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| 1 | Co-seismic slip distribution of the 2011 Tohoku(MW 9.0)earthquake inverted from GPS and space-borne gravimetric data显示文摘Data obtained by GRACE(Gravity Recovery and Climate Experiment) have been used to invert for the seismic source parameters of megathrust earthquakes under the assumption of either uniform slip over an entire fault or a point-like seismic source.Herein, we further extend the inversion of GRACE long-wavelength gravity changes to heterogeneous slip distributions during the 2011 Tohoku earthquake using three fault models:(Ⅰ) a constant-strike and constant-dip fault,(Ⅱ) a variable dip fault, and(Ⅲ) a realistically varying strike fault. By removing the post-seismic signal from the time series, and taking the effect of ocean water redistribution into account, we invert for slip models I, II, and III using co-seismic gravity changes measured by GRACE, de-striped by DDK3 decorrelation filter. The total seismic moments of our slip models, with respective values of 4.9×10^(22) Nm, 5.1×10^(22) Nm, and 5.0×10^(22) Nm, are smaller than those obtained by other studies relying on GRACE data. The resulting centroids are also located at greater depths(20 km, 19.8 km,and 17.4 km, respectively). By combining onshore GPS, GPS-Acoustic, and GRACE data, we obtain a jointly inverted slip model with a seismic moment of 4.8×10^(22) Nm, which is larger than the seismic moment obtained using only the GPS displacements. We show that the slip inverted from low degree space-borne gravimetric data, which contains information at the ocean region, is affected by the strike of the arcuate trench. The space-borne gravimetric data help us constrain the source parameters of a megathrust earthquake within the frame of heterogeneous slip models. | Xin Zhou Gabriele Cambiotti WenKe Sun Roberto Sabadini | 2018 | Earth and Planetary Physics2018，2，2： | 16 |
| 2 | The Performance of Whole Genome Amplification Methods and Next-Generation Sequencing for Pre-Implantation Genetic Diagnosis of Chromosomal Abnormalities显示文摘Reliable and accurate pre-implantation genetic diagnosis(PGD) of patient's embryos by next-generation sequencing(NGS) is dependent on efficient whole genome amplification(WGA) of a representative biopsy sample. However, the performance of the current state of the art WGA methods has not been evaluated for sequencing. Using low template DNA(15 pg) and single cells, we showed that the two PCR-based WGA systems Sure Plex and MALBAC are superior to the REPLI-g WGA multiple displacement amplification(MDA) system in terms of consistent and reproducible genome coverage and sequence bias across the 24 chromosomes, allowing better normalization of test to reference sequencing data. When copy number variation sequencing(CNV-Seq) was applied to single cell WGA products derived by either Sure Plex or MALBAC amplification, we showed that known disease CNVs in the range of 3e15 Mb could be reliably and accurately detected at the correct genomic positions. These findings indicate that our CNV-Seq pipeline incorporating either Sure Plex or MALBAC as the key initial WGA step is a powerful methodology for clinical PGD to identify euploid embryos in a patient's cohort for uterine transplantation. | Na Li Li Wang Hui Wang Minyue Ma Xiaohong Wang Yi Li Wenke Zhang Jianguang Zhang David S.Cram Yuanqing Yao | 2015 | Journal of Genetics and Genomics2015，42，4： | 13 |
