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| 1 | The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey显示文摘Background:The seasonal influenza vaccine coverage rate in China is only 1.9%.There is no information available on the economic burden of influenza-associated outpatient visits and hospitalizations at the national level,even though this kind of information is important for informing national-level immunization policy decision-making.Methods:A retrospective telephone survey was conducted in 2013/14 to estimate the direct and indirect costs of seasonal influenza-associated outpatient visits and hospitalizations from a societal perspective.Study participants were laboratory-confirmed cases registered in the National Influenza-like Illness Surveillance Network and Severe Acute Respiratory Infections Sentinel Surveillance Network in China in 2013.Patient-reported costs from the survey were validated by a review of hospital accounts for a small sample of the inpatients.Results:The study enrolled 529 outpatients(median age:eight years;interquartile range[IQR]:five to 20 years)and 254 inpatients(median age:four years;IQR:two to seven years).Among the outpatients,22.1%(117/529)had underlying diseases and among the inpatients,52.8%(134/254)had underlying diseases.The average total costs related to influenza-associated outpatient visits and inpatient visits were US$155(standard deviation,SD US$122)and US$1,511(SD US$1,465),respectively.Direct medical costs accounted for 45 and 69%of the total costs related to influenza-associated outpatient and inpatient visits,respectively.For influenza outpatients,the mean cost per episode in children aged below five years(US$196)was higher than that in other age groups(US$129–153).For influenza inpatients,the mean cost per episode in adults aged over 60 years(US$2,735)was much higher than that in those aged below 60 years(US$1,417–1,621).Patients with underlying medical conditions had higher costs per episode than patients without underlying medical conditions(outpatients:US$186 vs.US$146;inpatients:US$1,800 vs.US$1,189).In the baseline analysis,inpatients reported costs were 18%higher than those found in the accounts review(n=38).Conclusion:The economic burden of influenza-associated outpatient and inpatient visits in China is substantial,particularly for young children,the elderly,and patients with underlying medical conditions.More widespread influenza vaccination would likely alleviate the economic burden of patients.The actual impact and cost-effectiveness analysis of the influenza immunization program in China merits further investigation. | Juan Yang Mark Jit Kathy S.Leung Ya-ming Zheng Lu-zhao Feng Li-ping Wang Eric H.Y.Lau Joseph T.Wu Hong-jie Yu | 2015 | Infectious Diseases of Poverty2015，4，1： | 44 |
| 2 | Global blue carbon accumulation in tidal wetlands increases with climate change显示文摘Coastal tidal wetlands produce and accumulate significant amounts of organic carbon(C)that help to mitigate climate change.However,previous data limitations have prevented a robust evaluation of the global rates and mechanisms driving C accumulation.Here,we go beyond recent soil C stock estimates to reveal global tidal wetland C accumulation and predict changes under relative sea level rise,temperature and precipitation.We use data from literature study sites and our new observations spanning wide latitudinal gradients and 20 countries.Globally,tidal wetlands accumulate 53.65(95%CI:48.52-59.01)Tg C yr^(-1),which is~30%of the organic C buried on the ocean floor.Modeling based on current climatic drivers and under projected emissions scenarios revealed a net increase in the global C accumulation by2100.This rapid increase is driven by sea level rise in tidal marshes,and higher temperature and precipitation in mangroves.Countries with large areas of coastal wetlands,like Indonesia and Mexico,are more susceptible to tidal wetland C losses under climate change,while regions such as Australia,Brazil,the USA and China will experience a significant C accumulation increase under all projected scenarios. | Faming Wang Christian J.Sanders Isaac R.Santos Jianwu Tang Mark Schuerch Matthew L.Kirwan Robert E.Kopp Kai Zhu Xiuzhen Li Jiacan Yuan Wenzhi Liu Zhian Li | 2021 | National Science Review2021，8，9： | 22 |
