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| 1 | Glucose metabolism and neurogenesis in the gerbil hippocampus after transient forebrain ischemia显示文摘Recent evidence exists that glucose transporter 3(GLUT3) plays an important role in the energy metabolism in the brain.Most previous studies have been conducted using focal or hypoxic ischemia models and have focused on changes in GLUT3 expression based on protein and m RNA levels rather than tissue levels.In the present study,we observed change in GLUT3 immunoreactivity in the adult gerbil hippocampus at various time points after 5 minutes of transient forebrain ischemia.In the sham-operated group,GLUT3 immunoreactivity in the hippocampal CA1 region was weak,in the pyramidal cells of the CA1 region increased in a time-dependent fashion 24 hours after ischemia,and in the hippocampal CA1 region decreased significantly between 2 and 5 days after ischemia,with high level of GLUT3 immunoreactivity observed in the CA1 region 10 days after ischemia.In a double immunofluorescence study using GLUT3 and glial-fibrillary acidic protein(GFAP),we observed strong GLUT3 immunoreactivity in the astrocytes.GLUT3 immunoreactivity increased after ischemia and peaked 7 days in the dentate gyrus after ischemia/reperfusion.In a double immunofluorescence study using GLUT3 and doublecortin(DCX),we observed low level of GLUT3 immunoreactivity in the differentiated neuroblasts of the subgranular zone of the dentate gyrus after ischemia.GLUT3 immunoreactivity in the sham-operated group was mainly detected in the subgranular zone of the dentate gyrus.These results suggest that the increase in GLUT3 immunoreactivity may be a compensatory mechanism to modulate glucose level in the hippocampal CA1 region and to promote adult neurogenesis in the dentate gyrus. | Dae Young Yoo Kwon Young Lee Joon Ha Park Hyo Young Jung Jong Whi Kim Yeo Sung Yoon Moo-Ho Won Jung Hoon Choi In Koo Hwang | 2016 | Neural Regeneration Research2016，11，8： | 4 |
| 2 | Cu^+-incorporated TiO_2 overlayer on Cu_2O nanowire photocathodes for enhanced photoelectrochemical conversion of CO_2 to methanol显示文摘In this paper, we report photoelectrochemical(PEC) conversion of carbon dioxide(CO_2) using photocathodes based on Cu_2O nanowires(NWs) overcoated with Cu^+-incorporated crystalline TiO_2(TiO_2–Cu^+ )shell. Cu_2O NW photocathodes show remanent photocurrent of 5.3% after 30 min of PEC reduction of CO_2.After coating Cu_2O with TiO_2–Cu^+ overlayer, the remanent photocurrent is 27.6%, which is an increase by5.2 fold. The charge transfer resistance of Cu_2O/TiO_2–Cu^+ is 0.423 k/cm2, whereas Cu_2O photocathode shows resistivity of 0.781 k/cm2 under irradiation. Mott–Schottky analysis reveals that Cu^+ species embedded in TiO_2 layer is responsible for enhanced adsorption of CO_2 on TiO_2 surface, as evidenced by the decrease of capacitance in the Helmholtz layer. On account of these electrochemical and electronic effects by the Cu^+ species, the Faradaic efficiency(FE) of photocathodes reaches as high as 56.5% when TiO_2–Cu^+ is added to Cu_2O, showing drastic increase from 23.6% by bare Cu_2O photocathodes. | Kangha Lee Seokwon Lee Hyunjin Cho Sunil Jeong Whi Dong Kim Sooho Lee Doh C.Lee | 2018 | Journal of Energy Chemistry2018，27，1： | 3 |
| 3 | Effect of carvedilol on left ventricular function and mass in hypertension显示文摘 | Why H J Richardson PJ | 1992 | J Cardiovasc Pharmacol1992，19，1： | 2 |