| 3 | Viscous lithospheric structure beneath Sumatra inferred from post-seismic gravity changes detected by GRACE显示文摘Satellite gravity data of the regional rheological structure of the lithosphere in the vicinity of Sumatra is used as evidence to enable a better understanding of the regional geodynamic environment.The data is interpreted using the theory of post-seismic viscoelastic relaxation.Coand post-seismic changes in the gravity field resulting from the 2004 M w 9.3 Sumatra earthquake were calculated from Gravity Recovery and Climate Experiment (GRACE) satellite data.A spatial Gaussian filter,500 km wide,was used in the calculation.The results indicate that there were significant co-seismic jumps in both uplifted and subducted regions.The magnitude of the jump in the subducted zone was ~9 10 8 m/s 2,more significant than the ~2 10 8 m/s 2 jump observed in the uplifted zone.However,a positive gravity change occurred in the uplifted zone very soon after the earthquake.The rheological structure of the lithosphere has a great effect on deformation and its determination is a fundamental part of developing reliable numerical simulations in geodynamics.Based on the temporally-variable gravity field observed by GRACE,the viscous lithospheric structure of the Sumatra area is investigated with a self-gravitating,half space,viscoelastic earth model.The estimated viscosity is of the order of 1.0 10 18 Pa·s and there are differences in the rheological parameters on the two sides of the fault.The factors that affect the viscosity are discussed in connection with the tectonic structure of the Sumatra area. | WANG WuXing SHI YaoLin SUN WenKe ZHANG Jing | 2011 | Science China Earth Sciences2011，54，8： | 9 |
| 4 | Efficacy of Shenzhuo formula on diabetic kidney disease:a retrospective study显示文摘OBJECTIVE:To observe the efficacy of a traditional Chinese medicine,Shenzhuo formula,on patients with diabetic kidney disease(DKD).METHODS:Eighty-eight outpatients with DKD were enrolled.Changes in estimated glomerular filtration rate(eGFR),creatinine clearance,serum creatinine,blood-urea-nitrogen,albuminuria,glycosylated hemoglobin(Hb_(A1C)),blood pressure,and lipid profile were measured and analyzed before and after intervention with Shenzhuo formula for 1,3,6,9,12,and 18 months.RESULTS:Compared with the baseline amounts,serum creatinine decreased,and eGFR and creatinine clearance increased,significantly after intervention for 1,3,6,9,12,and 18 months(all P < 0.05).Mean eGFR increased by 2.11 mL/min per 1.73 m7 y after18-month treatment.Urinary protein at 24 h decreased significantly after 1,3,9,and 12 months(P < 0.05).Hb_(A1C) decreased significantly(P < 0.05) after 3,6,9,12,and 18 months,and systolic blood pressure decreased significantly(P < 0.05) after 1,3,and 6 months.Total cholesterol decreased significantly(P < 0.05) after 1,3,6,and 18 months.Triglyceride and low-density lipoprotein-cholesterol decreased significantly(P < 0.05) after 1 and 3 months.CONCLUSION:Shenzhuo formula can improve eGFR and possibly slow DKD progression.Shenzhuo formula can also lower Hb_(A1C),lipid levels and blood pressure. | Tian Jiaxing Zhao Linhua Zhou Qiang Liu Wenke Chen Xinyan Lian Fengmei Tong Xiaolin | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 8 |
| 5 | Estimation of the potential performance in p-type SnSe crystals through evaluating weighted mobility and effective mass显示文摘It has been proved that the thermoelectric performance of p-type SnSe crystals can be optimized through enhancing carrier concentration.The calculations of electronic band structure elucidate that this approach can be interpreted by including multiple valence bands.To better estimate the potential performance,we proposed the transport properties for p-type SnSe crystals and analyzed the weighted mobility from the experimental results.The weighted mobility approaches~600 cm^(2)V1s1 when the carrier concentration is as high as~6.31019 cm3.Combined with obtained lattice thermal conductivity,through rising carrier concentration,the quality factor B possesses significant improvements of~235%and 138%at 300 K and 773 K,respectively.Through comparing weighted mobility and Hall mobility,two effective mass values~0.9 me and 1.8 me can be derived using carrier concentrations.It is expected that the ZT~1.0 at 300K and ZT~2.9 at 773 K can be obtained when the carrier concentration of~8.01019 cm3 and the effective mass~1.8 me were selected.This work provides an alternative way to comprehend the performance optimization in thermoelectric community. | Bingchao Qin Wenke He Li-Dong Zhao | 2020 | Journal of Materiomics2020，6，4： | 6 |