| 3 | Modification Design Method for an Enveloping Hourglass Worm Gear with Consideration of Machining and Misalignment Errors显示文摘The influences of machining and misalignment errors play a very critical role in the performance of the anti-backlash double-roller enveloping hourglass worm gear(ADEHWG).However,a corresponding efficient method for eliminating or reducing these errors on the tooth profile of the ADEHWG is seldom reported.The gear engagement equation and tooth profile equation for considering six different errors that could arise from the machining and gear misalignment are derived from the theories of differential geometry and gear meshing.Also,the tooth contact analysis(TCA) is used to systematically investigate the influence of the machining and misalignment errors on the contact curves and the tooth profile by means of numerical analysis and three-dimensional solid modeling.The research results show that vertical angular misalignment of the worm wheel(Δβ) has the strongest influences while the tooth angle error(Δα) has the weakest influences on the contact curves and the tooth profile.A novel efficient approach is proposed and used to minimize the effect of the errors in manufacturing by changing the radius of the grinding wheel and the approaching point of contact.The results from the TCA and the experiment demonstrate that this tooth profile design modification method can indeed reduce the machining and misalignment errors.This modification design method is helpful in understanding the manufacturing technology of the ADEHWG. | DENG Xingqiao WANG Jinge HORSTEMEYER Mark F | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 16 |
| 4 | Light-absorbing Particles in Snow and Ice: Measurement and Modeling of Climatic and Hydrological impact显示文摘Light absorbing particles(LAP, e.g., black carbon, brown carbon, and dust) influence water and energy budgets of the atmosphere and snowpack in multiple ways. In addition to their effects associated with atmospheric heating by absorption of solar radiation and interactions with clouds, LAP in snow on land and ice can reduce the surface reflectance(a.k.a., surface darkening), which is likely to accelerate the snow aging process and further reduces snow albedo and increases the speed of snowpack melt. LAP in snow and ice(LAPSI) has been identified as one of major forcings affecting climate change, e.g.in the fourth and fifth assessment reports of IPCC. However, the uncertainty level in quantifying this effect remains very high. In this review paper, we document various technical methods of measuring LAPSI and review the progress made in measuring the LAPSI in Arctic, Tibetan Plateau and other mid-latitude regions. We also report the progress in modeling the mass concentrations, albedo reduction, radiative forcing, and climatic and hydrological impact of LAPSI at global and regional scales. Finally we identify some research needs for reducing the uncertainties in the impact of LAPSI on global and regional climate and the hydrological cycle. | Yun QIAN Teppei J.YASUNARI Sarah J.DOHERTY Mark G.FLANNER William K.M.LAU MING Jing Hailong WANG Mo WANG Stephen G.WARREN Rudong ZHANG | 2015 | Advances in Atmospheric Sciences2015，32，1： | 16 |
| 5 | A new feathered maniraptoran dinosaur fossil that fills a morphological gap in avian origin显示文摘Recent fossil discoveries have substantially reduced the morphological gap between non-avian and avian dinosaurs, yet avians including Archaeopteryx differ from non-avian theropods in their limb proportions. In particular, avians have proportionally longer and more robust forelimbs that are capable of supporting a large aerodynamic surface. Here we report on a new maniraptoran dinosaur, Anchiornis huxleyi gen. et sp. nov., based on a specimen collected from lacustrine deposits of uncertain age in western Liaoning, China. With an estimated mass of 110 grams, Anchiornis is the smallest known non-avian theropod dinosaur. It exhibits some wrist features indicative of high mobility, presaging