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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Effect of feeding organic acids on selected intestinal content measurements at varying times postweaning in pigs显示文摘 | Risley C R Kornegay E T Lindemann M D Wood C M Eigel W N | 1992 | Journal of Animal Science1992，70，： | 1 |
| 3 | An alpha modication of Newmark's method显示文摘 | Wood W L Bossak M Zienkiewicz O C | 1980 | International Journal for Numerical Methods in Engineering1980，15，： | 1 |
| 4 | Strain softening and parameter for sand modeling显示文摘 | WOOD D M BELKHEIR K SHEN C K | 1994 | Geo- technique1994，44，2： | 1 |
| 5 | The effects of commonly prescribed premolar extraction sequences on the curvature of the upper and lower lips显示文摘 | Wholley C J Woods M G | 2003 | Angle Orthod2003，73，4： | 1 |
| 6 | Endotoxin-induced lung injury in mice : structural, functional, and biochemical responses显示文摘 | Rojas M Woods C R Mora A L | 2005 | Am J Physiol Lung Cell Mol Physiol2005，288，： | 1 |
| 7 | 显示文摘 | Rieke P C Marsh B D Wood M L | 1995 | Langmuir1995，11，1： | 1 |
| 8 | Flow analysis of natural rubber in a capillary rheometer( 1 ) : Rheological behavior and flow visualization in the barrel显示文摘 | Sombatsompop N Tan M C Wood A K | 1997 | Polym Eng Sci1997，37，2： | 1 |
| 9 | Bilateral sprea- ding cerebral hypoperfusion during spontanesous mi- graine headache显示文摘 | Woods R P Iacoboni M Mazziotta J C | 1994 | N Engl J Med1994，331，25： | 1 |
| 10 | Central nervous system control of food intake显示文摘 | Schwartz M W Woods S C Porte D Jr | 2000 | Nature2000，404，： | 1 |
| 11 | 显示文摘 | Rieke P C Tarasevich B J Wood M L | 1994 | Langmuir1994，10，3： | 1 |
| 12 | Flow analysis of natural rubber in a capillary rheometer(2) :Flow patterns and entrance velocity profiles in the die显示文摘 | Sombatsompop N Tan M C Wood A K | 1997 | Polym Eng Sci1997，37，2： | 1 |
| 13 | A microplate fluorimetric assay for the study of enzyme diversity in soils显示文摘 | Marx M C Wood M Jarvis S C | 2001 | Soil Biology & Biochemistry2001，，33： | 1 |
| 14 | Electrical measurements of the conduction band discontinuity of the abrupt Ge-GaAs (100) heterojunction显示文摘 | Ballingall J M C Wood E C Eastman L F | 1983 | Journal of Vacuum Science & Technology B1983，1，3： | 1 |
| 15 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 16 | A microplate fluorimetric assay for the study of enzyme diversity in soils显示文摘 | Marx M C Wood M Jarvis S C | 2001 | Soil Biology and Biochem- istry2001，33，1213： | 1 |
| 17 | Disco-vering shared interests u-sing graph analysis显示文摘 | SCHWARTZ M F WOOD D C M | 1993 | Communications of the ACM1993，36，8： | 1 |
| 18 | On-chip terahertz systems for spectroscopy and imaging显示文摘 | Cunningham J Bymc M B Wood C D | 2010 | Electronics Letters2010，46，26： | 1 |
| 19 | Chronic, sublethal nickel accli- mation alters the diffusive properties of renal brush border mem- brane vesicles (BBMVs) prepared from the freshwater rainbow trout 显示文摘 | Pane E F Patel M Wood C M | 2006 | Compara Biochem Physiol Part C2006，143，1： | 1 |
| 20 | Oncological efficacy and safety of nephron- sparing surgery for selected patients with locally ad- vanced renal cell carcinoma显示文摘 | Margulis V Tamboli P Jaeobsohn K M Swanson D A Wood C G | 2007 | BJU Int2007，100，： | 1 |
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