| 6 | Implementing single-scale wavelet transform processor with magnetostatic surface wave device显示文摘When the envelope of the conducting strips for the input transducer of magnetostatic surface wave(MSSW) device is designed according to the wavelet-function envelope,the impulse-response function of the input transducer for MSSW device is equal to the wavelet function,so that single-scale wavelet-transform processor of MSSW type is fabricated.First,according to the envelope function of the wavelet,the length function of the conducting strips is defined,then,the lengths of the conducting strips can be calculated from the length function of the conducting strips,finally,the input transducer can be designed according to the lengths and widths for the conducting strips.The compensation method of the insertion loss for single-scale wavelet trans-form processor of MSSW type is also given in the paper.When the output end of single-scale wavelet transform processor of MSSW type is connected to the amplifier,its insertion loss can be compensated. | LU WenKe ZHU ChangChun KUANG Lun ZHANG Ting LIU JunHua | 2011 | Science China(Technological Sciences)2011，54，6： | 6 |
| 7 | Interpretation of the Traditional Chinese Medicine portion of the diagnosis and treatment protocol for corona virus disease 2019(Trial Version 7)显示文摘The TCM protocol in the Diagnosis and Treatment Protocol for corona virus disease 2019(COVID-19)(Trial Version 7) has been updated from previous versions. The protocol was formulated under the direct leadership of the National Administration of Traditional Chinese Medicine, based on the experience of a panel of experts, supported by evidence from fever clinics and from the outcomes of emergency(EM) observation rooms and inpatients throughout China(especially in Wuhan, Hubei Province) in combination with the latest scientific research results and data. The present interpretation of the TCM protocol is based on an overall understanding of the revised content, and aims to guide and standardize its clinical application to provide a reference for clinicians. | Song Ping Zhao Linhua Li Xiuyang Su Jiansen Jiang Zhaoyuan Song Bin Liu Wenke Tang Shuang Lei Ye Ding Qiyou Yang Ze Lin Jiaran Wei Yu Tong Xiaolin | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 5 |
| 8 | Co3O4 nanocage derived from metal-organic frameworks: An excellent cathode catalyst for rechargeable Li-O2 battery显示文摘Rechargeable non-aqueous Li-O2 battery is regarded as one of the most promising energy-storage technologies on account of its high energy density.It is believed that the rational design of three-dimensional (3D) architecture for catalyst is a key factor for the remarkable performance.Metal-organic frameworks (MOFs) derived materials possess excellent architecture,which is beneficial for Li-O2 batteries.In this work,ZIF-67 is used as precursor template and calcinated under different temperature to produce Co3O4 crystals.When the anneal treatment is under 350℃,the derived Co3O4 nanocage holds the most complete skeleton,which provides better charge transfer ability as well as O2 and Li^+ diffusion.Meanwhile,the Co3O4 nanocage owns more oxygen vacancies,offering more active sites.With the synergistic effect of nanocage structure and active sites,the Co3O4 nanocage stably delivers a large specific capacity of 15,500 mAh·g^-1 as well as a long cycle-life of 132 cycles at limited discharge capacity of 1,000 mAh·g^-1 under discharge/charge current density of 0.5 A·g^-1. | Zhuoliang Jiang Hui Sun Wenke Shi Tianhang Zhou Jianyong Hu Jingyang Cheng Pengfei Hu Shigang Sun | 2019 | Nano Research2019，12，7： | 5 |