the wing-folding mechanisms seen in more derived birds and suggesting rapid evolution of the carpus. Otherwise, Anchiornis is intermediate in general morphology between non-avian and avian dinosaurs, particularly with regard to relative forelimb length and thickness, and represents a transitional step toward the avian condition. In contrast with some recent comprehensive phylogenetic analyses, our phylogenetic analysis incorporates subtle morphological variations and recovers a conventional result supporting the monophyly of Avialae. | XU Xing ZHAO Qi NORELL Mark SULLIVAN Corwin HONE David ERICKSON Gregory WANG XiaoLin HAN FengLu GUO Yu | 2009 | Chinese Science Bulletin2009，54，3： | 15 |
| 6 | Analysis of Autopilot Disengagements Occurring During Autonomous Vehicle Testing显示文摘In present-day highly-automated vehicles, there are occasions when the driving system disengages and the human driver is required to take-over. This is of great importance to a vehicle's safety and ride comfort. In the U.S state of California, the Autonomous Vehicle Testing Regulations require every manufacturer testing autonomous vehicles on public roads to submit an annual report summarizing the disengagements of the technology experienced during testing. On 1 January 2016,seven manufacturers submitted their first disengagement reports:Bosch, Delphi, Google, Nissan, Mercedes-Benz, Volkswagen, and Tesla Motors. This work analyses the data from these disengagement reports with the aim of gaining abetter understanding of the situations in which a driver is required to takeover, as this is potentially useful in improving the Society of Automotive Engineers(SAE) Level 2 and Level 3 automation technologies.Disengagement events from testing are classified into different groups based on attributes and the causes of disengagement are investigated and compared in detail. The mechanisms and time taken for take-over transition occurred in disengagements are studied. Finally, recommendations for OEMs, manufacturers, and government organizations are also discussed. | Chen Lv Dongpu Cao Yifan Zhao Daniel J. Auger Mark Sullman Huaji Wang Laura Millen Dutka Lee Skrypchuk Alexandros Mouzakitis | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，1： | 15 |
| 7 | Calcium phosphate cements for bone engineering and their biological properties显示文摘Calcium phosphate cements(CPCs) are frequently used to repair bone defects. Since their discovery in the 1980 s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enhance the biological performance of CPCs, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability,bioactivity, and interactions with cells. This review article focuses on the major recent developments in CPCs,including 3 D printing, injectability, stem cell delivery, growth factor and drug delivery, and prevascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis. | Hockin HK Xu Ping Wang Lin Wang Chongyun Bao Qianming Chen Michael D Weir Laurence C Chow Liang Zhao Xuedong Zhou Mark A Reynolds | 2017 | Bone Research2017，5，4： | 14 |
| 8 | Meeting 24-h movement guidelines: Prevalence, correlates, and the relationships with overweight and obesity among Chinese children and adolescents显示文摘Background:Meeting 24-h movement guidelines by children and adolescents has been associated with improved indicators of health,although it has been under-studied in China.Hence,this study aimed to investigate the prevalence of meeting the 24-h movement guidelines,its correlates,and its relationships with body mass index in children and adolescents in China.Methods:Cross-sectional data from the 2017 Youth Study in China of 114,072 children and adolescents(mean age=13.75 years,49.18%boys)were used.Meeting 24-h movement guidelines(60 min of daily moderate-to-vigorous physical activity,2 h of daily leisure screen time,911 h and 810 h nightly sleep duration for 613-year-olds and 1417-year-olds,respectively)and height and weight of all participants were assessed.The prevalence of meeting the 24-h movement guidelines and World Health Organization weight status categories were determined.Generalized linear models were used to determine the correlates of meeting the 