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| 1 | Terahertz metasurface zone plates with arbitrary polarizations to a fixed polarization conversion显示文摘Metasurfaces that can realize the polarization manipulation of electromagnetic waves on the sub-wavelength scale have become an emerging research field.Here,a novel strategy of combining the metasurface and Fresnel zone plate to form a metasurface zone plate is proposed to realize the conversion from nearly arbitrary polarizations to a fixed polarization.Specifically,when one polarized wave is incident on adjacent ring zones constructed by different types of meta-atoms,the transmitted waves generated by odd-numbered and even-numbered ring zones converge at the same focus and superimpose to generate a fixed polarized wave.As function demonstrations,we have designed two types of metasurface zone plates:one is a focused linear polarizer,and the other can convert nearly arbitrary polarized waves into focused circularly polarized waves.The simulated and measured results are consistent with theoretical expectations,suggesting that the proposed concept is flexible and feasible.Our work provides an alternative platform for polarization manipulation and may vigorously promote the development of polarization photonic devices. | Zhen Yue Jitao Li Jie Li Chenglong Zheng Jingyu Liu Guocui Wang Hang Xu Mingyang Chen Yating Zhang Yan Zhang Jianquan Yao | 2022 | Opto-Electronic Science2022，1，3： | 9 |
| 2 | Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes显示文摘Doxorubicin(DOX) is widely used in cancer therapy. However, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. In our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. The core region consisted of poly(lactic co-glycolic acid) and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin.DOX was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. This implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a DOX-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. Compared with the traditional intravenous administration,the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. Using a coaxial electrospinning process, it is promising to deliver different hydrophobic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity. | Mengyu Guo Guoqiang Zhou Zhu Liu Jing Liu Jinglong Tang Yating Xiao Wenshi Xu Ying Liu Chunying Chen | 2018 | Science Bulletin2018，63，2： | 4 |
| 3 | The petrographical and isotope geochemical tracers for deep ore-forming fluids from the Laowangzhai gold depoist in the northern part of the Ailao Mountains显示文摘Based on the petrological studies of wall rocks, mineralized rocks, ores and veins from the Laowangzhai gold deposit, it is discovered that with the development of silification, carbonation and sulfidation, a kind of black opaque ultracrystalline material runs through the space between grains and amphibole cleavages, which is the product of fast condensing consolidation with magma mantle fluids turning into hydrothermal crustal fluids in the process of mineralization and alteration. It is thought that the water in ore-forming fluids mainly derived from magmatic water through research on H-O isotopes, and C as well as S isotopic compositions, has clear mantle-derived characteristics, and rock (mine) stones contain high 87Sr/86 Sr ratios, low 143Nd/144 Nd ratios and high 206Pb/204 Pb ratios, which also reflects the ore-forming fluids were derived from the metasomatically enriched mantle. In combination with the features of H-O-C-S isotopes and Sr-Nd-Pb isotopes described above, the ore-forming fluids of the Laowangzhai gold deposit in the northern part of the Ailao Mountains were derived mainly from the deep interior of the mantle, and their properties were transformed from magma fluids to hydrothermal fluids in the course of metasomatism and alteration, which initiated crust-mantle contamination simultaneously to be in favor of mineralization. | DENG Biping LIU Xianfan ZHANG Min LU Qiuxia ZHAO Fufen LI Chunhui CHU Yating XU Yaoyao TIAN Xiaomin LI Hui | 2013 | Chinese Journal Of Geochemistry2013，32，3： | 4 |