| 9 | Research on the conversion relationships between the river and groundwater in the Yellow River drainage area显示文摘Conversion relationships between the river and groundwater in the Yellow River drainage area are studied in this paper based on the geologic and physiognomy conditions and the data of the groundwater regime, isotope, groundwater flow field and field survey. Then eight recharge and discharge modes on the relationships are put forward and the hydraulic characteristics of the modes are analysed, which provides a scientific basis for quantitatively simulating and assessing the conversion relationships, maintenance mechanism of the Yellow River and the regeneration ability of the groundwater in the area. | WANG Wenke KONG Jinling DUAN Lei WANG Yanlin MA Xiongde | 2004 | Science China(Technological Sciences)2004，47，z1： | 5 |
| 10 | Improved root zone temperature buffer capacity enhancing sweet pepper yield via soil-ridged substrate-embedded cultivation in solar greenhouse显示文摘A novel soilless cultivation method,called as soil-ridged substrate-embedded cultivation(SSC)was invented,and an experiment was designed to investigate root zone temperature and production efficiency of sweet pepper cultivated by two SSC patterns,i.e.,SSC-P(polyethylene groove inserted)and SSC-W(wire-mesh groove inserted),and also other two cultivation methods,i.e.,soil ridge(SR)and naked polyethylene groove(PG).Results showed that PG,SSC-P and SSC-W increased the average minimal root zone temperature by 1.01℃,0.75℃,and 1.16℃ compared to SR(16.33℃)during March 16-20,2015.During June 1-5,SSC-P and SSC-W decreased the average maximal root zone temperature by 1.28℃ and 1.29℃ compared to SR(34.99℃),while PG increased it by 1.44℃.PG,SSC-P,and SSC-W decreased the differences of average daytime and night time temperatures by 1.34℃,2.13℃,and 2.88℃ compared to SR(4.56℃)during early stage.However,SSC-P and SSC-W decreased temperature differences of average daytime and night time by 0.9℃ and 1.07℃ compared to SR(0.95℃)during later stage,but PG improved by 2.85℃.Temperature difference of daytime and night time of SSC-W was minimal,and the temperature difference between the diurnal highest and the lowest temperature of SSC-W was also minimal.The buffer capacity of SSC-W was slightly better than that of SSC-P.SSC-W significantly improved the growth of sweet pepper compared to SR.Similarly,fruit yield per square meter of sweet pepper cultivated on SSC-P and SSC-W improved by 21.24%and 50.33%,respectively compared to SR(3.06 kg/m^(2)),while PG lowered the yield by 13.72%.SSC-W was a better SSC pattern compared with SSC-P in terms of production efficiency. | Guohai Fu Zonggeng Li Wenke Liu Qichang Yang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 4 |
| 11 | Effects of Earth's curvature and radial heterogeneity in dislocation studies:Case studies of the 2008 Wenchuan earthquake and the 2004 Sumatra earthquake显示文摘Recently,effects of Earth's curvature and radial heterogeneity on coseismic deformations are often investigated based on the 2004 Sumatra earthquake.However,such effects are strongly related to earthquake types.As a low dip angle event,the 2004 Sumatra earthquake is not a good seismic case for such a topic since the effects for moderate dip angle events are much bigger.In this study,the half-space and spherical dislocation theories are used,respectively,to calculate coseismic displacements caused by the 2008 Wenchuan earthquake and the 2004 Sumatra earthquake.Effects of Earth's curvature and stratification are investigated through the discrepancies of results calculated using the two dislocation theories.Results show that the effects of Earth's curvature and stratification for the 2008 Wenchuan earthquake are much larger than those for the 2004 Sumatra earthquake.Ignoring the effects will cause errors up to 100%-200% in far field displacements for a moderate dip angle event like the 2008 Wenchuan earthquake.Such great effects are much bigger than those conclusions of previous studies.Besides,comparison with observations verifies that spherical dislocation theories yield better results than half-space ones in far fields. | Guangyu Fu Wenke Sun Yoichi Fukuda Shanghua Gao Takashi Hasegawa | 2010 | Earthquake Science2010，23，4： | 4 |