24-h movement guidelines and the relationships of meeting the 24-h movement guidelines with overweight(OW)and obesity(OB).Results:Only 5.12%of Chinese children and adolescents met the 24-h movement guidelines,and 22.44%were classified as OW/OB.Older children and adolescents were less likely to meet the 24-h movement guidelines.Parental education level and family income were positively related to meeting the 24-h movement guidelines.Children and adolescents meeting the 24-h movement guidelines showed lower odds ratios for OW/OB.Compared with participants meeting the 24-h movement guidelines,boys in 4th6th grades met none of the recommendations(OR=1.22,95%CI:1.061.40),met the screen time recommendation only(OR=1.13,95%CI:1.011.28),met the nightly sleep duration recommendation only(OR=1.14,95%CI:1.031.28),and had significantly higher odds ratios for OW/OB.Similar trends were observed for girls in 4th6th grades:meeting none of the guidelines(OR=1.35,95%CI:1.141.59),meeting sleep duration guidelines only(OR=1.23,95%CI:1.081.39),and meeting moderate-to-vigorous physical activity+nightly sleep duration guidelines(OR=1.24,95%CI:1.011.54).For girls in 7th9th grades,the following trend was observed:meeting none of the guidelines(OR=1.30,95%CI:1.011.67).Conclusion:Very few Chinese children and adolescents met the 24-h movement guidelines.Age(negatively correlated),parental education level,and family income(both positively correlated)were correlates of meeting the 24-h movement guidelines.Children and adolescents meeting the 24-h movement guidelines were more likely to have lower risks for OW/OB,especially in the youngest age group(Grades 46);and girls in the middle age group(Grades 79)were also more likely to have lower risks for OW/OB.Further research studies should explore additional correlates and determinants for meeting the 24-h movement guidelines.Also,future studies should use longitudinal or interventional designs to determine the relationships between meeting the 24-h movement guidelines and OW/OB and other health indicators,while taking sex and age differences into account. | Si-Tong Chen Yang Liu Mark S.Tremblay Jin-Tao Hong Yan Tang Zhen-Bo Cao Jie Zhuang Zheng Zhu Xueping Wu Lijuan Wang Yujun Cai Peijie Chen | 2021 | Journal of Sport and Health Science2021，10，3： | 12 |
| 9 | Lessons in bridge damage learned from the Wenchuan earthquake显示文摘A strong earthquake occurred in Wenchuan County,Sichuan Province,China,on May 12,2008.Shortly after the earthquake,the Turner-Fairbank Highway Research Center of the Federal Highway Administration,in partnership with the Research Institute of Highways,the Ministry of Communication of China,led a reconnaissance team to conduct a post-earthquake bridge performance investigation of the transportation system in the earthquake affected areas.The U.S.transportation system reconnaissance team visited the area during July 20-24,2008.This paper presents the fi ndings and lessons learned by the team. | W. Phillip Yen Genda Chen Mark Yashinski Youssef Hashash Curtis Holu Wang Kehai GuoXiaodong | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 11 |
| 10 | Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images显示文摘Super-resolution structured illumination microscopy(SR-SIM) provides an up to twofold enhanced spatial resolution of fluorescently labeled samples. The reconstruction of high-quality SR-SIM images critically depends on patterned illumination with high modulation contrast. Noisy raw image data(e.g., as a result of low excitation power or low exposure time), result in reconstruction artifacts. Here, we demonstrate deep-learning based SR-SIM image denoising that results in high-quality reconstructed images. A residual encoding–decoding convolutional neural network(RED-Net) was used to successfully denoise computationally reconstructed noisy SR-SIM images.We also demonstrate the end-to-end deep-learning based denoising and reconstruction of raw SIM images into high-resolution SR-SIM images. Both image reconstruction methods prove to be very robust against image reconstruction artifacts and generalize very well across various noise levels. The combination of computational image reconstruction and subsequent denoising via RED-Net shows very robust performance during inference after training even if the microscope settings change. | ZAFRAN HUSSAIN SHAH MARCEL MÜLLER TUNG-CHENG WANG PHILIP MAURICE SCHEIDIG AXEL SCHNEIDER MARK SCHÜTTPELZ THOMAS HUSER WOLFRAM SCHENCK | 2021 | Photonics Research2021，9，5： | 11 |
