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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Student learning with concept mapping of care plans in community-based education显示文摘 | Hinck S M Webb P Sims-Giddens S | 2006 | J Prof Nurs2006，22，1： | 1 |
| 3 | Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion-preliminary report显示文摘 | Laron Z Ginsberg S Webb M | 2008 | Growth Horm IGF Res2008，18，5： | 1 |
| 4 | Constrained customization of non-coplanar beam orientations in radiotherapy of brain turnouts 显示文摘 | Rowbottom CG Oldham M Webb S | 1999 | Phys Med Biol1999，44，2： | 1 |
| 5 | Comparison of University of Wisconsin and ET-Kyoto preservation solutions for the cryopr- eservation of primary human hepatocytes显示文摘 | llouz S Nakamura T Webb M | 2008 | Transplant Proc2008，40，5： | 1 |
| 6 | Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection显示文摘 | Protzer U Seyfried S Quasdorff M Sass G Svorcova M Webb D | | Gastroenterology0，，： | 1 |
| 7 | XAS speciation of arsenic in a hyper-accumulating fern显示文摘 | Webb S M Gaillard J F Ma L Q | 2003 | Environmental Science & Technology2003，37，4： | 1 |
| 8 | Rhythms in pineal immunoreactive somatostatin in the Syrian hamster, mouse and gerbil 显示文摘 | Webb S M Peinado M A Puig-Domingo M | 1988 | J Pineal Res1988，5，3： | 1 |
| 9 | Structm and evolutionary implication of a'cysteine-rich'Campoletis sonorensis polydnavirus gene family Proc显示文摘 | Dib-Hajj S D Webb B A Summer M D | 1993 | Natl Acad Sci1993，90，： | 1 |
| 10 | Phylodiversitydependent seedling mortality,size structure,and disease in a Bornean rain forest显示文摘 | Webb C O Gilbert G S Donoghue M J | 2006 | Ecology2006，87，： | 1 |
| 11 | Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease 显示文摘 | O'Donnell D E Revill S M Webb K A | 2001 | Am J Respir Crit Care Med2001，164，5： | 1 |
| 12 | Poly(acrylate/siloxane) hybrid adhesives for polymers with low surface energy显示文摘 | Sonnenschein M F Webb S P Wendt B L | 2008 | International Journal of Adhesion & Adhesives2008，28，3： | 1 |
| 13 | Student Learning with Concept Mapping of Care Plans in Community-Based Education显示文摘 | Hinck S M Webb P Sims-Giddens S | 2006 | J Prof Nurs2006，22，1： | 1 |
| 14 | Resistance gene complexes: evolution and utilization显示文摘 | HULBERT S H WEBB C A SMITH S M SUN Q | 2001 | Annual Review of Phytopathology2001，39，： | 1 |
| 15 | Shivering during epidural analgesia in women in labor显示文摘 | Webb P J James F M Wheeler A S | | 0，，06： | 1 |
| 16 | Resistance gene complexes:Evolution and utilization显示文摘 | Hulbert S H Webb C A Smith S M Sun Q | | 0，，： | 1 |
| 17 | Discrete particle motion on sieves-a numerical study using the DEM simulation显示文摘 | Li J Webb C Pandiella S S Campbell G M | 2003 | Powder Technology2003，133，： | 1 |
| 18 | Resistance gene complexes:evolution and utilization 显示文摘 | HULBERT S H WEBB C A SMITH S M | 2001 | Annu Rev Phyto-pathol2001，39，： | 1 |
| 19 | Arsenic localization, speciation, and with iron on rice (Oryza sativa L) roots having variable Fe coatings显示文摘 | Seyfferth A L Webb S M Andrews J C | 2010 | Environmental Science & Technology2010，44，21： | 1 |
| 20 | Mannitol in cardioplegia as an oxygen free radical scanvenger measured by malondialdehyde 显示文摘 | Larsen M Webb G Kennington S | 2002 | Perfusion2002，17，1： | 1 |
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