7 | A Special TMCP Used to Develop a 800MPa Grade HSLA Steel显示文摘The effect of relaxation after finished rolling on structures and properties of four microalloyed steel with different content of Nb and Ti was investigated. By alloy designing and control rolling + relaxation-precipitation-control phase transformation (RPC) process, a new 800 MPa grade HSLA plate steel could be obtained, the microstructure is composite ultra- fine lath bainite/martensite. The tempering process and mechanical properties of this kind of HSLA steel were investigated. The yield strength can achieve 800 MPa, and the ductility and impact toughness is satisfied. | Chengjia Shang,Xuemin Wang, Xinlai He, Shanwu Yang, Yi Yuan Material Science and Engineering School, University of Science and Technology Beijing, Beijing, 100083, China | 2001 | Journal of University of Science and Technology Beijing2001，8，3： | 20 |
| 8 | Acupuncture at the Taixi(KI3) acupoint activates cerebral neurons in elderly patients with mild cognitive impairment显示文摘Our previous findings have demonstrated that acupuncture at the Taixi(KI3) acupoint in healthy youths can activate neurons in cognitive-related cerebral cortex. Here, we investigated whether acupuncture at this acupoint in elderly patients with mild cognitive impairment can also activate neurons in these regions. Resting state and task-related functional magnetic resonance imaging showed that the pinprick senstation of acupuncture at the Taixi acupoint differed significantly between elderly patients with mild cognitive impairment and healthy elderly controls. Results showed that 20 brain regions were activated in both groups of participants, including the bilateral anterior cingulate gyrus(Brodmann areas [BA] 32, 24), left medial frontal cortex(BA 9, 10, 11), left cuneus(BA 19), left middle frontal gyrus(BA 11), left lingual gyrus(BA 18), right medial frontal gyrus(BA 11), bilateral inferior frontal gyrus(BA 47), left superior frontal gyrus(BA11), right cuneus(BA 19, 18), right superior temporal gyrus(BA 38), left subcallosal gyrus(BA 47), bilateral precuneus(BA 19), right medial frontal gyrus(BA 10), right superior frontal(BA 11), left cingulate gyrus(BA 32), left precentral gyrus(BA 6), and right fusiform gyrus(BA 19). These results suggest that acupuncture at the Taixi acupoint in elderly patients with mild cognitive impairment can also activate some brain regions. | Shangjie Chen Maosheng Xu Hong Li Jiuping Liang Liang Yin Xia Liu Xinyan Jia Fen Zhu Dan Wang Xuemin Shi Lihua Zhao | 2014 | Neural Regeneration Research2014，9，11： | 18 |
| 9 | A Weakly Supervised Deep Learning Framework for Sorghum Head Detection and Counting显示文摘The yield of cereal crops such as sorghum(Sorghum bicolor L.Moench)depends on the distribution of crop-heads in varying branching arrangements.Therefore,counting the head number per unit area is critical for plant breeders to correlate with the genotypic variation in a specific breeding field.However,measuring such phenotypic traitsmanually is an extremely labor-intensive process and suffers from low efficiency and human errors.Moreover,the process is almost infeasible for large-scale breeding plantations or experiments.Machine learning-based approaches like deep convolutional neural network(CNN)based object detectors are promising tools for efficient object detection and counting.However,a significant limitation of such deep learningbased approaches is that they typically require a massive amount of hand-labeled images for training,which is still a tedious process.Here,we propose an active learning inspired weakly supervised deep learning framework for sorghum head detection and counting from UAV-based images.We demonstrate that it is possible to significantly reduce human labeling effort without compromising final model performance(��2 between human count and machine count is 0.88)by using a semitrained CNN model(i.e.,trained with limited labeled data)to perform synthetic annotation.In addition,we also visualize key features that the network learns.This improves trustworthiness by enabling users to better understand and trust the decisions that the trained deep learning model makes. | Sambuddha Ghosal Bangyou Zheng Scott CChapman Andries BPotgieter David RJordan Xuemin Wang Asheesh KSingh Arti Singh Masayuki Hirafuji Seishi Ninomiya Baskar Ganapathysubramanian Soumik Sarkar Wei Guo | 2019 | Plant Phenomics2019，1，1： | 16 |