| 11 | Clinical significance of main pancreatic duct dilation on computed tomography: Single and double duct dilation显示文摘AIM: To study the patients with main pancreatic duct dilation on computed tomography (CT) and thereby to provide the predictive criteria to identify patients at high risk of significant diseases, such as pancreatic cancer, and to avoid unnecessary work up for patients at low risk of such diseases. METHODS: Patients with dilation of the main pancreatic duct on CT at Emory University Hospital in 2002 were identified by computer search. Clinical course and ultimate diagnosis were obtained in all the identified patients by abstraction of their computer database records. RESULTS: Seventy-seven patients were identified in this study. Chronic pancreatitis and pancreatic cancer were the most common causes of the main pancreatic duct dilation on CT. Although the majority of patients with isolated dilation of the main pancreatic duct (single duct dilation) had chronic pancreatitis, one-third of patients with single duct dilation but without chronic pancreatitis had pancreatic malignancies, whereas most of patients with concomitant biliary duct dilation (double duct dilation) had pancreatic cancer. CONCLUSION: Patients with pancreatic double duct dilation need extensive work up and careful followup since a majority of these patients are ultimately diagnosed with pancreatic cancer. Patients with single duct dilation, especially such patients without any evidence of chronic pancreatitis, also need careful follow-up since the possibility of pancreatic malignancy, including adenocarcinoma and intraductal papillary mucinous tumors, is still high. | Mark D Edge Maarouf Hoteit Amil P Patel Xiaoping Wang Deborah A Baumgarten Qiang Cai | 2007 | World Journal of Gastroenterology2007，13，11： | 9 |
| 12 | Central Asian aridification during the late Eocene to early Miocene inferred from preliminary study of shallow marine-eolian sedimentary rocks from northeastern Tajik Basin显示文摘The tempo-spatial development of the Cenozoic Asian aridification across the Eocene-Oligocene and its controlling factors are important scientific topics in Earth Sciences, which are pertinent to regional and global tectonic and climatic events. However, sedimentary rocks preserving the record of aridification during this time from central Asia(ACA) are rare. Here we present a preliminary analysis of sedimentary facies of the lower Paleogene in the northeastern Tajik Basin, which reveals that: the lower part of the studied section is dominated by shallow marine deposits of the Paratethys, the middle part is typical of alternations of eolian dune and fluvial deposits, the upper part is represented by eolian loess-sandy loess(L&SL) like facies, and the top exhibits alternations of fluvial-lacustrine and loess like facies. Based on a chronological framework derived from preliminary magnetostratigraphy, published U-Pb dating of a volcanic ash, and regional litho-stratigraphic correlations, we determine that eolian and L&SL facies accumulated in the northeastern Tajik Basin during the Late Eocene and through most of the Oligocene. These sedimentary units indicate that semi-arid to arid environments of ACA had developed at least since the late Eocene. This initial aridification is closely linked to the westward retreat of the Paratethys that was likely driven by a combination of tectonic activity and sea level changes. | WANG Xin Brian KRAATZ Jin MENG Barbara CARRAPA Peter DECELLES Mark CLEMENTZ Sherzod ABDULOV CHEN FaHu | 2016 | Science China Earth Sciences2016，59，6： | 9 |
