|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Mitochondrial DNA variation in chinook (Oncorhynchus ischawyscha)and chum salmon (oncorhynchus keta)deleted by restriction enzyme analysis of polymerase chain reaction (PCR) products显示文摘 | Cronn M A Spearman W J Wilmot R L | 1993 | Can J Fish Aquat Sci1993，50，4： | 1 |
| 3 | The mathematics of financial derivatives显示文摘 | WILMOT Paul HOWISON Sam DEWYNNE Jeff | 1995 | Cambridge: Cambridge University Press1995，，： | 1 |
| 4 | Transferability analysis of disaggregate choice models显示文摘 | Koppelman F S Wilmot C G | 1982 | Transportation Research Record1982，27，6： | 1 |
| 5 | Early onset type 2 diabetes:risk factors, clinical impact and management显示文摘 | Wilmot E Idris I | 2014 | Ther Adv Chronic Dis2014，5，6： | 1 |
| 6 | Establishing pragmatic estimated GFR thresholds to guide metformin prescribing显示文摘 | Shaw JS Wilmot RL Kitpatrick ES | 2007 | Diabet Med2007，24，： | 1 |
| 7 | A negative electroretinogram (ERG) in a case of probable muhiple system atrophy (MSA) 显示文摘 | Barnes CS Yan J Wilmot GR | 2009 | Doc Ophthalmol2009，118，3： | 1 |
| 8 | Urban land uses, socio-demograph-ic attributes and commuting: A multilevel modeling approach显示文摘 | AntipovaA Wang F Wilmot C | 2011 | Applied Geography2011，31，3： | 1 |
| 9 | Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis显示文摘 | Fahim A Crooks MG Wilmot R | 2012 | Respirotogy2012，17，8： | 1 |
| 10 | Senecio disease or cirrhosis of the liver due to Senecio poisoning显示文摘 | Wilmot F C Robertson G W | 1920 | Lancet1920，2，： | 1 |
| 11 | A case of transient hyperphosphatasemia of infancy and early childhood in an HIV-positive adult possibly related to atazanavir显示文摘 | Trower K Wilmot R Barlow G | 2006 | AIDS2006，20，1： | 1 |
| 12 | XPS study of condensed phase combustion in double base rocket propellant with and without lead salt burning rate modifier显示文摘 | Sharma J Wilmot G B Camoplattaro A A | 1991 | Combustion and Flame1991，85，： | 1 |
| 13 | Early onset type 2 diabetes: risk factors, Clinical impact and management 显示文摘 | Wilmot E Idris I | 2014 | Ther Adv Chronic Dis2014，5，6： | 1 |
| 14 | The effects of the electroejaculation procedure on sperm motility显示文摘 | Wilmot C Anderson RU | 1989 | Paraplegia1989，27，6： | 1 |
| 15 | Distribution, type, and origin of Parkin mutations: review and case studies显示文摘 | HEDRICH K ESKELSON C WILMOT B | 2004 | Mov Disord2004，19，： | 1 |
| 16 | Distribution,type,and origin of Parkin mutations:review and case studies显示文摘 | Hedrich K Eskelson C Wilmot B | 2004 | Mov Disord2004，19，10： | 1 |
| 17 | The use of genetic algorithm to solve the economic lot size scheduling problem 显示文摘 | Khouja M Michalewicz Z Wilmot M | 1998 | European Journal of Operational Research1998，110，3： | 1 |
| 18 | lmmunohistochemistry is highly sensitive and specific for the detection of V6OOE BRAF mu- tation in melanoma显示文摘 | Long G V Wilmot! J S Capper D | 2013 | Am J Surg Pathol2013，37，1： | 1 |
| 19 | Type 2 diabetes in younger adults: Clinical characteristics, diabetes-related complications and management of risk factors显示文摘 | Benhalima K Wilmot E Khunti K | 2010 | Prim Care Diabetes2010，16，： | 1 |
| 20 | Motor neuron disease with parkinsonism显示文摘 | Qureshi AI Wilmot G Dihenia B | 1996 | Arch Neurol1996，53，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员