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| 1 | Pharmacological effects of lipid-lowering drugs on circulating adipokines显示文摘The cardioprotective effects of lipid-lowering drugs have been primarily attributed to their effects on blood lipid metabolism.However,emerging evidence indicates that lipid-lowering drugs also modulate the synthesis and secretion of adipose tissue-secreted proteins referred to as adipokines.Adipokines influence energy homeostasis and metabolism and have also been shown to modulate the vascular inflammatory cascade.The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs(statins,fibrates,niacin and omega-3-fatty acids) on the circulating concentrations of leptin,adiponectin,tumor necrosisfactor-α(TNF-α),Retinol binding protein 4(RBP4) and resistin.Overall,the lipid-lowering drugs reviewed have minimal effects on leptin and resistin concentrations.Conversely,circulating adiponectin concentrations are consistently increased by each lipid-lowering drug reviewed with the greatest effects produced by niacin.Studies that have examined the effects of statins,niacin and omega-3-fatty acids on TNF-α demonstrate that these agents have little effect on circulating TNF-α concentrations.Niacin and fibrates appear to lower RBP4 but not resistin concentrations.The results of the available studies suggest that a strong relationship exists between pharmacological reductions in blood lipids and adiponectin that is not obvious for other adipokines reviewed. | Desiree Wanders Eric P Plaisance Robert L Judd | 2010 | World Journal of Diabetes2010，1，4： | 5 |
| 2 | Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and early-onset liver cirrhosis in two sibllngs显示文摘 | Maldergem L V Tuerlinckx D Wanders R J | 2000 | Eur J Pediatr2000，159，12： | 1 |
| 3 | Soil quality: Sciencc and process显示文摘 | Wander M M Walter O L | 2002 | Agron J2002，94，1： | 1 |
| 4 | Coping with toxieities of docetaxel (Taxotere)显示文摘 | Schrijvers D Wanders J Dirix L | | 0，，07： | 1 |
| 5 | Sudden infant death and long-chain 3-hydroxyacyl-CoA dehydrogenase显示文摘 | Wanders RJA Duran M Ij1st L | 1989 | Lancet1989，2，： | 1 |
| 6 | Coping with toxicities of docetaxel (Taxotere) 显示文摘 | Schrijvers D Wanders J Dirix L | 1993 | Ann Oncol1993，4，7： | 1 |
| 7 | Impact of nine common type 2 diabetes risk polymor- phisms in Asian Indian Sikhs:PPARG2 (Pro12Ala), IGF2BP2, TCFTL2 and FTO variants confer a significant risk显示文摘 | Sanghera D K Ortega L Han S Singh J Ralhan S K Wander G S | 2008 | BMC Med Genet2008，9，： | 1 |
| 8 | Molecular basis of long - chain 3 - hydroxyacyl - CoA dehydrogenase deficiency : identification of the major disease - causing mutation in the alpha - subunit of the mitechondrial trifunctional protein 显示文摘 | IJlst L Wanders RJA Ushikubo S | 1994 | Biechirn Biophys Acta1994，12，15： | 1 |
| 9 | Sudden infant death and long-chain 3-hydroxyacyl-CoA dehydrogenase显示文摘 | Wanders RJA Duran M Ijlst L | 1989 | Lancet1989，2，： | 1 |
| 10 | Use of Copper and Gold Electrodes as Sensitive Elements for Fabrication of an Electronic Tongue:Discrimination of Wines and Whiskies显示文摘 | Wander N Mauro B Thiago R L C | 2011 | Micrhemical lournal2011，99，1： | 1 |
| 11 | Delputte Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus显示文摘 | Hanne V G Wander V B Peter L | 2008 | J Gen Virol2008，89，29： | 1 |
| 12 | Molecularbasisoflongchain3-hydroxyacyl-CoA dehydrogenase deficiency:identification of the major disease-causing mutation in the alpha-subunit of the mito-chondrial trifunctional protein显示文摘 | Ijlst L Wanders RJ Ushikubo S | 1994 | Biochim Biophys Acta1994，1215，： | 1 |
| 13 | Adaptation of soil quality indices and application to three tillage systems in southern Illinois显示文摘 | Hussain I Olson K R Wander M M Karlen D L | 1999 | Soil and Tillage Research1999，50，： | 1 |
| 14 | The potential of field spectroscopy for the assessment of sediment properties in river floodplains显示文摘 | Kooistra L Wanders J Epema G F | 2003 | Analytica Chimiea Acta2003，484，： | 1 |
| 15 | The potential of field spectroscopy for the assessment of sediment properties in river floodplains显示文摘 | Kooistra L Wanders J Epema G F | 2003 | Analytica Chimica Acta2003，，484： | 1 |
| 16 | Soil quality: Science and process显示文摘 | Wander M M Walter G L | 2002 | Agronomy Journal2002，94，1： | 1 |
| 17 | Fibular malreduction in AO/Weber type C ankle fractures 显示文摘 | WANDERS L OLIVER CW | 1998 | Injury1998，29，2： | 1 |
| 18 | New guidelines to evaluate the response ti treatmant in solid tumors显示文摘 | Therasse P Arbuck SG Eiseenhauer FA Wanders J Kaplan RS Rubinsteein L Verweij J Van Glabbeke M Van Oosterom AT Christian MC Gwyther SG | 2000 | JNCI2000，，92： | 1 |
| 19 | The potential of field spectroscopy for the assessment of sediment properties in river floodplains显示文摘 | Kooistra L Wanders J Epema G F | 2003 | Analytica Chimica Acta2003，484，： | 1 |
| 20 | A high intake of conjugated linoleic acid does not affect liver and kidney function tests in healthy human subjects 显示文摘 | WANDERS A J LEDER L BANGA J D | 2010 | Food Chem Toxicol2010，48，2： | 1 |
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