| 13 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 14 | Hepatocellular carcinoma-specific immunotherapy with synthesized α1,3-galactosyl epitope-pulsed dendritic cells and cytokine-induced killer cells显示文摘AIM: To evaluate the safety and clinical efficacy of a new immunotherapy using both α-Gal epitope-pulsed dendritic cells (DCs) and cytokine-induced killer cells.METHODS: Freshly collected hepatocellular carcinoma(HCC) tumor tissues were incubated with a mixture of neuraminidase and recombinant α1,3-galactosyltransferase (α1,3GT) to synthesize α-Gal epitopes on carbohydrate chains of the glycoproteins of tumor membranes. The subsequent incubation of the processed membranes in the presence of human natural anti-Gal IgG resulted in the effective phagocytosis to the tumor membrane by DCs. Eighteen patients aged 38-78 years with stage Ⅲ primary HCC were randomLy chosen for the study; 9 patients served as controls, and 9 patients were enrolled in the study group.RESULTS: The evaluation demonstrated that the procedure was safe; no serious side effects or autoimmune diseases were observed. The therapy significantly prolonged the survival of treated patients as compared with the controls (17.1 ± 2.01 mo vs 10.1 ± 4.5 mo,P = 0.00121). After treatment, all patients in the study group had positive delayed hyper sensitivity and robust systemic cytotoxicity in response to tumor lysate as measured by interferon-γ-expression in peripheral blood mononuclear cells using enzyme-linked immunosorbent spot assay. They also displayed increased numbers of CD8-, CD45RO-and CD56-positive cells in the peripheral blood and decreased α-fetoprotein level in the serum.CONCLUSION: This new tumor-specific immunotherapy is safe, effective and has a great potential for the treatment of tumors. | Ying Qiu Ming-Bao Xu Mark M Yun Yi-Zhong Wang Rui-Ming Zhang Xing-Kai Meng Xiao-Hui Ou-Yang Sheng Yun | 2011 | World Journal of Gastroenterology2011，17，48： | 8 |
| 15 | Measuring the resilience of an airport network显示文摘Resilience is the ability of a system to withstand and stay operational in the face of an unexpected disturbance or unpredicted changes. Recent studies on air transport system resilience focus on topology characteristics after the disturbance and measure the robustness of the network with respect to connectivity. The dynamic processes occurring at the node and link levels are often ignored. Here we analyze airport network resilience by considering both structural and dynamical aspects. We develop a simulation model to study the operational performance of the air transport system when airports operate at degraded capacity rather than completely shutting down. Our analyses show that the system deteriorates soon after disruptive events occur but returns to an acceptable level after a period of time. Static resilience of the airport network is captured by a phase transition in which a small change to airport capacity will result in a sharp change in system punctuality. After the phase transition point, decreasing airport capacity has little impact on system performance. Critical airports which have significant influence on the performance of whole system are identified, and we find that some of these cannot be detected based on the analysis of network structural indicators alone. Our work shows that air transport system’s resilience can be well understood by combining network science and operational dynamics. | Yanjun WANG Jianming ZHAN Xinhua XU Lishuai LI Ping CHEN Mark HANSEN | 2019 | Chinese Journal of Aeronautics2019，32，12： | 8 |
| 16 | Detecting prostate cancer and prostatic calcifications using advanced magnetic resonance imaging显示文摘前列腺癌症和 prostatic 石灰化在老人有高发生。我们试图在检测前列腺癌症和 prostatic 石灰化调查危险性加权的成像的诊断能力。156 个人的一个全部的数字,与前列腺癌症包括 34 并且 122 在这研究与良性的前列腺被注册。计算断层摄影术,常规磁性的回声成像,散开加权的成像,和危险性加权的成像在所有病人上被执行。112 prostatic 石灰化在 87 个病人被检测。常规磁性的回声成像,明显的散开系数,和在检测前列腺癌症和 prostatic 石灰化的过滤危险性的阶段图象的敏感和特性是计算的。McNemars Chi 平方测试被用来在在这些技术之间的敏感和特性比较差别。结果证明在检测 prostatic 癌症的过滤危险性的阶段图象的敏感和特性比常规磁性的回声成像和明显的散开系数的大(P < 0.05 ) 。另外,在检测 prostatic 石灰化的过滤危险性的阶段图象的敏感和特性比得上计算断层摄影术的并且比常规磁性的回声成像和明显的散开系数的大(P < 0.05 ) 。在前列腺癌症给危险性加权的成像(SWI ) 的高发生反常,我们断定危险性加权的成像在检测前列腺癌症比常规磁性的回声成像,散开加权的成像,和计算断层摄影术更敏感、特定。而且,危险性加权的成像能识别类似于计算断层摄影术的 prostatic 石灰化,并且它比常规磁性的回声成像和散开加权的成像好一些。 | Shewei Dou Yan Bai Ankit Shandil Degang Ding Dapeng Shi E Mark Haacke Meiyun Wang | 2017 | Asian Journal of Andrology2017，19，4： | 7 |
