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| 1 | Optimization of phenol degradation by Candida tropicalis Z-04 using Plackett-Burman design and response surface methodology显示文摘Statistical experimental designs were used to optimize the process of phenol degradation by Candida tropicalis Z-04,isolated from phenol-degrading aerobic granules.The most important factors influencing phenol degradation (p<0.05),as identified by a two-level Plackett-Burman design with 11 variables,were yeast extract,phenol,inoculum size,and temperature.Steepest ascent method was undertaken to determine the optimal regions of these four significant factors.Central composite design (CCD) and response surface analysis were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum phenol degradation.The analysis results indicated that interactions between yeast extract and temperature,phenol and temperature,inoculum size and temperature affected the response variable (phenol degradation) significantly.The predicted results showed that the maximum removal efficiency of phenol (99.10%) could be obtained under the optimum conditions of yeast extract 0.41 g/L,phenol 1.03 g/L,inoculum size 1.43% (V/V) and temperature 30.04°C.These predicted values were further verified by validation experiments.The excellent correlation between predicted and experimental values confirmed the validity and practicability of this statistical optimum strategy.This study indicated the excellent ability of C.tropicalis Z-04 in degrading high-strength phenol.Optimal conditions obtained in this experiment laid a solid foundation for further use of this microorganism in the treatment of highstrength phenol effluents. | Jiangya Zhou Xiaojuan Yu Cong Ding Zhiping Wang Qianqian Zhou Hao Pao Weimin Ca | 2011 | Journal of Environmental Sciences2011，23，1： | 48 |
| 2 | Analysis on the decadal scale variation of the dust storm in North China显示文摘In this paper, the temporal variation characteristics of the dust storm in North China are investigated. Based on power spectrum analysis and wavelet analysis, 1956-1970 and 1985-1999 are chosen as the high-frequency and low-frequency dust storm decades respectively. Analysis results clearly show that the spring and wintertime anomalous atmospheric circulation between these two dec-ades are significantly different. Compared with the former decade, there are a strengthened polar vortex, enhanced westerlies near 50°N, and a weak East Asian major though in the winter of the latter decade. The north and center parts of the Siberian high and the Aleutian low become weak. The southerly and easterly wind anomalies appear over the north and east parts of China, which implies the weakening of East Asian winter monsoon. Meanwhile, northern China experiences warmer winters and wetter springs, which are in favor of the weakening of dust storm intensity in North China. There are significant out-of-phase relationships between dust frequency and wintertime westerly intensity, as well as between dust frequency and Arctic Oscillation. It is also found that the frequency of dust weather is strongly re-lated to winter-springtime East Asian monsoon intensity. | KANG Dujuan1,2 & WANG Huijun1 1. NZC/LASG, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100871, China 2. Environmental Fluid Mechanics Laboratory, Stanford University, Stanford CA 94305, USA | 2005 | Science China Earth Sciences2005，48，12： | 14 |
| 3 | 盆地演化认识中的几个问题显示文摘本文论述了盆地演化认识中的几个主要问题。一是陆缘裂解过程,华南边缘传统上认为是被动裂谷边缘的一个例子,其东部沉积物记录了压实的历史,它明显不同于被动裂谷作用模式,而是显示早第三纪大规模上隆和侵蚀的特征;而且,该地区覆盖在下地壳楔形体上面,具有比周围地壳明显要高的地震速度和密度,指示岩浆底侵作用。这些证据说明,与被动裂谷作用模式相比,华南边缘与主动裂谷作用模式较为一致,它是由早第三纪华南边缘东部底下地幔柱形成的主动裂谷。另一个问题是关于页岩的浅部破裂作用机理。大多数研究者认为,微裂隙的形成需要高孔隙压力,它限于深埋、低渗透率的岩石。然而,最近从北海观察表明,在第三纪页岩中,整个盆地范围内的破裂型式从未达到大于几百米的埋藏深度。这说明泥质源岩经历了水压破裂和浅部脱水,在破裂前可能达到深埋后生作用所需要的深度,实质上渗透率的改变是由于源岩的浅部破裂作用可能根本上改变了烃类的初次运移时间和效率。 | Wang Chiyuen(Department of Geology and Geophysics University of California,Berkeley,CA 94720)Yang Jiaming Zhu Weilin(Exploration and Development Research Center,China National Offshore Oil Corporation,Xincheng,074010)Zheng Mingling(Scientific Research Ce | 1995 | 地学前缘1995，2，3： | 14 |
