|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis显示文摘瞄准:门静脉高血压是肝肝硬化的普通复杂并发症。肝内压力能以几个方法被提高。从内脏的内脏影响脉管系统, vasoconstrictors 的增加和增加的循环进门静脉系统的反常建筑学都可以作出贡献。因而内长的血管扩张药也许能减轻高血压。我们因此试图调查内长的血管扩张药的层次,氮的氧化物(没有) 并且通过氮的氧化物 synthase (NOS ) 的表示的一氧化碳(公司) 并且他我氧合酶(惊讶) 。方法:肝脏硬化症(n=20 ) 并且非肝脏硬化症(n=20 ) 肝从经历了外科的病人被获得。NOS 的各种各样的 isoforms 的 mRNA 和蛋白质表情并且惊讶用竞争 PCR,西方的污点和免疫组织化学被检验。结果:当内皮 NOS (eNOS ) 在硬变肝是起来调整的时,在可诱导的 NOS (i NOS ) 或神经元 NOS (nNOS ) 表情没有重要变化。附随地, caveolin-1, eNOS 的一个确定的下面管理者,是起来调整的。可诱导的 HO-1 和组成的 HO-2 被发现在不同本地化在硬变肝虽然显示出增加的表示。结论:NOS 表示力量的差别由于他们在在肝硬化的病理维持肝动态平衡或参与的不同角色。在高血压的肝以内的纯粹的应力可以导致 eNOS 的增加的表示。接着, caveolin-1 也被增加。这是否对进一步的肝硬化用作一个防御机理或是肝硬化的后果,是还未知的。HO-1 和 HO-2 的提高的表示建议公司可以微弱地作为血管扩张药虽然在它的角色补偿。它是可能的那个公司并且不在肝以内有平行或协调的功能并且可以在门静脉高血压的病理生理学反对地工作。 | Beatrice J Goh Bee Tee Tan Wei Min Hon Kang Hoe Lee Hoon Eng Khoo | 2006 | World Journal of Gastroenterology2006，12，4： | 19 |
| 2 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 3 | Hydrogen Storage Properties of Ti_(1.2)Fe+xCa Hydrogen Storage Alloys显示文摘The hydrogen storage properties of Ti1,2Fe+xCa (x=1%, 3% and 5% in mass fraction) alloys was Investl- gated. Results show that the modified alloys can be activated without any thermal treatment at room temperatrLre due to the addition of Ca and excess Ti in the alloys. Hydrogen storage properties of these modified alloys vary with Ca amount and reaction temperature. In addition, the influence mechanism of the addition of Ca and excessive Ti on the activation behavior and hydrogen storage capacity of the alloys was discussed. | Wei Wang, Changpin Chen, Haiou Xu, Hon gbo Li, Qidong Wang Department Materiak Science and Engineering, Zhejiang University, Hangvhou 310027. China | 2001 | Rare Metals2001，20，4： | 4 |
| 4 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 5 | A Fundamental Solution Method For Inverse Heat Conduction Problem显示文摘 | Hon Y C Wei T | 2004 | Engineering Analysis with Boundary Elements2004，28，5： | 1 |
| 6 | A fundamental solution method for inverse heat conduction problem显示文摘 | HON Y C WEI T | 2004 | Engrg Anal Bound Elem2004，28，： | 1 |
| 7 | The method of fundamental solutions for solving multidimensional inverse heat conduction problems显示文摘 | HON Y C WEI T | 2005 | CMES:Comput Model Engrg Sci2005，7，： | 1 |
| 8 | Method of fundamental solutions with regularization techniques for Cauchy problems of elliptic operators显示文摘 | Ting Wei Y.C. Hon Leevan Ling | 2006 | Engineering Analysis with Boundary Elements2006，，4： | 1 |
| 9 | The method of fundamental solution for solving multidimensional inverse heat conduction显示文摘 | Hon Y C Wei T | 2005 | Computer Modeling in Engineering & Sciences2005，7，2： | 1 |
| 10 | Numerical computation of a cauchy problem for laplace' s equation显示文摘 | CHENG J HON Y C WEI T | 2001 | ZAMM Z Angew Math Mech2001，81，4： | 1 |
| 11 | Backus-gilbert algorithm for the cauchy problem of laplace equation显示文摘 | HON Y C WEI T | 2001 | Inverse Probl2001，17，2： | 1 |
| 12 | Method of fundamental solu-tions with regularization techniques for Cauchy problems ofelliptic operators 显示文摘 | Wei Ting Hon Y C Ling L | 2007 | Engineering Analysis with BoundaryElements2007，31，4： | 1 |
| 13 | A fundamental solution method for inverse heat conduction problem 显示文摘 | HON Y C WEI T | 2004 | Eng Anal Bound Elem2004，28，5： | 1 |
| 14 | The Method of Fundamental Solution for Solving Muhidimensional Inverse Heat Conduction显示文摘 | Hon Y C Wei T | 2005 | Computer Modeling in Engineering & Sciences2005，7，2： | 1 |
| 15 | A fundamental solution method for inverse heat conduction problem显示文摘 | HON Y C WEI T | 2004 | Engrg Anal Bound Elem2004，28，5： | 1 |
| 16 | The method of fundamental solutions for solving multidimensionalinverse heat conduction problems显示文摘 | HON Y C WEI T | 2005 | CMES ? Comput Model Engrg Sci2005，7，2： | 1 |
| 17 | A fundamental solution method for inverse heat conduction problem显示文摘 | Hon Y C Wei T | 2004 | Engineering Analysis with Boundary Elements2004，28，5： | 1 |
| 18 | A fundamental solution method for inverse heat conduction problem显示文摘 | HON Y C WEI T | 2004 | Engrg Anal Bound Elem2004，28，： | 1 |
| 19 | The method of fundamental solu tion for solving multidimensional inverse heat conduc tion problems显示文摘 | HON Y C WEI T | 2005 | CMES: Comput Model Engrg Sci2005，7，： | 1 |
| 20 | Reconstruction of numerical derivatives from scattered noisy data显示文摘 | Wei T Hon Y C Wang Y B | 2005 | Inverse Problems2005，21，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员