| 10 | Refinement of packet size in low carbon bainitic steel by special thermo-mechanical control process显示文摘The packet size of bainitic steel can be refined by a special relaxation-precipitation-control phase transformation (RPC)technology. When processed by RPC process, the low carbon bainitic steel composes of two kinds of main intermediate transformation phases. One is ultra-fine lath-like bainitic ferrite and the lath is less than 1 μm in width and about 6 μm in length; the alignment of laths forms a refined packet, and the size of packets is about 5-7 μm in length and about 3-4 μm in width. The other is acicular structure. The morphology and distribution of these acicular structures are influenced by relaxation process, the thin and short acicular structures cut the prior austenite grain and refine the bainitic packet size. For the optimum relaxation time, the packet size can be refined to the finest. The mechanical properties are influenced by relaxation time and the 800 Mpa grade low carbon bainitic steel with excellent toughness can be obtained by RPC process. | Chengjia Shang Xuemin Wang Shanwu Yang Xinlai He Materials Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2004 | Journal of University of Science and Technology Beijing2004，11，3： | 15 |
| 11 | Analysis of ionospheric anomaly preceding the Mw7.3 Yutian earthquake显示文摘On February 12,2014,a large Mw7. 3 earthquake occurred in Yutian of Xijiang Province,China.We processed the global ionosphere maps provided by CODE( the Center for Orbit Determination in Europe)and the foF2( the critical frequency of F2-layer) data of Chongqing ionosonde station to analyze the preearthquake ionospheric anomalies. Solar activities and magnetic storm were checked by the sliding inter quartile range method to remove their effects on the ionosphere. A positive ionospheric anomaly with the large amplitude of 20 TECU was observed near the epicenter on February 3( 10th day before the earthquake). In addition,the foF2 at Chongqing station had an unusual increase of more than 40% on the day,which was consistent with the TEC( Total Electron Content) anomaly. The global disturbance represents that the peak of TEC anomaly didn't coincide with the vertical projection of epicenter. The TEC anomalous area was closer to the equator,and it mainly occurred from local time 16 ∶ 00 to 20 ∶ 00. An enhancement of TEC with the small amplitude also appeared in the magnetically conjugated region. | Li Wang Guo Jinyun Yu Xuemin Yu Hongjuan | 2014 | Geodesy and Geodynamics2014，5，2： | 15 |
| 12 | Preliminary analysis on the relationships between Tibetan Plateau NDVI change and its surface heat source and precipitation of China显示文摘Using the automatic weather station data obtained from the Tibetan Plateau (TP), the normalized dif- ference vegetation index and the monthly precipitation data of China and by the methods of correlation and composite analysis, preliminary analytical results are achieved concerning the relationships be- tween TP NDVI change and its surface heat source and precipitation of China. The results of our re- search may lead to the following conclusions: (1) A positive correlation relationship exists between TP NDVI change and its surface heat source, including the sensible heat and the latent heat. As to the correlation of the former, it is more remarkable in western TP than in eastern TP, and as to the correla- tion of the latter, however it turns out contrary. (2) With the improvement of TP vegetation, its surface heat source of every season is also mainly reinforced, especially in summer. As to the contribution of the sensible heat and the latent heat to the increment of the TP surface heat source intensity, the for- mer is comparatively more significant than the latter in winter and spring, while in summer and autumn, the two have almost the same importance. (3) The correlation coefficient between summer NDVI over TP and the corresponding period precipitation of China displays a belt distribution of '+?+' from south to north China. (4) Anomalous surface heating field over TP derived from vegetation change is probably an important factor to affect summer precipitation of China. | HUA Wei FAN GuangZhou ZHOU DingWen NI ChangJian LI XueMin WANG YongLi LIU YaQin HUANG XianLun | 2008 | Science China Earth Sciences2008，51，5： | 14 |
| 13 | The earthquake-related disturbances in ionosphere and project of the first China seismo-electromagnetic satellite显示文摘Based on the case studies and statistical analysis of earthquake-related ionospheric disturbances mainly from DEMETER satellite,ground-based GPS and ionosounding data,this paper summarizes the statistical characteristics of earthquake-related ionospheric disturbances,including electromagnetic emissions,plasma perturbations and variation of energetic particle flux.According to the main results done by Chinese scientists, fusing with the existed study from global researches,seismo-ionospheric disturbances usually occurred a few days or hours before earthquake occurrence.Paralleling to these case studies,lithosphere-atmosphere-ionosphere (LAI) coupling mechanisms are checked and optimized.A thermo-electric model was proposed to explain the seismo-electromagnetic effects before earthquakes.A