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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Intracellular localization of hyaluronan in proliferating cells显示文摘 | Evanko S P Wight T N | 1999 | J Histochem Cytochem1999，47，10： | 2 |
| 3 | Model-free and model-fitting approaches to kinetic analysis of isothermal and nonisothermal data显示文摘 | Vyazovkin S Wight Charles A | 1999 | Thermochimica Acta1999，34，14： | 1 |
| 4 | Kinetics of the thermal and thermo-oxidative degradation of polystyrene, polyethylene and poly (propylene) 显示文摘 | PETERSON J D VYAZOVKIN S WIGHT C A | 2001 | Macromol Chem Phys2001，202，6： | 1 |
| 5 | Kinetics in solids显示文摘 | Vyazovkin S and Wight C A | 1997 | Annual Review of Physical Chemistry1997，48，： | 1 |
| 6 | Isothermal and non-iso- thermal kinetics of thermally stimulated reactions of sol- ids显示文摘 | VYAZOVKIN S WIGHT C A | 1998 | Int Rev Phys Chem1998，17，： | 1 |
| 7 | Isothermal and non-isothermal kinetics of thermally stimulated reactions of solids显示文摘 | Vyazovkin S Wight C A | 1998 | International Reviews in Physical Chemistry1998，17，3： | 1 |
| 8 | Model-free and model- fitting approaches to kinetic analysis of isothermal and non-isothermal data显示文摘 | VYAZOVKIN S WIGHT C A | 1999 | Thermochimica Acta1999，34，： | 1 |
| 9 | The epidemiology of inhibitors in haemophilia A : a systematic review 显示文摘 | Wight J Paisley S | 2003 | Haemophilia2003，9，4： | 1 |
| 10 | The epidemiology of inhibitors in haemophilia A: a systematic review显示文摘 | Wight J Paisley S | 2003 | Haemophilia2003，9，： | 1 |
| 11 | Thermal decomposition kinetics of PBAN-binder and composite solid rocket propellants显示文摘 | Sell T Vyazovkin S Wight C A | 1999 | Combustion and Flame1999，119，： | 1 |
| 12 | Treatments for spasticity and pain in mul- tiple sclerosis: a systematic review 显示文摘 | Beard S Hunn A Wight J | 2003 | Health Technol Assess2003，7，40： | 1 |
| 13 | Ammonium dinitramide: Kinetics andmechanism of thermal decomposition 显示文摘 | Vyazovkin S Wight C | 1997 | journal of PhysicalChemistry’1997，101，31： | 1 |
| 14 | Isothermal and nonisothermal reaction kinetics in solids: In search of ways toward consensus显示文摘 | Vyazovkin S and Wight C A | 1997 | Journal of Physical Chemistry A1997，101，44： | 1 |
| 15 | Isothermal and non-isother- mal kinetics of thermally stimulated reactions of solids 显示文摘 | VYAZOVKIN S WIGHT C A | 1998 | Reviews in Physical Chemistry1998，17，3： | 1 |
| 16 | Model-free and model-fitting approaches to kinetic analysis of isothermal and nonisothermal data显示文摘 | VYAZOVKIN S WIGHT C A | 1999 | Thermochimica Acta1999，340，： | 1 |
| 17 | Kinetics in solids显示文摘 | Vyazovkin S Wight C A | 1997 | Annual Review of Physical Chemistry1997，48，： | 1 |
| 18 | Kinetics of the thermal and thermo-oxidative degradation of polystyrene, polyethylene and poly (propylene) 显示文摘 | PETERSON J D VYAZOVKIN S WIGHT C A | 2001 | Macromolecular Chemistry and Physics2001，202，6： | 1 |
| 19 | Perceived HIV stigma in AIDS caregiving dyads显示文摘 | Wight R G Aneathensel C S Murphy D A | 2006 | Social Science and Medicine2006，62，2： | 1 |
| 20 | Model-free and model-fitting approa- ches to kinetic analysis of isothermal and nonisothermal data 显示文摘 | Vyazovkin S Wight C A | 1999 | Thermochimica Acta1999，34，14： | 1 |
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