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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | ^137Cs tracing dynamics of soil erosion,organic carbon,and total nitrogen in terraced fields and forestland in the Middle Mountains of Nepal显示文摘The Middle Mountains is one of the regions of Nepal most vulnerable to water erosion, where fragile geology, steep topography, anomalous climatic conditions, and intensive human activity have resulted in serious soil erosion and enhanced land degradation. Based on the 137 Cs tracing method, spatial variations in soil erosion, organic carbon, and total nitrogen(TN) in terraced fields lacking field banks and forestland were determined. Soil samples were collected at approximately 5 m and 20 m intervals along terraced field series and forestland transects respectively. Mean 137 Cs inventories of the four soil cores from the reference site was estimated at 574.33 ± 126.22 Bq m-2(1 Bq(i.e., one Becquerel) is equal to 1 disintegration per second(1 dps)). For each terrace, the 137 Cs inventory generally increased fromupper to lower slope positions, accompanied by a decrease in the soil erosion rate. Along the entire terraced toposequence, 137 Cs data showed that abrupt changes in soil erosion rates could occur between the lower part of the upper terrace and the upper part of the immediate terrace within a small distance. This result indicated that tillage erosion is also a dominant erosion type in the sloping farmland of this area. At the same time, we observed a fluctuant decrease in soil erosion rates for the whole terraced toposequence as well as a net deposition at the toe terrace. Although steep terraces(lacking banks and hedgerows) to some extent could act to limit soil sediment accumulation in catchments, soil erosion in the terraced field was determined to be serious. For forestland, with the exception of serious soil erosion that had taken place at the top of slopes due to concentrated flows from a country road situated above the forestland site, spatialvariation in soil erosion was similar to the 'standard' water erosion model. Soil organic carbon(SOC) and TN inventories showed similar spatial patterns to the 137 Cs inventory for both toposequences investigated. However, due to the different dominant erosion processes between the two, we found similar patterns between the <0.002 mm soil particle size fraction(clay sized) and 137 Cs inventories in terraced fields, while different patterns could be found between 137 Cs inventories and the <0.002 mm soil particle size fraction in the forestland site. Such results confirm that 137 Cs can successfully trace soil erosion, SOC and soil nitrogen dynamics in steep terraced fields and forestland in the Middle Mountains of Nepal. | SU Zheng-an XIONG Dong-hong DENG Wei DONG Yi-fan MA Jing PADMA C Poudel GURUNG B Sher | 2016 | Journal of Mountain Science2016，13，10： | 4 |
| 3 | Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice显示文摘Epigenetic 基因规定畸形包括精神分裂症和消沉在各种各样的 neuropsychiatric 混乱,以及在心情和焦虑的规定被含有。另外, epigenetic 机制涉及精神病学的药的行动。当前的 anxiolytic 药有新药的重要缺点,和开发被保证。二蛋白质, G9a (也作为 EHMT2 或 KMT1C 知道) 并且 GLP (象 G9a 一样蛋白质,也作为 EHMT1 或 KMT1D 知道) ,它甲醇化物离氨酸 9 histone H3 (H3K9 ) ,能正在答应 anxiolytic 目标。G9a 的出生后的基因大美人减少焦虑相关的行为,与由过去常对待焦虑(amitriptyline, imipramine 和 paroxetine ) 的一些药的 G9a 层次的减小一致。相反地,在有 GLP haplodeficiency 的老鼠有增加的像焦虑的行为。我们寻求了决定是否 G9a/GLP, UNC0642 和 A-366 的二个药理学禁止者,将有类似的效果到基因 G9a/GLP 不足。当予成年老鼠以时,我们发现有任何一个化合物的 G9a/GLP 抑制减少了像焦虑的行为,与在大脑的减少的 H3K9 methylation 一起。相反,到这些的暴露从胚胎的白天加重(E9.5 ) 9.5 增加了像焦虑的行为直到出生并且减少在成人生活的社会相互作用,当 H3K9 methylation 在在成年老鼠的大脑的正常层次时。