|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Cognitive outcomes after carotid revascularization:the role of cerebral emboli and hypoperfusion显示文摘 | Ghogawala Z Westerveld M Amin-Hanjani S | 2008 | Neurosurgery2008，62，2： | 1 |
| 3 | Language latera-lization in epilepsy patients:fMRI validated with the Wadaprocedure显示文摘 | Arora J Pugh K Westerveld M | 2009 | Epilepsia2009，50，10： | 1 |
| 4 | Functional MRI of language processing:dependence on input modality and temporal lobe epilepsy显示文摘 | Carpentier A Pugh KR Westerveld M | 2001 | Epilepsia2001，42，10： | 1 |
| 5 | Functional MRI of language processing: dependence on input modality and temporal lobe ep/lepsy显示文摘 | Carpentier A Pugh KR Westerveld M | 2001 | Epilepsia2001，42，： | 1 |
| 6 | Cardio-metabolic abnormalities in the polycystic ovary syndromePhar- macotherapeutic insights 显示文摘 | Westerveld HE Hoogendoorn M de Jong AW | 2008 | Pharmacol Ther2008，119，3： | 1 |
| 7 | Cardiometabolic abnormalities in the polycystic ovary syndrome: Pharmacother-apeutic insights 显示文摘 | Westerveld HE Hoogendoorn M de Jong AW | 2008 | PharmacolTher2008，119，3： | 1 |
| 8 | Language latera- lization in epilepsy patients: flVIRI validated with the Wada procedure 显示文摘 | Arora J Pugh K Westerveld M et ol | 2009 | Epilepsia2009，50，10： | 1 |
| 9 | Language lateraliza- tion in epilepsy patients: fMRI validated with the Wada procedure 显示文摘 | Arora J Pugh K Westerveld M | 2009 | Eilepsia2009，50，： | 1 |
| 10 | Selective frontal,parietal,and temporal networks in generalized seizures显示文摘 | Blumenfeld H Westerveld M Ostroff R B | 2003 | Neuroimage2003，19，： | 1 |
| 11 | Functional MRI of language processing: Dependence on input modality and temporal lobe epilepsy 显示文摘 | Carpentier A Pugh KR Westerveld M | 2001 | Epilepsia2001，42，10： | 1 |
| 12 | Molec- ular cloning of a human DNA repair gene显示文摘 | Westerveld A Hoeijmakers J H van Duin M | 1984 | Nature1984，310，5976： | 1 |
| 13 | Temporal lobectomy in children:cognitive outcome显示文摘 | Westerveld M Sass KJ Chelune GJ | 2000 | J Neurosurg2000，92，1： | 1 |
| 14 | High- resolution localization of 69 potential human zinc finger protein genes : a number are clustered 显示文摘 | Hoovers J M Mannens M John R Bliek J van Heyningen V Porteous D J Leschot N J Westerveld A Little P F | 1992 | Genomics1992，12，2： | 1 |
| 15 | Selective frontal,parietal,and temporal networks ingeneralized seizures显示文摘 | Blumenfeld H Westerveld M Ostroff R B | 2003 | Neuroimage2003，19，： | 1 |
| 16 | Release rates of A1 from inorganic and organic compounds in a sandy podzol, during laboratory experiments显示文摘 | Vander S C Westerveld J W Verstraten J M | 2000 | Geoderma2000，96，3： | 1 |
| 17 | Worsening of quality of life after epilepsy surgery:effect of seizures and memory decline显示文摘 | Langfitt JT Westerveld M Hamberger MJ | 2007 | Neurology2007，68，： | 1 |
| 18 | FunctionalMRI of language processing: Dependence on input modalityand temporal lobe epilepsy 显示文摘 | Carpentier A Pugh KR Westerveld M | 2001 | Epilepsia2001，42，10： | 1 |
| 19 | Cognitive outcomes after carotid revascularization:the role of cerebral emboli and hypo perfusion显示文摘 | Ghogawala Z Westerveld M Amin-Hanjani S | | Neurosurgery0，62，2： | 1 |
| 20 | Temperature prior to harvest influences the incidence and severity of clubroot on two Asian Brassica vegetables显示文摘 | MCDONALD M R WESTERVELD S M | 2008 | Hort Science2008，43，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员