| 4 | No apparent lock-in depth of the Laschamp geomagnetic excursion: Evidence from the Malan loess显示文摘The first-order chronological framework of the long-term Chinese loess/paleosol sequences was based mainly on magnetostratigraphy. However, there remain arguments on the lock-in ages of the major geomagnetic reversals. This study systematically compared the stratigraphic locations of the Laschamp excursion and Henrich events (H4 at~39 ka and H5 at~48 ka) recorded by the Luochuan loess profile in the central Chinese Loess Plateau. Results show that the Lascchamp excursion is bracketed well by these two cold events, and the corresponding estimated age is between about 41.7-43.7 ka, which is close to the widely accepted age of ~40-41 ka for the excursion.Therefore, our new results do not suggest apparent lock-in effects in the last glacial Malan loess. | ZHU Rixiang1, LIU Qingsong1,2, PAN Yongxin1, DENG Chenglong1, ZHANG Rui1 & WANG Xianfeng3 1. Paleomagnetism and Geochronology Laboratory (SKL of Lithosphere Evolution), Institute of Geology and Geophysics, Chi- nese Academy of Sciences, Beijing 100029, China 2. Institute of Geophysics and Planetary Geophysics, University of California, Santa Cruz, CA 95064, USA 3. Department of Geology and Geophysics, University of Minnesota, Minneapolis, MN 55455, USA | 2006 | Science China Earth Sciences2006，49，9： | 12 |
| 5 | Characterization of cancer stem-like cells in the side population cells of human gastric cancer cell line MKN-45显示文摘Objective:Side population(SP) cells may play a crucial role in tumorigenesis and the recurrence of cancer.Many kinds of cell lines and tissues have demonstrated the presence of SP cells,including several gastric cancer cell lines.This study is aimed to identify the cancer stem-like cells in the SP of gastric cancer cell line MKN-45.Methods:We used fluorescence activated cell sorting(FACS) to sort SP cells in the human gastric carcinoma cell line MKN-45(cells labeled with Hoechst 33342) and then characterized the cancer stem-like properties of SP cells.Results:This study found that the SP cells had higher clone formation efficiency than major population(MP) cells.Five stemness-related gene expression profiles,including OCT-4,SOX-2,NANOG,CD44,and adenosine triphosphate(ATP)-binding cassette transporters gene ABCG2,were tested in SP and MP cells using quantitative real-time reverse transcription polymerase chain reaction(RT-PCR).Western blot was used to show the difference of protein expression between SP and MP cells.Both results show that there was significantly higher protein expression in SP cells than in MP cells.When inoculated into non-obese diabetic/severe combined immunodeficiency(NOD/SCID) mice,SP cells show higher tumorigenesis tendency than MP cells.Conclusions:These results indicate that SP cells possess cancer stem cell properties and prove that SP cells from MKN-45 are gastric cancer stem-like cells. | Hai-hong ZHANG Ai-zhen CA Xue-ming WEI Li DING Feng-zhi LI Ai-ming ZHENG Da-jiang DAI Rong-rong HUANG Hou-jun CAO Hai-yang ZHOU Jian-mei WANG Xue-jing WANG Wei SHI Heng ZHU Xiao-ying YUAN Lin CHEN | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，3： | 9 |
| 6 | Comparative studies on epithelial lesions at gastric cardia and pyloric antrum in subjects from a high incidence area for esophageal cancer in Henan,China显示文摘ComparativestudiesonepitheliallesionsatgastriccardiaandpyloricantruminsubjectsfromahighincidenceareaforesophagealcancerinHena... | GAO ShanShan1, ZHOU Qi1, LI YongXin1, BAI YongMin1, ZHENG ZuoYu1, ZOU JianXiang1, LIU Gang1, FAN ZongMin1, QI YiJun1, ZHAO Xin1 and WANG LiDong1,2Keywords esophageal neoplasms stomach neoplasms gastric ca | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 7 | On Ohtsuki's Invariants of Integral Homology 3-Spheres | Xiaosong Lin Zhenghan Wang Department of Mathematics, University of California, Riverside, CA 92521, U. S. A.Department of Mathematics, Indiana University, Bloomington, IN 47405, U. S. A. Department of Mathematics, University of California, La Jolla, CA 92093, U. S. A. | 1999 | Acta Mathematica Sinica,English Series1999，15，3： | 6 |