| 12 | Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury显示文摘 | Yuhua Wang Yanlong Liu Irina Kirpich Zhenhua Ma Cuiling Wang Min Zhang Jill Suttles Craig McClain Wenke Feng | 2013 | The Journal of Nutritional Biochemistry2013，，： | 4 |
| 13 | Effects of Gaussian filter in processing GRACE data: Gravity rate of change at Lhasa,southern Tibet显示文摘In this paper, the spatial gravity distribution over Tibetan Plateau and the gravity rate of change at Lhasa for different Gaussian filter radii are computed using GRACE data. Results show that the estimate of the gravity rate of change is spatial radius-dependent of the Gaussian filter. The GRACE-estimated gravity rate of change agrees well with the surface measured one. In other words, the GRACE-estimated gravity rate of change has a limited value as that obtained by surface measurement when the spatial filter radius reaches zero. Then numerical simulations are made for different spatial radii of the Gaussian filter to investigate its behaviors when applied to surface signals. Results show that the estimate of a physical signal is filter-radius dependent. If the computing area is equal to or less than the mass area, especially for a uniformly distributed mass, the estimate gives an almost correct result, no matter what filter radius is used. The estimate has large error because of the signal leakage caused by harmonic truncation if the computing area is much bigger than the mass distribution (or inverse for a small mass anomaly). If a mass anomaly is too small, it is difficult to recover it from space observation unless the filter radius is extremely small. If the computing point (or area) is outside the mass distribution, the estimated result is almost zero, particularly for small filter radii. These properties of the Gaussian filter are helpful in applying GRACE data in different geophysical problems with different spatial position and geometrical size. We further discuss physical sources causing the scalar gravity change at Lhasa. Discussions indicate that the gravity rate of change at Lhasa is not caused by the present-day ice melting (PDIM) (or Little Ice Age, LIA) effect because no ice melting occurs in Lhasa city and nearby. The gravity rate of change is attributable mainly to tectonic deformation associated with the Indian Plate collision. Simultaneous surface displacement, surface denudation, and GIA effects are not negligible. | SUN WenKe HASEGAWA Takashi ZHANG XinLin FUKUDA Yoichi SHUM C. K. WANG Lei | 2011 | Science China Earth Sciences2011，54，9： | 4 |
| 14 | PARALLEL FINITE ELEMENT ANALYSIS OF HIGH FREQUENCY VIBRATIONS OF QUARTZ CRYSTAL RESONATORS ON LINUX CLUSTER显示文摘石英水晶共鸣器是典型压电的声学的波浪设备因为有在无线电频率(RF ) 的机械颤动频率的频率控制应用变化。颤动和变丑的精确分析通常在共鸣器设计和改进过程被要求。考虑包括电极,增长,象温度那样的偏爱地,起始的压力,和加速的存在。自然地,有限元素方法是为有多物理自然的如此的 a coupled 问题的唯一的有效工具。主要挑战是结果的线性方程的极其大的尺寸。为这个原因,我们一直在采用 Mindlin 板方程减少计算困难。另外,我们不得不在 Linux 簇上利用并行计算技术,它现在为学术、工业的应用程序是广泛地可得到的,到改进计算效率。我们的研究的一般原则是使用开放源代码软件部件和公共领域技术在 Linux 簇上为开发者和用户减少费用。我们明确地以一个网孔发电机开始因为矩形、圆形的类型的石英水晶共鸣器,和 Mindlin 板方程为有限元素分析被实现。象并行处理,处理的稀少的矩阵,和最近的特征值抽取包裹一样的计算技术集成于程序。它从我们簇上的这些算法和方法的联合能显著地满足记忆要求和还原剂计算时间的计算是清楚的。 | Ji Wang Yu Wang Wenke Hu Wenhua Zhao Jianke Du Dejin Huang | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 4 |
| 15 | Improved two-way satellite time and frequency transfer with Multi-GEO in BeiDou navigation system显示文摘Due to the limitation of Geostationary Earth Orbit(GEO)satellite resources,only very few TWSTFT links with parallel counterpart operating via diferent GEO satellites between two ground stations are available.There are 5 GEO satellites in BeiDou Navigation System,which enables an improved TWSTFT with Multi-GEO.Two algorithms are put forward to take the advantage of Multi-GEO links to improve the performance of time and frequency transfer respectively.The dynamic weight average algorithm based on a newly proposed dynamic time variance aiming at improving the