| 4 | Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration显示文摘Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes(CMs).However,the signaling mechanisms by which injury induces CM renewal remain incompletely understood.Here,we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors,including Dickkopf 1(Dkkl),Dkk3,secreted Frizzled-related protein 1(sFrpl),and sFrp2,in cardiac tissue adjacent to injury sites.Experimental blocking of Wnt activity via Dkkl overexpression enhances CM proliferation and heart regeneration,whereas ectopic activation of Wnt8 signaling blunts injury-induced CM dedifferentiation and proliferation.Although Wnt signaling is dampened upon injury,the cytoplasmic β-catenin is unexpectedly increased at disarrayed CM sarcomeres in myocardial wound edges.Our analyses indicated that p21-activated kinase 2(Pak2)is induced at regenerating CMs,where it phosphorylates cytoplasmic β-catenin at Ser 675 and increases its stability at disassembled sarcomeres.Myocardial-specific induction of the phospho-mimeticβ-catenin(S675E)enhances CM dedifferentiation and sarcomere disassembly in response to injury.Conversely,inactivation of Pak2 kinase activity reduces the Ser 675-phosphorylatedβ-catenin(pS675-β-catenin)and attenuates CM sarcomere disorganization and dedifferentiation・Taken together,these findings demonstrate that coordination of Wnt signaling inhibition and Pak2/pS675-βYatenin signaling enhances zebrafish heart regeneration by supporting CM dedifferentiation and proliferation. | Xiangwen Peng Kaa Seng Lai Peilu She Junsu Kang Tingting Wang Guobao Li Yating Zhou jianjian Sun Daqing Jin Xiaolei Xu Lujian Liao Jiandong Liu Ethan Lee Kenneth D.Poss Tao P.Zhong | 2021 | Journal of Molecular Cell Biology2021，13，1： | 3 |
| 5 | Forest disturbances and the attribution derived from yearly Landsat time series over 1990–2020 in the Hengduan Mountains Region of Southwest China显示文摘Background:Natural forests in the Hengduan Mountains Region(HDMR)have pivotal ecological functions and provide diverse ecosystem services.Capturing long-term forest disturbance and drivers at a regional scale is crucial for sustainable forest management and biodiversity conservation.Methods:We used 30-m resolution Landsat time series images and the LandTrendr algorithm on the Google Earth Engine cloud platform to map forest disturbances at an annual time scale between 1990 and 2020 and attributed causal agents of forest disturbance,including fire,logging,road construction and insects,using disturbance properties and spectral and topographic variables in the random forest model.Results:The conventional and area-adjusted overall accuracies(OAs)of the forest disturbance map were 92.3% and 97.70%±0.06%,respectively,and the OA of mapping disturbance agents was 85.80%.The estimated disturbed forest area totalled 3313.13 km^(2)(approximately 2.31% of the total forest area in 1990)from 1990 to 2020,with considerable interannual fluctuations and significant regional differences.The predominant disturbance agent was fire,which comprised approximately 83.33% of the forest area disturbance,followed by logging(12.2%),insects(2.4%)and road construction(2.0%).Massive forest disturbances occurred mainly before 2000,and the post-2000 annual disturbance area significantly dropped by 55% compared with the pre-2000 value.Conclusions:This study provided spatially explicit and retrospective information on annual forest disturbance and associated agents in the HDMR.The findings suggest that China’s logging bans in natural forests combined with other forest sustainability programmes have effectively curbed forest disturbances in the HDMR,which has implications for enhancing future forest management and biodiversity conservation. | Yating Li Zhenzi Wu Xiao Xu Hui Fan Xiaojia Tong Jiang Liu | 2021 | Forest Ecosystems2021，8，4： | 2 |