| 8 | Applications of stable isotopes to study plant-animal relationships in terrestrial ecosystems显示文摘As natural tracers, stable isotopes have been extensively used in plant physiological, ecological and envi- ronmental research. Recently, animal physiological ecologists have also applied stable isotope techniques to study plant- animal relationships. The isotopic compositions of animal body generally reflect and integrate their diets over a time period ranging from hours to years to the lifetime of an indi- vidual. When animal living habitat changes or animals move to a new environment, the animal isotopic compositions will shift accordingly. Thus, stable isotope signatures of an ani- mal can truly reflect its food sources, habitat, distribution and movement patterns during a given time period. More- over, by analyzing animal-tissue isotopic compositions at different temporal scales, we can improve our understanding of animal adaptation to environmental changes. Stable iso- tope technique also provides an ideal tool to study animal foodweb relationship and community structure because of isotopic fractionation during the processes of nutrient as- similation by animals. Stable isotope technique can continu- ously measure animal trophic position in a foodweb, which can eventually reveal the predator-prey relationship and its role in determining matter balance and energy flow in the entire ecosystem. Stable isotope technique has been one of the most important and efficient tools in studying plant-animal relationship. In this paper, we first review recent advances in the application of stable isotope techniques to plant-animal relationship research then evaluate their advantages and disadvantages, and finally discuss some future directions associated with stable isotope applications to plant-animal relationship research. | WANG Jianzhu1,LIN Guanghui1,2,HUANG Jianhui1 & HAN Xingguo1 1.Key Laboratory of Quantitative Vegetation Sciences and Research Center for Plant Ecology and Biodiversity Conservation,Institute of Botany,Chinese Academy of Sciences,Beijing 100093,China 2.Department of Global Ecology,Carnegie Institution of Washington,Stanford,CA 94305,USA | 2004 | Chinese Science Bulletin2004，49，22： | 6 |
| 9 | Geological thermal events in Tarim Basin显示文摘TARIM Basin is the biggest sedimentary basin in China, and it is also an important area of | Chen, HL Yang, SF Dong, CW Zhu, GQ Jia, CA Wei, GQ Wang, ZG | 1997 | Chinese Science Bulletin1997，42，7： | 5 |
| 10 | Internet-based collaborative pseudo-dynamic testing of multi-span bridge structure显示文摘In this paper, the first Internet-based collaborative pseudo-dynamic testing of a multi-span bridge system in China's Mainland is presented in detail, which has been carried out by the collaboration of Hunan University (HNU), Harbin Institute of Technology (HIT) and Tsinghua University (TU) in China's Mainland, and the University of Southern California (USC) in the USA. The prototype system of Russion River Bridge at Southern California in America is illustrated. Different testing specimens, testing equipments and substructure boundary conditions at HNU and HIT laboratories are described. A network protocol platform for collaborative pseudo-dynamic testing, called NetSLab, and some function modules developed on the use of its standardized interface are introduced. Aiming at the MTS system widely used in structural testing, two approaches are presented to implement the communication interface between NetSLab and testing equipment, respectively, studied by