propagation model was put forward to explain the electromagnetic waves into the ionosphere.According to the requirement of earthquake prediction research,China seismo-electromagnetic satellite,the first space-based platform of Chinese earthquake stereoscopic observation system,is proposed and planned to launch at about the end of 2014.It focuses on checking the LAI model and distinguishing earthquake-related ionospheric disturbance.The preliminary design for the satellite will adopt CAST-2000 platform with eight payloads onboard.It is believed that the satellite will work together with the ground monitoring network to improve the capability to capture seismo-electromagnetic information,which is beneficial for earthquake monitoring and prediction researches. | Xuhui Shen Xuemin Zhang Lanwei Wang Huaran Chen Yun Wu Shigeng Yuan Junfeng Shen Shufan Zhao Jiadong Qian Jianhai Ding | 2011 | Earthquake Science2011，24，6： | 13 |
| 14 | Dual Functions of Phospholipase Dα1 in Plant Response to Drought显示文摘Phospholipase D1 (PLD1 ) 被显示了调停有气孔的运动的 abscisic 酸规定。而 PLD1-overexpressing 烟草减少了,在 PLD1 缺乏的 Arabidopsis 植物增加了, transpirational 水损失。在干旱的早阶段,在水损失的减少与快速的有气孔的闭合在 PLD1-overexpressing 植物由 PLD 的高水平引起了被联系。在干旱的迟了的阶段,然而, overexpressing 植物比控制植物显示了更多的危险性到干旱。在 overexpressing 植物的 PLD1 活动比干旱也在 PLD1 活动在导致了增加的控制植物的高得多。PLD1 活动的高水平在干旱的迟了的阶段被相关到膜降级,由离子的漏和类脂化合物 peroxidation 示威了。这些调查结果显示 PLD1 表示的高水平有植物反应上的不同效果浇赤字。它在更早的阶段支持有气孔的闭合,但是在延长干旱应力破坏膜。这些调查结果在与 PLD 功能和潜在的应用的理解的关系被讨论。 | Yueyun Hong Suqin Zheng Xuemin Wang | 2008 | Molecular Plant2008，1，2： | 12 |
| 15 | Game Theory Algorithm of Reconfiguration for Shipboard Power System显示文摘船舶电力系统故障重构通过改变系统供电路径来恢复重要负载的供电,对增强系统的存活性有着重要意义。在多智能体(agent)架构的基础上,构建船舶电力系统博弈重构模型并提出求解方法。该模型以船舶电力系统中不同区域的agent作为博弈参与者,将船舶电力系统的重构问题转化为各agent之间的合作一竞争问题,从而保证重要负载的恢复供电。论文进一步提出该模型的求解算法,该算法首先判断博弈模式的合作与非合作属性,之后通过agent或agent联盟之间的博弈过程,计算各agent所属的负载/发电机的投切及转移策略。仿真算例表明,该算法能够快速有效地求解船舶电力系统重构问题,最大程度保证系统的存活性。 | WANG Guanqun ZHANG Xuemin LIU Feng MEI Shengwei | 2012 | 中国电机工程学报2012，32，13： | 11 |
| 16 | Parallel Planning:A New Motion Planning Framework for Autonomous Driving显示文摘Motion planning is one of the most significant technologies for autonomous driving. To make motion planning models able to learn from the environment and to deal with emergency situations, a new motion planning framework called as'parallel planning' is proposed in this paper. In order to generate sufficient and various training samples, artificial traffic scenes are firstly constructed based on the knowledge from the reality.A deep planning model which combines a convolutional neural network(CNN) with the Long Short-Term Memory module(LSTM) is developed to make planning decisions in an end-toend mode. This model can learn from both real and artificial traffic scenes and imitate the driving style of human drivers.Moreover, a parallel deep reinforcement learning approach is also presented to improve the robustness of planning model and reduce the error rate. To handle emergency situations, a hybrid generative model including a variational auto-encoder(VAE) and a generative adversarial network(GAN) is utilized to learn from virtual emergencies generated in artificial traffic scenes. While an autonomous vehicle is moving, the hybrid generative model generates multiple video clips in parallel, which correspond to different potential emergency scenarios. Simultaneously, the deep planning model makes planning decisions for both virtual and current real scenes. The final planning decision is determined by analysis of real observations. Leveraging the parallel planning approach, the planner is able to make rational decisions without heavy calculation burden when an emergency occurs. | Long Chen Xuemin Hu Wei Tian Hong Wang Dongpu Cao Fei-Yue Wang | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 9 |
| 17 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 18 | Detection of ALK translocation in non-small cell lung carcinoma(NSCLC) and its clinicopathological significance using the Ventana immunohistochemical staining method: a single-center large-scale investigation of 1,504 Chinese Han patients显示文摘Objective: The novel fully automated immunohistochemistry(IHC) assay-Ventana anaplastic lymphoma kinase(ALK)-D5F3 for screening ALK rearrangements has been approved by China's Food and Drug Administration in 2013, our previous study disclosed a highly specificity and sensitivity nearly 100%, and its efficacy needs to be evaluated in a large cohort of primary lung adenocarcinoma patients, and to compare clinicopathological features with ALK(+) and ALK(-) lung adenocarcinoma.Methods: A total of 1,504 consecutive surgical lung adenocarcinoma cases of Chinese Han population were collected and re-diagnosed according to the 2011 multidisciplinary classification of lung adenocarcinoma.Fully automated Ventana ALK-D5F3 IHC staining with