| 6 | Genetic diversity analysis of forty-three insertion/deletion loci for forensic individual identification in Han Chinese from Beijing based on a novel panel显示文摘Due to the virtues of no stutter peaks,low rates of mutation,and short amplicon sizes,insertion/deletion(InDei)polymorphism is an indispensable tool for analyzing degraded DNA samples from crime scenes for human identifications(Wang et al.,2021).Herein,a self-developed panel of 43 InDei loci constructed previously by our group was utilized to evaluate the genetic diversities and explore the genetic background of the Han Chinese from Beijing(HCB)including 301 random healthy individuals. | Congying ZHAO Jinlong YANG Hui XU Shuyan MEI Yating FANG Qiong LAN Yajun DENG Bofeng ZHU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，3： | 2 |
| 7 | Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57CDKN1C and TP53INP1 in mantle cell lymphoma显示文摘Objective: To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on the proliferation in MCL and the underlying mechanisms.Methods: In this study, we elucidated the role of EZH1 and EZH2 overexpression by immunohistochemistry and correlated them to clinical outcome in 41 MCL patients.Quantitative real-time PCR and Western blot were applied to confirm the level of EZH1 and EZH2 in well-characterized MCL cell lines which were compared to those of na?ve B cells.Then we manipulated the expression of EZH1 and EZH2 in MCL cells using CRISPR/Cas9 system to directly investigate their functional roles in MCL.We also evaluated the effect of two small molecule selective inhibitors, EPZ005687 and UNC1999, on MCL cell proliferation, cell cycle distribution and apoptosis in vitro.Finally, we performed RNA-sequencing(RNA-Seq) and Chromatin immunoprecipitation(ChIP) assay to further gain insight into the underlying molecular mechanisms.Results: We found that EZH2 protein is overexpressed in approximately half of this cohort of MCL cases.More importantly, the overexpression of EZH2 is associated with poor OS in the patients.Nevertheless, simple EZH2 depletion in vitro has little impact on the viability of MCL cells, predominantly because of the consequent up-regulation of EZH1.Consistently, UNC1999, a dual EZH1/2 inhibitor, unlike the EZH2 selective inhibitor EPZ005687, exerts a potent inhibitory effect on MCL cells.Furthermore, we discover CDKN1C and TP53 INP1 as the two important cell cycle regulators, the expression of which are repressed by EZH1/2 mediated epigenetic regulation and are restored by EZH1/2 dual inhibition.Conclusions: Our study suggests that EZH2 participates in the pathogenesis of MCL which may serve as a potential biomarker for prognosis prediction.The dual inhibition of EZH1/2 is a promising therapeutic strategy for MCL. | Wei Li Chengfeng Bi Yating Han Tian Tian Xianhuo Wang Huijing Bao Xiaoying Xu Xuhan Zhang Lu Liu Weiwei Zhang Hai Gao Huaqing Wang Huilai Zhang Bin Meng Xi Wang Kai Fu | 2019 | Cancer Biology & Medicine2019，16，3： | 2 |
| 8 | A wideband vibration en- ergy harvester based on a folded asymmetric gapped cantilever 显示文摘 | Hu Yating Xu Yong | 2014 | Applied physics letters2014，，05： | 1 |
| 9 | 4-(Trifluoromethyl)-benzonitrile: A novel electrolyte additive for lithium nickel manganese oxide cathode of high voltage lithium ion battery显示文摘 | Wenna Huang Lidan Xing Yating Wang Mengqing Xu Weishan Li Fengchao Xie Shengan Xia | 2014 | Journal of Power Sources2014，，： | 1 |
| 10 | Sedative and hypnotic activities of the ethanol fraction from Fructus Schisandrae in mice and rats显示文摘 | Fang Huang Yating Xiong Lihua Xu Shiping Ma Changgui Dou | 2006 | Journal of Ethnopharmacology2006，，3： | 1 |
| 11 | Decreased regional homogeneity in insula and cerebellum: A resting-state fMRI study in patients with major depression and subjects at high risk for major depression显示文摘 | Zhifen Liu Cheng Xu Yong Xu Yanfang Wang Bing Zhao Yating Lv Xiaohua Cao Kerang Zhang Chongxi Du | 2010 | Psychiatry Research: Neuroimaging2010，，3： | 1 |