| 4 | Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia显示文摘In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin(ferritin-H), and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham controls, iron reactivity increased significantly in the stratum pyramidale and stratum oriens at 12 hours following ischemic insult, transiently decreased at 1–2 days and then increased once again within the CA1 region at 4–7 days after ischemia. One day after ischemia, ferritin-H immunoreactivity increased significantly in the stratum pyramidale and decreased at 2 days. At 4–7 days after ischemia, ferritin-H immunoreactivity in the glial components in the CA1 region was significantly increased. Transferrin immunoreactivity was increased significantly in the stratum pyramidale at 12 hours, peaked at 1 day, and then decreased significantly at 2 days after ischemia. Seven days after ischemia, Transferrin immunoreactivity in the glial cells of the stratum oriens and radiatum was significantly increased. Western blot analyses supported these results, demonstrating that compared to sham controls, ferritin H and transferrin protein levels in hippocampal homogenates significantly increased at 1 day after ischemia, peaked at 4 days and then decreased. These results suggest that iron overload-induced oxidative stress is most prominent at 12 hours after ischemia in the stratum pyramidale, suggesting that this time window may be the optimal period for therapeutic intervention to protect neurons from ischemia-induced death. | Dae Young Yoo Ki-Yeon Yoo Joon Ha Park Hyun Jung Kwon Hyo Young Jung Jong Whi Kim Goang-Min Choi Seung Myung Moon Dae Won Kim Yeo Sung Yoon Moo-Ho Won In Koo Hwang | 2016 | Neural Regeneration Research2016，11，6： | 2 |
| 5 | Identification of induced acidification in iron-enriched cultures of Bacillus subtilis during biosurfactant fermentation显示文摘 | WHI Yuhong WANG Lifen CHANG Joshu | 2003 | Journal of Bioscience and Bioengineering2003，96，2： | 1 |
| 6 | Cardiac protein abnormalities in dilated cardiomyopathy detected by two-dimensional polyacrylamide gel electrophoresis显示文摘 | Corbett J Why H Wheeler C | | 0，，11： | 1 |
| 7 | Who'Won' Libya? The Force-diplomacy Debate and Its Implications for Theory and Policy 显示文摘 | JENTLESON B W WHY TOCK C A | 2005 | International Security2005，，3： | 1 |
| 8 | Concurrent poststreptococcal glomerutonephritis and autoimmune hemolytic anemia显示文摘 | Greenbaum LA Kerlin BA van Why S | 2003 | Pediatr Nephrol2003，18，12： | 1 |
| 9 | A new gene for pachyonychia congenitatype 2-Keratin K6B is the expression partner of K17 in epidermal appendages显示文摘 | McLean WHI Smith FJD van Goor H | 1998 | J Invest Dermatol1998，110，4： | 1 |
| 10 | Induction and intracellular location of HSP72 after renal ischemia 显示文摘 | 14,Van Why SK Hildelrandt F Ardito T | 1992 | Am J Physiol1992，263，52： | 1 |
| 11 | Efeet ofearve- dilol on left ventricular function and mass in hypertension 显示文摘 | Why HJ Richardson PJ | 1992 | J Card - lo- vase Phannaeol1992，19，1： | 1 |
| 12 | Risk and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial显示文摘 | WHI investigators | 2002 | JAMA2002，288，3： | 1 |
| 13 | A novel mutation in the helix termination motif of keratin K12 in a US family with Meesmann corneal dystrophy显示文摘 | Coleman CM Hannush S Covello SP Smith FJD Uitto J Mclean WHI | 1999 | Am J Ophthalmol1999，128，： | 1 |
| 14 | Anctworka Igor i thmforcmptyf r c i ght cara 11oca t ion 显示文摘 | Whi toWW | 1969 | IB MSys temJournal1969，15，2： | 1 |
| 15 | Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women显示文摘 | WHI Investigators | | JAMA0，289，24： | 1 |
| 16 | 显示文摘 | Weinstein Ha perin Why Democracies Excel | 2004 | Foreign Affairs2004，583，： | 1 |
| 17 | Effects of conjugated equine estrogens on breast cancer and mammography screening in postmeno?pausal women with hysterectomy显示文摘 | WHI Investigators | 2006 | JAMA2006，295，14： | 1 |
| 18 | Risks and benefits of estrogen plus progestin in healthy postmenopausal women显示文摘 | WHI Investigators | 2002 | J Am Med Assoc2002，288，3： | 1 |
| 19 | Effects of conjugated equine estrogen in postmenopausal women with hysterectomy显示文摘 | WHI Steering Committee | 2004 | J Am Med Assoc2004，291，14： | 1 |
| 20 | Carbon-nanotube based field-emission displays for large area and color applications显示文摘 | Won Bong Choi Nae Sung Lee Whi Kun Yi | | Journal of information display0，11，1： | 1 |
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