performance of time transfer is shown to be able to reduce the dynamic time deviation of the two-way measurement result to 1/√N dynamic time deviation of the single link using N-GEO links,if each link has similar level of link noises.The algorithm of cancelling out the link noise Allan variances with 2-GEO links is expected to obtain the Allan variance of clock diference between two ground stations.The experiment results using 2-GEO links in BeiDou Navigation System show that the dynamic weight average algorithm can improve the dynamic time deviation of the two-way measurement to around 0.6 of that of the single link in an average concept.And the estimated Allan deviation of the clock diference using the algorithm for cancelling the noise Allan variances of both links can reach 7×10 12(τ0.65)for the averaging time 1–105s which is within the same order of magnitude as the estimated Allan deviation based on carrier Doppler measurement for the averaging time 10 s–104s,despite the noisy links with the Allan deviation follows 3×10 10(τ1). | YANG WenKe GONG Hang LIU ZengJun LI YuanLing SUN GuangFu | 2014 | Science China(Information Sciences)2014，57，2： | 4 |
| 16 | Preparation and Application of Light-weight Raw Materials Using Natural Forsterite显示文摘In order to develop new basic light-weight refractory raw materials,natural forsterite(<0.045 mm)and magnesite(<0.045 mm)were batched according to the chemical composition of forsterite(2MgO·SiO_(2)),wet milled,semi-dry molded and calcined at different temperatures.Then cylinder samples with diameter of 36 mm were prepared.The effects of the wet milling jar rotation speed,the calcination temperature and the anthracite addition on the properties of the samples were researched.The results show that:when the calcination temperature exceeds 1300℃,all the mineral phases have converted to the desired phases;with the increase of the rotation speed and the calcination temperature,the bulk density of the samples increases,the apparent porosity decreases and the compressive strength improves.By comprehensive consideration,400 r·min^(-1) and 1450℃ are taken as the optimal scheme.High addition of anthracite makes the samples light,so series of light-weight raw materials with uniformly distributed micro-pores can be gained.The light-weight raw materials achieved were used for insulation refractory castables,obtaining good application. | MENG Chao MENG Qingxin LI Xiaolong CAI Xiangyu GAO Wenke CHEN Qiuyang | 2021 | China's Refractories2021，30，3： | 3 |
| 17 | Light Triggers the miRNA-Biogenetic Inconsistency for De-etiolated Seedling Survivability in Arabidopsis thaliana显示文摘The shift of dark-grown seedlings into light causes enormous transcriptome changes followed by a dramatic developmental transition.Here,we show that microRNA(miRNA)biogenesis also undergoes regulatory changes during de-etiolation.Etiolated seedlings maintain low levels of primary miRNAs(pri-miRNAs)and miRNA processing core proteins,such as Dicer-like 1,SERRATE,and HYPONASTIC LEAVES 1,whereas during de-etiolation both pri-miRNAs and the processing components accumulate to high levels.However,the levels of most miRNAs do not notably increase in response to light.To reconcile this inconsistency,we demonstrated that an unknown suppressor decreases miRNA-processing activity and light-induced SMALL RNA DEGRADING NUCLEASE 1 shortens the half-life of several miRNAs in de-etiolated seedlings.Taken together,these data suggest a novel mechanism,miRNA-biogenetic inconsistency,which accounts for the intricacy of miRNA biogenesis during de-etiolation.This mechanism is essential for the survival of de-etiolated seedlings after long-term skotomorphogenesis and their optimal adaptation to ever-changing light conditions. | Suk Won Choi Moon Young Ryu Andras Viczian Hyun Ju Jung Gu Min Kim Agustin LArce Natalia PAchkar Pablo Manavella Ulla Dolde Stephan Wenke Attila Molnar Ferenc Nagy Seok Keun Cho Seong Wook Yang | 2020 | Molecular Plant2020，13，3： | 3 |