| 12 | MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct axtions on cardimyocytes and fibroblasts via MK2 inhibition显示文摘 | Xu L Yates CC Lockyer P | 2014 | J Mol Cell Cardiol2014，77，： | 1 |
| 13 | Broadband and tunable terahertz absorption via photogenerated carriers in undoped silicon显示文摘Terahertz absorbers based on doped silicon have achieved broadband and high-efficiency absorption due to their high concentration of carriers.However,their tunable performance is obviously insufficient.Here,we propose a new scheme for active terahertz absorption based on undoped silicon with a metamaterial antireflection layer,which realizes both strong absorption and ultrahigh modulation depth.Benefiting from the weak absorption and high transmission of undoped silicon for 1064-nm continuous wave,uniformly distributed carriers across the entire thickness of the absorber are excited,and efficient free carrier absorption of the terahertz wave is obtained.We use only a 500-μm thick absorber and achieve absorption greater than 90%in the range of 0.58 to 1.92 THz,with a peak value of 99%.More important,the absorber can be switched between two working states of nonabsorption and high-efficiency absorption by changing the pump power,which means the modulation depth reaches 100%.This simple and high-performance implementation scheme provides a new idea for the design of terahertz tunable absorbers. | Jie Li Jitao Li Chenglong Zheng Longhai Liu Zhen Yue Hang Xu Xuanruo Hao Fuyu Li Tingting Tang Yating Zhang Jianquan Yao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，1： | 1 |
| 14 | MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition显示文摘 | Xu L Yates C C Lockyer P Xie L Bevilacqua A He J | 2014 | J Mol Cell Cardiol2014，77，： | 1 |
| 15 | MMI-O100 inhibits cardiac fibro- sis in myocardial infarction by direct actions on cardiomyocytes and fibmblasts v/a MK2 inhibition 显示文摘 | Xu L Yates CC Lockyer P | 2014 | J Mol Cell Cardiol2014，77，： | 1 |
| 16 | Structural mechanisms underlying near-zero thermal expansion in β-eucryptite: A combined synchrotron x-ray and neutron Rietveld analysis 显示文摘 | XU H HEANEY P J YATES D M | 1999 | J Mater Res1999，14，： | 1 |
| 17 | IRAS study of the ad- sorption of CO on Ni (111 ) : interrelation between various bonding modes of chemisorbed CO 显示文摘 | SURMEV L XU Z YATES J T | 1988 | Surface Science1988，201，1： | 1 |
| 18 | Incorporation of Fumigants into Soil Organic Matter 显示文摘 | Xu J M Gan J Papienlik S K Becker J O Yates S R | 2003 | Environmental Scinece & Technology2003，37，7： | 1 |
| 19 | Magnesium ion-implantation-based gallium nitride p-i-n photodiode for visible-blind ultraviolet detection显示文摘In this work, a GaN p-i-n diode based on Mg ion implantation for visible-blind UV detection is demonstrated.With an optimized implantation and annealing process, a p-GaN layer and corresponding GaN p-i-n photodiode are achieved via Mg implantation. As revealed in the UV detection characterizations, these diodes exhibit a sharp wavelength cutoff at 365 nm, high UV/visible rejection ratio of 1.2 × 10~4, and high photoresponsivity of 0.35 A/W, and are proved to be comparable with commercially available GaN p-n photodiodes. Additionally, a localized states-related gain mechanism is systematically investigated, and a relevant physics model of electricfield-assisted photocarrier hopping is proposed. The demonstrated Mg ion-implantation-based approach is believed to be an applicable and CMOS-process-compatible technology for GaN-based p-i-n photodiodes. | WEIZONG XU YATING SHI FANGFANG REN DONG ZHOU LINLIN SU QING LIU LIANG CHENG JIANDONG YE DUNJUN CHEN RONG ZHANG YOUDOU ZHENG HAI LU | 2019 | Photonics Research2019，7，8： | 1 |
| 20 | Structural mechanisms underlying near-zero thermal expansion in β-eueryptire: A combined synchrotron X-ray and neutron Rietveld analysis 显示文摘 | Xu Hongwu Heaney Peter J Yates Doughlas M | 1999 | Journal of Materials Research1999，，14： | 1 |
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