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| 1 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 2 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 3 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 4 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 5 | Environmental and Psycho-social Factors Related to Prostate Cancer Risk in the Chinese Population:a Case-control Study显示文摘Objective To study the risk environmental and psycho-social factors associated to prostate cancer(PCa) in Chinese population. Methods 250 PCa patients and 500 controls were enrolled in this case-control study. Information was collected and logistic regression analysis was used to estimate the odds ratios(OR) and 95% confidence intervals(95% CI) for relationship between lifestyle, eating habits and psycho-social factors with PCa risk. Results Green vegetables and green tea were associated with a decreased risk of PCa(OR=0.39, 95% CI: 0.28-0.53; OR=0.59, 95% CI: 0.40-0.87, respectively). Family history of PCa(OR=7.16, 95% CI: 2.01-25.49), history of prostate diseases(OR=2.28, 95% CI: 1.53-3.41), alcohol consumption(OR=1.97, 95% CI: 1.33-2.90), red meat consumption(OR=1.74, 95% CI: 1.20-2.52), barbecued(OR=2.29, 95% CI: 1.11-4.73) or fried(OR=2.35, 95% CI: 1.24-4.43) foods were related with increased PCa risk. Negative psycho-social factors including occupational setbacks(OR=1.61, 95% CI: 1.00-2.59), marital separation(OR=1.94, 95% CI: 1.29-2.91), self-contained suffering(OR=2.37, 95% CI: 1.58-3.55), and high sensitivity to the personal comments(OR=1.73, 95% CI: 1.18-2.54) were related to PCa. Conclusion Regular consumption of green vegetables and green tea may suggest protective effects on PCa. Alcohol consumption, red meat consumption and barbecued or fried foods were associated with PCa. Negative psycho-social factors may also play a role in the incidence of PCa in Chinese population. | LI Mei Ling LIN Ji HOU Jian Guo XU Lei CUI Xin Gang XU Xing Xing YU Yong Wei HAN Xue WANG Guo Min GUO Jian Ming XU Dan Feng THOMPSON Timothy C CAO Guang Wen ZHANG Hong Wei | 2014 | Biomedical and Environmental Sciences2014，27，9： | 5 |
| 6 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 7 | Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors 显示文摘 | ZENDER L XUE W CORDON-CARI30 C | 2005 | Cold Spring Harb Symp Quant Biol2005，70，： | 1 |
| 8 | Transfer hydrogenation of activatied C=C bonds catalyzed by ruthenium amido complexes: Reaction scope, limitation, and enantioselectivity 显示文摘 | Xue D Chen Y C Cui X | 2005 | Journal of Organic Chemistry2005，70，9： | 1 |
| 9 | Effect of micro-arc discharge surface treat-ment on the tensile properties of Al CuMg alloy显示文摘 | XUE W WANG C LI Y | 2002 | Mater Lett2002，56，： | 1 |
| 10 | Characterization and expression of a new subfamily member of penaeidin antimicrobial peptides(penaeidin5)from Fenneropenaeus chinensis显示文摘 | Kang C J Xue J F Liu N | 2007 | Molecular Immunology2007，44，7： | 1 |
| 11 | Fuzzy neural networks with application to sales for casting显示文摘 | Kuo R J Xue K C | 1999 | Fuzzy Sets and Systems1999，108，： | 1 |
| 12 | Studies on the reaction methanism of CH4/CO2reforming over Co/γ-Al2O3 catalyst显示文摘 | Lu Y Yu C C Xue J Z | 1997 | Chem Lett1997，，2： | 1 |
| 13 | Development of a mode of application of bioorganic fertilizer for improving the biocontrol efficacy to Fusarium wilt 显示文摘 | Ling N Xue C Huang Q W | 2010 | Biocontro12010，55，： | 1 |
| 14 | Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic eff ect and improves mineral ion homeostasis in mice that are homozygous for both the 1AKPha-hydroxylase and parathyroid hormone null alleles显示文摘 | Xue Y Karaplis A C Hendy G N | | 0，，： | 1 |
| 15 | Abnormal Fas/FasL and Caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus显示文摘 | Xue C Lan-Lan W Bei C | 2006 | Cell Immunol2006，239，2： | 1 |
| 16 | Room Temperature Fabrication of Hollow ZnS and ZnO Architectures by a Sacrificial Template Route 显示文摘 | Yah C L Xue D F | 2006 | J Phys Chem B2006，0，14： | 1 |
| 17 | Molecular mechanism of pancreaticβ-cell adaptive proliferation:studies during pregnancy in rats and in vitro显示文摘 | Chen G Liu C Xue Y | 2011 | Endocrine2011，39，2： | 1 |
| 18 | ERCC1 and BRCA1 mRNA expressions are associated with clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy 显示文摘 | Zhao L P Xue C Zhang J W | 2012 | Chin J Cancer2012，31，10： | 1 |
| 19 | Novel predictors of soil genesis following natural weathering processes of bauxite residues显示文摘 | ZHU F XUE S G WILLIAM H HUANG L WU C LI X F | 2016 | Environmental Science and Pollution Research2016，23，： | 1 |
| 20 | Bolus oral glutamine protects rats against CPT-1 I-induced diarrhea and differentially activates cytopro- tective mechanisms in host intestine but not tumor显示文摘 | Xue H Sawyer MB Field C J | 2008 | Nut~2008，38，4： | 1 |
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