| 18 | Weakened anisotropy of mechanical properties in rolled ZK60 magnesium alloy sheets with elevated deformation temperature显示文摘The rolling direction(RD) and the transverse direction(TD) samples were obtained from an as-rolled ZK60 magnesium alloy sheet with strong anisotropy of initial texture and their mechanical properties were tested at various deformation temperatures. Meanwhile, the microstructure and texture of these samples after fracture were investigated. Results revealed that a higher flow stress along the RD than that along the TD at room temperature were ascribed to the strong anisotropy of transitional texture, and this texture effect was remarkably weakened with the increase of deformation temperature. Deformation structure was dominant at 100?C, and was replaced by dynamic recrystallization structure when the deformation temperature increased to 200?C and 300?C. The texture presented a strong texture(transitional texture in the RD sample and basal texture in the TD sample) at 100?C, but its intensity visibly decreased and texture components became more disperse at 200?C and 300?C. These microstructure and texture results were employed in conjunction with calculated results to argue that raising deformation temperature could increase the activity of non-basal slip by tailoring the relative critical resolved shear stress of each deformation mode and finally result in low texture effect on mechanical anisotropy. | Wenke Wang Wenzhen Chen Wencong Zhang Guorong Cui Erde Wang | 2018 | Journal of Materials Science & Technology2018，34，11： | 3 |
| 19 | Cardiac fibroblast heat shock protein 47 aggravates cardiac fibrosis post myocardial ischemia-reperfusion injury by encouraging ubiquitin specific peptidase 10 dependent Smad4 deubiquitination显示文摘Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention(PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling significantly contribute to poor prognosis and rehabilitation in AMI patients. We revealed the effects of HSP47 on myocardial ischemia-reperfusion injury(IRI) and shed light on the underlying molecular mechanism.We generated adult mice with lentivirus-mediated or miRNA(mi1/133TS)-aided cardiac fibroblastselective HSP47 overexpression. Myocardial IRI was induced by 45-min occlusion of the left anterior descending(LAD) artery followed by 24 h reperfusion in mice, while ischemia-mediated cardiac remodeling was induced by four weeks of reperfusion. Also, the role of HSP47 in fibrogenesis was evaluated in cardiac fibroblasts following hypoxia-reoxygenation(HR). Extensive HSP47 was observed in murine infarcted hearts, human ischemic hearts, and cardiac fibroblasts and accelerated oxidative stress and apoptosis after myocardial IRI. Cardiac fibroblast-selective HSP47 overexpression exacerbated cardiac dysfunction caused by chronic myocardial IRI and presented deteriorative fibrosis and cell proliferation.HSP47 upregulation in cardiac fibroblasts promoted TGFβ1-Smad4 pathway activation and Smad4 deubiquitination by recruiting ubiquitin-specific peptidase 10(USP10) in fibroblasts. However, cardiac fibroblast specific USP10 deficiency abolished HSP47-mediated fibrogenesis in hearts. Moreover, blockage of HSP47 with Col003 disturbed fibrogenesis in fibroblasts following HR. Altogether, cardiac fibroblast HSP47 aggravates fibrosis post-myocardial IRI by enhancing USP10-dependent Smad4 deubiquitination,which provided a potential strategy for myocardial IRI and cardiac remodeling. | Saiyang Xie Yun Xing Wenke Shi Min Zhang Mengya Chen Wenxi Fang Shiqiang Liu Tong Zhang Xiaofeng Zeng Si Chen Shasha Wang Wei Deng Qizhu Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 3 |
| 20 | Lactobacillus rhamnosusGG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury显示文摘 | Yuhua Wang Yanlong Liu Anju Sidhu Zhenhua Ma Craig McClain Wenke Feng | 2012 | AJP: Gastrointestinal and Liver Physiology2012，，1： | 3 |
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