| 17 | Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy显示文摘Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy.In the present study,a streptozotocin-induced diabetic animal model was given an intraperitoneal injection of tauroursodeoxycholic acid.Results from immunofluorescent co-localization experiments showed that both caspase-12 protein and c-Jun N-terminal kinase 1 phosphorylation levels significantly increased,which was associated with retinal ganglion cell death in diabetic retinas.The C/ERB homologous protein pathway directly contributed to glial reactivity,and was subsequently responsible for neuronal loss and vascular abnormalities in diabetic retinopathy.Our experimental findings indicate that endoplasmic reticulum stress plays an important role in diabetes-induced retinal neuronal loss and vascular abnormalities,and that inhibiting the activation of the endoplasmic reticulum stress pathway provides effective protection against diabetic retinopathy. | Liping Yang Lemeng Wu Dongmei Wang Ying Li Hongliang Dou Mark O.M.Tso Zhizhong Ma | 2013 | Neural Regeneration Research2013，8，33： | 7 |
| 18 | Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass显示文摘Considerable debate and controversy surround the cause(s) of Alzheimer's disease(AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD. | David J. Bonda Xinglong Wang Hyoung-Gon Lee Mark A. Smith George Perry Xiongwei Zhu | 2014 | Neuroscience Bulletin2014，30，2： | 7 |
| 19 | Vitamin A administration at birth promotes calf growth and intramuscular fat development in Angus beef cattle显示文摘Background: Marbling, or intramuscular fat, is an important factor contributing to the palatability of beef. Vitamin A, through its active metabolite, retinoic acid, promotes the formation of new fat cells(adipogenesis). As intramuscular adipogenesis is active during the neonatal stage, we hypothesized that vitamin A administration during the neonatal stage would enhance intramuscular adipogenesis and marbling.Methods: Angus steer calves(n = 30), in a completely randomized design, were randomly allotted to three treatment groups at birth, receiving 0, 150,000, or 300,000 IU of vitamin A at both birth and one month of age.A biopsy of the biceps femoris muscle was collected at two months of age. After weaning at 210 d of age, steers were fed a backgrounding diet in a feedlot until 308 d of age, when they were transitioned to a high concentrate finishing diet and implanted with trenbolone/estradiol/tylosin mixture. Steers were harvested at an average of 438 d of age. All diets were formulated to meet nutrient requirements.Results: Weaning weight and weight during the backgrounding phase were linearly increased(P < 0.05) by vitamin A level, though no difference in body weight was observed at harvest. Intramuscular fat of steers at 308 d of age, measured by ultrasound, quadratically increased(P < 0.05) with vitamin A level from 4.0±0.26 % to 4.9±0.26 %.Similarly, carcass marbling score in the ribeye quadratically increased(P < 0.05).Conclusion: Administration of vitamin A at birth increased weaning weight and enhanced marbling fat development.Thus, vitamin A administration provides a practical method for increasing marbling and early growth of beef cattle. | Corrine L.Harris Bo Wang Jeneane M.Deavila Jan R.Busboom Martin Maquivar Steven M.Parish Brent McCann Mark L.Nelson Min Du | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 7 |
| 20 | A 1,3-dipolar cycloaddition protocol to porphyrin- functionalized reduced graphene oxide with a push-pull motif显示文摘减少的 graphene 氧化物(RGO ) 是 covalently 有由二个方法的卟啉一半的 functionalized:直接 Prato 反应(即 1,3-dipolar cycloaddition ) 与 sarcosine 和包含甲酰的卟啉,并且用 4-hydroxybenzaldehyde 包含 1,3-dipolar cycloaddition 到 RGO 表面的一个逐步的方法,与适当卟啉由亲核的替换列在后面。到 RGO 表面的卟啉的化学结合被紫外 / 可见的吸收证实了,荧光, Fourier 变换红外线,并且拉曼光谱学, X 光检查粉末衍射和 X 光检查光电子光谱学,传播电子和原子力量显微镜学,和 thermogravimetric 分析;这个化学附件保证在 RGO 和卟啉之间的有效电子 / 精力转移,并且 RGO 先锋和太古的卟啉与那些相比负担得起改进光非线性。 | Aijian Wang Wang Yu Zhengguo Xiao Yinglin Song Lingliang Long Marie P. Cifuentes Mark G. Humphrey Chi Zhang | 2015 | Nano Research2015，8，3： | 7 |
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