HNU and HIT. The integrated networked testing system and collaborative testing procedures are presented. The testing results manifest that the networked collaborative testing system with powerful capability provides a testing platform with good coordination for complex models or actual structures, and achieves remote sharing of testing equipments. | Dapeng Wang a, Shizhu Tiana, Xinjiang Caia, Yunlei Fan b, Yan Xiaob,c a School of Civil Engineering, Harbin Institute of Technology, Harbin 150090, China b School of Civil Engineering, Hunan University, Changsha 410082, China c Department of Civil Engineering, University of Southern California, Los Angeles, CA 90089, USA | 2009 | Progress in Natural Science:Materials International2009，19，5： | 4 |
| 11 | Global existence of smooth solutions to two-dimensional compressible isentropic Euler equations for Chaplygin gases显示文摘In this paper we investigate the two-dimensional compressible isentropic Euler equations for Chaplygin gases. Under the assumption that the initial data is close to a constant state and the vorticity of the initial velocity vanishes, we prove the global existence of the smooth solution to the Cauchy problem for twodimensional flow of Chaplygin gases. | KONG DeXing 1 , LIU KeFeng 2 & WANG YuZhu 3, 1 Department of Mathematics, Zhejiang University, Hangzhou 310027, China 2 Department of Mathematics, University of California at Los Angeles, CA 90095, USA 3 Department of Mathematics, Shanghai Jiao Tong University, Shanghai 200248, China | 2010 | Science China Mathematics2010，53，3： | 4 |
| 12 | Editor’s note显示文摘In recent years, driven by ever-increasing market demand in computing, communication, and multimedia applications, the microelectronics industry has undergone rapid development. Because of technical innovation and advances in almost all aspects of materials, processes, equipment, devices, circuits and systems, siliconbased logic and memory IC technologies using nano-scaling continue to be the industry's major R&D focus. This maintains microelectronics industry adherence to the traditional 'Moore's Law', increasing the | HUANG Ru, Guest Editor Peking University Beijing 100871, China ZHAO Bin, Guest Editor Fairchild Semiconductor 32 Discovery, Irvine, CA 92618, USA WANG RunSheng, Guest Editor Assistant CAI YiMao, Guest Editor Assistant Peking University Beijing 100871, China | 2011 | Science China(Information Sciences)2011，54，5： | 3 |
| 13 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 14 | The ratio of matrix metalloproteinase to E-cadherin expression: a pilot study to assess mRNA and protein expression among African American prostate cancer patients显示文摘 | Pettaway CA Song R Wang X | 2008 | Prostate2008，68，3： | 1 |
| 15 | Evaluation of Water Soluble fl-D-Glucan from Auricularia Aurieular-Judae as Potential Anti-Tumor Agent显示文摘 | Ma Z C Wang J G Zhang L N et cA | 2010 | Carbohydrate Polymers2010，80，4： | 1 |
| 16 | Evidence for a susceptibility locus for schizophrenia on 6pter-p22 显示文摘 | Wang S Sun CE Walczak CA | 1995 | Nature Genet1995，10，1： | 1 |
| 17 | Absence of brainderived neurotrophic factor and trkB receptor immunoreactivity in glia of Alzheimer's disease显示文摘 | Soontomniyomki V Wang G Pittman CA | 2000 | Brain Res2000，76，： | 1 |
| 18 | Increase in calcium leak channel activity by metaboilc inhibition on hydrogen peroxide in rat ventricular myocytes and its inhibition by polycation 显示文摘 | WANG SY CLAGEE JR LANGER CA | 1995 | Mol Cell Cardiol1995，27，： | 1 |
| 19 | In vivo substrates and the contribution of the common phospholipase D, PLDa, towound-in- duced metabolism of lipids in Arabidopsis 显示文摘 | ZIEN CA WANG C WANG X | 2001 | Biochim Biophys Acta2001，1530，： | 1 |
| 20 | Inhibitory effects of Curcumin on tumor initiation by benzo pyrene and 7,12-dimethyl- benz anthracene 显示文摘 | Huang MT Wang ZY Georgiadis CA | 1992 | Carcinogenesis1992，13，11： | 1 |
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