这些调查结果增强 G9a/GLP 在大脑开发的不同阶段在像焦虑的行为上有不同效果的基因证据,并且建议指向这条 histone methyltransferase 小径能为开发新 anxiolytic 药是有用的。这些数据也建议在 utero 的抗抑郁剂暴露能在成人生活有否定效果,并且这些效果的进一步的调查被保证。 | Dong-yao WANG Joel KOSOWAN James SAMSOM Laura LEUNG Kai-lai ZHANG Ying-xiang LI Yan XIONG Jian JIN Arturas PETRONIS Gabriel OH Albert H C WONG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 4 | Control architecture in optical burst-switched WDM networks显示文摘 | Xiong Y J Vandenhoute M Cankaya H C | 2000 | IEEE Journal on Selected Areas in Communications2000，18，10： | 2 |
| 5 | Alkaline syenites in eastern Cathaysia (South China): Link to Permian-Triassic transtension显示文摘 | Wang Q Li J W Jian P Zhao Z H Xiong X L Bao Z W Xu J F Li C F Ma J L | 2005 | Emth Planet Sci Lett2005，230，34： | 1 |
| 6 | Protective effect of breviscapineon ischemic vascular dementia in rats显示文摘 | Xiong Z Liu C Wang F | 2006 | Biol Pharm Bull2006，29，9： | 1 |
| 7 | Patterns of cytosine methylation in an elite rice hybrid and its parental lines, detected by a methylation - sensitive amplification polymorphism technique 显示文摘 | Xiong L Z Xu C G Saghai Maroof M A Zhang Q F | 1999 | Molecular and General Genetics1999，261，3： | 1 |
| 8 | Dissemination of CTX- M type β- lactamases in Enterobacteriaceae isolates in the People's Republic of China显示文摘 | Mundaya CJ Xiong J Li C | 2004 | Int J Antimicrob Agents2004，23，： | 1 |
| 9 | Performance characteristics of three aeration systems in the swine manure composting显示文摘 | Zhu N Deng C Xiong Y | 2004 | Bioresource Technology2004，95，3： | 1 |
| 10 | Three-Dimensional Modeling of Vertical-Horizontal Rolling Process显示文摘 | XIONG Shang-wu Rodrigues J M C Martins P A F | 2003 | Finite Elements in Analysis and Design2003，39，： | 1 |
| 11 | Dissemination of CTX-M type β-lactamases in Enterobacteriaceae isolates in the People's Republic of China显示文摘 | Munday CJ Xiong J Li C | 2004 | Int J Antimicrob Agents2004，23，2： | 1 |
| 12 | Whole exon 5 and intron 5 replaced byRHCEin DVa(Hus) 显示文摘 | Shao C Xiong W Wang W | 2004 | J Hum Genet2004，49，2： | 1 |
| 13 | Effects of PC-SPES on proliferation and expression of AR/PSA in androgen-responsive LNCaP cells are independent of estradiol显示文摘 | Hsieh T C Xiong W Traganos F | 2002 | Anticancer Res2002，22，4： | 1 |
| 14 | Effect of transglutaminase- induced cross - linking on gelation of myofibrillar/soy protein mixtures 显示文摘 | Ramirez- Suarez J C Xiong Y L | 2003 | Meat Science2003，65，： | 1 |
| 15 | A macroscopic approach to the lane for- mation phenomenon in pedestrian counterflow 显示文摘 | Xiong T Zhang P Wong S C Shu C W Zhang M | 2011 | Chinese Physical Letters2011，28，10： | 1 |
| 16 | Pancreaticoduodenectomy with vas-cular resection for local advanced pancreatic head cancer:a singlecenter retrospective study显示文摘 | Wang C Wu H Xiong J | 2008 | J Gastrointest Surg2008，12，12： | 1 |
| 17 | Effect of a-A12O3 on the properties of cold sprayed A1/a-AI203 composite coatings on AZ91D magnesium alloy显示文摘 | TAO Y S XIONG T Y SUN C | 2009 | Appl Surf Sci2009，256，1： | 1 |
| 18 | Turn-on ratiometric fluorescent sensor for Pb2 + detection显示文摘 | HOU C XIONG Y J FU N | 2011 | Tetrahedron Lett2011，52，21： | 1 |
| 19 | Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor显示文摘 | Xiong Y Mahmood A Qu C | | 0，，1： | 1 |
| 20 | Achieving secrecy of MISO fading wiretap channels via jamming and precoding with imperfect channel state information显示文摘 | XIONG Q GONG Y LIANG Y C | 2014 | IEEE Wireless Communications Letters2014，3，4： | 1 |
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