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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 3 | Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer显示文摘 | Marko NF Suh JH Chao ST Barnett GH Vogelbaum MA Toms S Well R J Angelov L | 2011 | 中国神经肿瘤杂志2011，9，1： | 4 |
| 4 | Mutations in the human retinal degeneration slow (RDS) gene can cause either retinitis pigmentosa or macular dystrophy显示文摘 | Wroblewski J Keen J | 1993 | Nat Genet1993，3，： | 1 |
| 5 | 显示文摘 | Wells J W Kallehauge J F Hofmann P | 2007 | J Phys:Condens Matter2007，19，17： | 1 |
| 6 | Importance of left atrial appendage flow as a predictor of thromboembolic events in patients with atrial fibrillation显示文摘 | Kamp O Verhorst P M J Welling R C | 1999 | Eur Heart J1999，20，13： | 1 |
| 7 | Activites,lnterests and Opinions显示文摘 | Wells D W Tigert D J | 1971 | Journal of Advertising Research1971，，8： | 1 |
| 8 | Risedronate for the primary andsecondary prevention of osteoporotic fractures in postmenopausal women显示文摘 | Wells GA Cranney A Peterson J | 2008 | Cochrane Database Syst Rev2008，，00： | 1 |
| 9 | A study of the use of milk replacers for dairy calves in the United States显示文摘 | Heinrichs A J Wells S J Losinger W C | 1995 | J Dairy Sci1995，，78： | 1 |
| 10 | Complexity of the discrete time-cost tradeoff problem for project networks 显示文摘 | De P Dunne E J Ghosh J B Wells C E | 1997 | Operations Research1997，45，2： | 1 |
| 11 | Earnouts in mergers and acquisitions: a game-theoretic option pricing approach 显示文摘 | Lukas E Reuer J J Welling A | 2012 | European Journal of Operational Research2012，223，1： | 1 |
| 12 | PRC1显示文摘 | Wei Jiang Gretchen Jimenez Nicholas J Wells Thomas J Hope Geoffrey M Wahl Tony Hunter Rikiro Fukunaga | 1998 | Molecular Cell1998，，： | 1 |
| 13 | Association of abnormal morphology and altered gene expression in human preimplantation embryos显示文摘 | Wells D Bermudez MG Steuerwald N Malter HE Thornhill AR Cohen J | 2005 | Fertil Steril2005，84，： | 1 |
| 14 | Considerations for measuring ground CO2 effluxes with chambers显示文摘 | Welles J M Demetriades-Shah T H MeDermitt D K | 2001 | Chemical Geology2001，177，： | 1 |
| 15 | Evaluation of time- temperature related quality changes in icecream during storage 显示文摘 | DOLAN K D SINGH R P WELLS J H | 1985 | Journal of Food Processing and Preservation1985，9，： | 1 |
| 16 | A Database Encryption System with Subkeys显示文摘 | Wells D B Kam J B | 1981 | ACM Trans on Database Systems1981，6，2： | 1 |
| 17 | GMG A guaranteed global optimization algorithm: Application to remote sensing 显示文摘 | D'HELON C PROTOPOPESCU V WELLS J C | 2007 | Mathem & Comput Model2007，45，6： | 1 |
| 18 | Activation of specific apoptotic caspases with an engineered small - molecule - activated protease显示文摘 | GRAY D C MAHRUS S WELLS J A | 2010 | Cell2010，142，4： | 1 |
| 19 | Transfusion requirements in critical care: a pilot study显示文摘 | Hebert PC Wells G Marshall J | 1995 | JAMA1995，273，： | 1 |
| 20 | The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses显示文摘 | Abbott M Wells D Fallon J | 1999 | J Neurosci1999，19，： | 1 |
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