a binary scoring was adopted to evaluate staining and correlated with clinicopathological characters, including age, sex, differentiation degree, histological subtype, lymph node metastasis, and clinical staging.ALK(+) patients were followed-up, and targeted therapy of ALKinhibitors was adopted and observed in patients with stage Ⅳ according to the NCCN guideline.Results: ALK positive adenocarcinomas were identified in 6.6% of the surgically resected 1,504 NSCLCs, and significantly younger than the negative group(P<0.05).Mucinous adenocarcinoma(28.2%) was determined to be predominant in ALK(+) cases, followed by the solid type(11.7%), specific type(6.8%), papillary type(5.6%), acinar type(5.5%), and lepidic type(3.1%), and the differences were statistically significant(χ~2=42.011, P<0.05).ALK(+) adenocarcinoma with lymph node metastasis(10.8%) were significantly higher than that without lymph node metastasis(4.5%)(χ~2=19.809, P<0.05); and ALK(+) in phase Ⅳ(20%) was significantly higher than phase Ⅲ(12.9%), phase Ⅱ(4.2%), phase Ⅰ(4.5%), and phase 0(0)(χ~2=36.068, P<0.05).Multivariate logistic regression disclosed that patient age, AJCC staging, and histological mucinous subtype were correlated with ALK positive staining(OR=0.959, 1.578, 5.036, respectively).Sixty eight patients had followed-up results, five patients out of which primarily diagnosed or progressed into Stage Ⅳ benefited well from targeted therapy with Crizotinib.Conclusions: The ALK fusion protein was seen in 6.6% Chinese NSCLC patients, and mostly seen in younger, clinically higher staging, mucinous and solid predominant adenocarcinoma.Clinical trials in patients of Stage Ⅳ confirmed that ALK-D5F3 Ventana IHC is serviceable in screening ALK-positive candidates for molecular targeted therapy. | Lin Yang Yun Ling Lei Guo Di Ma Xuemin Xue Bingning Wang Junling Li Jianming Ying | 2016 | Chinese Journal of Cancer Research2016，28，5： | 8 |
| 19 | THF_1 mutations lead to increased basal and wound-induced levels of oxylipins that stimulate anthocyanin biosynthesis via COI_1 signaling in Arabidopsis显示文摘Mutants defective in chloroplast development or photosynthesis are liable to accumulate higher levels of anthocyanin in photo-oxidative stress.However,regulatory mechanisms of anthocyanin biosynthesis in the mutants remain unclear.Here,we investigated the mechanism by which the deletion of thylakoid formation1(THF1) leads to an increased level of anthocyanin in Arabidopsis thaliana L.Physiological and genetic evidence showed that the increased level of anthocyanin in thf1 is dependent on coronatine-insensitive1(COM)signaling.Our data showed that thf1 had higher levels of basalα-linolenic acid(α-LeA),and methyl jasmonate(JA)-induced α-LeA and 12-oxophytodienoic acid(OPDA) than the wild type(WT).Consistently,expression levels of phospholipase genes including pPLAIIα and PLA-Iγ1 were elevated in thf1.Furthermore,inhibition of lipase activity by bromoenol lactone,a specific inhibitor of plant pPLA,led to producing identical levels of anthocyanins in WT and thf1 plants.Interestingly,OPDA biosynthesis was triggered by light illumination in isolated chloroplasts,indicating that new protein import into chloroplasts is not required for OPDA biosynthesis.Thus,we conclude that the elevated anthocyanin accumulation in thf1 is attributed to an increase in JA levels.This JA-mediated signaling to coordinate plant metabolism and growth in stress may be conserved in other photosensitive mutants. | Yi Gan Hong Li Ye Xie Wenjuan Wu Maoyin Li Xuemin Wang Jirong Huang | 2014 | Journal of Integrative Plant Biology2014，56，9： | 8 |
| 20 | Stress-strain behavior of multi-phase high performance structural steel显示文摘A series of ferrite/bainite(F/B) multi-phase steels containing different volume fractions of ferrite were obtained.The effect of soft phase(ferrite) content on the work-hardening behavior of the steel was studied by the finite element simulation with V-BCC model and the modified Crussard-Jaoul(C-J) analysis.It is shown that the multi-phase steels have an excellent anti-deformation ability,such as higher stress ratio(R t1.5 /R t0.5),higher uniform elongation and lower yield to tensile strength ratio.For the F/B multi-phase steels,increasing the proportion of ferrite would help to increase the uniform elongation.However,introducing much more fraction of ferrite would not be helpful to improve the stress ratio of multi-phase steel.The ferrite plastic strain constrained by bainite would be beneficial to increasing the work hardening rate.The optimum proportion of ferrite will result both higher stress ratio and uniform elongation in multi-phase steel. | NIE WenJin WANG XueMin WU ShengJie GUAN HaiLong SHANG ChengJia | 2012 | Science China(Technological Sciences)2012，55，7： | 8 |
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